Details of the Drug Combination

General Information of Drug Combination (ID: DCBTLGX)

Drug Combination Name
Etoposide Panobinostat
Indication
Disease Entry Status REF
Diffuse intrinsic pontine glioma Investigative [1]
Component Drugs Etoposide   DMNH3PG Panobinostat   DM58WKG
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: DIPG25
Zero Interaction Potency (ZIP) Score: 9.56
Bliss Independence Score: 12.89
Loewe Additivity Score: 0.64
LHighest Single Agent (HSA) Score: 6.61

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Etoposide
Disease Entry ICD 11 Status REF
Acute myelogenous leukaemia 2A41 Approved [2]
Adult acute monocytic leukemia N.A. Approved [2]
Adult kidney Wilms tumor N.A. Approved [2]
Beckwith-Wiedemann syndrome N.A. Approved [2]
Childhood kidney Wilms tumor N.A. Approved [2]
Hamartoma N.A. Approved [2]
Kidney neoplasm N.A. Approved [2]
Lung cancer 2C25.0 Approved [2]
Non-small-cell lung cancer 2C25.Y Approved [2]
Plasma cell myeloma 2A83.1 Approved [2]
Small-cell lung cancer 2C25.Y Approved [2]
Solid tumour/cancer 2A00-2F9Z Approved [3]
Testicular cancer 2C80 Approved [4]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [5]
Neuroblastoma 2D11.2 Investigative [2]
Etoposide Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
DNA topoisomerase II (TOP2) TT0IHXV TOP2A_HUMAN; TOP2B_HUMAN Modulator [30]
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Etoposide Interacts with 8 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [31]
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [32]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [33]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [34]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [35]
Multidrug resistance-associated protein 3 (ABCC3) DTQ3ZHF MRP3_HUMAN Substrate [36]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [37]
Organic anion transporting polypeptide 2B1 (SLCO2B1) DTPFTEQ SO2B1_HUMAN Substrate [35]
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⏷ Show the Full List of 8 DTP(s)
Etoposide Interacts with 9 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [38]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [38]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [9]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [39]
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Metabolism [40]
Glutathione S-transferase pi (GSTP1) DEK6079 GSTP1_HUMAN Metabolism [41]
Prostaglandin G/H synthase 1 (COX-1) DE073H6 PGH1_HUMAN Metabolism [42]
Glutathione S-transferase theta-1 (GSTT1) DE3PKUG GSTT1_HUMAN Metabolism [41]
Prostaglandin G/H synthase 2 (COX-2) DE492CE PGH2_HUMAN Metabolism [42]
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⏷ Show the Full List of 9 DME(s)
Etoposide Interacts with 347 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Expression [43]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Decreases Response To Substance [44]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Increases Phosphorylation [45]
Tumor protein p73 (TP73) OT0LUO47 P73_HUMAN Increases Expression [10]
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (CYP27B1) OTTK98BH CP27B_HUMAN Increases Expression [10]
Dihydropyrimidinase-related protein 4 (DPYSL4) OT3SBS2S DPYL4_HUMAN Increases Expression [11]
Copper chaperone for superoxide dismutase (CCS) OTXHT3QO CCS_HUMAN Increases Expression [11]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [11]
Ubiquitin-like protein ISG15 (ISG15) OT53QQ7N ISG15_HUMAN Increases Expression [11]
Integrin alpha-IIb (ITGA2B) OT4Y17PY ITA2B_HUMAN Increases Expression [11]
Ras-related protein R-Ras (RRAS) OTBBF28C RRAS_HUMAN Increases Expression [11]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [11]
Stomatin (STOM) OTC8R6EH STOM_HUMAN Increases Expression [11]
Cellular retinoic acid-binding protein 2 (CRABP2) OTY01V9G RABP2_HUMAN Increases Expression [11]
Tyrosine-protein kinase receptor UFO (AXL) OTKA2SUX UFO_HUMAN Increases Expression [11]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Increases Expression [11]
Galectin-7 (LGALS7) OTMSVI7R LEG7_HUMAN Increases Expression [11]
Rho GDP-dissociation inhibitor 2 (ARHGDIB) OT9PD6CS GDIR2_HUMAN Increases Expression [11]
Epithelial membrane protein 1 (EMP1) OTSZHUHQ EMP1_HUMAN Increases Expression [11]
Epithelial membrane protein 3 (EMP3) OTODMJ1D EMP3_HUMAN Increases Expression [11]
Protein ripply3 (RIPPLY3) OT1HK35I DSCR6_HUMAN Increases Expression [11]
Kinesin-like protein KIF1A (KIF1A) OT3JVEGV KIF1A_HUMAN Increases Expression [11]
Filamin-C (FLNC) OT3F8J6Y FLNC_HUMAN Increases Expression [11]
Immediate early response gene 5 protein (IER5) OTJPTXMD IER5_HUMAN Increases Expression [11]
Keratin, type II cytoskeletal 80 (KRT80) OTAU54U3 K2C80_HUMAN Increases Expression [11]
All-trans-retinol 13,14-reductase (RETSAT) OTC3AOPX RETST_HUMAN Increases Expression [11]
Mitochondria-eating protein (SPATA18) OTOEHTHU MIEAP_HUMAN Increases Expression [11]
Tumor necrosis factor receptor superfamily member 14 (TNFRSF14) OTB82PFO TNR14_HUMAN Increases Expression [11]
Major histocompatibility complex class I-related gene protein (MR1) OTZU3XX7 HMR1_HUMAN Increases Expression [11]
Roundabout homolog 3 (ROBO3) OTPVG40S ROBO3_HUMAN Increases Expression [11]
Neuronal PAS domain-containing protein 1 (NPAS1) OTZKO6ZN NPAS1_HUMAN Increases Expression [11]
Ankyrin repeat domain-containing protein 10 (ANKRD10) OTIZ2VK8 ANR10_HUMAN Decreases Expression [11]
Serine/threonine-protein kinase PLK2 (PLK2) OTKMJXJ8 PLK2_HUMAN Increases Expression [11]
Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6) OTVUZCLG GTR6_HUMAN Increases Expression [11]
Glutaminase liver isoform, mitochondrial (GLS2) OT08MSHL GLSL_HUMAN Increases Expression [11]
Endothelial protein C receptor (PROCR) OTRHED17 EPCR_HUMAN Increases Expression [11]
Fatty acid desaturase 3 (FADS3) OT9RVXGE FADS3_HUMAN Increases Expression [11]
NADH-ubiquinone oxidoreductase chain 4 (ND4) OT4RQVAA NU4M_HUMAN Increases Expression [46]
Transcription factor A, mitochondrial (TFAM) OTXXV5V7 TFAM_HUMAN Increases Expression [46]
TP53-binding protein 1 (TP53BP1) OTL8879S TP53B_HUMAN Increases Expression [46]
Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPARGC1B) OTN6FKCB PRGC2_HUMAN Increases Expression [46]
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) OTHCDQ22 PRGC1_HUMAN Increases Expression [46]
Calsequestrin-2 (CASQ2) OT09MNQ8 CASQ2_HUMAN Decreases Expression [12]
Telethonin (TCAP) OTQQMJ94 TELT_HUMAN Decreases Expression [12]
LIM domain-binding protein 3 (LDB3) OTGQL1AM LDB3_HUMAN Decreases Expression [12]
Creatine kinase M-type (CKM) OTME0KO7 KCRM_HUMAN Decreases Expression [12]
Myosin light chain 3 (MYL3) OTKD3RSX MYL3_HUMAN Decreases Expression [12]
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MYL2) OT78PC0C MLRV_HUMAN Decreases Expression [12]
Ankyrin-1 (ANK1) OTU79URK ANK1_HUMAN Increases Expression [12]
Desmin (DES) OTI09KBW DESM_HUMAN Decreases Expression [12]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Increases Expression [12]
CCN family member 2 (CCN2) OTC39NSU CCN2_HUMAN Increases Expression [12]
Thrombospondin-4 (THBS4) OTA1T9KK TSP4_HUMAN Increases Expression [12]
Gap junction alpha-5 protein (GJA5) OTRMZVO6 CXA5_HUMAN Decreases Expression [12]
Sodium/potassium-transporting ATPase subunit alpha-2 (ATP1A2) OTCF8OWW AT1A2_HUMAN Decreases Expression [12]
cAMP-dependent protein kinase catalytic subunit PRKX (PRKX) OTDAC6Z0 PRKX_HUMAN Increases Expression [12]
Myomesin-2 (MYOM2) OTD2UOXW MYOM2_HUMAN Decreases Expression [12]
Actin, alpha skeletal muscle (ACTA1) OTOVGLPG ACTS_HUMAN Decreases Expression [12]
Iroquois-class homeodomain protein IRX-4 (IRX4) OT0TV6WK IRX4_HUMAN Decreases Expression [12]
Arginase-2, mitochondrial (ARG2) OTCPI0E8 ARGI2_HUMAN Decreases Expression [12]
Cytochrome c oxidase subunit 6A2, mitochondrial (COX6A2) OTQR5SXD CX6A2_HUMAN Decreases Expression [12]
Pro-neuregulin-1, membrane-bound isoform (NRG1) OTZO6F1X NRG1_HUMAN Increases Expression [12]
Dual specificity protein phosphatase 4 (DUSP4) OT6WAO12 DUS4_HUMAN Increases Expression [12]
Krueppel-like factor 5 (KLF5) OT1ABI9N KLF5_HUMAN Increases Expression [12]
Four and a half LIM domains protein 2 (FHL2) OT0OAYWT FHL2_HUMAN Decreases Expression [12]
kinase isozyme 1, mitochondrial (PDK1) OTMABK9Z PDK1_HUMAN Decreases Expression [12]
kinase isozyme 4, mitochondrial (PDK4) OTCMHMBZ PDK4_HUMAN Increases Expression [12]
PDZ and LIM domain protein 3 (PDLIM3) OTVXQC81 PDLI3_HUMAN Increases Expression [12]
Nebulin-related-anchoring protein (NRAP) OTO6H3YF NRAP_HUMAN Decreases Expression [12]
Sodium channel subunit beta-4 (SCN4B) OT3JSUWO SCN4B_HUMAN Increases Expression [12]
Actin-binding Rho-activating protein (ABRA) OTBQ2C1J ABRA_HUMAN Increases Expression [12]
Transient receptor potential cation channel subfamily V member 1 (TRPV1) OTHHDR03 TRPV1_HUMAN Increases Expression [12]
Ryanodine receptor 2 (RYR2) OT0PF19E RYR2_HUMAN Decreases Expression [12]
Small conductance calcium-activated potassium channel protein 2 (KCNN2) OTQVTMK5 KCNN2_HUMAN Decreases Expression [12]
Regulator of cell cycle RGCC (RGCC) OTYJMLWM RGCC_HUMAN Increases Expression [12]
Myotilin (MYOT) OTCEW5XW MYOTI_HUMAN Increases Expression [12]
Protein ATP1B4 (ATP1B4) OT2YC9GZ AT1B4_HUMAN Increases Expression [12]
Succinate dehydrogenase assembly factor 1, mitochondrial (SDHAF1) OTDG5VW7 SDHF1_HUMAN Decreases Expression [14]
Agrin (AGRN) OTWJENAZ AGRIN_HUMAN Increases Expression [13]
E3 ubiquitin-protein ligase TRIM38 (TRIM38) OT6SP1M9 TRI38_HUMAN Decreases Expression [14]
Etoposide-induced protein 2.4 homolog (EI24) OTD4NOYS EI24_HUMAN Increases Expression [13]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Increases Expression [47]
Tax1-binding protein 3 (TAX1BP3) OTQ6IB4T TX1B3_HUMAN Increases Expression [13]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Increases Expression [48]
Transcription factor EC (TFEC) OTUST8MR TFEC_HUMAN Decreases Expression [14]
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK) OTLF4ZB1 IKKA_HUMAN Decreases Expression [49]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Increases Expression [50]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Increases Expression [51]
E3 ubiquitin-protein ligase RNF113A (RNF113A) OTR6N7HU R113A_HUMAN Decreases Expression [14]
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) OT0KMIYQ RIPK2_HUMAN Increases Expression [50]
Forkhead box protein O3 (FOXO3) OTHXQG4P FOXO3_HUMAN Increases Phosphorylation [52]
Cytoplasmic protein NCK2 (NCK2) OTUYPF55 NCK2_HUMAN Decreases Expression [13]
Protein regulator of cytokinesis 1 (PRC1) OTHD0XS0 PRC1_HUMAN Decreases Expression [13]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1) OT80DZMT BUB1_HUMAN Decreases Expression [53]
HMG box-containing protein 1 (HBP1) OTDPGGDV HBP1_HUMAN Decreases Expression [14]
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) OT8KME51 BUB1B_HUMAN Decreases Expression [53]
Cell division control protein 45 homolog (CDC45) OT6NNLOD CDC45_HUMAN Decreases Expression [53]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Increases Activity [54]
Kinesin-like protein KIF20A (KIF20A) OTXOQHE0 KI20A_HUMAN Decreases Expression [14]
Myelin protein zero-like protein 1 (MPZL1) OTJSUUHR MPZL1_HUMAN Decreases Expression [14]
Serine/threonine-protein kinase Chk2 (CHEK2) OT8ZPCNS CHK2_HUMAN Increases Phosphorylation [55]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Increases Expression [56]
Ferritin light chain (FTL) OTYQA8A6 FRIL_HUMAN Increases Expression [57]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Decreases Expression [58]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Increases Expression [59]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Decreases Expression [48]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Decreases Phosphorylation [60]
Annexin A4 (ANXA4) OTUCRYXL ANXA4_HUMAN Increases Expression [13]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [61]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [62]
C-C motif chemokine 3 (CCL3) OTW2H3ND CCL3_HUMAN Increases Expression [62]
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) OTPWI88U CEAM1_HUMAN Increases Expression [13]
HLA class I histocompatibility antigen, alpha chain E (HLA-E) OTX1CTFB HLAE_HUMAN Affects Expression [63]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Expression [64]
Receptor tyrosine-protein kinase erbB-3 (ERBB3) OTRSST0A ERBB3_HUMAN Decreases Expression [48]
rRNA 2'-O-methyltransferase fibrillarin (FBL) OTRODIE5 FBRL_HUMAN Affects Localization [65]
NADPH:adrenodoxin oxidoreductase, mitochondrial (FDXR) OTPDCK1F ADRO_HUMAN Increases Expression [13]
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) OTIN6G20 CPT2_HUMAN Decreases Expression [14]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Increases Phosphorylation [45]
M-phase inducer phosphatase 1 (CDC25A) OTSLKKCO MPIP1_HUMAN Decreases Expression [14]
M-phase inducer phosphatase 3 (CDC25C) OTPQI71S MPIP3_HUMAN Decreases Expression [53]
Replication factor C subunit 1 (RFC1) OT3L5PK3 RFC1_HUMAN Decreases Expression [14]
Tumor necrosis factor receptor superfamily member 3 (LTBR) OT2HVZGV TNR3_HUMAN Increases Expression [50]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Decreases Expression [66]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [53]
Transcription factor ETV6 (ETV6) OTCZMG61 ETV6_HUMAN Increases Mutagenesis [67]
Tumor necrosis factor ligand superfamily member 9 (TNFSF9) OTV9L89D TNFL9_HUMAN Increases Expression [13]
RNA-binding protein 34 (RBM34) OTX3LUGI RBM34_HUMAN Decreases Expression [14]
DNA repair protein RAD52 homolog (RAD52) OT0OTDHI RAD52_HUMAN Increases Expression [68]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [52]
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) OTI2OREX MP2K3_HUMAN Increases Expression [13]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Increases Activity [69]
Iron-responsive element-binding protein 2 (IREB2) OT747D24 IREB2_HUMAN Decreases Expression [57]
Nuclear receptor-interacting protein 1 (NRIP1) OTIZOJQV NRIP1_HUMAN Decreases Expression [70]
Centromere protein F (CENPF) OT7AG0SW CENPF_HUMAN Decreases Expression [53]
CCAAT/enhancer-binding protein alpha (CEBPA) OTOM9OE4 CEBPA_HUMAN Decreases Expression [71]
DNA replication licensing factor MCM2 (MCM2) OTGGORIQ MCM2_HUMAN Decreases Expression [53]
LIM/homeobox protein Lhx2 (LHX2) OTK61NP8 LHX2_HUMAN Decreases Expression [14]
Serine/threonine-protein kinase Nek2 (NEK2) OT1H27HO NEK2_HUMAN Decreases Expression [53]
DNA mismatch repair protein Msh6 (MSH6) OT46FP09 MSH6_HUMAN Decreases Expression [14]
Death-associated protein kinase 1 (DAPK1) OTNCNUCO DAPK1_HUMAN Increases Expression [49]
Mitogen-activated protein kinase 12 (MAPK12) OTTCKE27 MK12_HUMAN Increases Activity [72]
RecQ-like DNA helicase BLM (BLM) OTEJOAJX BLM_HUMAN Decreases Expression [14]
Ataxin-1 (ATXN1) OTQF0HNR ATX1_HUMAN Decreases Expression [14]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Increases Expression [50]
Triosephosphate isomerase (TPI1) OT14KP4B TPIS_HUMAN Increases Phosphorylation [73]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Increases Phosphorylation [74]
Protein BTG2 (BTG2) OTZF6K1H BTG2_HUMAN Increases Expression [14]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Affects Localization [59]
Myelin transcription factor 1 (MYT1) OTC3660I MYT1_HUMAN Decreases Expression [53]
POU domain, class 5, transcription factor 1 (POU5F1) OTDHHN7O PO5F1_HUMAN Increases Expression [57]
Histone-lysine N-methyltransferase 2A (KMT2A) OT9GLJI6 KMT2A_HUMAN Increases Cleavage [75]
CCAAT/enhancer-binding protein zeta (CEBPZ) OT11BATG CEBPZ_HUMAN Decreases Expression [13]
Chromatin assembly factor 1 subunit A (CHAF1A) OTXSSY4H CAF1A_HUMAN Decreases Expression [14]
Serine-protein kinase ATM (ATM) OTQVOHLT ATM_HUMAN Increases Phosphorylation [76]
DNA topoisomerase 3-alpha (TOP3A) OT3CKUI9 TOP3A_HUMAN Decreases Expression [14]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Decreases Expression [53]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Increases Expression [77]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Increases Expression [78]
Protein BTG3 (BTG3) OT9ANHVT BTG3_HUMAN Decreases Expression [14]
Histone RNA hairpin-binding protein (SLBP) OTVYYQRT SLBP_HUMAN Decreases Expression [14]
Hypermethylated in cancer 1 protein (HIC1) OTI9TWY4 HIC1_HUMAN Increases Expression [79]
Receptor tyrosine-protein kinase erbB-4 (ERBB4) OT9L6C41 ERBB4_HUMAN Decreases Expression [48]
