Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHSUQ1)

• Drug Name: R-ketoprofen Drug Info
• Synonyms: (R)-Ketoprofen; 56105-81-8; (R)-Ketoprophen; UNII-S03709D0TH; (R)-(-)-Ketoprofen; (R)-2-(3-benzoylphenyl)propanoic acid; CHEMBL372052; S03709D0TH; (R)-2-(3-Benzoylphenyl)propionic acid; Benzeneacetic acid,3-benzoyl-a-methyl-, (aR)-; Ketoprofen, (R)-; NCGC00016757-01; CAS-22071-15-4; (2R)-2-(3-benzoylphenyl)propanoic acid; Lopac-K-1751; SCHEMBL195303; ZINC2272; AC1L47D6; CTK5A4646; DTXSID50204652; DKYWVDODHFEZIM-LLVKDONJSA-N; BDBM50169048; AKOS022182275
• Cross-matching ID:
  PubChem CID: 180540
  CAS Number: CAS 56105-81-8
  TTD Drug ID: DMHSUQ1

Molecule-Related Drug Atlas

Drug(s) Targeting C-X-C chemokine receptor type 1 (CXCR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[1]
Reparixin	DMVBA7I	Pancreatic islet transplantation failure	NE84	Phase 3	[1]
SCH-527123	DMPUAOE	Chronic obstructive pulmonary disease	CA22	Phase 2	[3]
SX-682	DMHMG6X	Melanoma	2C30	Phase 1	[4]
INDOPROFEN	DM5QSKN	Gout	FA25	Withdrawn from market	[1]
2-(3-Isopropyl-phenyl)-propionic acid	DMUOWNE	Discovery agent	N.A.	Investigative	[1]
2-[3-(1-Phenyl-ethyl)-phenyl]-propionic acid	DMWIUR0	Discovery agent	N.A.	Investigative	[1]
(R)-2-(4-Isobutyl-phenyl)-propionamide	DMBQ0PR	Discovery agent	N.A.	Investigative	[1]
(R)-N-Hydroxy-2-(4-isobutyl-phenyl)-propionamide	DMWRIQG	Discovery agent	N.A.	Investigative	[1]
2-[3-(2-Methyl-butyl)-phenyl]-propionic acid	DMKSDT4	Discovery agent	N.A.	Investigative	[1]

Drug(s) Targeting Interleukin-8 (IL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[2]
ABX-IL8	DMCZFMS	Melanoma	2C30	Phase 2	[5]
BMS-986253	DM42B0C	Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[6]
MDX-018	DML5FX2	Autoimmune diabetes	5A10	Phase 1	[7]
2-(2-(2,5-dichlorophenylamino)phenyl)acetic acid	DM54M6C	Discovery agent	N.A.	Investigative	[2]
2-(2-(2-chlorophenylamino)phenyl)acetic acid	DMPLV3A	Discovery agent	N.A.	Investigative	[2]
2-(2-(2-fluorophenylamino)phenyl)acetic acid	DMVQ68F	Discovery agent	N.A.	Investigative	[2]
2-(2-(2-chlorophenoxy)phenyl)acetic acid	DMBP1TQ	Discovery agent	N.A.	Investigative	[2]
2-(2-(2-fluorophenoxy)phenyl)acetic acid	DMDSUR2	Discovery agent	N.A.	Investigative	[2]

Drug(s) Targeting C-X-C chemokine receptor type 2 (CXCR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[1]
Clotrimazole	DMMFCIH	Cutaneous candidiasis	1F23.14	Approved	[8]
Reparixin	DMVBA7I	Pancreatic islet transplantation failure	NE84	Phase 3	[1]
SCH-527123	DMPUAOE	Chronic obstructive pulmonary disease	CA22	Phase 2	[9]
SB-265610	DM8TKG5	Asthma	CA23	Phase 2	[10]
AZD-5069	DM3JSFK	Asthma	CA23	Phase 2	[11]
PS-938285	DMHZIFJ	Chronic obstructive pulmonary disease	CA22	Phase 2	[12]
GSK1325756	DMA6RBF	Chronic obstructive pulmonary disease	CA22	Phase 2	[13]
SB-656933	DMCY785	Chronic obstructive pulmonary disease	CA22	Phase 2	[14]
RIST4721	DMA3DKO	Hidradenitis suppurativa	ED92.0	Phase 2	[15]

