Details of the Drug

General Information of Drug (ID: DMKB79O)

• Drug Name: Bromfenac
• Synonyms: Bromfenaco; Bromfenacum; Duract; Xibrom; BROMFENAC SODIUM; Bromfenac [INN]; Bromfenaco [Spanish]; Bromfenacum [Latin]; AHR-10282; Bromfenac (INN); Duract (TN); Xibrom (TN); Sodium 2-amino-3-(4-bromobenzoyl) phenylacetate sesquihydrate; [2-amino-3-(4-bromobenzoyl)phenyl]acetic acid; {2-amino-3-[(4-bromophenyl)carbonyl]phenyl}acetic acid; [2-Amino-3-(4-bromo-benzoyl)-phenyl]-acetic acid; 2-Amino-3-(4-bromobenzoyl)benzeneacetic acid; 2-[2-amino-3-(4-bromobenzoyl)phenyl]acetic acid

Indication

Disease Entry	ICD 11	Status	REF
Pain	MG30-MG3Z	Approved	[1]
Postoperative inflammation	1A00-CA43.1	Approved	[2]
Inflammation	1A00-CA43.1	Withdrawn from market	[2]

• Therapeutic Class: Antiinflammatory Agents
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 334.16
  Logarithm of the Partition Coefficient (xlogp); 3.3
  Rotatable Bond Count (rotbonds); 4
  Hydrogen Bond Donor Count (hbonddonor); 2
  Hydrogen Bond Acceptor Count (hbondacc); 4
• ADMET Property:
  BDDCS Class: Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 2: low solubility and high permeability [3]
  Bioavailability: 67% of drug becomes completely available to its intended biological destination(s) [4]
  Clearance: The drug present in the plasma can be removed from the body at the rate of 1.3 mL/min/kg [5]
  Half-life: The concentration or amount of drug in body reduced by one-half in 2.6 hours [5]
  MRTD: The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 4.275 micromolar/kg/day [6]
  Unbound Fraction: The unbound fraction of drug in plasma is 0.0011% [5]
  Vd: Fluid volume that would be required to contain the amount of drug present in the body at the same concentration as in the plasma 0.11 L/kg [5]
• Chemical Identifiers:
  Formula: C15H12BrNO3
  IUPAC Name: 2-[2-amino-3-(4-bromobenzoyl)phenyl]acetic acid
  Canonical SMILES: C1=CC(=C(C(=C1)C(=O)C2=CC=C(C=C2)Br)N)CC(=O)O
  InChI: InChI=1S/C15H12BrNO3/c16-11-6-4-9(5-7-11)15(20)12-3-1-2-10(14(12)17)8-13(18)19/h1-7H,8,17H2,(H,18,19)
  InChIKey: ZBPLOVFIXSTCRZ-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 60726
  ChEBI ID: CHEBI:240107
  CAS Number: 91714-94-2
  DrugBank ID: DB00963
  TTD ID: D0U1OM
  VARIDT ID: DR01332
  INTEDE ID: DR1765
• Repurposed Drugs (RPD): Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin G/H synthase 1 (COX-1)	TT8NGED	PGH1_HUMAN	Inhibitor	[7]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Organic anion transporting polypeptide 1B1 (SLCO1B1)	DT3D8F0	SO1B1_HUMAN	Substrate	[8]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Substrate	[9]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Substrate	[9]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Substrate	[9]
UDP-glucuronosyltransferase 2B7 (UGT2B7)	DEB3CV1	UD2B7_HUMAN	Substrate	[9]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Antileukoproteinase (SLPI)	OTUNFUU8	SLPI_HUMAN	Gene/Protein Processing	[10]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Gene/Protein Processing	[11]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Gene/Protein Processing	[11]
Bone morphogenetic protein 6 (BMP6)	OT9WN536	BMP6_HUMAN	Gene/Protein Processing	[10]
Cystine/glutamate transporter (SLC7A11)	OTKJ6PXW	XCT_HUMAN	Gene/Protein Processing	[10]
Cytochrome P450 1A2 (CYP1A2)	OTLLBX48	CP1A2_HUMAN	Regulation of Drug Effects	[9]
Cytochrome P450 2C19 (CYP2C19)	OTFMJYYE	CP2CJ_HUMAN	Biotransformations	[9]
Cytochrome P450 2C8 (CYP2C8)	OTHCWT42	CP2C8_HUMAN	Biotransformations	[9]
Cytochrome P450 2C9 (CYP2C9)	OTGLBN29	CP2C9_HUMAN	Biotransformations	[9]
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Regulation of Drug Effects	[9]