Neutral amino acid transporter B(0) (SLC1A5) OTE2H26Q AAAT_HUMAN Decreases Expression [14]
Mothers against decapentaplegic homolog 2 (SMAD2) OTC6VB4K SMAD2_HUMAN Increases Phosphorylation [80]
Cyclin-G2 (CCNG2) OTII38K2 CCNG2_HUMAN Increases Expression [81]
Cyclin-dependent kinase inhibitor 3 (CDKN3) OTBE3H07 CDKN3_HUMAN Decreases Expression [53]
Quinone oxidoreductase PIG3 (TP53I3) OTSCM68G QORX_HUMAN Increases Expression [13]
Ribosomal protein eS27-like (RPS27L) OTZWHU0N RS27L_HUMAN Increases Expression [82]
Protein MCM10 homolog (MCM10) OTV0O3JN MCM10_HUMAN Decreases Expression [14]
EPM2A-interacting protein 1 (EPM2AIP1) OT21ALNF EPMIP_HUMAN Increases Expression [13]
Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B) OTE8GBUR RIR2B_HUMAN Increases Expression [83]
Partner and localizer of BRCA2 (PALB2) OT6DNDBG PALB2_HUMAN Decreases Expression [14]
Jouberin (AHI1) OT8K2YWY AHI1_HUMAN Increases Expression [84]
Leucine-rich repeat-containing protein 47 (LRRC47) OTSE8NAO LRC47_HUMAN Decreases Expression [14]
RelA-associated inhibitor (PPP1R13L) OTNCPLWE IASPP_HUMAN Increases Expression [85]
DNA repair and recombination protein RAD54-like (RAD54L) OTEGMAKG RAD54_HUMAN Increases Expression [15]
Cytochrome c oxidase assembly factor 7 (COA7) OTRQJYL6 COA7_HUMAN Decreases Expression [14]
Mitochondrial potassium channel (CCDC51) OTOJNHNA MITOK_HUMAN Decreases Expression [14]
Integrator complex subunit 15 (INTS15) OT3O4INM INT15_HUMAN Decreases Expression [14]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [78]
Krueppel-like factor 6 (KLF6) OTQY9S7F KLF6_HUMAN Decreases Expression [14]
Mitogen-activated protein kinase kinase kinase 5 (MAP3K5) OTQR6ENW M3K5_HUMAN Decreases Expression [13]
Cell division control protein 6 homolog (CDC6) OTX93FE7 CDC6_HUMAN Decreases Expression [53]
SOSS complex subunit B1 (NABP2) OTQU8081 SOSB1_HUMAN Increases Acetylation [86]
Protein pelota homolog (PELO) OTF3WLIM PELO_HUMAN Decreases Expression [14]
TIMELESS-interacting protein (TIPIN) OT9PZHXV TIPIN_HUMAN Decreases Expression [14]
Cell cycle regulator of non-homologous end joining (CYREN) OT5ZL00R CYREN_HUMAN Affects Localization [87]
Caspase recruitment domain-containing protein 10 (CARD10) OT2RPM4I CAR10_HUMAN Increases Expression [50]
Sulfiredoxin-1 (SRXN1) OTYDBO4L SRXN1_HUMAN Increases Expression [88]
tRNA pseudouridine(38/39) synthase (PUS3) OT6WG6M2 PUS3_HUMAN Decreases Expression [14]
Serine/threonine-protein kinase PLK3 (PLK3) OT19CT2Z PLK3_HUMAN Increases Expression [13]
Transmembrane protein 185B (TMEM185B) OTGNYS0J T185B_HUMAN Decreases Expression [14]
Interferon-stimulated 20 kDa exonuclease-like 2 (ISG20L2) OT3Q11WQ I20L2_HUMAN Decreases Expression [14]
GrpE protein homolog 1, mitochondrial (GRPEL1) OT8O00YJ GRPE1_HUMAN Decreases Expression [14]
Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) OT5V52LN TNR12_HUMAN Increases Expression [50]
Programmed cell death 1 ligand 1 (CD274) OTJ0VFDL PD1L1_HUMAN Increases Expression [89]
rRNA methyltransferase 2, mitochondrial (MRM2) OTRYA1HU MRM2_HUMAN Decreases Expression [14]
DNA helicase MCM8 (MCM8) OTC93H3S MCM8_HUMAN Decreases Expression [53]
Frizzled-1 (FZD1) OTZATHVS FZD1_HUMAN Decreases Expression [14]
Calcium-binding protein 39 (CAB39) OT2CL9ST CAB39_HUMAN Decreases Expression [13]
5'-AMP-activated protein kinase subunit beta-1 (PRKAB1) OT1OG4QZ AAKB1_HUMAN Increases Expression [14]
Sestrin-1 (SESN1) OTSFDZWL SESN1_HUMAN Increases Expression [14]
Molybdenum cofactor sulfurase (MOCOS) OT0TL3Q5 MOCOS_HUMAN Affects Response To Substance [19]
Tripartite motif-containing protein 2 (TRIM2) OT0V1YVC TRIM2_HUMAN Affects Response To Substance [19]
V-type proton ATPase 116 kDa subunit a 4 (ATP6V0A4) OT149Z7Q VPP4_HUMAN Affects Response To Substance [19]
Acid ceramidase (ASAH1) OT1DNGXL ASAH1_HUMAN Affects Response To Substance [19]
Calcipressin-1 (RCAN1) OT1MVXC7 RCAN1_HUMAN Affects Response To Substance [19]
Melanoma antigen recognized by T-cells 1 (MLANA) OT1N2S2K MAR1_HUMAN Affects Response To Substance [19]
Serine palmitoyltransferase small subunit A (SPTSSA) OT2PNKOP SPTSA_HUMAN Affects Response To Substance [19]
Large neutral amino acids transporter small subunit 1 (SLC7A5) OT2WPVXD LAT1_HUMAN Affects Response To Substance [19]
Chitinase-3-like protein 1 (CHI3L1) OT2Z7VJH CH3L1_HUMAN Decreases Response To Substance [90]
Syncytin-2 (ERVFRD-1) OT3064D7 SYCY2_HUMAN Affects Response To Substance [19]
DNA-directed RNA polymerase I subunit RPA12 (POLR1H) OT30S3SB RPA12_HUMAN Decreases Response To Substance [91]
Protein FAM171A1 (FAM171A1) OT33BHEP F1711_HUMAN Affects Response To Substance [19]
Fatty acid CoA ligase Acsl3 (ACSL3) OT3MWER1 ACSL3_HUMAN Affects Response To Substance [19]
Nuclear protein 1 (NUPR1) OT4FU8C0 NUPR1_HUMAN Affects Response To Substance [19]
DNA repair nuclease/redox regulator APEX1 (APEX1) OT53OI14 APEX1_HUMAN Decreases Response To Substance [92]
Lymphokine-activated killer T-cell-originated protein kinase (PBK) OT5Z27TW TOPK_HUMAN Affects Response To Substance [19]
Protein E7 (E7) OT6BIMFN VE7_HPV16 Increases ADR [93]
G-protein-signaling modulator 2 (GPSM2) OT6RPMRM GPSM2_HUMAN Affects Response To Substance [19]
CD40 ligand (CD40LG) OT75Z6A6 CD40L_HUMAN Decreases Response To Substance [94]
Monocarboxylate transporter 7 (SLC16A6) OT7BIIZX MOT7_HUMAN Affects Response To Substance [19]
Homeobox protein engrailed-2 (EN2) OT7EZCM2 HME2_HUMAN Affects Response To Substance [19]
Ras-related protein Rab-17 (RAB17) OT7NBUGQ RAB17_HUMAN Affects Response To Substance [19]
Myelin proteolipid protein (PLP1) OT8CM9CX MYPR_HUMAN Affects Response To Substance [19]
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5K1B) OT8JQ1F7 PI51B_HUMAN Affects Response To Substance [19]
Neuronal membrane glycoprotein M6-b (GPM6B) OT8Q1582 GPM6B_HUMAN Affects Response To Substance [19]
Melanoma-associated antigen 12 (MAGEA12) OT8ULELL MAGAC_HUMAN Affects Response To Substance [19]
Solute carrier family 22 member 18 (SLC22A18) OT9C3KR4 S22AI_HUMAN Affects Response To Substance [19]
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 (ST6GALNAC2) OT9PBQVT SIA7B_HUMAN Affects Response To Substance [19]
Splicing factor 45 (RBM17) OT9ROJCL SPF45_HUMAN Decreases Response To Substance [95]
CD44 antigen (CD44) OT9TTJ41 CD44_HUMAN Affects Response To Substance [96]
Retinoblastoma tumor suppressor (RB1) OT9VMY7B Q5J3Q9_FUNHE Increases ADR [93]
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM) OTA4P0FC ACADM_HUMAN Affects Response To Substance [19]
POM121 and ZP3 fusion protein (POMZP3) OTAH2JOK POZP3_HUMAN Affects Response To Substance [19]
Transmembrane protein 47 (TMEM47) OTAJ4CPX TMM47_HUMAN Affects Response To Substance [19]
Glutathione S-transferase theta-2 (GSTT2) OTANW3TJ GST2_HUMAN Affects Response To Substance [19]
Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1) OTAYZZE6 AL3A1_HUMAN Affects Response To Substance [97]
5-hydroxytryptamine receptor 4 (HTR4) OTBIB44K 5HT4R_HUMAN Affects Response To Substance [19]
Chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CSGALNACT1) OTBML9D9 CGAT1_HUMAN Affects Response To Substance [19]
Microtubule-associated tumor suppressor 1 (MTUS1) OTBPALMU MTUS1_HUMAN Affects Response To Substance [19]
Melanocyte protein PMEL (PMEL) OTCDDHHM PMEL_HUMAN Affects Response To Substance [19]
BMP and activin membrane-bound inhibitor homolog (BAMBI) OTCEJ8W5 BAMBI_HUMAN Affects Response To Substance [19]
Alkaline phosphatase, germ cell type (ALPG) OTCIM29R PPBN_HUMAN Affects Response To Substance [19]
Creatine kinase U-type, mitochondrial (CKMT1A) OTCINHH5 KCRU_HUMAN Affects Response To Substance [19]
Ras-interacting protein 1 (RASIP1) OTCRY2AN RAIN_HUMAN Affects Response To Substance [19]
Collagen alpha-3(IX) chain (COL9A3) OTCUJOEK CO9A3_HUMAN Affects Response To Substance [19]
A-kinase anchor protein 12 (AKAP12) OTCVRDDX AKA12_HUMAN Affects Response To Substance [19]
Interferon-stimulated gene 20 kDa protein (ISG20) OTCWRJJW ISG20_HUMAN Affects Response To Substance [19]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Increases Response To Substance [98]
P protein (OCA2) OTDWIGBF P_HUMAN Affects Response To Substance [19]
Cystatin-SN (CST1) OTE4I83Q CYTN_HUMAN Affects Response To Substance [19]
Alternative prion protein (PRNP) OTE85L1Q APRIO_HUMAN Decreases Response To Substance [99]
Fructose-bisphosphate aldolase C (ALDOC) OTEC13I5 ALDOC_HUMAN Affects Response To Substance [19]
Interferon-induced transmembrane protein 1 (IFITM1) OTECO1G8 IFM1_HUMAN Affects Response To Substance [19]
Epidermal growth factor-like protein 8 (EGFL8) OTECTJ7K EGFL8_HUMAN Affects Response To Substance [19]
dTDP-D-glucose 4,6-dehydratase (TGDS) OTEOFLOS TGDS_HUMAN Affects Response To Substance [19]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Increases ADR [93]
Ras association domain-containing protein 1 (RASSF1) OTEZIPB7 RASF1_HUMAN Increases Response To Substance [100]
Transcription factor SOX-10 (SOX10) OTF25ULQ SOX10_HUMAN Affects Response To Substance [19]
Eukaryotic translation initiation factor 3 subunit A (EIF3A) OTFABY9G EIF3A_HUMAN Increases Response To Substance [101]
Kelch-like ECH-associated protein 1 (KEAP1) OTFHOD0C KEAP1_HUMAN Increases Response To Substance [102]
Protein AF1q (MLLT11) OTG5RVHC AF1Q_HUMAN Affects Response To Substance [19]
Tudor domain-containing protein 3 (TDRD3) OTG83E2C TDRD3_HUMAN Affects Response To Substance [19]
Voltage-gated potassium channel subunit beta-2 (KCNAB2) OTH115IE KCAB2_HUMAN Affects Response To Substance [19]
Dual specificity protein phosphatase 2 (DUSP2) OTH54FMR DUS2_HUMAN Affects Response To Substance [19]
Melanoma-associated antigen C1 (MAGEC1) OTHMFHH8 MAGC1_HUMAN Affects Response To Substance [19]
Tribbles homolog 2 (TRIB2) OTHSX3MX TRIB2_HUMAN Affects Response To Substance [19]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Affects Response To Substance [19]
BAG family molecular chaperone regulator 2 (BAG2) OTI6LD27 BAG2_HUMAN Affects Response To Substance [19]
Nucleosome assembly protein 1-like 1 (NAP1L1) OTI7WBZV NP1L1_HUMAN Affects Response To Substance [19]
Prosaposin receptor GPR37 (GPR37) OTIMDDI3 GPR37_HUMAN Affects Response To Substance [19]
Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA) OTIOLNHE LICH_HUMAN Affects Response To Substance [19]
Baculoviral IAP repeat-containing protein 7 (BIRC7) OTITCGHB BIRC7_HUMAN Decreases Response To Substance [103]
Protein S100-P (S100P) OTJCXNJG S100P_HUMAN Increases Response To Substance [104]
cAMP-responsive element modulator (CREM) OTJIJ5AL CREM_HUMAN Affects Response To Substance [19]
Alpha-(1,6)-fucosyltransferase (FUT8) OTJJCVG1 FUT8_HUMAN Affects Response To Substance [19]
Trefoil factor 3 (TFF3) OTJJDRTU TFF3_HUMAN Affects Response To Substance [19]
Transcription factor-like 5 protein (TCFL5) OTJL4348 TCFL5_HUMAN Affects Response To Substance [19]
Uncharacterized protein C4orf19 (C4ORF19) OTJMU7N6 CD019_HUMAN Affects Response To Substance [19]
Sorbin and SH3 domain-containing protein 2 (SORBS2) OTJSX44Y SRBS2_HUMAN Affects Response To Substance [19]
Myc box-dependent-interacting protein 1 (BIN1) OTK8O0X8 BIN1_HUMAN Increases Response To Substance [105]
Transmembrane channel-like protein 6 (TMC6) OTKH50J4 TMC6_HUMAN Affects Response To Substance [19]
B-cell receptor-associated protein 31 (BCAP31) OTKSACR4 BAP31_HUMAN Increases ADR [93]
Myelin P2 protein (PMP2) OTKYV2NE MYP2_HUMAN Affects Response To Substance [19]
Histone-binding protein RBBP7 (RBBP7) OTLB56HX RBBP7_HUMAN Increases ADR [93]
Glycylpeptide N-tetradecanoyltransferase 2 (NMT2) OTLNA39Z NMT2_HUMAN Affects Response To Substance [19]
Tyrosine-protein kinase Fyn (FYN) OTLSLVZS FYN_HUMAN Affects Response To Substance [19]
Lymphocyte antigen 6E (LY6E) OTMG16BZ LY6E_HUMAN Affects Response To Substance [19]
Bridging integrator 3 (BIN3) OTMIWWDW BIN3_HUMAN Affects Response To Substance [19]
Bcl-2-like protein 2 (BCL2L2) OTMKVO0J B2CL2_HUMAN Decreases Response To Substance [106]
Histone-lysine N-methyltransferase 2B (KMT2B) OTMMAZQX KMT2B_HUMAN Increases ADR [93]
Copper-transporting ATPase 1 (ATP7A) OTMR3GXP ATP7A_HUMAN Decreases Response To Substance [107]
Transcription factor AP-2-alpha (TFAP2A) OTMYT3NK AP2A_HUMAN Increases Response To Substance [108]
Four and a half LIM domains protein 1 (FHL1) OTN535SU FHL1_HUMAN Affects Response To Substance [19]
Epithelial splicing regulatory protein 1 (ESRP1) OTNCS4SL ESRP1_HUMAN Affects Response To Substance [19]
Beta-secretase 2 (BACE2) OTO5YQVK BACE2_HUMAN Affects Response To Substance [19]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B) OTOA8WU2 PDE4B_HUMAN Affects Response To Substance [19]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) OTOWDUNT PTEN_HUMAN Increases Response To Substance [52]
Ras-related protein Rab-20 (RAB20) OTP9OOVS RAB20_HUMAN Affects Response To Substance [19]
DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C) OTPL0AI1 ABC3C_HUMAN Affects Response To Substance [19]
Epithelial membrane protein 2 (EMP2) OTPS2H0L EMP2_HUMAN Affects Response To Substance [19]
Ropporin-1A (ROPN1) OTPXKZTX ROP1A_HUMAN Affects Response To Substance [19]
Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) OTPYQX3K C1QBP_HUMAN Decreases Response To Substance [109]
Cyclic GMP-AMP phosphodiesterase SMPDL3A (SMPDL3A) OTQDYH8E ASM3A_HUMAN Affects Response To Substance [19]
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (ANKRD28) OTRBREQ9 ANR28_HUMAN Affects Response To Substance [19]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Response To Substance [110]
Disabled homolog 2 (DAB2) OTRMQTMZ DAB2_HUMAN Affects Response To Substance [19]
Large ribosomal subunit protein eL6 (RPL6) OTRU71O4 RL6_HUMAN Decreases Response To Substance [111]
Band 4.1-like protein 3 (EPB41L3) OTS6CHG2 E41L3_HUMAN Affects Response To Substance [19]
Heat shock-related 70 kDa protein 2 (HSPA2) OTSDET7B HSP72_HUMAN Affects Response To Substance [19]
MyoD family inhibitor domain-containing protein (MDFIC) OTSRYBWZ MDFIC_HUMAN Affects Response To Substance [19]
Terminal nucleotidyltransferase 5A (TENT5A) OTSYF511 TET5A_HUMAN Affects Response To Substance [19]
Collagen alpha-1(XV) chain (COL15A1) OTTFKK18 COFA1_HUMAN Affects Response To Substance [19]
Bcl-2-interacting killer (BIK) OTTH1T3D BIK_HUMAN Increases Response To Substance [112]
Serine/threonine-protein kinase Chk1 (CHEK1) OTTTI622 CHK1_HUMAN Affects Response To Substance [113]
Max-interacting protein 1 (MXI1) OTUQ9E0D MXI1_HUMAN Affects Response To Substance [19]
Calcium-dependent secretion activator 2 (CADPS2) OTV1FW0M CAPS2_HUMAN Affects Response To Substance [19]
Forkhead box protein F2 (FOXF2) OTV20NGX FOXF2_HUMAN Affects Response To Substance [19]
Metastasis-associated in colon cancer protein 1 (MACC1) OTV3DLX0 MACC1_HUMAN Increases ADR [114]
Matrilin-2 (MATN2) OTVDR68G MATN2_HUMAN Affects Response To Substance [19]
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (MACF1) OTVIHD77 MACF1_HUMAN Affects Response To Substance [19]
Poly polymerase tankyrase-1 (TNKS) OTVOUTPX TNKS1_HUMAN Affects Response To Substance [19]
Ensconsin (MAP7) OTVSSJ33 MAP7_HUMAN Affects Response To Substance [19]
Sorbin and SH3 domain-containing protein 1 (SORBS1) OTWH8762 SRBS1_HUMAN Affects Response To Substance [19]
Anamorsin (CIAPIN1) OTWS90F9 CPIN1_HUMAN Decreases Response To Substance [115]
S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) OTX8L3M5 SAHH2_HUMAN Affects Response To Substance [19]
Long-chain fatty acid transport protein 3 (SLC27A3) OTXB60L7 S27A3_HUMAN Affects Response To Substance [19]
Coiled-coil domain-containing protein 6 (CCDC6) OTXRQDYG CCDC6_HUMAN Decreases Response To Substance [116]
Arginine vasopressin-induced protein 1 (AVPI1) OTXSBR60 AVPI1_HUMAN Affects Response To Substance [19]
Carbamoyl-phosphate synthase , mitochondrial (CPS1) OTXV8NSR CPSM_HUMAN Affects Response To Substance [19]
Peripheral myelin protein 22 (PMP22) OTXWYWCZ PMP22_HUMAN Affects Response To Substance [19]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (HMG20B) OTY94WRA HM20B_HUMAN Affects Response To Substance [19]
Protein Niban 1 (NIBAN1) OTYOLI12 NIBA1_HUMAN Affects Response To Substance [19]
LIM and calponin homology domains-containing protein 1 (LIMCH1) OTYPC4XA LIMC1_HUMAN Affects Response To Substance [19]
L-dopachrome tautomerase (DCT) OTYVNTBG TYRP2_HUMAN Affects Response To Substance [19]
PRA1 family protein 3 (ARL6IP5) OTYZ6BEQ PRAF3_HUMAN Increases Response To Substance [117]
DNA (DNMT3B) OTZ0JCNP DNM3B_HUMAN Decreases Response To Substance [118]
Calcitonin (CALCA) OTZ11LHB CALC_HUMAN Decreases Response To Substance [119]
