Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5NW1E)

• Drug Name: Beclomethasone dipropionate Drug Info
• Synonyms: BECLOMETHASONE DIPROPIONATE; Beclometasone dipropionate; Beconase; Beclovent; Vancenase; Beclorhinol; Becloforte; Sanasthmyl; Beclazone; Sanasthmax; Propaderm; Beclomet; Vanceril; Aerobec; Becloturmant; Beclacin; Respocort; Entyderma; Korbutone; Viarox; Rino-clenil; Clenil-A; Beclometasone 17,21-dipropionate; Becotide; Aldecin; Turbinal; Aldecina; Rhinosol; Beclate; Atomase; Alanase; Benconase; Aldecine; Clenil; Spir; Beclocort Nasel; Beclomet Nasal; Propaderm Forte; Rhino Clenil; Inalone O; Inalone R; Qvar; QNASL; Beconase AQ; Qvar 80

Indication

Disease Entry	ICD 11	Status	REF
Allergic rhinitis	CA08.0	Approved	[1]
Nasal polyp	CA0J	Approved	[1]
Rhinitis	FA20	Approved	[1]
Vasomotor/allergic rhinitis	CA08	Approved	[1]
Asthma	CA23	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 21700
  ChEBI ID: CHEBI:3002
  CAS Number: CAS 5534-09-8
  TTD Drug ID: DM5NW1E
  VARIDT Drug ID: DR01665

Molecule-Related Drug Atlas

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[11]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[12]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[13]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[14]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[13]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[13]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[15]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[13]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[16]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[17]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[18]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[19]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[20]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[21]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[22]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[23]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[24]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[25]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[26]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[24]

Drug(s) Affected By Tartrate-resistant acid phosphatase type 5 (ACP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[33]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[34]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[35]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[36]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[38]
Haloperidol	DM96SE0	Delirium		Approved	[39]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Selenium	DM25CGV	N. A.	N. A.	Approved	[41]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[42]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[43]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[45]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]

Drug(s) Affected By Glutathione hydrolase 5 proenzyme (GGT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Fluticasone propionate	DMRWLB2	Allergic asthma	CA23.0	Approved	[50]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[51]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[34]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[52]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[53]
Maleic Acid	DM4L0R7	Discovery agent	N.A.	Investigative	[54]

Drug(s) Affected By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[55]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[56]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[57]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[57]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[58]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[59]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[61]

Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[34]
Indomethacin	DMSC4A7	Bursitis		Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[65]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[66]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[68]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[69]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[70]

Drug(s) Affected By Cytosolic phospholipase A2 (PLA2G4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[71]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[76]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[77]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[78]

Drug(s) Affected By Phosphatidylcholine translocator ABCB4 (ABCB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[79]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[80]
Methysergide	DM1EF73	Migraine	8A80	Approved	[81]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[82]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[83]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[84]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[85]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[86]

Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[87]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[88]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[89]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[90]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[91]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[92]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[93]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[94]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[95]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[95]

Drug(s) Affected By Cytochrome P450 2S1 (CYP2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[98]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[100]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[100]

Drug(s) Affected By Glucocorticoid receptor (NR3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[101]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[102]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[103]
Selenium	DM25CGV	N. A.	N. A.	Approved	[104]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[105]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[107]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[108]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[108]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[109]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[111]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[108]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[108]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[108]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[112]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[113]

Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[39]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[115]
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[115]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[120]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[121]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[122]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[123]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[124]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[123]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[125]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[126]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[127]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[130]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[131]
Fructose	DM43AN2	Vomiting	MD90	Approved	[39]
Ketoprofen	DMRKXPT	Bursitis		Approved	[39]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[132]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[133]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[134]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[135]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[136]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[139]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[140]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[141]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[142]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[144]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[145]

Drug(s) Affected By Interleukin-2 receptor subunit alpha (IL2RA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[83]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[146]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[147]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[148]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[150]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[151]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[153]

Drug(s) Affected By C-X-C motif chemokine 10 (CXCL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[155]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[156]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[157]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]

Drug(s) Affected By Lactotransferrin (LTF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[160]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[161]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[162]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[163]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[164]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[165]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[166]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[102]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[167]

Drug(s) Affected By Osteocalcin (BGLAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[168]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[169]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[171]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[172]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[173]
Falecalcitrol	DMBI9ZJ	Hyperparathyroidism	5A51	Approved	[174]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[176]

Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor (CSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[177]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[68]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[180]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[181]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[183]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[184]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[185]

Drug(s) Affected By Interleukin-5 (IL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[154]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[186]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[187]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[188]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[190]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[191]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[192]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[193]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[194]

Drug(s) Affected By Prostate-specific antigen (KLK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[102]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[195]
Selenium	DM25CGV	N. A.	N. A.	Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[197]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[198]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[199]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[200]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[201]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[202]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]

