General Information of Drug (ID: DM4L0R7)

Drug Name
Maleic Acid Drug Info
Synonyms 2-(2-ethoxyethyl)-3-ethylbut-2-enedioic acid; 6309-80-4; AC1L5ZJW; CTK6G3643; CTK5B7536; DTXSID10285386; Maleic acid,(2-ethoxyethyl)ethyl- (8CI)
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
444266
ChEBI ID
CHEMBL18300
CAS Number
CAS 110-16-7
TTD Drug ID
DM4L0R7

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Investigative Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
aminooxyacetic acid DMHNDTW Discovery agent N.A. Investigative [3]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [4]
Bivalirudin DMECRX1 Thrombocytopenia 3B64 Approved [5]
Flavin-Adenine Dinucleotide DM5S4GK Discovery agent N.A. Investigative [6]
CONESSINE DM4VYP0 Discovery agent N.A. Investigative [7]
1-(2'-chlorophenyl)penta-1,4-dien-3-one DMKTZSY Discovery agent N.A. Investigative [8]
CEPHARANTINE DMCE3NA Discovery agent N.A. Investigative [7]
Trypanothione DMDUGQ1 Discovery agent N.A. Investigative [6]
N-(5-chloro-2-(phenylthio)phenyl)butyramide DMHZ256 Discovery agent N.A. Investigative [9]
N1,N2-bis(dihydrocaffeoyl)spermine DMSDVGQ Discovery agent N.A. Investigative [7]
⏷ Show the Full List of 9 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [10]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [11]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [12]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [13]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [14]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [15]
Drug(s) Affected By Putative claudin-25 (CLDN25)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [16]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [17]
Methotrexate DM2TEOL Anterior urethra cancer Approved [18]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [20]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [21]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [19]
Testosterone enanthate DMB6871 N. A. N. A. Approved [22]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [23]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [24]
Sodium chloride DMM3950 Skin burns ME65.0 Approved [25]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [10]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [28]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [11]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [29]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [14]
Rapamycin Immunosuppressant Drug DM678IB Discovery agent N.A. Investigative [27]
PHENCYCLIDINE DMQBEYX Discovery agent N.A. Investigative [30]
paraquat DMR8O3X Discovery agent N.A. Investigative [31]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein S100-A3 (S100A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [15]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [32]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [33]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [34]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [10]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [36]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [37]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [38]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [39]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [34]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [10]
Fluticasone propionate DMRWLB2 Allergic asthma CA23.0 Approved [40]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [41]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [42]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [43]
Beclomethasone dipropionate DM5NW1E Allergic rhinitis CA08.0 Phase 4 [40]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [44]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [20]
Panobinostat DM58WKG Chronic graft versus host disease Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [10]
Arsenic DMTL2Y1 N. A. N. A. Approved [46]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [14]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [15]
methyl p-hydroxybenzoate DMO58UW Discovery agent N.A. Investigative [47]
⏷ Show the Full List of 7 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [48]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [20]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [49]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [51]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [24]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [35]
Ethanol DMDRQZU Chronic pain MG30 Approved [52]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [53]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [54]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [55]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [56]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [57]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [10]
Dihydroxyacetone DMM1LG2 Sunburn EJ40 Approved [58]
Atazanavir DMSYRBX Human immunodeficiency virus infection 1C62 Approved [57]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [59]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [43]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [42]
Urethane DM7NSI0 N. A. N. A. Phase 4 [60]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [61]
Methotrexate DM2TEOL Anterior urethra cancer Approved [62]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [20]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [37]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [64]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [14]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [65]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [66]
Nitrobenzanthrone DMN6L70 N. A. N. A. Investigative [67]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [10]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [68]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [69]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [64]
Arsenic DMTL2Y1 N. A. N. A. Approved [46]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [43]
Urethane DM7NSI0 N. A. N. A. Phase 4 [60]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [14]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [71]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [15]
KOJIC ACID DMP84CS Discovery agent N.A. Investigative [72]
⏷ Show the Full List of 9 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [10]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [73]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [74]
Methotrexate DM2TEOL Anterior urethra cancer Approved [75]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [76]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [14]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [77]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [78]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [17]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [80]
Testosterone DM7HUNW Hot flushes GA30 Approved [16]
Testosterone enanthate DMB6871 N. A. N. A. Approved [22]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [10]
Paclitaxel DMLB81S Breast carcinoma Approved [81]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [38]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [64]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [10]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [14]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [82]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [10]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [37]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [64]
Arsenic DMTL2Y1 N. A. N. A. Approved [84]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [42]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [43]
Urethane DM7NSI0 N. A. N. A. Phase 4 [60]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [14]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [15]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [85]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [42]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [14]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [15]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [11]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [42]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [43]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [14]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [71]
⏷ Show the Full List of 6 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [10]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [51]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [38]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [86]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [87]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [88]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [10]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [64]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [85]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [89]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [10]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [14]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [71]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [90]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [90]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [90]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [90]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [90]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [91]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [36]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [90]
Ziprasidone DMM58JY Bipolar disorder 6A60 Approved [90]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By F-box only protein 40 (FBXO40)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone enanthate DMB6871 N. A. N. A. Approved [22]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [92]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [42]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [43]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [71]
Drug(s) Affected By Protein FAM153A (FAM153A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [10]
Heroin diacetylmorphine DMDBWHY Neurological disorder 6B60 Approved [93]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [94]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [93]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [95]
Urethane DM7NSI0 N. A. N. A. Phase 4 [60]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [14]
⏷ Show the Full List of 7 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [15]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [10]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [96]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [96]
Arsenic DMTL2Y1 N. A. N. A. Approved [46]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [73]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [97]
Urethane DM7NSI0 N. A. N. A. Phase 4 [60]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cytoplasmic aspartate aminotransferase (GOT1) TTU507L AATC_HUMAN Inhibitor [1]
Trypanosoma Trypanothione reductase (Trypano TPR) TTRTKPV TYTR_TRYBB Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
5'-3' DNA helicase ZGRF1 OTFPSF6A ZGRF1_HUMAN Gene/Protein Processing [2]
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP1) OTVX8835 AGAP1_HUMAN Gene/Protein Processing [2]
Collagen and calcium-binding EGF domain-containing protein 1 (CCBE1) OTO4UIDB CCBE1_HUMAN Gene/Protein Processing [2]
EF-hand calcium-binding domain-containing protein 4A (CRACR2B) OT8L843R EFC4A_HUMAN Gene/Protein Processing [2]
F-box only protein 40 (FBXO40) OTS62YA2 FBX40_HUMAN Gene/Protein Processing [2]
Flavin-containing monooxygenase 1 (FMO1) OTTHSQKP FMO1_HUMAN Gene/Protein Processing [2]
Glutathione hydrolase 5 proenzyme (GGT5) OTDJYEO7 GGT5_HUMAN Gene/Protein Processing [2]
GRB2-associated-binding protein 3 (GAB3) OTKX1KEC GAB3_HUMAN Gene/Protein Processing [2]
High affinity immunoglobulin gamma Fc receptor I (FCGR1A) OTOBCS2O FCGR1_HUMAN Gene/Protein Processing [2]
Histone H2B type 1-C/E/F/G/I (H2BC10) OTLQH0D6 H2B1C_HUMAN Gene/Protein Processing [2]