Hephaestin (HEPH) OTZ2F15Z HEPH_HUMAN Affects Response To Substance [19]
Tissue factor pathway inhibitor 2 (TFPI2) OTZCRWOR TFPI2_HUMAN Affects Response To Substance [19]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Affects Response To Substance [19]
Suppressor of tumorigenicity 7 protein (ST7) OTZG8RC6 ST7_HUMAN Affects Response To Substance [19]
UPF0489 protein C5orf22 (C5ORF22) OTZN0DCX CE022_HUMAN Affects Response To Substance [19]
Alkaline phosphatase, placental type (ALPP) OTZU4G9W PPB1_HUMAN Affects Response To Substance [19]
Drebrin (DBN1) OTZVKG8A DREB_HUMAN Affects Response To Substance [19]
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⏷ Show the Full List of 347 DOT(s)
Indication(s) of Panobinostat
Disease Entry ICD 11 Status REF
Chronic graft versus host disease N.A. Approved [6]
Lung cancer 2C25.0 Approved [6]
Multiple myeloma 2A83 Approved [7]
Non-small-cell lung cancer 2C25.Y Approved [6]
Plasma cell myeloma 2A83.1 Approved [6]
Primary cutaneous T-cell lymphoma N.A. Approved [6]
Type-2 diabetes 5A11 Phase 3 [8]
Primary myelofibrosis 2A20.2 Phase 2 [8]
Panobinostat Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Histone deacetylase 1 (HDAC1) TT6R7JZ HDAC1_HUMAN Inhibitor [123]
------------------------------------------------------------------------------------
Panobinostat Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [124]
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Panobinostat Interacts with 1 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [125]
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Panobinostat Interacts with 866 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [126]
DNA-directed RNA polymerase II subunit RPB1 (POLR2A) OTHJQ1DZ RPB1_HUMAN Decreases Phosphorylation [126]
Diphosphoinositol polyphosphate phosphohydrolase NUDT4B (NUDT4) OTA6ICI2 NUD4B_HUMAN Increases Expression [120]
ADP-ribose glycohydrolase MACROD2 (MACROD2) OTNQCHC6 MACD2_HUMAN Decreases Expression [120]
Transmembrane protein 218 (TMEM218) OTM46L89 TM218_HUMAN Decreases Expression [120]
Cadherin-like and PC-esterase domain-containing protein 1 (CPED1) OTJJPZOZ CPED1_HUMAN Increases Expression [120]
Killer cell lectin-like receptor subfamily G member 2 (KLRG2) OTBLEXSC KLRG2_HUMAN Increases Expression [120]
Protein FAM149A (FAM149A) OTMDM0RI F149A_HUMAN Decreases Expression [120]
Developmental pluripotency-associated 5 protein (DPPA5) OTLZC371 DPPA5_HUMAN Increases Expression [120]
Metalloprotease TIKI2 (TRABD2B) OTI7B18G TIKI2_HUMAN Increases Expression [120]
RNA binding protein fox-1 homolog 3 (RBFOX3) OTL0F3D6 RFOX3_HUMAN Decreases Expression [120]
Coiled-coil domain-containing protein 69 (CCDC69) OT43MI0R CCD69_HUMAN Increases Expression [120]
Ras association domain-containing protein 10 (RASSF10) OTGB7EBG RASFA_HUMAN Decreases Expression [120]
Very-long-chain (HACD1) OTEC7EP7 HACD1_HUMAN Increases Expression [120]
NALCN channel auxiliary factor 1 (NALF1) OT8OMCFD NALF1_HUMAN Decreases Expression [120]
Rab GTPase-activating protein 1-like, isoform 10 (RABGAP1L) OT7QO47I RBG10_HUMAN Increases Expression [120]
Alternative prion protein (PRNP) OTE85L1Q APRIO_HUMAN Increases Expression [120]
Suppressyn (ERVH48-1) OT303JGE SUPYN_HUMAN Increases Expression [120]
PDZ and LIM domain protein 1 (PDLIM1) OT4EGCPG PDLI1_HUMAN Increases Expression [120]
Activator of apoptosis harakiri (HRK) OTR4GWJ0 HRK_HUMAN Increases Expression [120]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) OTQ4W7MT TR11B_HUMAN Increases Expression [120]
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2) OTKOZRZP PLOD2_HUMAN Increases Expression [120]
Beta-1,3-N-acetylglucosaminyltransferase manic fringe (MFNG) OTUX45ZF MFNG_HUMAN Decreases Expression [120]
Podocalyxin (PODXL) OTPNQXF3 PODXL_HUMAN Increases Expression [120]
E3 ubiquitin-protein ligase TRIM38 (TRIM38) OT6SP1M9 TRI38_HUMAN Increases Expression [120]
Nuclear factor 1 B-type (NFIB) OTX94PD0 NFIB_HUMAN Increases Expression [120]
Class E basic helix-loop-helix protein 40 (BHLHE40) OTITX14U BHE40_HUMAN Increases Expression [120]
Suppressor of cytokine signaling 2 (SOCS2) OTBPNKJQ SOCS2_HUMAN Increases Expression [120]
Astrotactin-1 (ASTN1) OT23FQIB ASTN1_HUMAN Decreases Expression [120]
Cytoplasmic dynein 1 intermediate chain 1 (DYNC1I1) OTFX1KCG DC1I1_HUMAN Increases Expression [120]
Transmembrane gamma-carboxyglutamic acid protein 1 (PRRG1) OTMH6OWG TMG1_HUMAN Increases Expression [120]
Putative transcription factor Ovo-like 1 (OVOL1) OTFJ62UI OVOL1_HUMAN Increases Expression [120]
Tumor necrosis factor ligand superfamily member 11 (TNFSF11) OTJEPKEQ TNF11_HUMAN Increases Expression [120]
Probable proton-coupled zinc antiporter SLC30A4 (SLC30A4) OTUYJNBS ZNT4_HUMAN Increases Expression [120]
Interferon regulatory factor 6 (IRF6) OTKJ44EV IRF6_HUMAN Increases Expression [120]
Calmegin (CLGN) OTEWVFQV CLGN_HUMAN Decreases Expression [120]
Semaphorin-3E (SEMA3E) OTD4S36H SEM3E_HUMAN Increases Expression [120]
Serine/threonine-protein kinase DCLK1 (DCLK1) OTVSPS98 DCLK1_HUMAN Increases Expression [120]
Phospholipid scramblase 1 (PLSCR1) OTGY9B5T PLS1_HUMAN Increases Expression [120]
Mitogen-activated protein kinase 13 (MAPK13) OT0W9GE7 MK13_HUMAN Increases Expression [120]
DNA-directed RNA polymerase III subunit RPC7 (POLR3G) OTU3TGQ9 RPC7_HUMAN Increases Expression [120]
Prosaposin receptor GPR37 (GPR37) OTIMDDI3 GPR37_HUMAN Increases Expression [120]
Monocarboxylate transporter 5 (SLC16A4) OT1YXBKC MOT5_HUMAN Increases Expression [120]
TOX high mobility group box family member 3 (TOX3) OTC9NR4W TOX3_HUMAN Decreases Expression [120]
Regulator of G-protein signaling 5 (RGS5) OTUY0Q2I RGS5_HUMAN Increases Expression [120]
Leucine-rich repeat transmembrane protein FLRT2 (FLRT2) OTGD8TID FLRT2_HUMAN Decreases Expression [120]
Rho GTPase-activating protein 6 (ARHGAP6) OTNVXXFX RHG06_HUMAN Increases Expression [120]
Disintegrin and metalloproteinase domain-containing protein 12 (ADAM12) OTZKOTDB ADA12_HUMAN Decreases Expression [120]
Proline dehydrogenase 1, mitochondrial (PRODH) OT7SQ1C7 PROD_HUMAN Increases Expression [120]
Transforming growth factor beta-1-induced transcript 1 protein (TGFB1I1) OTIK337D TGFI1_HUMAN Increases Expression [120]
Phospholipid-transporting ATPase IC (ATP8B1) OTALGS63 AT8B1_HUMAN Increases Expression [120]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Decreases Expression [120]
Carbonic anhydrase 12 (CA12) OT6WNFU8 CAH12_HUMAN Increases Expression [120]
Synaptotagmin-7 (SYT7) OTBWAOWY SYT7_HUMAN Increases Expression [120]
Protein sprouty homolog 1 (SPRY1) OT764FXI SPY1_HUMAN Decreases Expression [120]
Zinc finger protein SNAI2 (SNAI2) OT7Y8EJ2 SNAI2_HUMAN Increases Expression [120]
Synaptogyrin-1 (SYNGR1) OT0MBUK5 SNG1_HUMAN Increases Expression [120]
Protocadherin-7 (PCDH7) OTP091X8 PCDH7_HUMAN Increases Expression [120]
Kallikrein-8 (KLK8) OTGVGHXY KLK8_HUMAN Increases Expression [120]
Phospholipid-transporting ATPase IK (ATP8B3) OTZOGEJO AT8B3_HUMAN Increases Expression [120]
Periplakin (PPL) OTTM4WDO PEPL_HUMAN Increases Expression [120]
BMP/retinoic acid-inducible neural-specific protein 1 (BRINP1) OTEUVSCP BRNP1_HUMAN Increases Expression [120]
Homeobox protein DLX-3 (DLX3) OTARP5SQ DLX3_HUMAN Increases Expression [120]
Plexin-C1 (PLXNC1) OTJ5XKYY PLXC1_HUMAN Decreases Expression [120]
Gremlin-1 (GREM1) OTCK4IGV GREM1_HUMAN Increases Expression [120]
Cyclin-T2 (CCNT2) OTBDRH1J CCNT2_HUMAN Decreases Expression [120]
Histone H2B type 1-K (H2BC12) OTQ8V0KG H2B1K_HUMAN Decreases Expression [120]
Growth arrest-specific protein 7 (GAS7) OT0M5TNY GAS7_HUMAN Increases Expression [120]
Protein diaphanous homolog 2 (DIAPH2) OTBEYFEZ DIAP2_HUMAN Increases Expression [120]
Inward rectifier potassium channel 13 (KCNJ13) OTG1CNND KCJ13_HUMAN Decreases Expression [120]
Plexin-A2 (PLXNA2) OTNNBJMQ PLXA2_HUMAN Increases Expression [120]
Frizzled-7 (FZD7) OTTK3F6E FZD7_HUMAN Increases Expression [120]
Slit homolog 1 protein (SLIT1) OT35RBNT SLIT1_HUMAN Increases Expression [120]
Slit homolog 3 protein (SLIT3) OTU8MKEU SLIT3_HUMAN Increases Expression [120]
Probable phospholipid-transporting ATPase IIA (ATP9A) OT328F1L ATP9A_HUMAN Decreases Expression [120]
Microfibrillar-associated protein 3-like (MFAP3L) OTNMHSAH MFA3L_HUMAN Decreases Expression [120]
Protein cordon-bleu (COBL) OTTB4VFQ COBL_HUMAN Increases Expression [120]
Astrotactin-2 (ASTN2) OTF0W2FJ ASTN2_HUMAN Increases Expression [120]
Calcium-transporting ATPase type 2C member 2 (ATP2C2) OTGIHTYQ AT2C2_HUMAN Increases Expression [120]
Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B) OTL9I7LO GA45B_HUMAN Increases Expression [120]
Core histone macro-H2A.1 (MACROH2A1) OTV2DQDD H2AY_HUMAN Decreases Expression [120]
Filamin-B (FLNB) OTPCOYL6 FLNB_HUMAN Increases Expression [120]
Large neutral amino acids transporter small subunit 3 (SLC43A1) OTQJQY3S LAT3_HUMAN Increases Expression [120]
Transforming acidic coiled-coil-containing protein 1 (TACC1) OTGX20TE TACC1_HUMAN Increases Expression [120]
NADH dehydrogenase 1 beta subcomplex subunit 1 (NDUFB1) OTLMT95K NDUB1_HUMAN Decreases Expression [120]
Glypican-4 (GPC4) OTUJ14DW GPC4_HUMAN Decreases Expression [120]
Disabled homolog 1 (DAB1) OTPL9MA3 DAB1_HUMAN Decreases Expression [120]
Src kinase-associated phosphoprotein 2 (SKAP2) OTSF44KP SKAP2_HUMAN Increases Expression [120]
Forkhead box protein H1 (FOXH1) OTEXJ9SL FOXH1_HUMAN Increases Expression [120]
PR domain zinc finger protein 1 (PRDM1) OTQLSVBS PRDM1_HUMAN Increases Expression [120]
Scrapie-responsive protein 1 (SCRG1) OTBE7V0P SCRG1_HUMAN Increases Expression [120]
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (SLC25A12) OTB4YBVT S2512_HUMAN Increases Expression [120]
Leukocyte cell-derived chemotaxin 1 (CNMD) OTHND8EL CNMD_HUMAN Increases Expression [120]
Serine/threonine-protein kinase PAK 3 (PAK3) OT80M3BV PAK3_HUMAN Decreases Expression [120]
Lysozyme-like protein 6 (LYZL6) OT6XS67M LYZL6_HUMAN Increases Expression [120]
Nucleolar protein 4 (NOL4) OTWI587R NOL4_HUMAN Decreases Expression [120]
Kelch repeat and BTB domain-containing protein 11 (KBTBD11) OTBOY3WH KBTBB_HUMAN Decreases Expression [120]
Unconventional myosin-Id (MYO1D) OTP2RGPN MYO1D_HUMAN Increases Expression [120]
Protein transport protein Sec24D (SEC24D) OTXR3KC9 SC24D_HUMAN Increases Expression [120]
Neurofascin (NFASC) OTBDUXZT NFASC_HUMAN Decreases Expression [120]
Thymocyte selection-associated high mobility group box protein TOX (TOX) OTE8BL5Z TOX_HUMAN Increases Expression [120]
Glutaminase kidney isoform, mitochondrial (GLS) OTGOZG2M GLSK_HUMAN Increases Expression [120]
Rho-related BTB domain-containing protein 3 (RHOBTB3) OT1BFKPH RHBT3_HUMAN Increases Expression [120]
Serine protease 23 (PRSS23) OT6DQAM1 PRS23_HUMAN Decreases Expression [120]
Peripheral-type benzodiazepine receptor-associated protein 1 (TSPOAP1) OTAM8SGF RIMB1_HUMAN Decreases Expression [120]
Chondroitin sulfate proteoglycan 5 (CSPG5) OTXFEBWR CSPG5_HUMAN Decreases Expression [120]
Protocadherin-8 (PCDH8) OTDDOQM2 PCDH8_HUMAN Increases Expression [120]
Histone acetyltransferase KAT7 (KAT7) OTUN98IC KAT7_HUMAN Decreases Expression [120]
Ly6/PLAUR domain-containing protein 3 (LYPD3) OTLR2PYX LYPD3_HUMAN Increases Expression [120]
Homeobox protein SIX3 (SIX3) OTP5E3VU SIX3_HUMAN Decreases Expression [120]
Neuroendocrine secretory protein 55 (GNAS) OTMH8BKJ GNAS3_HUMAN Increases Expression [120]
Claudin-7 (CLDN7) OTNE0XHQ CLD7_HUMAN Increases Expression [120]
Homeobox protein SIX6 (SIX6) OTD1RD9D SIX6_HUMAN Decreases Expression [120]
Protein phosphatase 1 regulatory subunit 3D (PPP1R3D) OTZNC7R2 PPR3D_HUMAN Increases Expression [120]
C-X-C motif chemokine 14 (CXCL14) OTM189TA CXL14_HUMAN Increases Expression [120]
Heat shock 70 kDa protein 4L (HSPA4L) OT181WZB HS74L_HUMAN Increases Expression [120]
TBC1 domain family member 8 (TBC1D8) OT2011SS TBCD8_HUMAN Decreases Expression [120]
BAG family molecular chaperone regulator 2 (BAG2) OTI6LD27 BAG2_HUMAN Increases Expression [120]
Claudin-1 (CLDN1) OT27KV99 CLD1_HUMAN Increases Expression [120]
Histone-lysine N-methyltransferase NSD2 (NSD2) OTQ6SW4R NSD2_HUMAN Decreases Expression [120]
Argininosuccinate synthase (ASS1) OT4ZMG0Q ASSY_HUMAN Increases Expression [120]
Serine protease inhibitor Kazal-type 1 (SPINK1) OTSUVAL2 ISK1_HUMAN Increases Expression [120]
Proenkephalin-B (PDYN) OTEJ6430 PDYN_HUMAN Increases Expression [120]
Calcitonin (CALCA) OTZ11LHB CALC_HUMAN Increases Expression [120]
Pro-neuropeptide Y (NPY) OT4ICV3P NPY_HUMAN Increases Expression [120]
Alpha-1-acid glycoprotein 1 (ORM1) OTZKSBRE A1AG1_HUMAN Decreases Expression [120]
Annexin A1 (ANXA1) OT5OFDJC ANXA1_HUMAN Increases Expression [120]
Ornithine aminotransferase, mitochondrial (OAT) OTEKO8CT OAT_HUMAN Increases Expression [120]
HLA class II histocompatibility antigen gamma chain (CD74) OTO16X4Q HG2A_HUMAN Increases Expression [120]
Protein S100-B (S100B) OTHHDS33 S100B_HUMAN Increases Expression [120]
Glycophorin-C (GYPC) OTOEDR7O GLPC_HUMAN Increases Expression [120]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [120]
Fatty acid-binding protein, heart (FABP3) OT562DA1 FABPH_HUMAN Increases Expression [120]
Transcription factor AP-2-alpha (TFAP2A) OTMYT3NK AP2A_HUMAN Increases Expression [120]
Keratin, type I cytoskeletal 18 (KRT18) OTVLQFIP K1C18_HUMAN Increases Expression [120]
Keratin, type II cytoskeletal 8 (KRT8) OTTM4X11 K2C8_HUMAN Increases Expression [120]
Beta-crystallin A3 (CRYBA1) OT8617WJ CRBA1_HUMAN Decreases Expression [120]
Collagen alpha-2(V) chain (COL5A2) OT5VOSQE CO5A2_HUMAN Increases Expression [120]
Protein S100-A6 (S100A6) OTHHPZQ8 S10A6_HUMAN Increases Expression [120]
Neurofilament light polypeptide (NEFL) OTQESJV4 NFL_HUMAN Increases Expression [120]
Neurofilament medium polypeptide (NEFM) OT8VCBNF NFM_HUMAN Increases Expression [120]
Tyrosine-protein kinase Lyn (LYN) OTP686K2 LYN_HUMAN Increases Expression [120]
Collagen alpha-2(I) chain (COL1A2) OTY7G382 CO1A2_HUMAN Increases Expression [120]
Tumor necrosis factor receptor superfamily member 16 (NGFR) OTPKSM49 TNR16_HUMAN Increases Expression [120]
Retinol-binding protein 1 (RBP1) OTRP1MFC RET1_HUMAN Increases Expression [120]
Protein FAM200B (FAM200B) OTQMCR8C F200B_HUMAN Decreases Expression [120]
Apelin receptor early endogenous ligand (APELA) OTYY0P69 ELA_HUMAN Increases Expression [120]
COUP transcription factor 1 (NR2F1) OTGWZWYL COT1_HUMAN Increases Expression [120]
Chromogranin-A (CHGA) OTXYX5JH CMGA_HUMAN Increases Expression [120]
Mast/stem cell growth factor receptor Kit (KIT) OTHUY3VZ KIT_HUMAN Increases Expression [120]
Hyaluronan and proteoglycan link protein 1 (HAPLN1) OTXWR9TJ HPLN1_HUMAN Increases Expression [120]
Microtubule-associated protein 2 (MAP2) OT6UYT3X MTAP2_HUMAN Increases Expression [120]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3) OT2HZK5M GTR3_HUMAN Increases Expression [120]
Collagen alpha-1(VI) chain (COL6A1) OTYKSCOB CO6A1_HUMAN Increases Expression [120]
Collagen alpha-3(VI) chain (COL6A3) OTAS6R6I CO6A3_HUMAN Increases Expression [120]
Annexin A3 (ANXA3) OTDD8OI7 ANXA3_HUMAN Increases Expression [120]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Increases Expression [120]
Interferon-induced transmembrane protein 1 (IFITM1) OTECO1G8 IFM1_HUMAN Increases Expression [120]
Gamma-interferon-inducible lysosomal thiol reductase (IFI30) OT9DERT1 GILT_HUMAN Increases Expression [120]
Protein Cripto (CRIPTO) OT46DZXJ TDGF1_HUMAN Increases Expression [120]
Phospholipase A2, membrane associated (PLA2G2A) OT1NY7BF PA2GA_HUMAN Increases Expression [120]
Ras-related C3 botulinum toxin substrate 2 (RAC2) OTAOHFNH RAC2_HUMAN Increases Expression [120]
Ezrin (EZR) OTHBPF1Z EZRI_HUMAN Increases Expression [120]
CD44 antigen (CD44) OT9TTJ41 CD44_HUMAN Increases Expression [120]
Solute carrier family 25 member 16 (SLC25A16) OTTTUL91 GDC_HUMAN Increases Expression [120]
Epithelial cell adhesion molecule (EPCAM) OTHBZK5X EPCAM_HUMAN Increases Expression [120]
Atrial natriuretic peptide receptor 3 (NPR3) OT6MQP3A ANPRC_HUMAN Increases Expression [120]
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) OTAKDCMR KAPCA_HUMAN Increases Expression [120]
Integrin beta-5 (ITGB5) OT21MF51 ITB5_HUMAN Decreases Expression [120]
Pituitary adenylate cyclase-activating polypeptide (ADCYAP1) OT0LQH93 PACA_HUMAN Increases Expression [120]
Cadherin-2 (CDH2) OTH0Y56P CADH2_HUMAN Decreases Expression [120]
Hexokinase-1 (HK1) OTMPHE8O HXK1_HUMAN Increases Expression [120]
Alpha-1-acid glycoprotein 2 (ORM2) OTRJGZP8 A1AG2_HUMAN Decreases Expression [120]
