Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKVTZN)

Drug Name
Go 6983 Drug Info
Synonyms Goe 6983; Go-6893
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
3499
ChEBI ID
CHEBI:91455
CAS Number
CAS 133053-19-7
TTD Drug ID
DMKVTZN

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Protein kinase C alpha (PRKCA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sodium phenylbutyrate DMXLBCQ Spinal muscular atrophy 8B61 Approved [5]
Sotrastaurin acetate DME53YS Renal transplantation NE84 Phase 2 [6]
PMID28460551-Compound-3 DMA1FRM N. A. N. A. Patented [7]
ISIS 3521 DMZFS69 N. A. N. A. Discontinued in Phase 2 [8]
BALANOL DMDLN9E N. A. N. A. Terminated [9]
RO-320432 DMFZ1YW N. A. N. A. Terminated [10]
LY-317644 DMM20PI N. A. N. A. Terminated [11]
Acteoside DM0YHKB Nephritis GB40 Terminated [12]
RO-316233 DMAGLPW Discovery agent N.A. Investigative [13]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole DMN9YOB Discovery agent N.A. Investigative [14]
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Drug(s) Targeting Protein kinase C beta (PRKCB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Enzastaurin DM5H0R9 Diffuse large B-cell lymphoma 2A81 Phase 3 [15]
RUBOXISTAURIN HYDROCHLORIDE DMQOCD8 Lymphoma 2A80-2A86 Phase 3 [16]
Sotrastaurin acetate DME53YS Renal transplantation NE84 Phase 2 [6]
LY333531 DMGMC8H Solid tumour/cancer 2A00-2F9Z Phase 2 [17]
MS-553 DM7ER9J Chronic lymphocytic leukaemia 2A82.0 Phase 1 [18]
Linetastine DMF8B62 Rhinitis FA20 Discontinued in Phase 2 [19]
BALANOL DMDLN9E N. A. N. A. Terminated [9]
RO-320432 DMFZ1YW N. A. N. A. Terminated [10]
LY-317644 DMM20PI N. A. N. A. Terminated [11]
RO-316233 DMAGLPW Discovery agent N.A. Investigative [13]
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Drug(s) Targeting Protein kinase C gamma (PRKCG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [20]
BALANOL DMDLN9E N. A. N. A. Terminated [9]
RO-320432 DMFZ1YW N. A. N. A. Terminated [10]
LY-317644 DMM20PI N. A. N. A. Terminated [11]
RO-316233 DMAGLPW Discovery agent N.A. Investigative [13]
Bisindolylmaleimide-I DMOQJZC Discovery agent N.A. Investigative [21]
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione DMDO175 Discovery agent N.A. Investigative [22]
3,4-diphenyl-1H-pyrrole-2,5-dione DMPK6YT Discovery agent N.A. Investigative [22]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione DMGC7RY Discovery agent N.A. Investigative [22]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione DM3EV9N Discovery agent N.A. Investigative [22]
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Drug(s) Targeting PKC-delta messenger RNA (PRKCD mRNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BALANOL DMDLN9E N. A. N. A. Terminated [9]
Bisindolylmaleimide-I DMOQJZC Discovery agent N.A. Investigative [21]
LY-326449 DMN53M4 Discovery agent N.A. Investigative [23]
PROSTRATIN DM1HMJ5 Human immunodeficiency virus infection 1C62 Investigative [24]
8-Octyl-benzolactam-V9 DM4Z15M Discovery agent N.A. Investigative [25]
Diheptan-3-yl 5-(hydroxymethyl)isophthalate DMBAY7P Discovery agent N.A. Investigative [26]
Dihexan-3-yl 5-(hydroxymethyl)isophthalate DM8TBQ9 Discovery agent N.A. Investigative [26]
ISIS 10310 DMT6H9S Discovery agent N.A. Investigative [27]
ISIS 17252 DMW40NK Discovery agent N.A. Investigative [28]
ISIS 10303 DM205TE Discovery agent N.A. Investigative [27]
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Drug(s) Targeting PKC-zeta messenger RNA (PRKCZ mRNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BALANOL DMDLN9E N. A. N. A. Terminated [9]
LY-326449 DMN53M4 Discovery agent N.A. Investigative [23]
ISIS 9008 DMQDZF2 Discovery agent N.A. Investigative [27]
ISIS 9022 DM7TRSB Discovery agent N.A. Investigative [27]
ISIS 9023 DMO2V5C Discovery agent N.A. Investigative [27]
ISIS 9007 DMGK2TQ Discovery agent N.A. Investigative [27]
ISIS 9025 DMAQ7XH Discovery agent N.A. Investigative [27]
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Drug(s) Affected By Transient receptor potential cation channel subfamily A member 1 (TRPA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [29]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [31]
Capsaicin DMGMF6V Back pain ME84.Z Approved [32]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [33]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [30]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [34]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [35]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [3]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [36]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [37]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [38]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [39]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [40]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [41]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [42]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [43]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [44]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [45]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [43]