Molecular Expression Atlas of This Drug

• The Studied Disease: Pain
• ICD Disease Classification: MG30-MG3Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Prostaglandin G/H synthase 1 (COX-1)	DTT	PTGS1	3.97E-03	0.16	0.43
Organic anion transporting polypeptide 1B1 (SLCO1B1)	DTP	OATP1B1	8.15E-01	6.20E-03	5.61E-02
Cytochrome P450 2C8 (CYP2C8)	DME	CYP2C8	1.82E-04	-1.35E-01	-5.84E-01
Mephenytoin 4-hydroxylase (CYP2C19)	DME	CYP2C19	2.40E-01	-3.31E-02	-1.97E-01
Cytochrome P450 2C9 (CYP2C9)	DME	CYP2C9	1.90E-01	-9.81E-03	-5.96E-02

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Bromfenac (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Remdesivir	DMBFZ6L	Moderate	Increased risk of hepatotoxicity by the combination of Bromfenac and Remdesivir.	1D6YCoronavirus Disease 2019 [1D6YCoronavirus Disease 2019]	[12]
Glibenclamide	DM8JXPZ	Moderate	Increased risk of hypoglycemia by the combination of Bromfenac and Glibenclamide.	Acute diabete complication [5A2Y]	[13]
Glipizide	DMZA5PQ	Moderate	Increased risk of hypoglycemia by the combination of Bromfenac and Glipizide.	Acute diabete complication [5A2Y]	[13]
Inotersen	DMJ93CT	Major	Increased risk of nephrotoxicity by the combination of Bromfenac and Inotersen.	Amyloidosis [5D00]	[14]
Bedaquiline	DM3906J	Moderate	Increased risk of hepatotoxicity by the combination of Bromfenac and Bedaquiline.	Antimicrobial drug resistance [MG50-MG52]	[15]
Cilostazol	DMZMSCT	Moderate	Increased risk of bleeding by the combination of Bromfenac and Cilostazol.	Arterial occlusive disease [BD40]	[16]
Budesonide	DMJIBAW	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Bromfenac and Budesonide.	Asthma [CA23]	[17]
Ofloxacin	DM0VQN3	Moderate	Additive CNS stimulant effects by the combination of Bromfenac and Ofloxacin.	Bacterial infection [1A00-1C4Z]	[18]
Kanamycin	DM2DMPO	Moderate	Increased risk of nephrotoxicity by the combination of Bromfenac and Kanamycin.	Bacterial infection [1A00-1C4Z]	[19]
Streptomycin	DME1LQN	Moderate	Increased risk of nephrotoxicity by the combination of Bromfenac and Streptomycin.	Bacterial infection [1A00-1C4Z]	[19]
Gemifloxacin	DMHT34O	Moderate	Additive CNS depression effects by the combination of Bromfenac and Gemifloxacin.	Bacterial infection [1A00-1C4Z]	[18]
Norfloxacin	DMIZ6W2	Moderate	Additive CNS stimulant effects by the combination of Bromfenac and Norfloxacin.	Bacterial infection [1A00-1C4Z]	[20]
ABT-492	DMJFD2I	Moderate	Additive CNS depression effects by the combination of Bromfenac and ABT-492.	Bacterial infection [1A00-1C4Z]	[18]
Levofloxacin	DMS60RB	Moderate	Additive CNS stimulant effects by the combination of Bromfenac and Levofloxacin.	Bacterial infection [1A00-1C4Z]	[18]
Etidronic acid	DM1XHYJ	Moderate	Increased risk of nephrotoxicity by the combination of Bromfenac and Etidronic acid.	Bone paget disease [FB85]	[21]
Pexidartinib	DMS2J0Z	Major	Increased risk of hepatotoxicity by the combination of Bromfenac and Pexidartinib.	Bone/articular cartilage neoplasm [2F7B]	[22]
Trastuzumab Emtansine	DMU1LXS	Moderate	Increased risk of bleeding by the combination of Bromfenac and Trastuzumab Emtansine.	Breast cancer [2C60-2C6Y]	[16]
Levomilnacipran	DMV26S8	Moderate	Increased risk of bleeding by the combination of Bromfenac and Levomilnacipran.	Chronic pain [MG30]	[23]
Anisindione	DM2C48U	Moderate	Increased risk of bleeding by the combination of Bromfenac and Anisindione.	Coagulation defect [3B10]	[16]
Regorafenib	DMHSY1I	Major	Increased risk of bleeding by the combination of Bromfenac and Regorafenib.	Colorectal cancer [2B91]	[14]
Drospirenone	DM1A9W3	Moderate	Increased risk of hyperkalemia by the combination of Bromfenac and Drospirenone.	Contraceptive management [QA21]	[24]
Ardeparin	DMYRX8B	Major	Increased risk of bleeding by the combination of Bromfenac and Ardeparin.	Coronary thrombosis [BA43]	[25]
