General Information of Drug (ID: DM6USPC)

Drug Name
TRISMETHOXYRESVERATROL Drug Info
Synonyms
22255-22-7; trans-Trimethoxyresveratrol; (E)-1,3-Dimethoxy-5-(4-methoxystyryl)benzene; (E)-3,5,4'-Trimethoxystilbene; 3,4',5-trimethoxy-trans-stilbene; 3,4',5-trimethoxystilbene; 3,5,4'-trimethoxystilbene; TRIMETHOXYSTILBENE; TRISMETHOXYRESVERATROL; E-Resveratrol trimethyl ether; CHEMBL296411; 1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]benzene; trans-3,4',5-trimethoxystilbene; GDHNBPHYVRHYCC-SNAWJCMRSA-N; (E)-3,4',5-Trimethoxystilbene; 5-[2-(4-Methoxyphenyl)Ethenyl]-1,3-Dimethoxy Benzene
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5388063
CAS Number
CAS 22255-22-7
TTD Drug ID
DM6USPC

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Approved Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
EDP-322 DMWTVM1 Bacterial infection 1A00-1C4Z Phase 1 [7]
W-198 DMJ2R69 Solid tumour/cancer 2A00-2F9Z Phase 1 [8]
LY335979 DM2KITF Acute myeloid leukaemia 2A60 Discontinued in Phase 3 [9]
CBT-1 DM097UP Non-small-cell lung cancer 2C25.Y Discontinued in Phase 3 [10]
Biricodar DM65JCM Ovarian cancer 2C73 Discontinued in Phase 2 [11]
Tariquidar DMJG7VP Adrenocortical carcinoma 2D11.Z Discontinued in Phase 2 [12]
Elacridar DMURVE8 Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 1 [13]
ONT-093 DMB8T5U Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 1 [14]
[1,1':2',1'']-terphenyl-4,3'',5''-triol DMVOY4D Discovery agent N.A. Investigative [2]
XR-9456 DMTUFI1 Discovery agent N.A. Investigative [15]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ponatinib DMYGJQO Acute lymphoblastic leukaemia 2A85 Approved [16]
Bosutinib DMTI8YE Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [17]
SKI-758 DMQ8E9R Ischemia 8B10-8B11 Approved [18]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [19]
Saracatinib DMBLHGP Hematologic tumour 2B33.Y Phase 2 [20]
Flumatinib DM0G5O6 Chronic myelogenous leukaemia 2A20.0 Phase 2 [21]
DCC-2036 DMJKFNU Chronic myeloid leukaemia 2A20 Phase 1/2 [22]
ISIS-CRP DMQDUG4 Cardiovascular disease BA00-BE2Z Phase 1 [23]
KW-2449 DMFO7RP Acute myeloid leukaemia 2A60 Phase 1 [24]
IkT-148009 DMMJ9HY Parkinson disease 8A00.0 Phase 1 [25]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
PINOCEMBRIN DM96VWD N. A. N. A. Phase 2 [26]
NARINGENIN DMHAZLM N. A. N. A. Phase 1 [26]
Chrysin DM7V2LG Discovery agent N.A. Investigative [26]
APIGENIN DMI3491 Discovery agent N.A. Investigative [26]
KAEMPFEROL DMHEMUB Discovery agent N.A. Investigative [26]
ISORHAMNETIN DMQ4Z6E Discovery agent N.A. Investigative [26]
ACACETIN DMQOB0X Discovery agent N.A. Investigative [26]
Galangin DM5TQ2O Discovery agent N.A. Investigative [26]
CHRYSOERIOL DM96ECL Discovery agent N.A. Investigative [26]
DIOSMETIN DM4KXIM Discovery agent N.A. Investigative [26]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [27]
Selenium DM25CGV N. A. N. A. Approved [28]
Methotrexate DM2TEOL Anterior urethra cancer Approved [29]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [30]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [31]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [32]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [33]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [34]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [35]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [36]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [37]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [38]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [39]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [40]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [41]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [42]
Ethacrynic acid DM60QMR Edema MG29 Approved [43]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [44]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [45]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [46]
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Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [47]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [47]
Etoricoxib DM6A4NW Rheumatoid arthritis FA20 Approved [47]
Capsaicin DMGMF6V Back pain ME84.Z Approved [48]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [49]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [50]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [51]
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [52]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [53]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [54]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [55]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [56]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [57]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [58]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [59]
Quercetin DM3NC4M Obesity 5B81 Approved [60]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [61]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [62]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [63]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [64]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [55]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [65]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [69]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [70]
Leflunomide DMR8ONJ Arthritis FA20 Approved [71]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [72]
Sanguinarine DMDINFS Dental plaque DA08.4 Approved [73]
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Drug(s) Affected By Protein c-Fos (FOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [35]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [74]
Verapamil DMA7PEW Angina pectoris BA40 Approved [75]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [76]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [75]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [77]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [27]
Methotrexate DM2TEOL Anterior urethra cancer Approved [78]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [79]
Quercetin DM3NC4M Obesity 5B81 Approved [80]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [81]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [76]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [77]
Gefitinib DM15F0X Colon adenocarcinoma Approved [82]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
Selenium DM25CGV N. A. N. A. Approved [84]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [85]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [86]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [87]
Methotrexate DM2TEOL Anterior urethra cancer Approved [29]