Serine protease inhibitor Kazal-type 2 (SPINK2) OTSFBT0G ISK2_HUMAN Increases Expression [120]
POU domain, class 3, transcription factor 3 (POU3F3) OT6BBXPD PO3F3_HUMAN Increases Expression [120]
Protachykinin-1 (TAC1) OTM842YW TKN1_HUMAN Increases Expression [120]
Serine/threonine-protein kinase MAK (MAK) OTEU2G41 MAK_HUMAN Decreases Expression [120]
Ephrin-A1 (EFNA1) OTU2NUA2 EFNA1_HUMAN Increases Expression [120]
Neurofibromin (NF1) OTC29NHH NF1_HUMAN Decreases Expression [120]
Kit ligand (KITLG) OTB9AVQ4 SCF_HUMAN Increases Expression [120]
Diamine acetyltransferase 1 (SAT1) OT52AU22 SAT1_HUMAN Increases Expression [120]
Receptor tyrosine-protein kinase erbB-3 (ERBB3) OTRSST0A ERBB3_HUMAN Increases Expression [120]
CD9 antigen (CD9) OT2184XU CD9_HUMAN Increases Expression [120]
Bone morphogenetic protein 5 (BMP5) OTC0Y6E0 BMP5_HUMAN Increases Expression [120]
Alpha-(1,3)-fucosyltransferase 4 (FUT4) OTIBXRTL FUT4_HUMAN Increases Expression [120]
Cadherin-3 (CDH3) OTKNLQU7 CADH3_HUMAN Increases Expression [120]
Calretinin (CALB2) OTSNMCG9 CALB2_HUMAN Increases Expression [120]
Carbonic anhydrase 4 (CA4) OT3K93LZ CAH4_HUMAN Decreases Expression [120]
Peptidyl-prolyl cis-trans isomerase B (PPIB) OTLPH6KN PPIB_HUMAN Increases Expression [120]
Colorectal mutant cancer protein (MCC) OTQVI1EM CRCM_HUMAN Increases Expression [120]
Paired box protein Pax-7 (PAX7) OTDMQRPO PAX7_HUMAN Increases Expression [120]
Paired box protein Pax-3 (PAX3) OTN5PJZV PAX3_HUMAN Increases Expression [120]
Endothelial transcription factor GATA-2 (GATA2) OTBP2QQ2 GATA2_HUMAN Increases Expression [120]
Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) OTGP7D5Y GATA3_HUMAN Increases Expression [120]
Laminin subunit alpha-2 (LAMA2) OTFROQWE LAMA2_HUMAN Increases Expression [120]
COUP transcription factor 2 (NR2F2) OTJFS67N COT2_HUMAN Decreases Expression [120]
Endothelin receptor type B (EDNRB) OTLLZV3P EDNRB_HUMAN Increases Expression [120]
Protein kinase C eta type (PRKCH) OTC498N5 KPCL_HUMAN Increases Expression [120]
Signal transducer CD24 (CD24) OT7CODJ4 CD24_HUMAN Increases Expression [120]
Atypical chemokine receptor 3 (ACKR3) OTA6GA4F ACKR3_HUMAN Increases Expression [120]
Myelin protein P0 (MPZ) OTAR2YXH MYP0_HUMAN Increases Expression [120]
Collagen alpha-3(V) chain (COL5A3) OTCGC4DM CO5A3_HUMAN Increases Expression [120]
Paired box protein Pax-6 (PAX6) OTOC9876 PAX6_HUMAN Decreases Expression [120]
Protein S100-A4 (S100A4) OTLRGFSQ S10A4_HUMAN Increases Expression [120]
Threonine--tRNA ligase 1, cytoplasmic (TARS1) OT0PWST5 SYTC_HUMAN Increases Expression [120]
Homeobox protein MSX-1 (MSX1) OT5U41ZP MSX1_HUMAN Increases Expression [120]
Gamma-aminobutyric acid receptor subunit beta-3 (GABRB3) OT80C3D4 GBRB3_HUMAN Increases Expression [120]
Cellular retinoic acid-binding protein 2 (CRABP2) OTY01V9G RABP2_HUMAN Increases Expression [120]
GTP cyclohydrolase 1 feedback regulatory protein (GCHFR) OTEOT8GI GFRP_HUMAN Increases Expression [120]
CAMPATH-1 antigen (CD52) OT02LDQN CD52_HUMAN Increases Expression [120]
Fibroblast growth factor 9 (FGF9) OT2SKDGM FGF9_HUMAN Decreases Expression [120]
Syndecan-4 (SDC4) OTKUVUGZ SDC4_HUMAN Increases Expression [120]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Increases Expression [120]
Protein S100-A11 (S100A11) OTI57KDN S10AB_HUMAN Increases Expression [120]
ETS-related transcription factor Elf-1 (ELF1) OTV5LKIA ELF1_HUMAN Increases Expression [120]
Intercellular adhesion molecule 3 (ICAM3) OTTZ5A5D ICAM3_HUMAN Increases Expression [120]
Long-chain-fatty-acid--CoA ligase 1 (ACSL1) OTB06ESI ACSL1_HUMAN Increases Expression [120]
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (MAN1A1) OT6LIGJP MA1A1_HUMAN Increases Expression [120]
Carbonic anhydrase-related protein (CA8) OT9Y8GA8 CAH8_HUMAN Increases Expression [120]
Thrombospondin-2 (THBS2) OTXET551 TSP2_HUMAN Increases Expression [120]
Homeobox protein MSX-2 (MSX2) OT1WDKE1 MSX2_HUMAN Increases Expression [120]
Fibrillin-1 (FBN1) OTYCJT63 FBN1_HUMAN Decreases Expression [120]
Transcription factor SOX-11 (SOX11) OT4LG7LA SOX11_HUMAN Decreases Expression [120]
Amiloride-sensitive sodium channel subunit alpha (SCNN1A) OTE2KVZV SCNNA_HUMAN Increases Expression [120]
Kappa-type opioid receptor (OPRK1) OTXCZF4L OPRK_HUMAN Decreases Expression [120]
Transcription factor SOX-3 (SOX3) OT1CRCOB SOX3_HUMAN Decreases Expression [120]
Pituitary adenylate cyclase-activating polypeptide type I receptor (ADCYAP1R1) OTNBHULA PACR_HUMAN Increases Expression [120]
C-X-C motif chemokine 5 (CXCL5) OTZOUPCA CXCL5_HUMAN Increases Expression [120]
Netrin receptor DCC (DCC) OT2C1SHW DCC_HUMAN Increases Expression [120]
Transcription factor GATA-4 (GATA4) OTQHWAZG GATA4_HUMAN Decreases Expression [120]
Peptidyl-prolyl cis-trans isomerase C (PPIC) OTY5Q42N PPIC_HUMAN Increases Expression [120]
Radiation-inducible immediate-early gene IEX-1 (IER3) OTZJI5FZ IEX1_HUMAN Increases Expression [120]
Ras GTPase-activating-like protein IQGAP1 (IQGAP1) OTZRWTGA IQGA1_HUMAN Increases Expression [120]
Gamma-aminobutyric acid receptor subunit beta-2 (GABRB2) OTAOZIGX GBRB2_HUMAN Increases Expression [120]
Retinaldehyde dehydrogenase 3 (ALDH1A3) OT1C9NKQ AL1A3_HUMAN Increases Expression [120]
DNA-binding protein inhibitor ID-4 (ID4) OTPMJ39I ID4_HUMAN Increases Expression [120]
Sodium- and chloride-dependent creatine transporter 1 (SLC6A8) OT88C8JA SC6A8_HUMAN Decreases Expression [120]
Tissue factor pathway inhibitor 2 (TFPI2) OTZCRWOR TFPI2_HUMAN Increases Expression [120]
Transcription factor SOX-9 (SOX9) OTVDJFGN SOX9_HUMAN Increases Expression [120]
Potassium voltage-gated channel subfamily C member 1 (KCNC1) OTW9WF1J KCNC1_HUMAN Decreases Expression [120]
Nuclear receptor-interacting protein 1 (NRIP1) OTIZOJQV NRIP1_HUMAN Increases Expression [120]
Protein ERGIC-53 (LMAN1) OTYHKDEO LMAN1_HUMAN Decreases Expression [120]
CCAAT/enhancer-binding protein delta (CEBPD) OTNBIPMY CEBPD_HUMAN Increases Expression [120]
Selenoprotein P (SELENOP) OT02B8IR SEPP1_HUMAN Increases Expression [120]
Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A) OT5QQB5L IDH3A_HUMAN Increases Expression [120]
Motor neuron and pancreas homeobox protein 1 (MNX1) OTXP9FH1 MNX1_HUMAN Increases Expression [120]
Homeobox protein MOX-1 (MEOX1) OTJEMT2D MEOX1_HUMAN Increases Expression [120]
Serpin B9 (SERPINB9) OTJ811IF SPB9_HUMAN Increases Expression [120]
LIM/homeobox protein Lhx2 (LHX2) OTK61NP8 LHX2_HUMAN Decreases Expression [120]
ETS translocation variant 1 (ETV1) OT6PMJIK ETV1_HUMAN Decreases Expression [120]
Amiloride-sensitive sodium channel subunit gamma (SCNN1G) OTSJYQVQ SCNNG_HUMAN Increases Expression [120]
Probable global transcription activator SNF2L2 (SMARCA2) OTSGJ8SV SMCA2_HUMAN Increases Expression [120]
Ephrin-A5 (EFNA5) OTOH4DRR EFNA5_HUMAN Decreases Expression [120]
Homeobox protein GBX-2 (GBX2) OTW0ZI4D GBX2_HUMAN Increases Expression [120]
Beta-crystallin A4 (CRYBA4) OTQJ5XGE CRBA4_HUMAN Decreases Expression [120]
Mitogen-activated protein kinase 10 (MAPK10) OTC46VX1 MK10_HUMAN Decreases Expression [120]
Calcipressin-1 (RCAN1) OT1MVXC7 RCAN1_HUMAN Increases Expression [120]
Voltage-dependent calcium channel subunit alpha-2/delta-1 (CACNA2D1) OT5YLZIH CA2D1_HUMAN Increases Expression [120]
Paired mesoderm homeobox protein 1 (PRRX1) OTTZK5G8 PRRX1_HUMAN Increases Expression [120]
Tyrosine-protein phosphatase non-receptor type 5 (PTPN5) OT2H1KDK PTN5_HUMAN Decreases Expression [120]
Epithelial membrane protein 1 (EMP1) OTSZHUHQ EMP1_HUMAN Increases Expression [120]
Cadherin-8 (CDH8) OTS3SRZ6 CADH8_HUMAN Decreases Expression [120]
Homeobox protein DLX-6 (DLX6) OT0FIJHY DLX6_HUMAN Decreases Expression [120]
Transcription factor SOX-10 (SOX10) OTF25ULQ SOX10_HUMAN Increases Expression [120]
Transcription factor SOX-8 (SOX8) OTEJXYZM SOX8_HUMAN Increases Expression [120]
Potassium channel subfamily K member 10 (KCNK10) OT93GC7V KCNKA_HUMAN Decreases Expression [120]
Inhibin beta E chain (INHBE) OTOI2NYG INHBE_HUMAN Increases Expression [120]
Myelin proteolipid protein (PLP1) OT8CM9CX MYPR_HUMAN Increases Expression [120]
Protein S100-A10 (S100A10) OTI71243 S10AA_HUMAN Increases Expression [120]
Rho-related GTP-binding protein RhoE (RND3) OTXMXPIH RND3_HUMAN Increases Expression [120]
Neurocalcin-delta (NCALD) OTJZ8UEL NCALD_HUMAN Decreases Expression [120]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 (GNG11) OTHIXBGW GBG11_HUMAN Increases Expression [120]
Rho-related GTP-binding protein RhoB (RHOB) OTHQFQF7 RHOB_HUMAN Increases Expression [120]
Small ribosomal subunit protein eS24 (RPS24) OTSNKIL5 RS24_HUMAN Increases Expression [120]
Large ribosomal subunit protein eL31 (RPL31) OTV9E1OE RL31_HUMAN Decreases Expression [120]
Iroquois-class homeodomain protein IRX-1 (IRX1) OT0ZN9EJ IRX1_HUMAN Increases Expression [120]
Iroquois-class homeodomain protein IRX-3 (IRX3) OTLJ48FG IRX3_HUMAN Increases Expression [120]
Reelin (RELN) OTLKMW1O RELN_HUMAN Increases Expression [120]
ETS-related transcription factor Elf-3 (ELF3) OTUTLEQO ELF3_HUMAN Increases Expression [120]
4-aminobutyrate aminotransferase, mitochondrial (ABAT) OTXAGR7J GABT_HUMAN Increases Expression [120]
Single-stranded DNA-binding protein 2 (SSBP2) OTYG1G80 SSBP2_HUMAN Decreases Expression [120]
Serine beta-lactamase-like protein LACTB, mitochondrial (LACTB) OTRWGNBF LACTB_HUMAN Increases Expression [120]
Matrix-remodeling-associated protein 7 (MXRA7) OTVQLYIY MXRA7_HUMAN Decreases Expression [120]
Low-density lipoprotein receptor-related protein 2 (LRP2) OTZ6W681 LRP2_HUMAN Decreases Expression [120]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PPP2R2B) OTSFVC82 2ABB_HUMAN Decreases Expression [120]
Norrin (NDP) OTGDJ4US NDP_HUMAN Decreases Expression [120]
Sodium channel protein type 7 subunit alpha (SCN7A) OTK05PXY SCN7A_HUMAN Decreases Expression [120]
Large neutral amino acids transporter small subunit 1 (SLC7A5) OT2WPVXD LAT1_HUMAN Increases Expression [120]
ATP-dependent 6-phosphofructokinase, platelet type (PFKP) OTFP7AA8 PFKAP_HUMAN Increases Expression [120]
POU domain, class 5, transcription factor 1 (POU5F1) OTDHHN7O PO5F1_HUMAN Increases Expression [120]
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) OTEUYEW6 ROR1_HUMAN Increases Expression [120]
Pro-neuregulin-1, membrane-bound isoform (NRG1) OTZO6F1X NRG1_HUMAN Decreases Expression [120]
Desmocollin-2 (DSC2) OTODVH8K DSC2_HUMAN Increases Expression [120]
A-kinase anchor protein 12 (AKAP12) OTCVRDDX AKA12_HUMAN Decreases Expression [120]
Paired box protein Pax-2 (PAX2) OTKP1N8F PAX2_HUMAN Increases Expression [120]
Dystonin (DST) OTHZBM4X DYST_HUMAN Decreases Expression [120]
POU domain, class 3, transcription factor 1 (POU3F1) OTYARA94 PO3F1_HUMAN Decreases Expression [120]
Histone-lysine N-methyltransferase MECOM (MECOM) OTP983W8 MECOM_HUMAN Decreases Expression [120]
Transducin-like enhancer protein 4 (TLE4) OT4QEH6T TLE4_HUMAN Decreases Expression [120]
Collagen alpha-1(XIV) chain (COL14A1) OTLNJ13O COEA1_HUMAN Increases Expression [120]
Myocyte-specific enhancer factor 2C (MEF2C) OTZGF1Y5 MEF2C_HUMAN Increases Expression [120]
Putative POU domain, class 5, transcription factor 1B (POU5F1B) OT0FKQ51 P5F1B_HUMAN Increases Expression [120]
Protein CBFA2T1 (RUNX1T1) OT30DED5 MTG8_HUMAN Increases Expression [120]
Voltage-dependent L-type calcium channel subunit beta-2 (CACNB2) OT53K8W2 CACB2_HUMAN Decreases Expression [120]
3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D) OT1RWFV0 PDE4D_HUMAN Increases Expression [120]
Neuroblast differentiation-associated protein AHNAK (AHNAK) OT6KH1WG AHNK_HUMAN Increases Expression [120]
Divergent protein kinase domain 1C (DIPK1C) OT4POSL2 DIK1C_HUMAN Decreases Expression [120]
Cingulin-like protein 1 (CGNL1) OTRE9DGT CGNL1_HUMAN Increases Expression [120]
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (ST3GAL1) OTFCO8QX SIA4A_HUMAN Increases Expression [120]
Rho GTPase-activating protein 5 (ARHGAP5) OTOQELUN RHG05_HUMAN Decreases Expression [120]
Dual specificity protein phosphatase 4 (DUSP4) OT6WAO12 DUS4_HUMAN Decreases Expression [120]
RE1-silencing transcription factor (REST) OTLL92LQ REST_HUMAN Increases Expression [120]
BMP and activin membrane-bound inhibitor homolog (BAMBI) OTCEJ8W5 BAMBI_HUMAN Increases Expression [120]
Noggin (NOG) OTGRHHPG NOGG_HUMAN Increases Expression [120]
N-myc-interactor (NMI) OTYVG3NM NMI_HUMAN Increases Expression [120]
Zinc transporter ZIP6 (SLC39A6) OTCYF466 S39A6_HUMAN Decreases Expression [120]
Frizzled-5 (FZD5) OTXFFY56 FZD5_HUMAN Decreases Expression [120]
Protein phosphatase 1 regulatory subunit 1A (PPP1R1A) OTGTAGCV PPR1A_HUMAN Increases Expression [120]
Semaphorin-5A (SEMA5A) OTUOIOJV SEM5A_HUMAN Decreases Expression [120]
Cadherin-18 (CDH18) OTC06P9H CAD18_HUMAN Increases Expression [120]
Ras-related protein Rab-31 (RAB31) OTMLXQZ0 RAB31_HUMAN Increases Expression [120]
CD166 antigen (ALCAM) OTCO4LP7 CD166_HUMAN Increases Expression [120]
Laminin subunit gamma-2 (LAMC2) OTJMTM72 LAMC2_HUMAN Increases Expression [120]
Integrin alpha-9 (ITGA9) OTHN1IKA ITA9_HUMAN Increases Expression [120]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (ENPP2) OTTUU92F ENPP2_HUMAN Increases Expression [120]
Krueppel-like factor 5 (KLF5) OT1ABI9N KLF5_HUMAN Increases Expression [120]
Collagen alpha-3(IX) chain (COL9A3) OTCUJOEK CO9A3_HUMAN Increases Expression [120]
Ras-related protein Rab-33A (RAB33A) OTHHU6WA RB33A_HUMAN Decreases Expression [120]
Tripartite motif-containing protein 14 (TRIM14) OTLQKUG0 TRI14_HUMAN Increases Expression [120]
Frizzled-2 (FZD2) OT952ML1 FZD2_HUMAN Decreases Expression [120]
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (PDE3A) OTKUW1WT PDE3A_HUMAN Increases Expression [120]
Polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3) OT7M67WT GALT3_HUMAN Increases Expression [120]
Protein disulfide-isomerase A5 (PDIA5) OT76ZSX5 PDIA5_HUMAN Increases Expression [120]
Inositol 1,4,5-trisphosphate receptor type 2 (ITPR2) OTPHGZ19 ITPR2_HUMAN Increases Expression [120]
AT-rich interactive domain-containing protein 5B (ARID5B) OTUQ4CQY ARI5B_HUMAN Increases Expression [120]
Nuclear factor of activated T-cells, cytoplasmic 4 (NFATC4) OTTDCUAO NFAC4_HUMAN Decreases Expression [120]
Opioid-binding protein/cell adhesion molecule (OPCML) OT93PQ6Y OPCM_HUMAN Increases Expression [120]
Uncharacterized protein KIAA0040 (KIAA0040) OT27EBY3 K0040_HUMAN Increases Expression [120]
Ras GTPase-activating protein 2 (RASA2) OTL06RG2 RASA2_HUMAN Decreases Expression [120]
Ankyrin repeat domain-containing protein 1 (ANKRD1) OTHJ7JV9 ANKR1_HUMAN Increases Expression [120]
Ryanodine receptor 3 (RYR3) OT4EHIP4 RYR3_HUMAN Decreases Expression [120]
SH2 domain-containing adapter protein B (SHB) OTF2HSC0 SHB_HUMAN Increases Expression [120]
Homeobox protein SIX1 (SIX1) OT70YYWM SIX1_HUMAN Increases Expression [120]
ALX homeobox protein 1 (ALX1) OTZVARA5 ALX1_HUMAN Increases Expression [120]
Myosin light chain kinase, smooth muscle (MYLK) OT78QB4A MYLK_HUMAN Decreases Expression [120]
Metallophosphoesterase MPPED2 (MPPED2) OT7XLMJ6 MPPD2_HUMAN Decreases Expression [120]
Mothers against decapentaplegic homolog 2 (SMAD2) OTC6VB4K SMAD2_HUMAN Decreases Expression [120]
Laminin subunit alpha-4 (LAMA4) OTHI7TA0 LAMA4_HUMAN Increases Expression [120]
Exostosin-1 (EXT1) OTRPALJK EXT1_HUMAN Decreases Expression [120]
Cyclin-G2 (CCNG2) OTII38K2 CCNG2_HUMAN Decreases Expression [120]
Prostasin (PRSS8) OT5KLL35 PRSS8_HUMAN Increases Expression [120]
Gamma-interferon-inducible protein 16 (IFI16) OT4SPU0U IF16_HUMAN Increases Expression [120]
Melanoma-derived growth regulatory protein (MIA) OTG5FN5S MIA_HUMAN Increases Expression [120]
Dual specificity protein phosphatase 5 (DUSP5) OTH96RA7 DUS5_HUMAN Increases Expression [120]
NADP-dependent malic enzyme, mitochondrial (ME3) OT3XMLYG MAON_HUMAN Decreases Expression [120]
Reticulon-1 (RTN1) OTCX1SMK RTN1_HUMAN Decreases Expression [120]
Receptor-type tyrosine-protein phosphatase O (PTPRO) OTFLKWOY PTPRO_HUMAN Decreases Expression [120]
Tumor protein D53 (TPD52L1) OTSA6U0I TPD53_HUMAN Increases Expression [120]
Protein inscuteable homolog (INSC) OTP16ERR INSC_HUMAN Increases Expression [120]
Inverted formin-2 (INF2) OT8ZM13C INF2_HUMAN Increases Expression [120]
MHC class I polypeptide-related sequence B (MICB) OTS2DVDW MICB_HUMAN Increases Expression [120]
Centrosomal protein kizuna (KIZ) OT5VCKSM KIZ_HUMAN Decreases Expression [120]
UPF0561 protein C2orf68 (C2ORF68) OTNNFK6R CB068_HUMAN Decreases Expression [120]
FH1/FH2 domain-containing protein 3 (FHOD3) OT1WUBQX FHOD3_HUMAN Decreases Expression [120]