Danaparoid	DM6CLBN	Moderate	Increased risk of bleeding by the combination of Bromfenac and Danaparoid.	Deep vein thrombosis [BD71]	[16]
Rivaroxaban	DMQMBZ1	Major	Increased risk of bleeding by the combination of Bromfenac and Rivaroxaban.	Deep vein thrombosis [BD71]	[26]
Sertraline	DM0FB1J	Moderate	Increased risk of bleeding by the combination of Bromfenac and Sertraline.	Depression [6A70-6A7Z]	[23]
Vilazodone	DM4LECQ	Moderate	Increased risk of bleeding by the combination of Bromfenac and Vilazodone.	Depression [6A70-6A7Z]	[23]
Vortioxetine	DM6F1PU	Moderate	Increased risk of bleeding by the combination of Bromfenac and Vortioxetine.	Depression [6A70-6A7Z]	[23]
Milnacipran	DMBFE74	Moderate	Increased risk of bleeding by the combination of Bromfenac and Milnacipran.	Depression [6A70-6A7Z]	[23]
Escitalopram	DMFK9HG	Moderate	Increased risk of bleeding by the combination of Bromfenac and Escitalopram.	Depression [6A70-6A7Z]	[23]
Desvenlafaxine	DMHD4PE	Moderate	Increased risk of bleeding by the combination of Bromfenac and Desvenlafaxine.	Depression [6A70-6A7Z]	[23]
Clomipramine	DMINRKW	Moderate	Increased risk of bleeding by the combination of Bromfenac and Clomipramine.	Depression [6A70-6A7Z]	[23]
Cannabidiol	DM0659E	Moderate	Increased risk of hepatotoxicity by the combination of Bromfenac and Cannabidiol.	Epileptic encephalopathy [8A62]	[14]
Tazemetostat	DMWP1BH	Moderate	Increased risk of bleeding by the combination of Bromfenac and Tazemetostat.	Follicular lymphoma [2A80]	[16]
Avapritinib	DMK2GZX	Major	Increased risk of bleeding by the combination of Bromfenac and Avapritinib.	Gastrointestinal stromal tumour [2B5B]	[14]
Sulfinpyrazone	DMEV954	Moderate	Increased risk of bleeding by the combination of Bromfenac and Sulfinpyrazone.	Gout [FA25]	[16]
Brentuximab vedotin	DMWLC57	Moderate	Increased risk of hepatotoxicity by the combination of Bromfenac and Brentuximab vedotin.	Hodgkin lymphoma [2B30]	[27]
Mipomersen	DMGSRN1	Major	Increased risk of hepatotoxicity by the combination of Bromfenac and Mipomersen.	Hyper-lipoproteinaemia [5C80]	[28]
Teriflunomide	DMQ2FKJ	Major	Increased risk of hepatotoxicity by the combination of Bromfenac and Teriflunomide.	Hyper-lipoproteinaemia [5C80]	[29]
BMS-201038	DMQTAGO	Major	Increased risk of hepatotoxicity by the combination of Bromfenac and BMS-201038.	Hyper-lipoproteinaemia [5C80]	[30]
Hydrochlorothiazide	DMUSZHD	Moderate	Antagonize the effect of Bromfenac when combined with Hydrochlorothiazide.	Hypertension [BA00-BA04]	[31]
Dipyridamole	DMXY30O	Moderate	Increased risk of bleeding by the combination of Bromfenac and Dipyridamole.	Hypertension [BA00-BA04]	[16]
Balsalazide	DM7I1T9	Moderate	Increased risk of nephrotoxicity by the combination of Bromfenac and Balsalazide.	Indeterminate colitis [DD72]	[32]
Calaspargase pegol	DMQZBXI	Moderate	Increased risk of bleeding by the combination of Bromfenac and Calaspargase pegol.	Malignant haematopoietic neoplasm [2B33]	[33]
Idelalisib	DM602WT	Moderate	Increased risk of hepatotoxicity by the combination of Bromfenac and Idelalisib.	Mature B-cell leukaemia [2A82]	[34]
Acalabrutinib	DM7GCVW	Major	Increased risk of bleeding by the combination of Bromfenac and Acalabrutinib.	Mature B-cell lymphoma [2A85]	[35]
Ibrutinib	DMHZCPO	Major	Increased risk of bleeding by the combination of Bromfenac and Ibrutinib.	Mature B-cell lymphoma [2A85]	[36]
Ponatinib	DMYGJQO	Major	Increased risk of bleeding by the combination of Bromfenac and Ponatinib.	Mature B-cell lymphoma [2A85]	[37]
Exjade	DMHPRWG	Major	Increased risk of nephrotoxicity by the combination of Bromfenac and Exjade.	Mineral absorption/transport disorder [5C64]	[38]
Panobinostat	DM58WKG	Major	Increased risk of bleeding by the combination of Bromfenac and Panobinostat.	Multiple myeloma [2A83]	[12]