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Drug(s) Affected By Neurotensin/neuromedin N (NTS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [46]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [49]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [50]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [51]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [52]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [53]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [47]
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Drug(s) Affected By Calponin-1 (CNN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [55]
Testosterone DM7HUNW Hot flushes GA30 Approved [56]
Leflunomide DMR8ONJ Arthritis FA20 Approved [57]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [58]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [31]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [59]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [33]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [60]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [61]
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Drug(s) Affected By Transgelin (TAGLN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [62]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [64]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [62]
Methotrexate DM2TEOL Anterior urethra cancer Approved [65]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [62]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
Fluoxetine DM3PD2C Bipolar depression Approved [62]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [55]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [64]
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Drug(s) Affected By Transient receptor potential cation channel subfamily V member 1 (TRPV1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
Leflunomide DMR8ONJ Arthritis FA20 Approved [57]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [69]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [70]
Menthol DMG2KW7 Back pain ME84.Z Approved [32]
Capsaicin DMGMF6V Back pain ME84.Z Approved [71]
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [72]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PKC-delta messenger RNA (PRKCD mRNA) TT7A1BO KPCD_HUMAN Inhibitor [1]
PKC-zeta messenger RNA (PRKCZ mRNA) TTBSN0L KPCZ_HUMAN Inhibitor [1]
Protein kinase C alpha (PRKCA) TTFJ8Q1 KPCA_HUMAN Inhibitor [1]
Protein kinase C beta (PRKCB) TTYPXQF KPCB_HUMAN Inhibitor [1]
Protein kinase C gamma (PRKCG) TTRFOXJ KPCG_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Calponin-1 (CNN1) OTVPG39Z CNN1_HUMAN Gene/Protein Processing [2]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [3]
Neurotensin/neuromedin N (NTS) OTPGDNQS NEUT_HUMAN Gene/Protein Processing [4]
Transgelin (TAGLN) OTAEZ0KP TAGL_HUMAN Gene/Protein Processing [2]
Transient receptor potential cation channel subfamily A member 1 (TRPA1) OTRDIR5M TRPA1_HUMAN Gene/Protein Processing [3]
Transient receptor potential cation channel subfamily V member 1 (TRPV1) OTHHDR03 TRPV1_HUMAN Gene/Protein Processing [3]

References

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62 A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol Sci. 2005 Feb;83(2):282-92.
63 Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
64 In vitro detection of drug-induced phospholipidosis using gene expression and fluorescent phospholipid based methodologies. Toxicol Sci. 2007 Sep;99(1):162-73.
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66 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
67 Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br J Pharmacol. 2001 Oct;134(4):845-52. doi: 10.1038/sj.bjp.0704327.
68 Comparison of protective effect of ascorbic acid on redox and endocannabinoid systems interactions in in vitro cultured human skin fibroblasts exposed to UV radiation and hydrogen peroxide. Arch Dermatol Res. 2017 May;309(4):285-303. doi: 10.1007/s00403-017-1729-0. Epub 2017 Mar 11.
69 Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
70 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
71 Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures. Exp Dermatol. 2004 Mar;13(3):129-39. doi: 10.1111/j.0906-6705.2004.0178.x.
72 The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons. J Clin Invest. 2008 Feb;118(2):763-76. doi: 10.1172/JCI32751.