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Drug(s) Affected By Transcription factor Jun (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [88]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [89]
Fructose DM43AN2 Vomiting MD90 Approved [54]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [90]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [91]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [76]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [92]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [93]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [94]
Methotrexate DM2TEOL Anterior urethra cancer Approved [95]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [96]
Selenium DM25CGV N. A. N. A. Approved [97]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [98]
Quercetin DM3NC4M Obesity 5B81 Approved [99]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [101]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [102]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [103]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [104]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [105]
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Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [106]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [65]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [107]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [108]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [109]
Quercetin DM3NC4M Obesity 5B81 Approved [110]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [111]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [62]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [112]
Panobinostat DM58WKG Chronic graft versus host disease Approved [113]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [114]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [115]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [116]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [117]
Gefitinib DM15F0X Colon adenocarcinoma Approved [118]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [119]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [120]
Selenium DM25CGV N. A. N. A. Approved [28]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [85]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [121]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [122]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [123]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [124]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [116]
Gefitinib DM15F0X Colon adenocarcinoma Approved [125]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [126]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [127]
Selenium DM25CGV N. A. N. A. Approved [28]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [128]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [85]
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Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [90]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [27]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [129]
Quercetin DM3NC4M Obesity 5B81 Approved [130]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [101]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [131]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [132]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [133]
Testosterone DM7HUNW Hot flushes GA30 Approved [134]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [135]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [136]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [116]
Selenium DM25CGV N. A. N. A. Approved [28]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [137]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [138]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [139]
Quercetin DM3NC4M Obesity 5B81 Approved [110]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [140]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [141]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [142]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cytochrome P450 1B1 (CYP1B1) TTI84H7 CP1B1_HUMAN Inhibitor [1]
Multidrug resistance protein 1 (ABCB1) TT3OT40 MDR1_HUMAN Inhibitor [2]
Tyrosine-protein kinase ABL1 (ABL) TT3PJMV ABL1_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Gene/Protein Processing [3]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Protein Interaction/Cellular Processes [4]
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Gene/Protein Processing [5]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Gene/Protein Processing [6]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Post-Translational Modifications [6]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [5]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Gene/Protein Processing [5]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [6]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Gene/Protein Processing [6]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Gene/Protein Processing [3]

References

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2 Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. J Med Chem. 2006 May 18;49(10):3012-8.
3 Resveratrol analog-3,5,4'-trimethoxy-trans-stilbene inhibits invasion of human lung adenocarcinoma cells by suppressing the MAPK pathway and decreasing matrix metalloproteinase-2 expression. Mol Nutr Food Res. 2009 Mar;53(3):407-16. doi: 10.1002/mnfr.200800123.
4 Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides. J Biol Chem. 2005 Nov 11;280(45):37377-82.
5 Hydroxystilbenes and methoxystilbenes activate human aryl hydrocarbon receptor and induce CYP1A genes in human hepatoma cells and human hepatocytes. Food Chem Toxicol. 2017 May;103:122-132.
6 3,5,4'-Trimethoxystilbene, a natural methoxylated analog of resveratrol, inhibits breast cancer cell invasiveness by downregulation of PI3K/Akt and Wnt/-catenin signaling cascades and reversal of epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2013 Nov 1;272(3):746-56. doi: 10.1016/j.taap.2013.07.019. Epub 2013 Aug 3.
7 In vitro activities of the novel bicyclolides modithromycin (EDP-420, EP-013420, S-013420) and EDP-322 against MDR clinical Neisseria gonorrhoeae isolates and international reference strains. J Antimicrob Chemother. 2015 Jan;70(1):173-7.
8 Mechanisms of tetrandrine and 5-bromotetrandrine in reversing multidrug resistance may relate to down-regulation of multidrug resistance associated protein 7 expression. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Jun;20(3):558-63.
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10 A pharmacodynamic study of the P-glycoprotein antagonist CBT-1 in combination with paclitaxel in solid tumors. Oncologist.2012;17(4):512.
