Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJ7A0H)

• Drug Name: Cefdinir Drug Info
• Synonyms: CFDN; Cefdinirum; Cefdinyl; Cefdirnir; Cefzon; Omnicef; BMY 28488; FK 482; PD 134393; Cefdinir [USAN:INN]; Cefdinirum [INN-Latin]; Cefzon (TN); FK-482; FR-80482; KS-1038; Omnicef (TN); PD-134393; Cefdinir (JP15/USAN/INN); Omnicef, FK-482, BMY-28488, PD 134393, CI-983, Cefdinir; (-)-(6R,7R)-7-(2-(2-Amino-4-thiazolyl)glyoxylamido)-8-oxo-3-vinyl-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7(sup 2)-(Z)-oxime; (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-hydroxyiminoacetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(hydroxyimino)acetyl]amino}-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7-(2 (2-aminothiazol-4-yl)-2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4-carboxylic acid; 7beta-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(hydroxyimino)acetamido]-3-ethenyl-3,4-didehydrocepham-4-carboxylic acid

Indication

Disease Entry	ICD 11	Status	REF
Bacterial infection	1A00-1C4Z	Approved	[1]
Staphylococcus aureus infection		Approved	[2]

• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 6915944
  ChEBI ID: CHEBI:3485
  CAS Number: CAS 91832-40-5
  TTD Drug ID: DMJ7A0H
  VARIDT Drug ID: DR00692
  ACDINA Drug ID: D00106

Molecule-Related Drug Atlas

Drug(s) Targeting Bacterial Penicillin binding protein (Bact PBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[6]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[7]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[8]
Ticarcillin	DM4ME02	Aspiration pneumonia		Approved	[9]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[10]
Meropenem	DM62UHC	Bacterial infection	1A00-1C4Z	Approved	[8]
Cefadroxil	DMMC345	Bacterial infection	1A00-1C4Z	Approved	[11]
Clofarabine	DMCVJ86	Acute lymphoblastic leukaemia	2A85	Approved	[12]
Cephalexin	DMD5JU8	Acute otitis media	AB00	Approved	[13]
Carbenicillin	DMLEDNK	Infection of the upper and lower urinary tract	GC08	Approved	[14]

Drug(s) Transported By Peptide transporter 1 (SLC15A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[15]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[16]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[17]
Losartan	DM72JXH	Diabetic kidney disease	GB61.Z	Approved	[18]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[19]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[20]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[21]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[16]
Cefadroxil	DMMC345	Bacterial infection	1A00-1C4Z	Approved	[18]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[18]

Drug(s) Transported By Organic anion transporter 3 (SLC22A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[23]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[24]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[25]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[26]
L-Tryptophan	DMIBH7M	Depression	6A70-6A7Z	Approved	[27]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[28]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[29]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[30]
Cilostazol	DMZMSCT	Intermittent claudication	BD40.00	Approved	[31]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[32]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[33]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[34]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[25]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[35]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[35]
Cefaclor	DMJXDGC	Bacterial infection	1A00-1C4Z	Approved	[5]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[36]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[38]

Drug(s) Affected By Solute carrier family 22 member 6 (SLC22A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[33]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[39]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[38]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[39]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[39]
Succinic acid	DMDWICP	Malnutrition	5B50-5B71	Approved	[40]
Mefenamic acid	DMK7HFI	Dysmenorrhea	GA34.3	Approved	[39]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[41]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[39]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Penicillin binding protein (Bact PBP)	TTJP4SM	NOUNIPROTAC	Binder	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Peptide transporter 1 (SLC15A1)	DT9G7XN	S15A1_HUMAN	Substrate	[4]
Organic anion transporter 3 (SLC22A8)	DTVP67E	S22A8_HUMAN	Substrate	[5]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Organic anion transporter 3 (SLC22A8)	OT8BY933	S22A8_HUMAN	Regulation of Drug Effects	[5]
Solute carrier family 22 member 6 (SLC22A6)	OTKRCBVM	S22A6_HUMAN	Regulation of Drug Effects	[5]

References

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• [2] Cefdinir FDA Label
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• [22] Methotrexate-loxoprofen interaction: involvement of human organic anion transporters hOAT1 and hOAT3. Drug Metab Pharmacokinet. 2004 Oct;19(5):369-74.
• [23] Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8.
• [24] Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24.
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• [31] Aspirin and probenecid inhibit organic anion transporter 3-mediated renal uptake of cilostazol and probenecid induces metabolism of cilostazol in the rat. Drug Metab Dispos. 2014 Jun;42(6):996-1007.
• [32] Uric acid accumulation in the kidney triggers mast cell degranulation and aggravates renal oxidative stress. Toxicology. 2023 Jan 1;483:153387. doi: 10.1016/j.tox.2022.153387. Epub 2022 Dec 1.
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• [38] Potent Inhibitors of Organic Anion Transporters 1 and 3 From Natural Compounds and Their Protective Effect on Aristolochic Acid Nephropathy. Toxicol Sci. 2020 Jun 1;175(2):279-291. doi: 10.1093/toxsci/kfaa033.
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