Drug(s) Affected By Beta-2 adrenergic receptor (ADRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salmeterol	DMIEU69	Allergic asthma	CA23.0	Approved	[203]
Bambuterol	DMKLSHF	Asthma	CA23	Approved	[204]
Terbutaline	DMD4381	Asthma	CA23	Approved	[205]
Salbutamol	DMN9CWF	Acute asthma	CA23	Approved	[206]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[207]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[83]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[208]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[209]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[210]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[211]

Drug(s) Affected By Mineralocorticoid receptor (NR3C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[212]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[213]
Triamcinolone	DM98IXF	Acute adrenal insufficiency		Approved	[214]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[215]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[214]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[214]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[216]

Drug(s) Affected By Fibroblast growth factor 2 (FGF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[217]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[122]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[218]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[219]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[220]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[221]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[222]
Isradipine	DMA5XGH	Hypertension	BA00-BA04	Approved	[223]
Valdecoxib	DMAY7H4	Osteoarthritis	FA00-FA05	Approved	[224]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[225]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[226]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[227]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[228]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[229]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[139]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[230]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[141]

Drug(s) Affected By C-C motif chemokine 3 (CCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[231]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[68]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[234]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[8]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[8]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[231]

Drug(s) Affected By Non-secretory ribonuclease (RNASE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[235]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Salmeterol	DMIEU69	Allergic asthma	CA23.0	Approved	[236]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[238]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[239]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[240]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[241]

Drug(s) Affected By Eosinophil cationic protein (RNASE3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[242]
Salmeterol	DMIEU69	Allergic asthma	CA23.0	Approved	[243]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[242]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[244]
Arformoterol	DMYM974	Chronic obstructive pulmonary disease	CA22	Approved	[245]
PHENCYCLIDINE	DMQBEYX	Discovery agent	N.A.	Investigative	[246]

Drug(s) Affected By C-C motif chemokine 4 (CCL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[68]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[234]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[247]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[8]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[8]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[248]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[231]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[102]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[249]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[250]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[251]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[252]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[253]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[155]

Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[254]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[154]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[256]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[156]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[234]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[257]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[258]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[102]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Selenium	DM25CGV	N. A.	N. A.	Approved	[116]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[259]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[260]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[261]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[262]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[263]

Drug(s) Affected By Interleukin-1 receptor antagonist protein (IL1RN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[265]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[266]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[264]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[267]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[98]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[268]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]

Drug(s) Affected By Interleukin-10 (IL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[177]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[154]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[187]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[269]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[270]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[271]
Bisoprolol	DM3UZ95	Hypertension	BA00-BA04	Approved	[272]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[273]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[274]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[157]

Drug(s) Affected By Interleukin-13 (IL13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[275]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[276]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[277]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[190]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[278]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[279]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[280]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[190]
Ethambutol	DMR87LC	Pulmonary tuberculosis	1B10.Z	Approved	[278]

Drug(s) Affected By B1 bradykinin receptor (BDKRB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[266]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[78]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[281]
Enalaprilat	DMFYAM1	Congestive heart failure	BD10	Approved	[282]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[283]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[284]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[52]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[285]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[286]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[287]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[288]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[289]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[290]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[291]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[292]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[293]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[294]

Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[295]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[295]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[296]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[39]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[297]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[298]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[299]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[300]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[301]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[302]

Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[303]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[304]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[305]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[306]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[307]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[308]
Oxymetholone	DMFXUT8	Aplastic anemia	3A70	Approved	[309]

Drug(s) Affected By Pyrin (MEFV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[310]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[240]

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)	OTHF4H9U	DHI2_HUMAN	Regulation of Drug Effects	[3]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[4]
B1 bradykinin receptor (BDKRB1)	OT1DHSVQ	BKRB1_HUMAN	Gene/Protein Processing	[5]
Beta-2 adrenergic receptor (ADRB2)	OTSDOX4Q	ADRB2_HUMAN	Gene/Protein Processing	[6]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Gene/Protein Processing	[7]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Gene/Protein Processing	[8]
C-C motif chemokine 3 (CCL3)	OTW2H3ND	CCL3_HUMAN	Gene/Protein Processing	[8]
C-C motif chemokine 4 (CCL4)	OT6B8P25	CCL4_HUMAN	Gene/Protein Processing	[8]
C-C motif chemokine 5 (CCL5)	OTSCA5CK	CCL5_HUMAN	Gene/Protein Processing	[9]
C-X-C motif chemokine 10 (CXCL10)	OTTLQ6S0	CXL10_HUMAN	Protein Interaction/Cellular Processes	[10]

References

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• [5] Comparison of kinin B(1) and B(2) receptor expression in neutrophils of asthmatic and non-asthmatic subjects. Int Immunopharmacol. 2007 Dec 20;7(14):1862-8. doi: 10.1016/j.intimp.2007.07.012. Epub 2007 Aug 6.
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• [8] Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents. Leuk Res. 2010 Jul;34(7):917-24. doi: 10.1016/j.leukres.2009.12.002. Epub 2010 Feb 8.
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