References

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2 Profiling transcriptomes of human SH-SY5Y neuroblastoma cells exposed to maleic acid. PeerJ. 2017 Apr 5;5:e3175.
3 Aspartate aminotransferase isotope exchange reactions: implications for glutamate/glutamine shuttle hypothesis. Am J Physiol Cell Physiol. 2002 Jun;282(6):C1404-13.
4 Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40.
5 8-Methoxy-naphtho[2,3-b]thiophen-4,9-quinone, a non-competitive inhibitor of trypanothione reductase. Mem Inst Oswaldo Cruz. 2003 Jun;98(4):565-8.
6 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
7 The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors. Bioorg Med Chem. 2008 Jul 15;16(14):6689-95.
8 Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate. J Med Chem. 2005 Nov 17;48(23):7400-10.
9 Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class ... J Med Chem. 2005 Dec 15;48(25):8087-97.
10 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
11 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
12 Comparative proteomics reveals concordant and discordant biochemical effects of caffeine versus epigallocatechin-3-gallate in human endothelial cells. Toxicol Appl Pharmacol. 2019 Sep 1;378:114621. doi: 10.1016/j.taap.2019.114621. Epub 2019 Jun 10.
13 Characterization of the Molecular Alterations Induced by the Prolonged Exposure of Normal Colon Mucosa and Colon Cancer Cells to Low-Dose Bisphenol A. Int J Mol Sci. 2022 Oct 1;23(19):11620. doi: 10.3390/ijms231911620.
14 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
15 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
16 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
17 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
18 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
19 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
20 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
21 Delta9-tetrahydrocannabinol inhibits cytotrophoblast cell proliferation and modulates gene transcription. Mol Hum Reprod. 2006 May;12(5):321-33. doi: 10.1093/molehr/gal036. Epub 2006 Apr 5.
22 Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
23 Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
24 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
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26 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
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28 Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.
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31 CD34+ derived macrophage and dendritic cells display differential responses to paraquat. Toxicol In Vitro. 2021 Sep;75:105198. doi: 10.1016/j.tiv.2021.105198. Epub 2021 Jun 9.
32 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
33 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
34 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
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