Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6USPC)

Drug Name

TRISMETHOXYRESVERATROL Drug Info

Synonyms

22255-22-7; trans-Trimethoxyresveratrol; (E)-1,3-Dimethoxy-5-(4-methoxystyryl)benzene; (E)-3,5,4'-Trimethoxystilbene; 3,4',5-trimethoxy-trans-stilbene; 3,4',5-trimethoxystilbene; 3,5,4'-trimethoxystilbene; TRIMETHOXYSTILBENE; TRISMETHOXYRESVERATROL; E-Resveratrol trimethyl ether; CHEMBL296411; 1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]benzene; trans-3,4',5-trimethoxystilbene; GDHNBPHYVRHYCC-SNAWJCMRSA-N; (E)-3,4',5-Trimethoxystilbene; 5-[2-(4-Methoxyphenyl)Ethenyl]-1,3-Dimethoxy Benzene

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5388063
ChEBI ID: CHEMBL296411
CAS Number: CAS 22255-22-7
TTD Drug ID: DM6USPC

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Approved Drug(s)

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Drug(s) Targeting Multidrug resistance protein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
EDP-322	DMWTVM1	Bacterial infection	1A00-1C4Z	Phase 1	[6]
W-198	DMJ2R69	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
LY335979	DM2KITF	Acute myeloid leukaemia	2A60	Discontinued in Phase 3	[8]
CBT-1	DM097UP	Non-small-cell lung cancer	2C25.Y	Discontinued in Phase 3	[9]
Biricodar	DM65JCM	Ovarian cancer	2C73	Discontinued in Phase 2	[10]
Tariquidar	DMJG7VP	Adrenocortical carcinoma	2D11.Z	Discontinued in Phase 2	[11]
Elacridar	DMURVE8	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 1	[12]
ONT-093	DMB8T5U	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 1	[13]
[1,1':2',1'']-terphenyl-4,3'',5''-triol	DMVOY4D	Discovery agent	N.A.	Investigative	[2]
XR-9456	DMTUFI1	Discovery agent	N.A.	Investigative	[14]
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Drug(s) Targeting Tyrosine-protein kinase ABL1 (ABL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ponatinib	DMYGJQO	Acute lymphoblastic leukaemia	2A85	Approved	[15]
Bosutinib	DMTI8YE	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[16]
SKI-758	DMQ8E9R	Ischemia	8B10-8B11	Approved	[17]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[18]
Saracatinib	DMBLHGP	Hematologic tumour	2B33.Y	Phase 2	[19]
Flumatinib	DM0G5O6	Chronic myelogenous leukaemia	2A20.0	Phase 2	[20]
DCC-2036	DMJKFNU	Chronic myeloid leukaemia	2A20	Phase 1/2	[21]
ISIS-CRP	DMQDUG4	Cardiovascular disease	BA00-BE2Z	Phase 1	[22]
KW-2449	DMFO7RP	Acute myeloid leukaemia	2A60	Phase 1	[23]
IkT-148009	DMMJ9HY	Parkinson disease	8A00.0	Phase 1	[24]
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Drug(s) Targeting Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PINOCEMBRIN	DM96VWD	N. A.	N. A.	Phase 2	[25]
NARINGENIN	DMHAZLM	N. A.	N. A.	Phase 1	[25]
Chrysin	DM7V2LG	Discovery agent	N.A.	Investigative	[25]
APIGENIN	DMI3491	Discovery agent	N.A.	Investigative	[25]
KAEMPFEROL	DMHEMUB	Discovery agent	N.A.	Investigative	[25]
ISORHAMNETIN	DMQ4Z6E	Discovery agent	N.A.	Investigative	[25]
ACACETIN	DMQOB0X	Discovery agent	N.A.	Investigative	[25]
Galangin	DM5TQ2O	Discovery agent	N.A.	Investigative	[25]
CHRYSOERIOL	DM96ECL	Discovery agent	N.A.	Investigative	[25]
DIOSMETIN	DM4KXIM	Discovery agent	N.A.	Investigative	[25]
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Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Selenium	DM25CGV	N. A.	N. A.	Approved	[27]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[29]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[30]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[33]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[35]
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Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[36]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[41]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[42]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[44]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[45]
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Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[46]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[47]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[48]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[47]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[49]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[53]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[48]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[49]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[54]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[57]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[58]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[59]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
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Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[60]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[61]
Fructose	DM43AN2	Vomiting	MD90	Approved	[62]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[63]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[64]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[48]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[65]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[68]
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Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[69]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[70]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[71]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[73]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[76]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[77]
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Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[63]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[82]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[83]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[84]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[85]
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Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[86]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[87]
Selenium	DM25CGV	N. A.	N. A.	Approved	[27]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[88]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[89]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[73]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[93]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cytochrome P450 1B1 (CYP1B1)	TTI84H7	CP1B1_HUMAN	Inhibitor	[1]
Multidrug resistance protein 1 (ABCB1)	TT3OT40	MDR1_HUMAN	Inhibitor	[2]
Tyrosine-protein kinase ABL1 (ABL)	TT3PJMV	ABL1_HUMAN	Inhibitor	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Amyloid-beta precursor protein (APP)	OTKFD7R4	A4_HUMAN	Protein Interaction/Cellular Processes	[3]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Gene/Protein Processing	[4]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Post-Translational Modifications	[4]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Gene/Protein Processing	[4]
Protein c-Fos (FOS)	OTJBUVWS	FOS_HUMAN	Gene/Protein Processing	[5]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Gene/Protein Processing	[5]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Gene/Protein Processing	[5]
Vimentin	OTGZLW4J	VIME_HUMAN	Gene/Protein Processing	[4]
Zinc finger protein SNAI1 (SNAI1)	OTDPYAMC	SNAI1_HUMAN	Gene/Protein Processing	[4]

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