Complement component receptor 1-like protein (CR1L) OTX3KR7U CR1L_HUMAN Increases Expression [120]
Transcription factor RFX4 (RFX4) OTYFRHPA RFX4_HUMAN Increases Expression [120]
Cell cycle control protein 50B (TMEM30B) OTNSBH84 CC50B_HUMAN Increases Expression [120]
Transcription factor Sp6 (SP6) OTRAB1PN SP6_HUMAN Increases Expression [120]
Mitochondrial 10-formyltetrahydrofolate dehydrogenase (ALDH1L2) OTCH86VF AL1L2_HUMAN Increases Expression [120]
Uncharacterized protein C8orf34 (C8ORF34) OTXCTHDG CH034_HUMAN Increases Expression [120]
Cell adhesion molecule-related/down-regulated by oncogenes (CDON) OT81X593 CDON_HUMAN Increases Expression [120]
Extracellular tyrosine-protein kinase PKDCC (PKDCC) OTVXJR26 PKDCC_HUMAN Increases Expression [120]
Raftlin-2 (RFTN2) OT4WYAD9 RFTN2_HUMAN Increases Expression [120]
Seizure protein 6 homolog (SEZ6) OTCD8K5D SEZ6_HUMAN Increases Expression [120]
Acyl-coenzyme A synthetase ACSM3, mitochondrial (ACSM3) OT0AE1IV ACSM3_HUMAN Increases Expression [120]
Pleckstrin homology-like domain family A member 2 (PHLDA2) OTMV9DPP PHLA2_HUMAN Increases Expression [120]
Rho GTPase-activating protein 15 (ARHGAP15) OT9CKHDC RHG15_HUMAN Decreases Expression [120]
Fibulin-7 (FBLN7) OT1XRDP6 FBLN7_HUMAN Decreases Expression [120]
Cordon-bleu protein-like 1 (COBLL1) OTQFN1TC COBL1_HUMAN Increases Expression [120]
Protein Largen (PRR16) OTG4TEGR LARGN_HUMAN Increases Expression [120]
TPA-induced transmembrane protein (C3ORF52) OTI0JAT8 TTMP_HUMAN Increases Expression [120]
FRAS1-related extracellular matrix protein 1 (FREM1) OTMHRV87 FREM1_HUMAN Increases Expression [120]
Solute carrier family 25 member 53 (SLC25A53) OTNHVTOB S2553_HUMAN Decreases Expression [120]
Protein BEX5 (BEX5) OTZ2RB6L BEX5_HUMAN Increases Expression [120]
Protein phosphatase 1J (PPM1J) OTM6GDJJ PPM1J_HUMAN Increases Expression [120]
Uncharacterized protein KIAA1755 (KIAA1755) OT1FCGEW K1755_HUMAN Increases Expression [120]
Collectin-12 (COLEC12) OTIQTK9G COL12_HUMAN Increases Expression [120]
EGF domain-specific O-linked N-acetylglucosamine transferase (EOGT) OT4A2A8P EOGT_HUMAN Increases Expression [120]
Neurite extension and migration factor (NEXMIF) OT576F40 NEXMI_HUMAN Decreases Expression [120]
Uncharacterized protein C6orf141 (C6ORF141) OTUS3SIQ CF141_HUMAN Decreases Expression [120]
Centrosomal protein of 85 kDa-like (CEP85L) OTSHJFOT CE85L_HUMAN Increases Expression [120]
Transmembrane protein 170B (TMEM170B) OT4AS8RJ T170B_HUMAN Decreases Expression [120]
Protein FAM162B (FAM162B) OTZ31RP5 F162B_HUMAN Increases Expression [120]
LINE-1 type transposase domain-containing protein 1 (L1TD1) OTB2W20Y LITD1_HUMAN Increases Expression [120]
KN motif and ankyrin repeat domain-containing protein 4 (KANK4) OT5WC0Q8 KANK4_HUMAN Increases Expression [120]
Transcription factor HES-5 (HES5) OTW7JEHV HES5_HUMAN Decreases Expression [120]
PX domain-containing protein 1 (PXDC1) OTQUA3TG PXDC1_HUMAN Increases Expression [120]
Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF3) OTGQV0CU BIG3_HUMAN Decreases Expression [120]
Glycoprotein endo-alpha-1,2-mannosidase-like protein (MANEAL) OT248IN0 MANEL_HUMAN Increases Expression [120]
G kinase-anchoring protein 1 (GKAP1) OTHZRJ56 GKAP1_HUMAN Decreases Expression [120]
Myomegalin (PDE4DIP) OTS15WNF MYOME_HUMAN Increases Expression [120]
Uncharacterized protein C1orf53 (C1ORF53) OTQTOA4D CA053_HUMAN Decreases Expression [120]
Scm-like with four MBT domains protein 2 (SFMBT2) OTZQT61Q SMBT2_HUMAN Increases Expression [120]
DDB1- and CUL4-associated factor 12-like protein 2 (DCAF12L2) OTLEF5TY DC122_HUMAN Decreases Expression [120]
Proteasome adapter and scaffold protein ECM29 (ECPAS) OT1C0KOI ECM29_HUMAN Decreases Expression [120]
B box and SPRY domain-containing protein (BSPRY) OTVVZRKY BSPRY_HUMAN Increases Expression [120]
Meteorin-like protein (METRNL) OTB0DDL0 METRL_HUMAN Increases Expression [120]
Metalloreductase STEAP3 (STEAP3) OTS9GZK5 STEA3_HUMAN Increases Expression [120]
E3 ubiquitin-protein ligase RNF43 (RNF43) OT2R9YDP RNF43_HUMAN Increases Expression [120]
LIM/homeobox protein Lhx8 (LHX8) OT0DFL7C LHX8_HUMAN Increases Expression [120]
Transcription factor Sp5 (SP5) OT4HUP9B SP5_HUMAN Increases Expression [120]
Volume-regulated anion channel subunit LRRC8E (LRRC8E) OTUZTANF LRC8E_HUMAN Increases Expression [120]
MFS-type transporter SLC18B1 (SLC18B1) OT9EVUN1 S18B1_HUMAN Increases Expression [120]
TMF-regulated nuclear protein 1 (TRNP1) OTYYV8LN TRNP1_HUMAN Increases Expression [120]
Epithelial splicing regulatory protein 1 (ESRP1) OTNCS4SL ESRP1_HUMAN Increases Expression [120]
Cdc42 effector protein 5 (CDC42EP5) OTQQDUCD BORG3_HUMAN Increases Expression [120]
Protein C3orf33 (C3ORF33) OTP8MJAN CC033_HUMAN Decreases Expression [120]
DENN domain-containing protein 1B (DENND1B) OT3VCNPE DEN1B_HUMAN Decreases Expression [120]
Phospholipase B-like 1 (PLBD1) OTHYEB4W PLBL1_HUMAN Increases Expression [120]
Polypeptide N-acetylgalactosaminyltransferase 18 (GALNT18) OTKIIELC GLT18_HUMAN Increases Expression [120]
Volume-regulated anion channel subunit LRRC8B (LRRC8B) OTH2LMJ4 LRC8B_HUMAN Decreases Expression [120]
Transmembrane protein 154 (TMEM154) OTEAFLJE TM154_HUMAN Increases Expression [120]
Transmembrane protein 88 (TMEM88) OTA96YEL TMM88_HUMAN Decreases Expression [120]
Interleukin-27 receptor subunit alpha (IL27RA) OTSQBAKI I27RA_HUMAN Increases Expression [120]
Lactase-like protein (LCTL) OTN36T21 LCTL_HUMAN Decreases Expression [120]
Layilin (LAYN) OT9A9Q1X LAYN_HUMAN Increases Expression [120]
ALK and LTK ligand 2 (ALKAL2) OTTLHL64 ALKL2_HUMAN Increases Expression [120]
Inactive serine protease PAMR1 (PAMR1) OT83ZH5U PAMR1_HUMAN Decreases Expression [120]
Nephronectin (NPNT) OTFZAO1G NPNT_HUMAN Increases Expression [120]
Interleukin-20 receptor subunit beta (IL20RB) OTHFXK95 I20RB_HUMAN Increases Expression [120]
R-spondin-2 (RSPO2) OT3HHXU0 RSPO2_HUMAN Decreases Expression [120]
Transmembrane channel-like protein 5 (TMC5) OTO5D86M TMC5_HUMAN Increases Expression [120]
Transmembrane protein 64 (TMEM64) OTO9IDFD TMM64_HUMAN Increases Expression [120]
Nesprin-3 (SYNE3) OTEOJBYB SYNE3_HUMAN Increases Expression [120]
Metastasis-associated in colon cancer protein 1 (MACC1) OTV3DLX0 MACC1_HUMAN Increases Expression [120]
Zinc finger protein basonuclin-2 (BNC2) OTU22H9Z BNC2_HUMAN Increases Expression [120]
Lysophospholipid acyltransferase 1 (MBOAT1) OT4XR6TE MBOA1_HUMAN Increases Expression [120]
FYVE, RhoGEF and PH domain-containing protein 5 (FGD5) OT5VIRP2 FGD5_HUMAN Increases Expression [120]
Solute carrier organic anion transporter family member 4C1 (SLCO4C1) OTVILUUN SO4C1_HUMAN Increases Expression [120]
RNA-binding protein with multiple splicing 2 (RBPMS2) OTY24L1F RBPS2_HUMAN Increases Expression [120]
Leucine-rich repeat-containing protein 55 (LRRC55) OT8LQI1W LRC55_HUMAN Decreases Expression [120]
RNA-binding protein 43 (RBM43) OTANIFBG RBM43_HUMAN Increases Expression [120]
Acyl-CoA dehydrogenase family member 11 (ACAD11) OT3T9HAX ACD11_HUMAN Increases Expression [120]
BTB/POZ domain-containing protein KCTD1 (KCTD1) OT89U5MB KCTD1_HUMAN Increases Expression [120]
Mediator of RNA polymerase II transcription subunit 13-like (MED13L) OTSP1W0F MD13L_HUMAN Increases Expression [120]
Eukaryotic translation initiation factor 3 subunit M (EIF3M) OTVWEV60 EIF3M_HUMAN Decreases Expression [120]
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 (LINGO2) OT3N88Q1 LIGO2_HUMAN Increases Expression [120]
CXXC-type zinc finger protein 5 (CXXC5) OTGCN3B5 CXXC5_HUMAN Increases Expression [120]
Monocarboxylate transporter 14 (SLC16A14) OTUGDEUV MOT14_HUMAN Decreases Expression [120]
C-myc promoter-binding protein (DENND4A) OT8FFZ29 MYCPP_HUMAN Increases Expression [120]
E3 ubiquitin-protein ligase RNF144B (RNF144B) OTN7FCDE R144B_HUMAN Increases Expression [120]
Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein (BNIPL) OTDHOA74 BNIPL_HUMAN Increases Expression [120]
Cilia- and flagella-associated protein 91 (CFAP91) OTVDRDGX CFA91_HUMAN Decreases Expression [120]
Transmembrane protein 144 (TMEM144) OT66EYSR TM144_HUMAN Increases Expression [120]
Uncharacterized protein C11orf96 (C11ORF96) OTEQU0V7 CK096_HUMAN Increases Expression [120]
Amphoterin-induced protein 2 (AMIGO2) OTPAIT1O AMGO2_HUMAN Increases Expression [120]
Armadillo-like helical domain-containing protein 4 (ARMH4) OT25GBJM ARMD4_HUMAN Decreases Expression [120]
Sodium/hydrogen exchanger 9B2 (SLC9B2) OTZVOY8T SL9B2_HUMAN Decreases Expression [120]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (MAGI2) OTXDDKZS MAGI2_HUMAN Increases Expression [120]
Regulating synaptic membrane exocytosis protein 1 (RIMS1) OT10T7CK RIMS1_HUMAN Increases Expression [120]
Inter-alpha-trypsin inhibitor heavy chain H5 (ITIH5) OTP46PZM ITIH5_HUMAN Increases Expression [120]
Protein FAM124A (FAM124A) OTF1DJX0 F124A_HUMAN Decreases Expression [120]
Glucocorticoid-induced transcript 1 protein (GLCCI1) OTU0R1CU GLCI1_HUMAN Decreases Expression [120]
Four-jointed box protein 1 (FJX1) OT8SVTSS FJX1_HUMAN Decreases Expression [120]
Catechol O-methyltransferase domain-containing protein 1 (COMTD1) OTLQJTBI CMTD1_HUMAN Increases Expression [120]
SEC14 domain and spectrin repeat-containing protein 1 (SESTD1) OTHH06X8 SESD1_HUMAN Decreases Expression [120]
Juxtaposed with another zinc finger protein 1 (JAZF1) OTXTYSYD JAZF1_HUMAN Increases Expression [120]
Myotubularin-related protein 13 (SBF2) OTBB8NO8 MTMRD_HUMAN Increases Expression [120]
Ras association domain-containing protein 3 (RASSF3) OT4V9SRK RASF3_HUMAN Increases Expression [120]
E3 ubiquitin-protein ligase TRIM69 (TRIM69) OTTEGTRD TRI69_HUMAN Increases Expression [120]
Probable D-lactate dehydrogenase, mitochondrial (LDHD) OTTKLJWP LDHD_HUMAN Increases Expression [120]
Chondroitin sulfate synthase 1 (CHSY1) OTB1XSSF CHSS1_HUMAN Increases Expression [120]
Dynein regulatory complex protein 11 (IQCA1) OTFBF3FI DRC11_HUMAN Increases Expression [120]
Protein phosphatase 1 regulatory subunit 3B (PPP1R3B) OTVCRXEZ PPR3B_HUMAN Increases Expression [120]
Collagen alpha-1(XXIII) chain (COL23A1) OTYE0N3I CONA1_HUMAN Increases Expression [120]
Testis development-related protein (TDRP) OTEFLMGF TDRP_HUMAN Increases Expression [120]
Podoplanin (PDPN) OTBUV19I PDPN_HUMAN Increases Expression [120]
Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPARGC1B) OTN6FKCB PRGC2_HUMAN Increases Expression [120]
Rab11 family-interacting protein 4 (RAB11FIP4) OTIGHER7 RFIP4_HUMAN Increases Expression [120]
Inactive tyrosine-protein kinase PRAG1 (PRAG1) OTV83SGI PRAG1_HUMAN Increases Expression [120]
Purine nucleoside phosphorylase LACC1 (LACC1) OT4SBHI8 LACC1_HUMAN Increases Expression [120]
LysM and putative peptidoglycan-binding domain-containing protein 2 (LYSMD2) OT1VCC2M LYSM2_HUMAN Increases Expression [120]
Proline-rich protein 15 (PRR15) OTJHSY8G PRR15_HUMAN Increases Expression [120]
Neuron navigator 3 (NAV3) OT97M1TR NAV3_HUMAN Increases Expression [120]
Immunoglobulin superfamily DCC subclass member 3 (IGDCC3) OTGR1KA4 IGDC3_HUMAN Increases Expression [120]
Sodium channel subunit beta-4 (SCN4B) OT3JSUWO SCN4B_HUMAN Increases Expression [120]
Sphingosine-1-phosphate phosphatase 2 (SGPP2) OTIDIJCR SGPP2_HUMAN Increases Expression [120]
Uncharacterized protein C12orf56 (C12ORF56) OT4KDTKF CL056_HUMAN Increases Expression [120]
Solute carrier family 35 member F2 (SLC35F2) OTSAD4EQ S35F2_HUMAN Increases Expression [120]
Transcription factor Sp8 (SP8) OTLCMPKH SP8_HUMAN Decreases Expression [120]
Ras and EF-hand domain-containing protein (RASEF) OTGSAM2E RASEF_HUMAN Increases Expression [120]
Myocardin (MYOCD) OTSJNHTH MYCD_HUMAN Increases Expression [120]
Protein SIX6OS1 (C14ORF39) OTFKQ6HO S6OS1_HUMAN Decreases Expression [120]
Neuroligin-1 (NLGN1) OTGHRRFQ NLGN1_HUMAN Decreases Expression [120]
Protein FAM43A (FAM43A) OT5RPQRE FA43A_HUMAN Increases Expression [120]
Glycerol-3-phosphate dehydrogenase 1-like protein (GPD1L) OTVLWW9T GPD1L_HUMAN Increases Expression [120]
ELMO domain-containing protein 1 (ELMOD1) OT0WRVJC ELMD1_HUMAN Increases Expression [120]
Rho GTPase-activating protein 18 (ARHGAP18) OTYMJP6H RHG18_HUMAN Increases Expression [120]
MICAL-like protein 1 (MICALL1) OTHG9B2U MILK1_HUMAN Increases Expression [120]
Protein phosphatase Mn(2+)-dependent 1K (PPM1K) OTNZ4N4E PPM1K_HUMAN Increases Expression [120]
Thioredoxin domain-containing protein 3 (NME8) OT4RULP5 TXND3_HUMAN Increases Expression [120]
Inactive carboxypeptidase-like protein X2 (CPXM2) OTDJNOTR CPXM2_HUMAN Increases Expression [120]
Secreted frizzled-related protein 1 (SFRP1) OT0U9G41 SFRP1_HUMAN Decreases Expression [120]
Protein limb expression 1 homolog (LIX1) OT1CPNCC LIX1_HUMAN Decreases Expression [120]
RING finger protein 175 (RNF175) OTKAZ8ZW RN175_HUMAN Decreases Expression [120]
Reprimo-like protein (RPRML) OTPOESFN RPRML_HUMAN Increases Expression [120]
Serine/threonine-protein kinase DCLK2 (DCLK2) OTT0AU1C DCLK2_HUMAN Decreases Expression [120]
Ephexin-1 (NGEF) OT9QUXJ3 NGEF_HUMAN Increases Expression [120]
Eukaryotic translation initiation factor 4E type 3 (EIF4E3) OTTWVS2R IF4E3_HUMAN Decreases Expression [120]
E3 ubiquitin-protein ligase RNF182 (RNF182) OT08FLHZ RN182_HUMAN Decreases Expression [120]
CUGBP Elav-like family member 5 (CELF5) OT02OG9N CELF5_HUMAN Decreases Expression [120]
Protocadherin-20 (PCDH20) OTFSNRXK PCD20_HUMAN Increases Expression [120]
Leucine-rich repeat-containing protein 17 (LRRC17) OT3NZSX3 LRC17_HUMAN Increases Expression [120]
APC membrane recruitment protein 2 (AMER2) OTA1Q07C AMER2_HUMAN Increases Expression [120]
BMP-binding endothelial regulator protein (BMPER) OTBYON4H BMPER_HUMAN Increases Expression [120]
V-type proton ATPase subunit d 2 (ATP6V0D2) OTMOZJO0 VA0D2_HUMAN Increases Expression [120]
Tetratricopeptide repeat protein 29 (TTC29) OT37KCUL TTC29_HUMAN Increases Expression [120]
Fibronectin type III domain-containing protein 5 (FNDC5) OT5CSK9X FNDC5_HUMAN Decreases Expression [120]
Transmembrane protein 178A (TMEM178A) OTQZY4NP T178A_HUMAN Decreases Expression [120]
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) OTBIN5IP SCPDL_HUMAN Decreases Expression [120]
Carbohydrate sulfotransferase 4 (CHST4) OTESMIW5 CHST4_HUMAN Increases Expression [120]
Potassium voltage-gated channel subfamily H member 5 (KCNH5) OTVAHEAQ KCNH5_HUMAN Decreases Expression [120]
Protein FAM13C (FAM13C) OTVAGUOV FA13C_HUMAN Increases Expression [120]
Zinc finger protein GLIS3 (GLIS3) OTBC960E GLIS3_HUMAN Decreases Expression [120]
Neuron navigator 1 (NAV1) OT667KTL NAV1_HUMAN Decreases Expression [120]
Nesprin-1 (SYNE1) OTSBSLUH SYNE1_HUMAN Increases Expression [120]
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 (B3GNT7) OT8UTTXF B3GN7_HUMAN Increases Expression [120]
Interleukin-17 receptor D (IL17RD) OTKD9XST I17RD_HUMAN Decreases Expression [120]
Bestrophin-4 (BEST4) OT6S406I BEST4_HUMAN Decreases Expression [120]
Semaphorin-6D (SEMA6D) OTU0UAZS SEM6D_HUMAN Decreases Expression [120]
Cell adhesion molecule 4 (CADM4) OT0TFMFE CADM4_HUMAN Decreases Expression [120]
Nuclear receptor coactivator 7 (NCOA7) OT2CNBOG NCOA7_HUMAN Decreases Expression [120]
LIM domain only protein 3 (LMO3) OTR7AJHN LMO3_HUMAN Decreases Expression [120]
Fibroblast growth factor-binding protein 3 (FGFBP3) OTWM1KCM FGFP3_HUMAN Increases Expression [120]
DEP domain-containing mTOR-interacting protein (DEPTOR) OTCBP1BT DPTOR_HUMAN Increases Expression [120]
3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic (HMGCLL1) OT9SQ5PU HMGC2_HUMAN Decreases Expression [120]
E3 ubiquitin-protein ligase LNX (LNX1) OTZWFMAZ LNX1_HUMAN Increases Expression [120]
Synaptoporin (SYNPR) OTNCJ9L0 SYNPR_HUMAN Increases Expression [120]
Fez family zinc finger protein 2 (FEZF2) OTU4TXIW FEZF2_HUMAN Decreases Expression [120]
Transmembrane protein 163 (TMEM163) OTCT1Y1L TM163_HUMAN Decreases Expression [120]
E3 ubiquitin-protein ligase RNF217 (RNF217) OTAX91ES RN217_HUMAN Increases Expression [120]
Fibronectin type 3 and ankyrin repeat domains protein 1 (FANK1) OT5641YJ FANK1_HUMAN Decreases Expression [120]
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (PREX1) OTUTPVA9 PREX1_HUMAN Increases Expression [120]
Mucolipin-3 (MCOLN3) OTCRPRVS MCLN3_HUMAN Increases Expression [120]
Protocadherin Fat 3 (FAT3) OT3C6H8W FAT3_HUMAN Decreases Expression [120]
A disintegrin and metalloproteinase with thrombospondin motifs 15 (ADAMTS15) OTYB6JS3 ATS15_HUMAN Increases Expression [120]