11 ClinicalTrials.gov (NCT00003847) VX-710, Doxorubicin, and Vincristine for the Treatment of Patients With Recurrent Small Cell Lung Cancer. U.S. National Institutes of Health.
12 Inhibition of P-glycoprotein (ABCB1)- and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1((R)).Biochem Pharmacol.2008 Mar 15;75(6):1302-12.
13 2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties. J Med Chem. 2008 Dec 11;51(23):7602-13.
14 A phase I pharmacokinetic study of the P-glycoprotein inhibitor, ONT-093, in combination with paclitaxel in patients with advanced cancer. Invest New Drugs. 2005 Aug;23(4):311-5.
15 Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors. Bioorg Med Chem. 2008 Mar 1;16(5):2448-62.
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18 Synthesis and Src kinase inhibitory activity of a series of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-furyl-3-quinolinecarbonitriles. J Med Chem. 2006 Dec 28;49(26):7868-76.
19 Targeted chronic myeloid leukemia therapy: Seeking a cure. Am J Health Syst Pharm. 2007 Dec 15;64(24 Suppl 15):S9-15.
20 Novel dual Src/Abl inhibitors for hematologic and solid malignancies.Expert Opin Investig Drugs.2010 Aug;19(8):931-45.
21 Flumatinib, a selective inhibitor of BCR-ABL/PDGFR/KIT, effectively overcomes drug resistance of certain KIT mutants. Cancer Sci. 2014 Jan;105(1):117-25.
22 Company report (Deciphera Pharmaceuticals: Tumor-Targeted Programs and Indications)
23 Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines. J Med Chem. 2008 Mar 13;51(5):1252-9.
24 KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation. Blood. 2009 Aug 20;114(8):1607-17.
25 The c-Abl inhibitor IkT-148009 suppresses neurodegeneration in mouse models of heritable and sporadic Parkinson's disease. Sci Transl Med. 2023 Jan 18;15(679):eabp9352.
26 Selective inhibition of methoxyflavonoids on human CYP1B1 activity. Bioorg Med Chem. 2010 Sep 1;18(17):6310-5.
27 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
28 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
29 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
30 Simvastatin protects neurons from cytotoxicity by up-regulating Bcl-2 mRNA and protein. J Neurochem. 2007 Apr;101(1):77-86. doi: 10.1111/j.1471-4159.2006.04375.x. Epub 2007 Jan 4.
31 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
32 Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease. J Struct Biol. 2000 Jun;130(2-3):209-16. doi: 10.1006/jsbi.2000.4285.
33 Increased processing of APLP2 and APP with concomitant formation of APP intracellular domains in BDNF and retinoic acid-differentiated human neuroblastoma cells. J Neurochem. 2005 Nov;95(4):1059-68. doi: 10.1111/j.1471-4159.2005.03440.x. Epub 2005 Sep 7.
34 Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq. Arch Toxicol. 2018 Aug;92(8):2517-2531.
35 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
36 Synergistic effects of iron and aluminum on stress-related gene expression in primary human neural cells. J Alzheimers Dis. 2005 Nov;8(2):117-27; discussion 209-15. doi: 10.3233/jad-2005-8204.
37 Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells. Eur J Clin Pharmacol. 2002 Nov;58(8):537-42.
38 Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167.
39 Anti-androgenic effect of 6-formylindolo[3,2-b]carbazole (FICZ) in LNCaP cells is mediated by the aryl hydrocarbon-androgen receptors cross-talk. Steroids. 2020 Jan;153:108508. doi: 10.1016/j.steroids.2019.108508. Epub 2019 Oct 3.
40 Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition. Arch Toxicol. 2008 Dec;82(12):909-21.
41 Effect of CYP1A1 gene polymorphisms on estrogen metabolism and bone density. J Bone Miner Res. 2005 Feb;20(2):232-9. doi: 10.1359/JBMR.041110. Epub 2004 Nov 16.
42 Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
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44 Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol. Toxicol Lett. 2005 Aug 14;158(2):95-107.
45 The metallohormone cadmium modulates AhR-associated gene expression in the small intestine of rats similar to ethinyl-estradiol. Arch Toxicol. 2013 Apr;87(4):633-43.
46 Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites. Gastroenterology. 2004 Nov;127(5):1436-45.
47 In vitro inhibition of CYP1A2 by model inhibitors, anti-inflammatory analgesics and female sex steroids: predictability of in vivo interactions. Basic Clin Pharmacol Toxicol. 2008 Aug;103(2):157-65.
48 Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo. J Asian Nat Prod Res. 2012;14(4):382-95.
49 Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36.
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