Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMUE8P)

• Drug Name: TEBUFELONE Drug Info
• Synonyms: Tebufelone; 112018-00-5; Tebufelone [USAN:INN]; Tebufelonum [INN-Latin]; Tebufelona [INN-Spanish]; UNII-O048K9ZFHO; O048K9ZFHO; NE 11740; CHEMBL13878; 3',5'-Di-tert-butyl-4'-hydroxy-5-hexynophenone; NE-11740; 1-(3,5-ditert-butyl-4-hydroxyphenyl)hex-5-yn-1-one; 1-(3,5-di-tert-butyl-4-hydroxyphenyl)hex-5-yn-1-one; Tebufelonum; Tebufelona; 5-Hexyn-1-one, 1-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-; 5-Hexyn-1-one, 1-(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)-; Tebufelone (USAN/INN); AC1Q5DB7; AC1L1TG2; SCHEMBL43674

Indication

Disease Entry	ICD 11	Status	REF
Pain	MG30-MG3Z	Discontinued in Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 60542
  CAS Number: CAS 112018-00-5
  TTD Drug ID: DMMUE8P

Molecule-Related Drug Atlas

Drug(s) Targeting Arachidonate 5-lipoxygenase (5-LOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[4]
Diethylcarbamazine	DM1TJ8F	Elephantiasis		Approved	[5]
Silymarin	DMXBYQR	N. A.	N. A.	Phase 4	[6]
3,4-Dihydroxycinnamic Acid	DMVZL26	Thrombocytopenia	3B64	Phase 4	[7]
Avastin+/-Tarceva	DMA86FL	Non-small-cell lung cancer	2C25.Y	Phase 3	[8]
ABT-761	DM3FIC2	Asthma	CA23	Phase 3	[9]
Tenidap	DMHQRYE	Rheumatoid arthritis	FA20	Phase 3	[10]
FPL-62064	DMGF8MZ	Inflammation	1A00-CA43.1	Phase 3	[11]
Flobufen	DMPSG4D	Rheumatoid arthritis	FA20	Phase 3	[12]
Darbufelone	DMYVKM5	Asthma	CA23	Phase 2/3	[13]

Drug(s) Targeting Prostaglandin G/H synthase 1 (COX-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[14]
Naproxen	DMZ5RGV	Bursitis		Approved	[15]
Mesalazine	DMOL5IU	Diverticulitis		Approved	[16]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[17]
Bromfenac	DMKB79O	Pain	MG30-MG3Z	Approved	[18]
Aminosalicylic Acid	DMENSL5	Crohn disease	DD70	Approved	[19]
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[20]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[19]
Suprofen	DMKXJZ7	Miosis	LA11.62	Approved	[21]
Gamma-Homolinolenic acid	DMSXKYG	Malnutrition	5B50-5B71	Approved	[22]

Drug(s) Targeting Prostaglandin G/H synthase 2 (COX-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[23]
Naproxen	DMZ5RGV	Bursitis		Approved	[15]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[24]
Indomethacin	DMSC4A7	Bursitis		Approved	[19]
Celecoxib	DM6LOQU	Dysmenorrhea	GA34.3	Approved	[25]
Nabumetone	DMAT2XH	Osteoarthritis	FA00-FA05	Approved	[26]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[27]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[28]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[17]
Aminosalicylic Acid	DMENSL5	Crohn disease	DD70	Approved	[19]

Drug(s) Targeting LOX-5 messenger RNA (ALOX5 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ZD-2138	DMVFCX7	Asthma	CA23	Discontinued in Phase 2	[29]
BW A4C	DMNUMDG	Arthritis	FA20	Terminated	[30]
KAEMPFEROL	DMHEMUB	Discovery agent	N.A.	Investigative	[31]
2,4'-Dimethoxy-5,3'-di-(2-propenyl)-biphenyl	DMWNJ84	Discovery agent	N.A.	Investigative	[32]
METHYLHONOKIOL	DM9YE6K	Discovery agent	N.A.	Investigative	[32]
HONOKIOL	DMJWT3X	Discovery agent	N.A.	Investigative	[32]
PUUPEHEDIONE	DMF28IU	Discovery agent	N.A.	Investigative	[33]
PUUPEHENONE	DMF3BCK	Discovery agent	N.A.	Investigative	[33]
Isojaspic acid	DMHTBDN	Discovery agent	N.A.	Investigative	[33]
5,3'-Dipropyl-biphenyl-2,4'-diol	DMJRXLD	Discovery agent	N.A.	Investigative	[32]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 5-lipoxygenase (5-LOX)	TT2J34L	LOX5_HUMAN	Inhibitor	[2]
LOX-5 messenger RNA (ALOX5 mRNA)	TTSJ6Q4	LOX5_HUMAN	Inhibitor	[3]
Prostaglandin G/H synthase 1 (COX-1)	TT8NGED	PGH1_HUMAN	Inhibitor	[2]
Prostaglandin G/H synthase 2 (COX-2)	TTVKILB	PGH2_HUMAN	Inhibitor	[2]

References

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