A disintegrin and metalloproteinase with thrombospondin motifs 19 (ADAMTS19) OTEG5Q2G ATS19_HUMAN Increases Expression [120]
Grainyhead-like protein 3 homolog (GRHL3) OT1V4ZEH GRHL3_HUMAN Increases Expression [120]
Actin filament-associated protein 1-like 1 (AFAP1L1) OTWNTNDB AF1L1_HUMAN Increases Expression [120]
DENN domain-containing protein 1A (DENND1A) OTONDAA0 DEN1A_HUMAN Decreases Expression [120]
Serine/threonine-protein kinase 32A (STK32A) OTONYLYO ST32A_HUMAN Decreases Expression [120]
RelA-associated inhibitor (PPP1R13L) OTNCPLWE IASPP_HUMAN Increases Expression [120]
Protein prune homolog 2 (PRUNE2) OTGW2974 PRUN2_HUMAN Decreases Expression [120]
DEP domain-containing protein 1B (DEPDC1B) OTMVFOT1 DEP1B_HUMAN Decreases Expression [120]
DDB1- and CUL4-associated factor 4 (DCAF4) OTQU0EUO DCAF4_HUMAN Increases Expression [120]
Pleckstrin homology-like domain family A member 1 (PHLDA1) OTFTWMIQ PHLA1_HUMAN Increases Expression [120]
PH-interacting protein (PHIP) OTZY806Z PHIP_HUMAN Decreases Expression [120]
Cholesterol transporter ABCA5 (ABCA5) OT4B9D92 ABCA5_HUMAN Decreases Expression [120]
Adhesion G-protein coupled receptor V1 (ADGRV1) OTLVXHHP AGRV1_HUMAN Decreases Expression [120]
Connector enhancer of kinase suppressor of ras 2 (CNKSR2) OTAGERJ2 CNKR2_HUMAN Decreases Expression [120]
BRI3-binding protein (BRI3BP) OTWCFPRM BRI3B_HUMAN Increases Expression [120]
Nanos homolog 1 (NANOS1) OT3UNZZY NANO1_HUMAN Decreases Expression [120]
E3 ubiquitin-protein ligase MYLIP (MYLIP) OTL0PFGV MYLIP_HUMAN Increases Expression [120]
Jun dimerization protein 2 (JDP2) OTW35WKX JDP2_HUMAN Increases Expression [120]
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (ARAP2) OTBXYFRH ARAP2_HUMAN Increases Expression [120]
Transcription factor AP-2-beta (TFAP2B) OTR1T8E9 AP2B_HUMAN Increases Expression [120]
Protein FAM168A (FAM168A) OTDXQCS5 F168A_HUMAN Decreases Expression [120]
Transcription factor AP-2 gamma (TFAP2C) OTUDIW05 AP2C_HUMAN Increases Expression [120]
Secreted frizzled-related protein 3 (FRZB) OTTO3DPY SFRP3_HUMAN Decreases Expression [120]
Ras-responsive element-binding protein 1 (RREB1) OT62460U RREB1_HUMAN Increases Expression [120]
Hyaluronan synthase 2 (HAS2) OTTD3PAL HYAS2_HUMAN Increases Expression [120]
Coronin-2A (CORO2A) OTVK7PK3 COR2A_HUMAN Increases Expression [120]
Protein kinase C-binding protein NELL1 (NELL1) OTF3TX3N NELL1_HUMAN Increases Expression [120]
Kinesin-associated protein 3 (KIFAP3) OT450PAO KIFA3_HUMAN Increases Expression [120]
BLOC-3 complex member HPS1 (HPS1) OTKS5I7T HPS1_HUMAN Increases Expression [120]
Deleted in azoospermia-like (DAZL) OTZMTD4R DAZL_HUMAN Decreases Expression [120]
Receptor-type tyrosine-protein phosphatase N2 (PTPRN2) OTL6SH28 PTPR2_HUMAN Decreases Expression [120]
Stathmin-2 (STMN2) OT0FUHLH STMN2_HUMAN Increases Expression [120]
Protein naked cuticle homolog 1 (NKD1) OTY3MO97 NKD1_HUMAN Increases Expression [120]
Protein TMEPAI (PMEPA1) OTY8Z9UF PMEPA_HUMAN Increases Expression [120]
Mitochondrial amidoxime reducing component 2 (MTARC2) OT8B6LVD MARC2_HUMAN Increases Expression [120]
Terminal nucleotidyltransferase 5B (TENT5B) OTO2P28B TET5B_HUMAN Increases Expression [120]
Copine-4 (CPNE4) OTTAGM5L CPNE4_HUMAN Increases Expression [120]
SPRY domain-containing SOCS box protein 4 (SPSB4) OTG9MLO4 SPSB4_HUMAN Increases Expression [120]
SOSS complex subunit B2 (NABP1) OTFTNFHW SOSB2_HUMAN Increases Expression [120]
Ras-related protein Rab-7b (RAB7B) OT60A0E9 RAB7B_HUMAN Increases Expression [120]
Transmembrane protein 125 (TMEM125) OTWF8MC1 TM125_HUMAN Increases Expression [120]
Claudin-23 (CLDN23) OTN5RV40 CLD23_HUMAN Increases Expression [120]
Transmembrane protein 18 (TMEM18) OT05YQ1E TMM18_HUMAN Decreases Expression [120]
SH3 domain-containing kinase-binding protein 1 (SH3KBP1) OTIUA60B SH3K1_HUMAN Increases Expression [120]
Serine/threonine-protein kinase Sgk3 (SGK3) OTQ6QO99 SGK3_HUMAN Increases Expression [120]
BTB/POZ domain-containing protein KCTD12 (KCTD12) OTPYKT4Z KCD12_HUMAN Increases Expression [120]
Endoplasmic reticulum resident protein 27 (ERP27) OTVMGE2H ERP27_HUMAN Increases Expression [120]
Polyadenylate-binding protein 5 (PABPC5) OTLUTQ02 PABP5_HUMAN Increases Expression [120]
Ras-related protein Rab-3C (RAB3C) OTFTJNGA RAB3C_HUMAN Increases Expression [120]
Elongator complex protein 4 (ELP4) OTP5GZ9V ELP4_HUMAN Decreases Expression [120]
Multivesicular body subunit 12A (MVB12A) OT3737K0 MB12A_HUMAN Decreases Expression [120]
CB1 cannabinoid receptor-interacting protein 1 (CNRIP1) OTXPWJ56 CNRP1_HUMAN Increases Expression [120]
Protein FAM89A (FAM89A) OTNASAXT FA89A_HUMAN Increases Expression [120]
Secreted frizzled-related protein 2 (SFRP2) OT8GZ0CA SFRP2_HUMAN Decreases Expression [120]
Transmembrane protein 169 (TMEM169) OTKXDYVC TM169_HUMAN Decreases Expression [120]
4-hydroxyphenylpyruvate dioxygenase-like protein (HPDL) OTW7D1SV HPDL_HUMAN Increases Expression [120]
Epithelial-stromal interaction protein 1 (EPSTI1) OT75I1UH ESIP1_HUMAN Increases Expression [120]
Leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1) OTY5HZN5 LRIG1_HUMAN Decreases Expression [120]
Microtubule-associated protein 6 (MAP6) OTPUI00F MAP6_HUMAN Decreases Expression [120]
Coiled-coil domain-containing protein 136 (CCDC136) OTPOV391 CC136_HUMAN Decreases Expression [120]
Golgi-associated RAB2 interactor protein 1B (GARIN1B) OTWPN527 GAR1B_HUMAN Decreases Expression [120]
Phospholipase A and acyltransferase 5 (PLAAT5) OT9JFFO2 PLAT5_HUMAN Increases Expression [120]
Sushi domain-containing protein 3 (SUSD3) OTERJTUL SUSD3_HUMAN Increases Expression [120]
Guanine nucleotide exchange factor C9orf72 (C9ORF72) OT0WH38E CI072_HUMAN Decreases Expression [120]
Kremen protein 1 (KREMEN1) OTGJFSAC KREM1_HUMAN Increases Expression [120]
Transmembrane protein 74 (TMEM74) OT3IZBM0 TMM74_HUMAN Decreases Expression [120]
TOX high mobility group box family member 2 (TOX2) OT7RZRVK TOX2_HUMAN Decreases Expression [120]
Patched domain-containing protein 1 (PTCHD1) OTFDLU5S PTHD1_HUMAN Increases Expression [120]
Dachshund homolog 2 (DACH2) OT33KEUZ DACH2_HUMAN Increases Expression [120]
Chloride intracellular channel protein 6 (CLIC6) OTFMSU5U CLIC6_HUMAN Increases Expression [120]
Noelin-3 (OLFM3) OTBHPDTL NOE3_HUMAN Increases Expression [120]
Leucine-rich repeat-containing protein 3B (LRRC3B) OT9VDGPR LRC3B_HUMAN Decreases Expression [120]
Secretoglobin family 3A member 2 (SCGB3A2) OTB63PHR SG3A2_HUMAN Increases Expression [120]
VPS10 domain-containing receptor SorCS2 (SORCS2) OTBF3DYK SORC2_HUMAN Decreases Expression [120]
Rho GTPase-activating protein 7 (DLC1) OTP8LMCR RHG07_HUMAN Increases Expression [120]
DEP domain-containing protein 7 (DEPDC7) OT62C942 DEPD7_HUMAN Increases Expression [120]
Rab-3A-interacting protein (RAB3IP) OT3UPQAA RAB3I_HUMAN Decreases Expression [120]
Homeobox protein ARX (ARX) OTBGYH25 ARX_HUMAN Decreases Expression [120]
Lipase maturation factor 1 (LMF1) OTOL14ZD LMF1_HUMAN Increases Expression [120]
Doublesex- and mab-3-related transcription factor A2 (DMRTA2) OTWQR1M7 DMTA2_HUMAN Increases Expression [120]
Mucin-4 (MUC4) OTLT11V1 MUC4_HUMAN Increases Expression [120]
Glutamate decarboxylase 1 (GAD1) OT52Z39J DCE1_HUMAN Increases Expression [120]
Protein kinase C-binding protein NELL2 (NELL2) OTS4MJZ7 NELL2_HUMAN Decreases Expression [120]
Krueppel-like factor 6 (KLF6) OTQY9S7F KLF6_HUMAN Increases Expression [120]
Fasciculation and elongation protein zeta-1 (FEZ1) OTWCXPRE FEZ1_HUMAN Decreases Expression [120]
Pituitary homeobox 2 (PITX2) OTWMXAOY PITX2_HUMAN Increases Expression [120]
Endothelial PAS domain-containing protein 1 (EPAS1) OTRE3O8U EPAS1_HUMAN Increases Expression [120]
Epidermal growth factor-like protein 8 (EGFL8) OTECTJ7K EGFL8_HUMAN Increases Expression [120]
Cbp/p300-interacting transactivator 2 (CITED2) OT812TV7 CITE2_HUMAN Increases Expression [120]
Retinoic acid receptor responder protein 2 (RARRES2) OT1BJE8K RARR2_HUMAN Increases Expression [120]
Semaphorin-3C (SEMA3C) OTEGUY7F SEM3C_HUMAN Increases Expression [120]
Fermitin family homolog 1 (FERMT1) OT626PBA FERM1_HUMAN Increases Expression [120]
Synaptotagmin-11 (SYT11) OTLRTZEI SYT11_HUMAN Decreases Expression [120]
Brain-enriched guanylate kinase-associated protein (BEGAIN) OTT3UD2K BEGIN_HUMAN Decreases Expression [120]
Protein ABHD14A (ABHD14A) OT94GKE1 ABHEA_HUMAN Decreases Expression [120]
Ribonuclease P protein subunit p25 (RPP25) OTEN6QN7 RPP25_HUMAN Increases Expression [120]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) OTJGE772 CHAC1_HUMAN Increases Expression [120]
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 (ST6GALNAC5) OTH91ETM SIA7E_HUMAN Decreases Expression [120]
Cell cycle regulator of non-homologous end joining (CYREN) OT5ZL00R CYREN_HUMAN Decreases Expression [120]
Brother of CDO (BOC) OTXBCY9W BOC_HUMAN Increases Expression [120]
RNA-binding protein 24 (RBM24) OTQI1AR1 RBM24_HUMAN Decreases Expression [120]
Receptor for retinol uptake STRA6 (STRA6) OT2IDF27 STRA6_HUMAN Increases Expression [120]
Sal-like protein 3 (SALL3) OTJ2LZKQ SALL3_HUMAN Decreases Expression [120]
Oxysterol-binding protein-related protein 10 (OSBPL10) OT0TFMBE OSB10_HUMAN Increases Expression [120]
Complement C1q tumor necrosis factor-related protein 4 (C1QTNF4) OTHD4Y9D C1QT4_HUMAN Decreases Expression [120]
Microtubule-associated proteins 1A/1B light chain 3C (MAP1LC3C) OTM4ECDK MLP3C_HUMAN Increases Expression [120]
Dedicator of cytokinesis protein 9 (DOCK9) OT84H8AD DOCK9_HUMAN Increases Expression [120]
Iroquois-class homeodomain protein IRX-2 (IRX2) OTBHXXQ2 IRX2_HUMAN Increases Expression [120]
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 (NMNAT2) OT5JLP2H NMNA2_HUMAN Increases Expression [120]
Thiamine transporter 2 (SLC19A3) OTOWP1CT S19A3_HUMAN Increases Expression [120]
E3 ubiquitin-protein ligase TRIM9 (TRIM9) OTKYG33W TRIM9_HUMAN Increases Expression [120]
Tripartite motif-containing protein 6 (TRIM6) OTBSMX0B TRIM6_HUMAN Increases Expression [120]
Protein TANC1 (TANC1) OTF6TZ8E TANC1_HUMAN Increases Expression [120]
Ethanolaminephosphotransferase 1 (SELENOI) OTX2A47A EPT1_HUMAN Increases Expression [120]
SRC kinase signaling inhibitor 1 (SRCIN1) OTQZNQQ5 SRCN1_HUMAN Decreases Expression [120]
Metal cation symporter ZIP8 (SLC39A8) OT6C6MNV S39A8_HUMAN Increases Expression [120]
Immortalization up-regulated protein (C19ORF33) OTOYH74A IMUP_HUMAN Increases Expression [120]
PR domain zinc finger protein 14 (PRDM14) OTWZKY4L PRD14_HUMAN Increases Expression [120]
CYFIP-related Rac1 interactor A (CYRIA) OT2VJ767 CYRIA_HUMAN Increases Expression [120]
Ras-related protein Rab-17 (RAB17) OT7NBUGQ RAB17_HUMAN Increases Expression [120]
Kinesin-like protein KIF13A (KIF13A) OTSSZGBQ KI13A_HUMAN Decreases Expression [120]
Synaptotagmin-4 (SYT4) OTA1D7VL SYT4_HUMAN Increases Expression [120]
Cysteine-rich secretory protein LCCL domain-containing 1 (CRISPLD1) OT38HXJP CRLD1_HUMAN Increases Expression [120]
Sorting nexin-25 (SNX25) OT8JY8M1 SNX25_HUMAN Decreases Expression [120]
Leucine-rich repeat neuronal protein 3 (LRRN3) OT7X0AA7 LRRN3_HUMAN Increases Expression [120]
Calsyntenin-2 (CLSTN2) OT2PJYHX CSTN2_HUMAN Increases Expression [120]
SPARC-related modular calcium-binding protein 1 (SMOC1) OTJG2JQY SMOC1_HUMAN Decreases Expression [120]
DNA transposase THAP9 (THAP9) OTY4TSJO THAP9_HUMAN Decreases Expression [120]
SLIT and NTRK-like protein 6 (SLITRK6) OTLNWI5G SLIK6_HUMAN Increases Expression [120]
Epithelial splicing regulatory protein 2 (ESRP2) OTVTKJ4I ESRP2_HUMAN Increases Expression [120]
Dedicator of cytokinesis protein 5 (DOCK5) OT63I0CL DOCK5_HUMAN Increases Expression [120]
NIPA-like protein 2 (NIPAL2) OTX9UREP NPAL2_HUMAN Increases Expression [120]
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial (MTHFD2L) OTDYNXRG MTD2L_HUMAN Increases Expression [120]
Nuclear body protein SP140-like protein (SP140L) OTL30JKT SP14L_HUMAN Increases Expression [120]
Chondrolectin (CHODL) OTVCNOUQ CHODL_HUMAN Increases Expression [120]
Homeobox protein NANOG (NANOG) OTUEY1FM NANOG_HUMAN Increases Expression [120]
Adhesion G protein-coupled receptor L3 (ADGRL3) OT81Q8LY AGRL3_HUMAN Decreases Expression [120]
Netrin-4 (NTN4) OTDRRMP3 NET4_HUMAN Decreases Expression [120]
V-type proton ATPase 116 kDa subunit a 4 (ATP6V0A4) OT149Z7Q VPP4_HUMAN Increases Expression [120]
Collectrin (CLTRN) OTXGFJ3F CLTRN_HUMAN Decreases Expression [120]
Ethanolamine kinase 1 (ETNK1) OTDKB4DQ EKI1_HUMAN Increases Expression [120]
Popeye domain-containing protein 3 (POPDC3) OTN4FJ5J POPD3_HUMAN Decreases Expression [120]
Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2) OTAQD3YV ARNT2_HUMAN Decreases Expression [120]
Prokineticin-2 (PROK2) OT70IFEZ PROK2_HUMAN Decreases Expression [120]
Sodium/potassium/calcium exchanger 3 (SLC24A3) OTEJN38N NCKX3_HUMAN Increases Expression [120]
Mineralization regulator ANKH (ANKH) OTCN25R5 ANKH_HUMAN Increases Expression [120]
UPF0606 protein KIAA1549 (KIAA1549) OTA5B18F K1549_HUMAN Decreases Expression [120]
Band 4.1-like protein 5 (EPB41L5) OTPPQPLU E41L5_HUMAN Increases Expression [120]
Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) OT5V52LN TNR12_HUMAN Increases Expression [120]
Mid1-interacting protein 1 (MID1IP1) OTFCORJM M1IP1_HUMAN Increases Expression [120]
Frizzled-3 (FZD3) OTIWDN78 FZD3_HUMAN Decreases Expression [120]
Nuclear receptor-interacting protein 3 (NRIP3) OTU15GMK NRIP3_HUMAN Decreases Expression [120]
Signal peptide, CUB and EGF-like domain-containing protein 2 (SCUBE2) OT661S7D SCUB2_HUMAN Decreases Expression [120]
Solute carrier family 52, riboflavin transporter, member 3 (SLC52A3) OT1FHFMK S52A3_HUMAN Increases Expression [120]
E3 ubiquitin-protein ligase Jade-2 (JADE2) OTVG2MYF JADE2_HUMAN Increases Expression [120]
Ras-related GTP-binding protein D (RRAGD) OTXLVWAH RRAGD_HUMAN Decreases Expression [120]
Coiled-coil domain-containing protein 177 (CCDC177) OT44WWP5 CC177_HUMAN Decreases Expression [120]
Sialic acid synthase (NANS) OTMQ2FUH SIAS_HUMAN Increases Expression [120]
N-lysine methyltransferase SMYD2 (SMYD2) OTN8035R SMYD2_HUMAN Increases Expression [120]
Bromodomain adjacent to zinc finger domain protein 1A (BAZ1A) OTWHOVZS BAZ1A_HUMAN Increases Expression [120]
Olfactomedin-like protein 3 (OLFML3) OTDN45FN OLFL3_HUMAN Increases Expression [120]
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (C1GALT1) OT2ZSZ6P C1GLT_HUMAN Increases Expression [120]
Glutaredoxin-2, mitochondrial (GLRX2) OT4LIRBC GLRX2_HUMAN Increases Expression [120]
Protein reprimo (RPRM) OTNNBAS1 RPRM_HUMAN Increases Expression [120]
Probable G-protein coupled receptor 173 (GPR173) OT8F8XR1 GP173_HUMAN Decreases Expression [120]
Probable G-protein coupled receptor 27 (GPR27) OTH4KQPI GPR27_HUMAN Decreases Expression [120]
Asc-type amino acid transporter 1 (SLC7A10) OTN1S03Q AAA1_HUMAN Increases Expression [120]
EMILIN-3 (EMILIN3) OT2BZTSU EMIL3_HUMAN Decreases Expression [120]
Teneurin-2 (TENM2) OTPLUYEF TEN2_HUMAN Increases Expression [120]
Obg-like ATPase 1 (OLA1) OTAPOTTG OLA1_HUMAN Decreases Expression [120]
Muscleblind-like protein 3 (MBNL3) OT2T2YOK MBNL3_HUMAN Increases Expression [120]
RNA binding protein fox-1 homolog 1 (RBFOX1) OTFPKEL7 RFOX1_HUMAN Increases Expression [120]
Calcium uniporter regulatory subunit MCUb, mitochondrial (MCUB) OTXLLSIZ MCUB_HUMAN Decreases Expression [120]
Ras-related protein Rab-20 (RAB20) OTP9OOVS RAB20_HUMAN Increases Expression [120]
Very long chain fatty acid elongase 2 (ELOVL2) OTDAF6U3 ELOV2_HUMAN Decreases Expression [120]
Dapper homolog 1 (DACT1) OT19Z704 DACT1_HUMAN Increases Expression [120]
Endoplasmic reticulum aminopeptidase 1 (ERAP1) OT72S99B ERAP1_HUMAN Decreases Expression [120]
Transcription factor CP2-like protein 1 (TFCP2L1) OT7QIJ0X TF2L1_HUMAN Increases Expression [120]
Myoferlin (MYOF) OTRFC3IJ MYOF_HUMAN Increases Expression [120]
Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1) OTW3T4B2 IRPL1_HUMAN Decreases Expression [120]
Tropomodulin-2 (TMOD2) OTTTUH2W TMOD2_HUMAN Increases Expression [120]
Potassium voltage-gated channel subfamily D member 2 (KCND2) OTIFUVV7 KCND2_HUMAN Decreases Expression [120]
Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22) OT452ZDC ADA22_HUMAN Decreases Expression [120]
DOMON domain-containing protein FRRS1L (FRRS1L) OT24ABVC FRS1L_HUMAN Decreases Expression [120]
Peroxisomal sarcosine oxidase (PIPOX) OTWTCOTN SOX_HUMAN Increases Expression [120]
MyoD family inhibitor domain-containing protein (MDFIC) OTSRYBWZ MDFIC_HUMAN Increases Expression [120]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (PLCE1) OTJISZOX PLCE1_HUMAN Increases Expression [120]
