Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPEB0Z)

Drug Name
AA-861 Drug Info
Synonyms
aa-861; DOCEBENONE; 80809-81-0; Docebenonum; Docebenona; AA861; Docebenone [USAN:INN]; Docebenonum [INN-Latin]; Docebenona [INN-Spanish]; UNII-2XRX3BD53M; 2-(12-hydroxydodeca-5,10-diyn-1-yl)-3,5,6-trimethylcyclohexa-2,5-diene-1,4-dione; CHEBI:2340; A-61589; 2-(12-Hydroxy-5,10-dodecadiynyl)-3,5,6-trimethyl-p-benzoquinone; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone; 2XRX3BD53M; MLS000028467; A 61589; NCGC00015053-05; SMR000058412; 2-(12-hydroxydodeca-5,10-diynyl)-3,5,6-trimethyl-1,4-benzoquinone
Indication
Disease Entry ICD 11 Status REF
Allergy 4A80-4A85 Terminated [1]
Cross-matching ID
PubChem CID
1967
ChEBI ID
CHEBI:2340
CAS Number
CAS 80809-81-0
TTD Drug ID
DMPEB0Z

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Arachidonate 5-lipoxygenase (5-LOX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [7]
Diethylcarbamazine DM1TJ8F Elephantiasis Approved [8]
Silymarin DMXBYQR N. A. N. A. Phase 4 [9]
3,4-Dihydroxycinnamic Acid DMVZL26 Thrombocytopenia 3B64 Phase 4 [10]
Avastin+/-Tarceva DMA86FL Non-small-cell lung cancer 2C25.Y Phase 3 [11]
ABT-761 DM3FIC2 Asthma CA23 Phase 3 [12]
Tenidap DMHQRYE Rheumatoid arthritis FA20 Phase 3 [13]
FPL-62064 DMGF8MZ Inflammation 1A00-CA43.1 Phase 3 [14]
Flobufen DMPSG4D Rheumatoid arthritis FA20 Phase 3 [15]
Darbufelone DMYVKM5 Asthma CA23 Phase 2/3 [16]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Polyunsaturated fatty acid 5-lipoxygenase (ALOX5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [17]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [18]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [19]
Fructose DM43AN2 Vomiting MD90 Approved [20]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [21]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [22]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [23]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [24]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [25]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [26]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [27]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Testosterone DM7HUNW Hot flushes GA30 Approved [29]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [29]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [31]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [32]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [33]
Ethanol DMDRQZU Chronic pain MG30 Approved [34]
Oxymetholone DMFXUT8 Aplastic anemia 3A70 Approved [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [36]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [37]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [38]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [39]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [40]
Selenium DM25CGV N. A. N. A. Approved [41]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [36]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [42]
Methotrexate DM2TEOL Anterior urethra cancer Approved [43]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [42]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [44]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [45]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [46]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [47]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [48]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [49]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [50]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [51]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [52]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [53]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Short transient receptor potential channel 6 (TRPC6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [54]
Flufenamic Acid DMC8VNH Dysmenorrhea GA34.3 Approved [55]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [57]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [54]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [58]
Geldanamycin DMS7TC5 Kidney cancer 2C90.0 Discontinued in Phase 2 [59]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [60]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [59]
⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Arachidonate 5-lipoxygenase (5-LOX) TT2J34L LOX5_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) OTHF4H9U DHI2_HUMAN Gene/Protein Processing [3]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [4]
Polyunsaturated fatty acid 5-lipoxygenase (ALOX5) OT7FOIK2 LOX5_HUMAN Gene/Protein Processing [5]
Short transient receptor potential channel 6 (TRPC6) OT5J7HVM TRPC6_HUMAN Gene/Protein Processing [4]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Gene/Protein Processing [6]

References

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