Deflazacort	DMV0RNS	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Bromfenac and Deflazacort.	Muscular dystrophy [8C70]	[17]
Ruxolitinib	DM7Q98D	Moderate	Increased risk of bleeding by the combination of Bromfenac and Ruxolitinib.	Myeloproliferative neoplasm [2A20]	[16]
Dasatinib	DMJV2EK	Major	Increased risk of bleeding by the combination of Bromfenac and Dasatinib.	Myeloproliferative neoplasm [2A20]	[39]
Omacetaxine mepesuccinate	DMPU2WX	Major	Increased risk of bleeding by the combination of Bromfenac and Omacetaxine mepesuccinate.	Myeloproliferative neoplasm [2A20]	[40]
Prasugrel	DM7MT6E	Major	Increased risk of bleeding by the combination of Bromfenac and Prasugrel.	Myocardial infarction [BA41-BA43]	[14]
Vorapaxar	DMA16BR	Major	Increased risk of bleeding by the combination of Bromfenac and Vorapaxar.	Myocardial infarction [BA41-BA43]	[41]
Sibutramine	DMFJTDI	Moderate	Increased risk of bleeding by the combination of Bromfenac and Sibutramine.	Obesity [5B80-5B81]	[42]
Polythiazide	DMCH80F	Moderate	Antagonize the effect of Bromfenac when combined with Polythiazide.	Oedema [MG29]	[43]
MK-4827	DMLYGH4	Moderate	Increased risk of bleeding by the combination of Bromfenac and MK-4827.	Ovarian cancer [2C73]	[14]
Epoprostenol	DMUTYR2	Moderate	Increased risk of bleeding by the combination of Bromfenac and Epoprostenol.	Pulmonary hypertension [BB01]	[44]
Iloprost	DMVPZBE	Moderate	Increased risk of bleeding by the combination of Bromfenac and Iloprost.	Pulmonary hypertension [BB01]	[44]
Everolimus	DM8X2EH	Major	Increased risk of nephrotoxicity by the combination of Bromfenac and Everolimus.	Renal cell carcinoma [2C90]	[45]
Temsirolimus	DMS104F	Major	Increased risk of nephrotoxicity by the combination of Bromfenac and Temsirolimus.	Renal cell carcinoma [2C90]	[45]
Gatifloxacin	DMSL679	Moderate	Additive CNS stimulant effects by the combination of Bromfenac and Gatifloxacin.	Respiratory infection [CA07-CA4Z]	[20]
Dexamethasone	DMMWZET	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Bromfenac and Dexamethasone.	Rheumatoid arthritis [FA20]	[17]
Leflunomide	DMR8ONJ	Major	Increased risk of hepatotoxicity by the combination of Bromfenac and Leflunomide.	Rheumatoid arthritis [FA20]	[29]
Trabectedin	DMG3Y89	Moderate	Increased risk of hepatotoxicity by the combination of Bromfenac and Trabectedin.	Solid tumour/cancer [2A00-2F9Z]	[14]
Pitolisant	DM8RFNJ	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Bromfenac and Pitolisant.	Somnolence [MG42]	[14]
Plicamycin	DM7C8YV	Moderate	Increased risk of bleeding by the combination of Bromfenac and Plicamycin.	Testicular cancer [2C80]	[16]
Caplacizumab	DMPUKA7	Moderate	Increased risk of bleeding by the combination of Bromfenac and Caplacizumab.	Thrombocytopenia [3B64]	[16]
Apixaban	DM89JLN	Major	Increased risk of bleeding by the combination of Bromfenac and Apixaban.	Thrombosis [DB61-GB90]	[14]
Cangrelor	DM8JRH0	Moderate	Increased risk of bleeding by the combination of Bromfenac and Cangrelor.	Thrombosis [DB61-GB90]	[16]
Brilinta	DMBR01X	Moderate	Increased risk of bleeding by the combination of Bromfenac and Brilinta.	Thrombosis [DB61-GB90]	[14]
Cabozantinib	DMIYDT4	Major	Increased risk of bleeding by the combination of Bromfenac and Cabozantinib.	Thyroid cancer [2D10]	[46]
Tolbutamide	DM02AWV	Moderate	Increased risk of hypoglycemia by the combination of Bromfenac and Tolbutamide.	Type 2 diabetes mellitus [5A11]	[47]
Olsalazine	DMZW9HA	Moderate	Increased risk of nephrotoxicity by the combination of Bromfenac and Olsalazine.	Ulcerative colitis [DD71]	[32]
Plazomicin	DMKMBES	Moderate	Increased risk of nephrotoxicity by the combination of Bromfenac and Plazomicin.	Urinary tract infection [GC08]	[48]
Betrixaban	DM2C4RF	Major	Increased risk of bleeding by the combination of Bromfenac and Betrixaban.	Venous thromboembolism [BD72]	[49]

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