Junctional cadherin 5-associated protein (JCAD) OT7G1WJW JCAD_HUMAN Increases Expression [120]
Protocadherin-10 (PCDH10) OT2GIT0E PCD10_HUMAN Increases Expression [120]
Kelch-like protein 14 (KLHL14) OTYOS55H KLH14_HUMAN Increases Expression [120]
Hairy/enhancer-of-split related with YRPW motif protein 2 (HEY2) OTU4J3ZI HEY2_HUMAN Increases Expression [120]
Homeobox expressed in ES cells 1 (HESX1) OT5E2Z4G HESX1_HUMAN Decreases Expression [120]
Small conductance calcium-activated potassium channel protein 3 (KCNN3) OT11KYA8 KCNN3_HUMAN Decreases Expression [120]
Testin (TES) OTL8PP6V TES_HUMAN Increases Expression [120]
Sushi domain-containing protein 2 (SUSD2) OTSJTAZP SUSD2_HUMAN Increases Expression [120]
Transcription factor COE1 (EBF1) OTZ61YYH COE1_HUMAN Increases Expression [120]
Zinc finger transcription factor Trps1 (TRPS1) OT7XPPEL TRPS1_HUMAN Increases Expression [120]
Scm-like with four MBT domains protein 1 (SFMBT1) OTKMZIBW SMBT1_HUMAN Decreases Expression [120]
Krueppel-like factor 15 (KLF15) OTGMQMVR KLF15_HUMAN Increases Expression [120]
E3 ISG15--protein ligase HERC5 (HERC5) OTZ5PR39 HERC5_HUMAN Increases Expression [120]
Potassium voltage-gated channel subfamily G member 1 (KCNG1) OTZ9ZRG8 KCNG1_HUMAN Increases Expression [120]
Forkhead box protein D3 (FOXD3) OTXYV6GO FOXD3_HUMAN Increases Expression [120]
Purine-rich element-binding protein gamma (PURG) OTXPQDWN PURG_HUMAN Decreases Expression [120]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 (GNG8) OT9YHSF1 GBG8_HUMAN Decreases Expression [120]
F-box only protein 2 (FBXO2) OTF3677S FBX2_HUMAN Increases Expression [120]
Nocturnin (NOCT) OTVSYP2D NOCT_HUMAN Increases Expression [120]
Adherens junction-associated protein 1 (AJAP1) OTAAW121 AJAP1_HUMAN Increases Expression [120]
TRAF2 and NCK-interacting protein kinase (TNIK) OTDZBJ4K TNIK_HUMAN Increases Expression [120]
Cdc42 effector protein 3 (CDC42EP3) OTUZ3U9Z BORG2_HUMAN Decreases Expression [120]
Disintegrin and metalloproteinase domain-containing protein 28 (ADAM28) OT3GBVHL ADA28_HUMAN Increases Expression [120]
ETS-related transcription factor Elf-5 (ELF5) OTLRU8YF ELF5_HUMAN Increases Expression [120]
Procollagen C-endopeptidase enhancer 2 (PCOLCE2) OTSUEQZ1 PCOC2_HUMAN Increases Expression [120]
DENN domain-containing protein 2A (DENND2A) OT01E1PL DEN2A_HUMAN Decreases Expression [120]
NACHT and WD repeat domain-containing protein 2 (NWD2) OTN47UBK NWD2_HUMAN Increases Expression [120]
Protein HEG homolog 1 (HEG1) OT3CUXA7 HEG1_HUMAN Decreases Expression [120]
Neurabin-1 (PPP1R9A) OTJL2TOC NEB1_HUMAN Decreases Expression [120]
RING finger protein 150 (RNF150) OTAMSBK5 RN150_HUMAN Increases Expression [120]
E3 ubiquitin-protein ligase CBL-C (CBLC) OT3RKZI9 CBLC_HUMAN Increases Expression [120]
Apoptosis-associated speck-like protein containing a CARD (PYCARD) OT67RON3 ASC_HUMAN Increases Expression [120]
Sex comb on midleg-like protein 1 (SCML1) OT7V5DAR SCML1_HUMAN Increases Expression [120]
DNA polymerase iota (POLI) OTBA4DCE POLI_HUMAN Decreases Expression [120]
LIM and calponin homology domains-containing protein 1 (LIMCH1) OTYPC4XA LIMC1_HUMAN Decreases Expression [120]
Catenin delta-2 (CTNND2) OTYKE30Y CTND2_HUMAN Decreases Expression [120]
Tenascin-N (TNN) OTQK2AMX TENN_HUMAN Increases Expression [120]
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 (FUT9) OTLIJBQY FUT9_HUMAN Decreases Expression [120]
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A) OT74EK7Z PDE10_HUMAN Decreases Expression [120]
Leucine zipper putative tumor suppressor 1 (LZTS1) OTXXL864 LZTS1_HUMAN Increases Expression [120]
C-C motif chemokine 26 (CCL26) OT2B7HR9 CCL26_HUMAN Increases Expression [120]
TBC1 domain family member 30 (TBC1D30) OTG8HGSI TBC30_HUMAN Decreases Expression [120]
Band 4.1-like protein 3 (EPB41L3) OTS6CHG2 E41L3_HUMAN Increases Expression [120]
Axin-2 (AXIN2) OTRMGQNU AXIN2_HUMAN Increases Expression [120]
Retinal homeobox protein Rx (RAX) OTJ3YCE7 RX_HUMAN Decreases Expression [120]
Tudor and KH domain-containing protein (TDRKH) OTV21BN1 TDRKH_HUMAN Decreases Expression [120]
Transmembrane emp24 domain-containing protein 5 (TMED5) OT70W1J8 TMED5_HUMAN Increases Expression [120]
C2 domain-containing protein 2 (C2CD2) OTL1K0OB C2CD2_HUMAN Decreases Expression [120]
Sal-like protein 2 (SALL2) OTQWI68Q SALL2_HUMAN Decreases Expression [120]
V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) OTJBDX0Y VPP2_HUMAN Decreases Expression [120]
Beta/gamma crystallin domain-containing protein 1 (CRYBG1) OTIPDI15 CRBG1_HUMAN Increases Expression [120]
Transcription factor HES-2 (HES2) OTMWY2KV HES2_HUMAN Increases Expression [120]
Intraflagellar transport protein 25 homolog (IFT25) OTDR1HG6 IFT25_HUMAN Decreases Expression [120]
Low-density lipoprotein receptor-related protein 12 (LRP12) OTRT1UJ7 LRP12_HUMAN Decreases Expression [120]
Protein mab-21-like 2 (MAB21L2) OTZM5VMX MB212_HUMAN Decreases Expression [120]
Protocadherin beta-14 (PCDHB14) OTFZF1ST PCDBE_HUMAN Decreases Expression [120]
Transcription factor MafB (MAFB) OTH2N3T8 MAFB_HUMAN Increases Expression [120]
Beta-secretase 2 (BACE2) OTO5YQVK BACE2_HUMAN Increases Expression [120]
Glypican-6 (GPC6) OTNJBESF GPC6_HUMAN Decreases Expression [120]
Adhesion G-protein coupled receptor G1 (ADGRG1) OTQBB8NT AGRG1_HUMAN Decreases Expression [120]
Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 (HS3ST3B1) OTK53GUD HS3SB_HUMAN Decreases Expression [120]
LHFPL tetraspan subfamily member 6 protein (LHFPL6) OTY6LHJY LHPL6_HUMAN Increases Expression [120]
Mitochondrial inner membrane protease ATP23 homolog (ATP23) OT303R2T ATP23_HUMAN Increases Expression [120]
Gap junction alpha-3 protein (GJA3) OTXV6ETF CXA3_HUMAN Increases Expression [120]
Sulfide:quinone oxidoreductase, mitochondrial (SQOR) OTTLD0KB SQOR_HUMAN Increases Expression [120]
Cadherin-10 (CDH10) OTK3D5WP CAD10_HUMAN Increases Expression [120]
Calpain-6 (CAPN6) OT8K5PR5 CAN6_HUMAN Decreases Expression [120]
AP-1 complex subunit mu-2 (AP1M2) OTUE5YLC AP1M2_HUMAN Increases Expression [120]
Collagen alpha-1(XI) chain (COL11A1) OTB0DRMS COBA1_HUMAN Increases Expression [127]
Neuronal growth regulator 1 (NEGR1) OT57ECW9 NEGR1_HUMAN Increases Expression [127]
Bone morphogenetic protein receptor type-1B (BMPR1B) OTGFN0OD BMR1B_HUMAN Affects Expression [122]
Huntingtin-interacting protein 1 (HIP1) OT7AKCFQ HIP1_HUMAN Increases Expression [121]
Homeobox protein Meis2 (MEIS2) OTG4ADLM MEIS2_HUMAN Affects Expression [122]
T-box transcription factor TBX3 (TBX3) OTM64N7K TBX3_HUMAN Affects Expression [122]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [128]
Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3 (ST8SIA3) OTG9MXV9 SIA8C_HUMAN Affects Expression [122]
Transmembrane and coiled-coil domains protein 2 (TMCC2) OT0D7IYD TMCC2_HUMAN Increases Expression [121]
Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G) OT8V1J4M GA45G_HUMAN Increases Expression [129]
Nuclear factor 1 C-type (NFIC) OTLMCUIB NFIC_HUMAN Affects Expression [122]
Myb-related protein A (MYBL1) OTBJMC2P MYBA_HUMAN Increases Expression [121]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Expression [130]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [129]
Interleukin-3 receptor subunit alpha (IL3RA) OTDC3Y8O IL3RA_HUMAN Increases Expression [121]
G-protein coupled receptor 183 (GPR183) OTRILX7G GP183_HUMAN Decreases Expression [121]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [131]
OX-2 membrane glycoprotein (CD200) OTQEQSRT OX2G_HUMAN Affects Expression [122]
Tyrosine-protein phosphatase non-receptor type 9 (PTPN9) OTNAR1I2 PTN9_HUMAN Affects Expression [122]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [131]
Actin, aortic smooth muscle (ACTA2) OTEDLG8E ACTA_HUMAN Decreases Expression [128]
Histone H4 (H4C1) OTB71W46 H4_HUMAN Increases Acetylation [132]
Guanylate cyclase soluble subunit alpha-1 (GUCY1A1) OTPTCBUN GCYA1_HUMAN Affects Expression [122]
Unconventional myosin-Ie (MYO1E) OTM9YSIZ MYO1E_HUMAN Increases Expression [121]
Cyclin-dependent kinase 5 activator 1 (CDK5R1) OTJELWK0 CD5R1_HUMAN Decreases Expression [121]
Histone H3.1t (H3-4) OTY6ITYF H31T_HUMAN Increases Acetylation [132]
Rho GTPase-activating protein 31 (ARHGAP31) OTUYTF4I RHG31_HUMAN Affects Expression [122]
Fidgetin (FIGN) OTJF6EZR FIGN_HUMAN Affects Expression [122]
NHS-like protein 2 (NHSL2) OT8U1P8E NHSL2_HUMAN Affects Expression [122]
Failed axon connections homolog (FAXC) OTU0RGB0 FAXC_HUMAN Affects Expression [122]
AT-rich interactive domain-containing protein 2 (ARID2) OTIRJXWM ARID2_HUMAN Affects Expression [122]
Male-specific lethal 1 homolog (MSL1) OTXLFYLB MSL1_HUMAN Decreases Expression [121]
Rab11 family-interacting protein 1 (RAB11FIP1) OT0T71OW RFIP1_HUMAN Increases Expression [121]
Protein lin-28 homolog B (LIN28B) OTVWP0FN LN28B_HUMAN Decreases Expression [122]
Leucine-rich repeat transmembrane neuronal protein 1 (LRRTM1) OTKI3IU9 LRRT1_HUMAN Affects Expression [122]
Transforming growth factor beta activator LRRC33 (NRROS) OT9WNOKY LRC33_HUMAN Decreases Expression [121]
tRNA-uridine aminocarboxypropyltransferase 1 (DTWD1) OT95QT6P DTWD1_HUMAN Decreases Expression [121]
TBC1 domain family member 16 (TBC1D16) OTPR3C6A TBC16_HUMAN Increases Expression [121]
Transforming growth factor-beta receptor-associated protein 1 (TGFBRAP1) OT80QNR5 TGFA1_HUMAN Affects Expression [122]
Alpha-2,8-sialyltransferase 8B (ST8SIA2) OTRBBBD8 SIA8B_HUMAN Affects Expression [122]
Protein FAN (NSMAF) OTYNVZ23 FAN_HUMAN Affects Expression [122]
Protein Jumonji (JARID2) OT14UM8H JARD2_HUMAN Increases Expression [121]
ELL-associated factor 2 (EAF2) OTSOET5L EAF2_HUMAN Increases Expression [121]
Abasic site processing protein HMCES (HMCES) OTVRDL6U HMCES_HUMAN Increases Expression [121]
Protein FAM163A (FAM163A) OT0MYZ0F F163A_HUMAN Affects Expression [122]
Bcl-2-modifying factor (BMF) OT90NSLI BMF_HUMAN Increases Expression [121]
Small integral membrane protein 14 (SMIM14) OT47IF19 SIM14_HUMAN Increases Expression [121]
Sialidase-1 (NEU1) OTH9BY8Y NEUR1_HUMAN Increases Expression [121]
Partner of Y14 and mago (PYM1) OTEZ2WUO PYM1_HUMAN Decreases Expression [121]
F-box-like/WD repeat-containing protein TBL1XR1 (TBL1XR1) OTM3B3OA TBL1R_HUMAN Affects Expression [122]
E3 ubiquitin-protein ligase TRIM8 (TRIM8) OTS6JFR0 TRIM8_HUMAN Affects Expression [122]
Sentrin-specific protease 6 (SENP6) OT05LLF4 SENP6_HUMAN Affects Expression [122]
Tumor protein 63 (TP63) OT0WOOKQ P63_HUMAN Increases Expression [133]
Popeye domain-containing protein 2 (POPDC2) OTDAZSY5 POPD2_HUMAN Affects Expression [122]
F-box only protein 8 (FBXO8) OTZNGJGW FBX8_HUMAN Affects Expression [122]
Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) OTTVT4MB TNR19_HUMAN Increases Expression [121]
AP-5 complex subunit sigma-1 (AP5S1) OTGS53SC AP5S1_HUMAN Decreases Expression [121]
Pre-mRNA-splicing factor RBM22 (RBM22) OTFW0IGK RBM22_HUMAN Decreases Expression [121]
Ral guanine nucleotide dissociation stimulator-like 1 (RGL1) OTY6ZHVA RGL1_HUMAN Increases Expression [121]
Programmed cell death 1 ligand 1 (CD274) OTJ0VFDL PD1L1_HUMAN Increases Expression [134]
Coiled-coil and C2 domain-containing protein 2A (CC2D2A) OTFGRGFR C2D2A_HUMAN Affects Expression [122]
RING finger protein 24 (RNF24) OTUZI597 RNF24_HUMAN Increases Expression [121]
Phosphatidylinositide phosphatase SAC2 (INPP5F) OTPKUY50 SAC2_HUMAN Increases Expression [121]
DmX-like protein 1 (DMXL1) OTWVL31L DMXL1_HUMAN Increases Expression [121]
N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) OT53SIZG NAA15_HUMAN Increases ADR [93]
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⏷ Show the Full List of 866 DOT(s)

References

1 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
2 Etoposide FDA Label
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6815).
4 FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 075635.
5 ClinicalTrials.gov (NCT04356690) Etoposide in Patients With COVID-19 Infection. U.S. National Institutes of Health.
6 Panobinostat FDA Label
7 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
8 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7489).
9 UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for etoposide glucuronidation in human liver and intestinal microsomes: structural characterization of phenolic and alcoholic glucuronides of etoposide and estimation of enzyme kinetics. Drug Metab Dispos. 2007 Mar;35(3):371-80.
10 Differential regulation of vitamin D receptor (VDR) by the p53 Family: p73-dependent induction of VDR upon DNA damage. J Biol Chem. 2007 Oct 12;282(41):29847-54.
11 Genomic profiling uncovers a molecular pattern for toxicological characterization of mutagens and promutagens in vitro. Toxicol Sci. 2011 Jul;122(1):185-97.
12 Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells. Arch Toxicol. 2018 Apr;92(4):1507-1524.
13 Characterization of DNA reactive and non-DNA reactive anticancer drugs by gene expression profiling. Mutat Res. 2007 Jun 1;619(1-2):16-29. doi: 10.1016/j.mrfmmm.2006.12.007. Epub 2007 Feb 8.
14 Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
15 New role for nuclear hormone receptors and coactivators in regulation of BRCA1-mediated DNA repair in breast cancer cell lines. Breast Cancer Res. 2006;8(1):R1. doi: 10.1186/bcr1362. Epub 2005 Dec 9.
16 Resveratrol Enhances Etoposide-Induced Cytotoxicity through Down-Regulating ERK1/2 and AKT-Mediated X-ray Repair Cross-Complement Group 1 (XRCC1) Protein Expression in Human Non-Small-Cell Lung Cancer Cells. Basic Clin Pharmacol Toxicol. 2015 Dec;117(6):383-91. doi: 10.1111/bcpt.12425. Epub 2015 Jun 30.
17 Identification of XAF1-MT2A mutual antagonism as a molecular switch in cell-fate decisions under stressful conditions. Proc Natl Acad Sci U S A. 2017 May 30;114(22):5683-5688. doi: 10.1073/pnas.1700861114. Epub 2017 May 15.
18 Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway. Blood. 2008 Apr 15;111(8):4365-74. doi: 10.1182/blood-2007-08-106336. Epub 2008 Feb 12.
19 Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
20 Inhibition of Wnt signaling downregulates Akt activity and induces chemosensitivity in PTEN-mutated prostate cancer cells. Prostate. 2005 Jan 1;62(1):61-8. doi: 10.1002/pros.20117.
21 Werner's syndrome lymphoblastoid cells are hypersensitive to topoisomerase II inhibitors in the G2 phase of the cell cycle. Mutat Res. 2000 Mar 20;459(2):123-33. doi: 10.1016/s0921-8777(99)00065-8.
22 Genetic and epigenetic control of UNC5C expression in human renal cell carcinoma. Eur J Cancer. 2011 Sep;47(13):2068-76. doi: 10.1016/j.ejca.2011.04.021. Epub 2011 May 18.
23 Human mitochondrial thioredoxin. Involvement in mitochondrial membrane potential and cell death. J Biol Chem. 2002 Sep 6;277(36):33249-57. doi: 10.1074/jbc.M203036200. Epub 2002 Jun 21.
24 An antisense oligonucleotide targeted to human Ku86 messenger RNA sensitizes M059K malignant glioma cells to ionizing radiation, bleomycin, and etoposide but not DNA cross-linking agents. Cancer Res. 2002 Oct 15;62(20):5888-96.
25 A novel tumor-promoting function residing in the 5' non-coding region of vascular endothelial growth factor mRNA. PLoS Med. 2008 May 20;5(5):e94. doi: 10.1371/journal.pmed.0050094.
26 Vascular endothelial growth factor-C modulates proliferation and chemoresistance in acute myeloid leukemic cells through an endothelin-1-dependent induction of cyclooxygenase-2. Biochim Biophys Acta. 2014 Feb;1843(2):387-97. doi: 10.1016/j.bbamcr.2013.10.015. Epub 2013 Oct 31.
27 The Wnt signaling pathway regulates Nalm-16 b-cell precursor acute lymphoblastic leukemic cell line survival and etoposide resistance. Biomed Pharmacother. 2010 Jan;64(1):63-72. doi: 10.1016/j.biopha.2009.09.005. Epub 2009 Oct 27.
28 Epigenetic determinants of resistance to etoposide regulation of Bcl-X(L) and Bax by tumor microenvironmental factors. J Natl Cancer Inst. 2000 Jan 5;92(1):18-23. doi: 10.1093/jnci/92.1.18.
29 Pharmacogenetics of outcome in children with acute lymphoblastic leukemia. Blood. 2005 Jun 15;105(12):4752-8. doi: 10.1182/blood-2004-11-4544. Epub 2005 Feb 15.
30 Etoposide, topoisomerase II and cancer.Curr Med Chem Anticancer Agents.2005 Jul;5(4):363-72.
31 Multidrug resistance-associated protein-1 functional activity in Calu-3 cells. J Pharmacol Exp Ther. 2001 Sep;298(3):1199-205.
32 Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). Drug Metab Dispos. 2002 Apr;30(4):457-63.
33 Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers. Pharm Res. 2003 Aug;20(8):1200-9.
