Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNTF2O)

Drug Name
Muscimol Drug Info
Synonyms
muscimol; 2763-96-4; Pantherine; Agarin; Agarine; 3(2H)-Isoxazolone, 5-(aminomethyl)-; Pantherin; 5-Aminomethyl-3-isoxyzole; 3-Hydroxy-5-aminomethylisoxazole; 5-Aminomethyl-3-hydroxyisoxazole; 5-(Aminomethyl)-3-isoxazolol; 3-Isoxazolol, 5-(aminomethyl)-; 5-(Aminomethyl)-3(2H)-isoxazolone; RCRA waste number P007; NSC 333569; 3-Hydroxy-5-aminomethyl-isoxazole; UNII-D5M179TY2E; 3-Hydroxy-5-aminomethylisoxazole-agarin; CCRIS 3720; C4H6N2O2; CHEBI:7035; HSDB 6036; EINECS 220-430-4; RCRA waste no. P007; 5-(Aminomethyl)isoxazol-3-ol hydr
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
4266
ChEBI ID
CHEBI:7035
CAS Number
CAS 2763-96-4
TTD Drug ID
DMNTF2O

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Glutamate receptor AMPA (GRIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [5]
E-2007 DMJDYNQ Diabetic neuropathy 8C0Z Approved [6]
Zopiclone DMPI6Z0 Insomnia 7A00-7A0Z Approved [7]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [8]
Enflurane DM0YJSB Anaesthesia 9A78.6 Approved [9]
Isoflurane DMY6T31 Anaesthesia 9A78.6 Approved [10]
Bromazepam DMY9TCW Anxiety disorder 6B00-6B0Z Approved [11]
Artemisinin SP DMFETDK Malaria 1F40-1F45 Approved [3]
Dihydroergotoxine DM5D6WZ Alzheimer disease 8A20 Approved [12]
Barbiturate DMJIA6T Anaesthesia 9A78.6 Approved [13]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Gamma-aminobutyric acid receptor (GAR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [14]
Allopregnanolone DMNLHAC Depression 6A70-6A7Z approved [15]
THIOCOLCHICOSIDE DMEPWYA Muscle spasm MB47.3 Approved [16]
Clonazepam DMTO13J Absence epilepsy Approved [17]
Piperazine DMTY9LU Ascariasis 1F62 Approved [18]
Alpidem DMN7Y9K Anxiety disorder 6B00-6B0Z Approved [19]
Moxidectin DMYGHX5 Onchocerciasis 1F6A Approved [20]
DP-VPA DMGOXPQ Bipolar disorder 6A60 Approved [21]
ANDROSTERONE DMITJAK N. A. N. A. Phase 3 [15]
ZK-93423 DMFWMKZ Epileptic seizures 8A61-8A6Z Phase 3 [22]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Gamma-aminobutyric acid receptor subunit alpha-1 (GABRA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diazepam DM08E9O Alcohol withdrawal Approved [23]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [24]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [25]
Flunitrazepam DMGR5Z3 Insomnia 7A00-7A0Z Approved [4]
Arsenic DMTL2Y1 N. A. N. A. Approved [26]
GSK683699 DMTW79H Inflammatory bowel disease DD72 Phase 2 [27]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [28]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [29]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [30]
TBPS DMFC3XP Discovery agent N.A. Investigative [31]
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Drug(s) Affected By Gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [32]
Flunitrazepam DMGR5Z3 Insomnia 7A00-7A0Z Approved [4]
Flumazenil DMPCG2L Benzodiazepine overdose PC91 Approved [33]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [34]
Diazepam DM08E9O Alcohol withdrawal Approved [35]
Methamphetamine DMPM4SK Anxiety Approved [36]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [37]
TBPS DMFC3XP Discovery agent N.A. Investigative [31]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [29]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Gamma-aminobutyric acid receptor subunit beta-3 (GABRB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Panobinostat DM58WKG Chronic graft versus host disease Approved [39]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [40]
Testosterone DM7HUNW Hot flushes GA30 Approved [41]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [42]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [25]
Flunitrazepam DMGR5Z3 Insomnia 7A00-7A0Z Approved [4]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [43]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [44]
Flumazenil DMPCG2L Benzodiazepine overdose PC91 Approved [33]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Gamma-aminobutyric acid receptor (GAR) TTNJYV2 NOUNIPROTAC Agonist [2]
Glutamate receptor AMPA (GRIA) TTAN6JD NOUNIPROTAC Agonist [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Gamma-aminobutyric acid receptor subunit alpha-1 (GABRA1) OTC2W96H GBRA1_HUMAN Protein Interaction/Cellular Processes [4]
Gamma-aminobutyric acid receptor subunit beta-3 (GABRB3) OT80C3D4 GBRB3_HUMAN Protein Interaction/Cellular Processes [4]
Gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2) OTGNDWUO GBRG2_HUMAN Protein Interaction/Cellular Processes [4]

References

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24 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
25 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
26 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
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32 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
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34 Characterization of DOK1, a candidate tumor suppressor gene, in epithelial ovarian cancer. Mol Oncol. 2011 Oct;5(5):438-53. doi: 10.1016/j.molonc.2011.07.003. Epub 2011 Jul 26.
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41 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
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