Drug(s) Targeting Prostaglandin G/H synthase 1 (COX-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[16]
Naproxen	DMZ5RGV	Bursitis		Approved	[17]
Mesalazine	DMOL5IU	Diverticulitis		Approved	[18]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[19]
Bromfenac	DMKB79O	Pain	MG30-MG3Z	Approved	[20]
Aminosalicylic Acid	DMENSL5	Crohn disease	DD70	Approved	[21]
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[22]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[21]
Suprofen	DMKXJZ7	Miosis	LA11.62	Approved	[23]
Gamma-Homolinolenic acid	DMSXKYG	Malnutrition	5B50-5B71	Approved	[24]

Drug(s) Targeting Prostaglandin G/H synthase 2 (COX-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[25]
Naproxen	DMZ5RGV	Bursitis		Approved	[17]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[26]
Indomethacin	DMSC4A7	Bursitis		Approved	[21]
Celecoxib	DM6LOQU	Dysmenorrhea	GA34.3	Approved	[27]
Nabumetone	DMAT2XH	Osteoarthritis	FA00-FA05	Approved	[28]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[29]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[30]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[19]
Aminosalicylic Acid	DMENSL5	Crohn disease	DD70	Approved	[21]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
C-X-C chemokine receptor type 1 (CXCR1)	TTMWT8Z	CXCR1_HUMAN	Inhibitor	[1]
C-X-C chemokine receptor type 2 (CXCR2)	TT30C9G	CXCR2_HUMAN	Inhibitor	[1]
Interleukin-8 (IL8)	TTCTE1G	IL8_HUMAN	Inhibitor	[2]
Prostaglandin G/H synthase 1 (COX-1)	TT8NGED	PGH1_HUMAN	Inhibitor	[1]
Prostaglandin G/H synthase 2 (COX-2)	TTVKILB	PGH2_HUMAN	Inhibitor	[1]

References

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• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] Inhibition of MDSC Trafficking with SX-682, a CXCR1/2 Inhibitor, Enhances NK-Cell Immunotherapy in Head and Neck Cancer Models. Clin Cancer Res. 2020 Mar 15;26(6):1420-1431.
• [5] Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma. Am J Pathol. 2002 Jul;161(1):125-34.
• [6] Phase I trial of HuMax-IL8 (BMS-986253), an anti-IL-8 monoclonal antibody, in patients with metastatic or unresectable solid tumors. J Immunother Cancer. 2019 Sep 5;7(1):240.
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• [14] Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
• [15] A Randomized, Double-Blind, Placebo-Controlled, Phase 2a Study to Evaluate the Efficacy and Safety of RIST4721 in Subjects with Palmoplantar Pustulosis. Dermatol Ther (Heidelb). 2021 Dec;11(6):2179-2193.
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• [17] Comparative inhibitory activity of rofecoxib, meloxicam, diclofenac, ibuprofen, and naproxen on COX-2 versus COX-1 in healthy volunteers. J Clin Pharmacol. 2000 Oct;40(10):1109-20.
• [18] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [19] Cox-2 inhibitory effects of naturally occurring and modified fatty acids. J Nat Prod. 2001 Jun;64(6):745-9.
• [20] Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodium. Curr Med Res Opin. 2006 Jun;22(6):1133-40.
• [21] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [22] Ouellet M, Percival MD: Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms. Biochem J. 1995 Feb 15;306 ( Pt 1):247-51.
• [23] Differential binding mode of diverse cyclooxygenase inhibitors. J Mol Graph Model. 2002 Mar;20(5):359-71.
• [24] Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2. Biochem J. 2002 Jul 15;365(Pt 2):489-96.
• [25] Maternal toxicity of nonsteroidal anti-inflammatory drugs as an important factor affecting prenatal development. Reprod Toxicol. 2009 Sep;28(2):239-44.
• [26] Membranous nephropathy associated with the relatively selective cyclooxygenase-2 inhibitor, etodolac, in a patient with early rheumatoid arthritis. Intern Med. 2007;46(13):1055-8.
• [27] Pfizer. Product Development Pipeline. March 31 2009.
• [28] Renal effects of nabumetone, a COX-2 antagonist: impairment of function in isolated perfused rat kidneys contrasts with preserved renal function in vivo. Exp Nephrol. 2001;9(6):387-96.
• [29] Privileged structures: a useful concept for the rational design of new lead drug candidates. Mini Rev Med Chem. 2007 Nov;7(11):1108-19.
• [30] Flurbiprofen, a cyclooxygenase inhibitor, protects mice from hepatic ischemia/reperfusion injury by inhibiting GSK-3 signaling and mitochondrial permeability transition.Mol Med.2012 Sep 25;18:1128-35.