34 Characterization of 3-methoxy flavones for their interaction with ABCG2 as suggested by ATPase activity. Biochim Biophys Acta. 2014 Nov;1838(11):2929-38.
35 Identification of drugs and drug metabolites as substrates of multidrug resistance protein 2 (MRP2) using triple-transfected MDCK-OATP1B1-UGT1A1-MRP2 cells. Br J Pharmacol. 2012 Mar;165(6):1836-1847.
36 Functional reconstitution of human ABCC3 into proteoliposomes reveals a transport mechanism with positive cooperativity. Biochemistry. 2009 May 26;48(20):4423-30.
37 Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. Eur J Pharmacol. 2008 Apr 14;584(1):57-65.
38 Effects of morin on the pharmacokinetics of etoposide in rats. Biopharm Drug Dispos. 2007 Apr;28(3):151-6.
39 Kinetics and regulation of cytochrome P450-mediated etoposide metabolism. Drug Metab Dispos. 2004 Sep;32(9):993-1000.
40 A study on the metabolism of etoposide and possible interactions with antitumor or supporting agents by human liver microsomes. J Pharmacol Exp Ther. 1998 Sep;286(3):1294-300.
41 Reactions of glutathione with the catechol, the ortho-quinone and the semi-quinone free radical of etoposide. Consequences for DNA inactivation. Biochem Pharmacol. 1992 Apr 15;43(8):1761-8.
42 Peroxidative free radical formation and O-demethylation of etoposide(VP-16) and teniposide(VM-26). Biochem Biophys Res Commun. 1986 Feb 26;135(1):215-20.
43 Transient resistance to DNA damaging agents is associated with expression of microRNAs-135b and -196b in human leukemia cell lines. Int J Biochem Mol Biol. 2016 Aug 5;7(2):27-47. eCollection 2016.
44 Drug sensitivity and drug resistance profiles of human intrahepatic cholangiocarcinoma cell lines. World J Gastroenterol. 2005 May 14;11(18):2748-53. doi: 10.3748/wjg.v11.i18.2748.
45 Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem. 2005 Sep 9;280(36):31498-507. doi: 10.1074/jbc.M505537200. Epub 2005 Jul 13.
46 Etoposide induces necrosis through p53-mediated antiapoptosis in human kidney proximal tubule cells. Toxicol Sci. 2015 Nov;148(1):204-19.
47 Transcription factor NF-kappaB differentially regulates death receptor 5 expression involving histone deacetylase 1. Mol Cell Biol. 2005 Jul;25(13):5404-16. doi: 10.1128/MCB.25.13.5404-5416.2005.
48 The DNA damaging agent VP16 induces the expression of a subset of ligands from the EGF system in bladder cancer cells, whereas none of the four EGF receptors are induced. Mol Cell Biochem. 2004 May;260(1-2):129-35. doi: 10.1023/b:mcbi.0000026063.96267.98.
49 Transcriptional repression of IKK by p53 in arsenite-induced GADD45 accumulation and apoptosis. Oncogene. 2019 Jan;38(5):731-746. doi: 10.1038/s41388-018-0478-7. Epub 2018 Sep 3.
50 Estrogen regulation of apoptosis in osteoblasts. Physiol Behav. 2010 Feb 9;99(2):181-5. doi: 10.1016/j.physbeh.2009.04.025. Epub 2009 May 5.
51 Selective and nonselective toxicity of TRAIL/Apo2L combined with chemotherapy in human bone tumour cells vs. normal human cells. Int J Cancer. 2003 Dec 20;107(6):929-40. doi: 10.1002/ijc.11503.
52 Phosphoinositide 3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death. Int J Cancer. 2008 Jan 15;122(2):433-43. doi: 10.1002/ijc.23049.
53 Responses of genes involved in cell cycle control to diverse DNA damaging chemicals in human lung adenocarcinoma A549 cells. Cancer Cell Int. 2005 Aug 24;5:28. doi: 10.1186/1475-2867-5-28.
54 Screening of a chemical library reveals novel PXR-activating pharmacologic compounds. Toxicol Lett. 2015 Jan 5;232(1):193-202. doi: 10.1016/j.toxlet.2014.10.009. Epub 2014 Oct 16.
55 Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. J Med Chem. 2011 Jan 27;54(2):580-90. doi: 10.1021/jm101150b. Epub 2010 Dec 27.
56 (-)-Xanthatin induces the prolonged expression of c-Fos through an N-acetyl-L-cysteine (NAC)-sensitive mechanism in human breast cancer MDA-MB-231 cells. J Toxicol Sci. 2013;38(4):547-57. doi: 10.2131/jts.38.547.
57 Lysosome Fe(2+) release is responsible for etoposide- and cisplatin-induced stemness of small cell lung cancer cells. Environ Toxicol. 2021 Aug;36(8):1654-1663. doi: 10.1002/tox.23161. Epub 2021 May 10.
58 Basal and UV-induced MMP-1 expression are inhibited by p53 in human dermal fibroblasts. Exp Dermatol. 2008 Nov;17(11):939-45. doi: 10.1111/j.1600-0625.2008.00729.x. Epub 2008 Jun 14.
59 Induction of mitochondrial manganese superoxide dismutase confers resistance to apoptosis in acute myeloblastic leukaemia cells exposed to etoposide. Br J Haematol. 2000 Mar;108(3):574-81. doi: 10.1046/j.1365-2141.2000.01852.x.
60 cAMP increasing agents attenuate the generation of apoptosis by etoposide in promonocytic leukemia cells. J Cell Sci. 1998 Mar;111 ( Pt 5):637-44. doi: 10.1242/jcs.111.5.637.
61 p21Cip1 gene expression is modulated by Egr1: a novel regulatory mechanism involved in the resveratrol antiproliferative effect. J Biol Chem. 2003 Jun 27;278(26):23360-8. doi: 10.1074/jbc.M300771200. Epub 2003 Apr 10.
62 Expression and release of chemokines associated with apoptotic cell death in human promonocytic U937 cells and peripheral blood mononuclear cells. Eur J Immunol. 1999 Oct;29(10):3225-35. doi: 10.1002/(SICI)1521-4141(199910)29:10<3225::AID-IMMU3225>3.0.CO;2-0.
63 Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. Chem Res Toxicol. 2015 May 18;28(5):927-34. doi: 10.1021/tx5005248. Epub 2015 Apr 3.
64 Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy. J Natl Cancer Inst. 2012 Mar 21;104(6):476-87. doi: 10.1093/jnci/djs002. Epub 2012 Feb 1.
65 Specific inhibition of rRNA transcription and dynamic relocation of fibrillarin induced by mercury. Exp Cell Res. 2000 Aug 25;259(1):225-38. doi: 10.1006/excr.2000.4923.
66 Development and applications of a real-time quantitative RT-PCR method (QRT-PCR) for BRCA1 mRNA. Clin Biochem. 2005 Jan;38(1):50-7. doi: 10.1016/j.clinbiochem.2004.09.012.
67 "Exposure to the insecticides permethrin and malathion induces leukemia and lymphoma-associated gene aberrations in vitro". Toxicol In Vitro. 2017 Oct;44:17-26. doi: 10.1016/j.tiv.2017.06.013. Epub 2017 Jun 15.
68 A molecular beacon approach to detecting RAD52 expression in response to DNA damage in human cells. Toxicol In Vitro. 2010 Mar;24(2):652-60. doi: 10.1016/j.tiv.2009.09.019. Epub 2009 Sep 30.
69 Nitric oxide inhibits apoptosis via AP-1-dependent CD95L transactivation. Cancer Res. 2000 May 1;60(9):2377-83.
70 Regulation of Hepatic Cholesteryl Ester Transfer Protein Expression and Reverse Cholesterol Transport by Inhibition of DNA Topoisomerase II. J Biol Chem. 2015 Jun 5;290(23):14418-29. doi: 10.1074/jbc.M115.643015. Epub 2015 Apr 25.
71 Protein kinase Cdelta stimulates proteasome-dependent degradation of C/EBPalpha during apoptosis induction of leukemic cells. PLoS One. 2009 Aug 7;4(8):e6552. doi: 10.1371/journal.pone.0006552.
72 Phosphorylation and stabilization of topoisomerase II protein by p38 mitogen-activated protein kinase sensitize breast cancer cells to its poisons. J Biol Chem. 2011 Oct 14;286(41):35883-35890. doi: 10.1074/jbc.M111.229260. Epub 2011 Aug 30.
73 Functional inactivation of triosephosphate isomerase through phosphorylation during etoposide-induced apoptosis in HeLa cells: potential role of Cdk2. Toxicology. 2010 Dec 5;278(2):224-8. doi: 10.1016/j.tox.2010.02.005. Epub 2010 Feb 10.
74 NF-B1 p50 promotes p53 protein translation through miR-190 downregulation of PHLPP1. Oncogene. 2014 Feb 20;33(8):996-1005. doi: 10.1038/onc.2013.8. Epub 2013 Feb 11.
75 The broken MLL gene is frequently located outside the inherent chromosome territory in human lymphoid cells treated with DNA topoisomerase II poison etoposide. PLoS One. 2013 Sep 25;8(9):e75871. doi: 10.1371/journal.pone.0075871. eCollection 2013.
76 Amsacrine downregulates BCL2L1 expression and triggers apoptosis in human chronic myeloid leukemia cells through the SIDT2/NOX4/ERK/HuR pathway. Toxicol Appl Pharmacol. 2023 Sep 1;474:116625. doi: 10.1016/j.taap.2023.116625. Epub 2023 Jul 13.
77 Translation of cellular inhibitor of apoptosis protein 1 (c-IAP1) mRNA is IRES mediated and regulated during cell stress. RNA. 2004 Mar;10(3):469-81. doi: 10.1261/rna.5156804.
78 Essential role of caspase-8 in p53/p73-dependent apoptosis induced by etoposide in head and neck carcinoma cells. Mol Cancer. 2011 Jul 31;10:95. doi: 10.1186/1476-4598-10-95.
79 The tumor suppressor gene hypermethylated in cancer 1 is transcriptionally regulated by E2F1. Mol Cancer Res. 2009 Jun;7(6):916-22. doi: 10.1158/1541-7786.MCR-08-0359. Epub 2009 Jun 2.
80 Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
81 Cotylenin A, a new differentiation inducer, and rapamycin cooperatively inhibit growth of cancer cells through induction of cyclin G2. Cancer Sci. 2008 Aug;99(8):1693-8. doi: 10.1111/j.1349-7006.2008.00867.x.
82 Ribosomal protein S27-like, a p53-inducible modulator of cell fate in response to genotoxic stress. Cancer Res. 2007 Dec 1;67(23):11317-26. doi: 10.1158/0008-5472.CAN-07-1088.
83 Validation of a genotoxicity test based on p53R2 gene expression in human lymphoblastoid cells. Mutat Res. 2011 Sep 18;724(1-2):76-85. doi: 10.1016/j.mrgentox.2011.06.003. Epub 2011 Jun 17.
84 [Expression and function of Ahi-1 gene in Jurkat cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Apr;17(2):445-9.
85 Expression of the RAI gene is conducive to apoptosis: studies of induction and interference. Exp Cell Res. 2007 Jul 15;313(12):2611-21. doi: 10.1016/j.yexcr.2007.05.006. Epub 2007 May 22.
86 Acetylation-dependent function of human single-stranded DNA binding protein 1. Nucleic Acids Res. 2015 Sep 18;43(16):7878-87. doi: 10.1093/nar/gkv707. Epub 2015 Jul 13.
87 A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining. J Biol Chem. 2014 Apr 18;289(16):10950-10957. doi: 10.1074/jbc.C113.533968. Epub 2014 Mar 7.
88 Comprehensive Landscape of Nrf2 and p53 Pathway Activation Dynamics by Oxidative Stress and DNA Damage. Chem Res Toxicol. 2017 Apr 17;30(4):923-933. doi: 10.1021/acs.chemrestox.6b00322. Epub 2016 Dec 16.
89 Chemopreventive agents induce programmed death-1-ligand 1 (PD-L1) surface expression in breast cancer cells and promote PD-L1-mediated T cell apoptosis. Mol Immunol. 2008 Mar;45(5):1470-6. doi: 10.1016/j.molimm.2007.08.013. Epub 2007 Oct 24.
90 CHI3L1 (YKL-40) is expressed in human gliomas and regulates the invasion, growth and survival of glioma cells. Int J Cancer. 2011 Mar 15;128(6):1316-26. doi: 10.1002/ijc.25466.
91 Overexpression of ZNRD1 promotes multidrug-resistant phenotype of gastric cancer cells through upregulation of P-glycoprotein. Cancer Biol Ther. 2004 Apr;3(4):377-81. doi: 10.4161/cbt.3.4.724. Epub 2004 Apr 17.
92 Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1. Oncogene. 2011 Jan 27;30(4):482-93. doi: 10.1038/onc.2010.435. Epub 2010 Sep 20.
93 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
94 CD40L induces multidrug resistance to apoptosis in breast carcinoma and lymphoma cells through caspase independent and dependent pathways. BMC Cancer. 2006 Mar 18;6:75. doi: 10.1186/1471-2407-6-75.
95 Human splicing factor SPF45 (RBM17) confers broad multidrug resistance to anticancer drugs when overexpressed--a phenotype partially reversed by selective estrogen receptor modulators. Cancer Res. 2005 Aug 1;65(15):6593-600. doi: 10.1158/0008-5472.CAN-03-3675.
96 CD44 promotes resistance to apoptosis in human colon cancer cells. Exp Mol Pathol. 2004 Aug;77(1):18-25. doi: 10.1016/j.yexmp.2004.03.002.
97 Human aldehyde dehydrogenase 3A1 inhibits proliferation and promotes survival of human corneal epithelial cells. J Biol Chem. 2005 Jul 29;280(30):27998-8006. doi: 10.1074/jbc.M503698200. Epub 2005 May 19.
98 Targeting BCL-2 family proteins to overcome drug resistance in non-small cell lung cancer. Int J Cancer. 2007 Dec 1;121(11):2387-94. doi: 10.1002/ijc.22977.
99 Overexpression and significance of prion protein in gastric cancer and multidrug-resistant gastric carcinoma cell line SGC7901/ADR. Int J Cancer. 2005 Jan 10;113(2):213-20. doi: 10.1002/ijc.20570.
100 RASSF1A and the BH3-only mimetic ABT-737 promote apoptosis in pediatric medulloblastoma cell lines. Neuro Oncol. 2011 Dec;13(12):1265-76. doi: 10.1093/neuonc/nor129. Epub 2011 Aug 31.
101 Effect of eIF3a on response of lung cancer patients to platinum-based chemotherapy by regulating DNA repair. Clin Cancer Res. 2011 Jul 1;17(13):4600-9. doi: 10.1158/1078-0432.CCR-10-2591. Epub 2011 May 24.
102 Suppression of NRF2-ARE activity sensitizes chemotherapeutic agent-induced cytotoxicity in human acute monocytic leukemia cells. Toxicol Appl Pharmacol. 2016 Feb 1;292:1-7. doi: 10.1016/j.taap.2015.12.008. Epub 2015 Dec 18.
103 Targeted inhibition of Livin resensitizes renal cancer cells towards apoptosis. Cell Mol Life Sci. 2007 May;64(9):1137-44. doi: 10.1007/s00018-007-6510-7.
104 S100P contributes to chemosensitivity of human ovarian cancer cell line OVCAR3. Oncol Rep. 2008 Aug;20(2):325-32.
105 c-MYC suppresses BIN1 to release poly(ADP-ribose) polymerase 1: a mechanism by which cancer cells acquire cisplatin resistance. Sci Signal. 2011 Mar 29;4(166):ra19. doi: 10.1126/scisignal.2001556.
106 Alteration in copy numbers of genes as a mechanism for acquired drug resistance. Cancer Res. 2004 Feb 15;64(4):1403-10. doi: 10.1158/0008-5472.can-3263-2.
107 Copper-transporting P-type ATPase, ATP7A, confers multidrug resistance and its expression is related to resistance to SN-38 in clinical colon cancer. Cancer Res. 2007 May 15;67(10):4860-8. doi: 10.1158/0008-5472.CAN-06-3096.
108 Activator protein 2alpha status determines the chemosensitivity of cancer cells: implications in cancer chemotherapy. Cancer Res. 2005 Oct 1;65(19):8628-34. doi: 10.1158/0008-5472.CAN-05-1059.
109 [Expression of C1QBP gene and its correlation with drug resistance in human resistance choriocarcinoma cell line]. Zhonghua Fu Chan Ke Za Zhi. 2014 Aug;49(8):616-20.
110 Ascorbic acid enhances arsenic trioxide-induced cytotoxicity in multiple myeloma cells. Blood. 2001 Aug 1;98(3):805-13. doi: 10.1182/blood.v98.3.805.
111 Regulation of multidrug resistance by ribosomal protein l6 in gastric cancer cells. Cancer Biol Ther. 2005 Feb;4(2):242-7. doi: 10.4161/cbt.4.2.1477. Epub 2005 Feb 20.
112 Caspase-independent induction of apoptosis in human melanoma cells by the proapoptotic Bcl-2-related protein Nbk / Bik. Oncogene. 2005 Nov 10;24(49):7369-80. doi: 10.1038/sj.onc.1208890.
113 Checkpoint kinase 1 down-regulation by an inducible small interfering RNA expression system sensitized in vivo tumors to treatment with 5-fluorouracil. Clin Cancer Res. 2008 Aug 15;14(16):5131-41. doi: 10.1158/1078-0432.CCR-08-0304.
114 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Cancer Sci. 2013 Aug;104(8):1074-82. doi: 10.1111/cas.12186. Epub 2013 Jun 10.
115 [Reversal of multidrug resistance of gastric cancer cells by down-regulation of CIAPIN1 with CIAPIN1 siRNA]. Mol Biol (Mosk). 2008 Jan-Feb;42(1):102-9.
116 Loss of CCDC6 affects cell cycle through impaired intra-S-phase checkpoint control. PLoS One. 2012;7(2):e31007. doi: 10.1371/journal.pone.0031007. Epub 2012 Feb 17.
117 JWA sensitizes P-glycoprotein-mediated drug-resistant choriocarcinoma cells to etoposide via JNK and mitochondrial-associated signal pathway. J Toxicol Environ Health A. 2009;72(11-12):774-81. doi: 10.1080/15287390902841649.
118 DNMT1 as a molecular target in a multimodality-resistant phenotype in tumor cells. Mol Cancer Res. 2008 Feb;6(2):243-9. doi: 10.1158/1541-7786.MCR-07-0373.
119 Calcitonin induces apoptosis resistance in prostate cancer cell lines against cytotoxic drugs via the Akt/survivin pathway. Cancer Biol Ther. 2005 Nov;4(11):1226-33. doi: 10.4161/cbt.4.11.2093. Epub 2005 Nov 5.
120 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
121 Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
122 The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects. Clin Cancer Res. 2016 May 15;22(10):2534-44. doi: 10.1158/1078-0432.CCR-15-1666. Epub 2016 Jan 5.
123 Protein methyltransferases as a target class for drug discovery. Nat Rev Drug Discov. 2009 Sep;8(9):724-32.
124 Panobinostat for the treatment of multiple myeloma: the evidence to date. J Blood Med. 2015 Oct 8;6:269-76.
125 Panobinostat for the treatment of relapsed or relapsed/refractory multiple myeloma: pharmacology and clinical outcomes. Expert Rev Clin Pharmacol. 2016;9(1):35-48.
126 Highly active combination of BRD4 antagonist and histone deacetylase inhibitor against human acute myelogenous leukemia cells. Mol Cancer Ther. 2014 May;13(5):1142-54.
127 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
128 Comparison of the antifibrotic effects of the pan-histone deacetylase-inhibitor panobinostat versus the IPF-drug pirfenidone in fibroblasts from patients with idiopathic pulmonary fibrosis. PLoS One. 2018 Nov 27;13(11):e0207915. doi: 10.1371/journal.pone.0207915. eCollection 2018.
129 SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-B/STAT3 complex to its promoter in malignant lymphoid cells. Cell Death Dis. 2013 May 16;4(5):e635. doi: 10.1038/cddis.2013.159.
130 Resveratrol sensitizes acute myelogenous leukemia cells to histone deacetylase inhibitors through reactive oxygen species-mediated activation of the extrinsic apoptotic pathway. Mol Pharmacol. 2012 Dec;82(6):1030-41. doi: 10.1124/mol.112.079624. Epub 2012 Aug 24.
131 Mitochondrial Bax translocation partially mediates synergistic cytotoxicity between histone deacetylase inhibitors and proteasome inhibitors in glioma cells. Neuro Oncol. 2008 Jun;10(3):309-19. doi: 10.1215/15228517-2007-063. Epub 2008 Apr 29.
132 A systematic assessment of radiation dose enhancement by 5-Aza-2'-deoxycytidine and histone deacetylase inhibitors in head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2009 Mar 1;73(3):904-12. doi: 10.1016/j.ijrobp.2008.10.032.
133 Induction of TAp63 by histone deacetylase inhibitors. Biochem Biophys Res Commun. 2010 Jan 22;391(4):1748-51. doi: 10.1016/j.bbrc.2009.12.147. Epub 2009 Dec 30.
134 Essential role of HDAC6 in the regulation of PD-L1 in?melanoma. Mol Oncol. 2016 May;10(5):735-750. doi: 10.1016/j.molonc.2015.12.012. Epub 2016 Jan 6.