Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBS370)

• Drug Name: Tofacitinib Drug Info
• Synonyms: Tasocitinib; 477600-75-2; 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile; CP-690550; CP 690550; racemic-tofacitinib; 1259404-17-5; tofacitinibum; CP-690,550; UNII-87LA6FU830; 3-((3R,4R)-rel-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile; 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile; Tofacitinib (CP-690550,Tasocitinib); CHEMBL221959; CHEBI:71200; Xeljanz (TN)

Indication

Disease Entry	ICD 11	Status	REF
Rheumatoid arthritis	FA20	Approved	[1]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[2]

• Cross-matching ID:
  PubChem CID: 9926791
  ChEBI ID: CHEMBL221959
  CAS Number: CAS 477600-75-2
  TTD Drug ID: DMBS370
  INTEDE Drug ID: DR1610
  ACDINA Drug ID: D00683

Molecule-Related Drug Atlas

Drug(s) Targeting Janus kinase 3 (JAK-3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ritlecitinib	DMYKNME	Alopecia areata	ED70.2	Approved	[10]
ASP-015K	DMZ1UOI	Psoriasis vulgaris	EA90	Phase 3	[11]
VX-509	DM2U3MX	Rheumatoid arthritis	FA20	Phase 2/3	[12]
Cerdulatinib	DMSCR2H	B-cell lymphoma	2A86	Phase 2	[10]
ATI-501	DMTY6OF	Alopecia	ED70	Phase 2	[13]
ATI-502	DM8NODR	Alopecia	ED70	Phase 2	[14]
TD-8236	DMTOMJN	Asthma	CA23	Phase 2	[15]
ALXN2075	DM1BSD8	Non-hodgkin lymphoma	2B33.5	Phase 1/2	[16]
SNA-125	DM8L1GJ	Atopic dermatitis	EA80	Phase 1	[10]
GDC-0214	DMCNSII	Asthma	CA23	Phase 1	[17]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[19]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[20]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[21]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[22]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[24]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[25]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[19]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[26]

Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[27]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[28]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[29]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[30]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[31]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[32]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[35]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[36]

Drug(s) Affected By Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[39]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[40]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[45]

Drug(s) Affected By Tyrosine-protein kinase JAK2 (JAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[46]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[51]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[47]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[54]

Drug(s) Affected By Cytochrome c oxidase subunit 1 (COX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[55]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[56]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[57]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[59]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[60]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[61]
Nicotinamide	DMUPE07	Acne vulgaris	ED80	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[62]

Drug(s) Affected By 2'-5'-oligoadenylate synthase 1 (OAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[65]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[39]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[67]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[68]

Drug(s) Affected By Interstitial collagenase (MMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[69]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[71]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[73]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[74]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[75]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]

Drug(s) Affected By Ubiquitin-like protein ISG15 (ISG15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]

Drug(s) Affected By Stromelysin-1 (MMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[83]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[83]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[83]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[83]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[85]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[87]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[76]

Drug(s) Affected By Keratin, type I cytoskeletal 16 (KRT16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[88]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[90]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[92]

Drug(s) Affected By Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[39]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[95]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[96]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]

Drug(s) Affected By Interferon-induced transmembrane protein 1 (IFITM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[93]
Selenium	DM25CGV	N. A.	N. A.	Approved	[98]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[102]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[105]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[106]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[107]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[109]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[95]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[111]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]

Drug(s) Affected By Interferon-induced GTP-binding protein Mx1 (MX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[98]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[114]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[39]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[43]

Drug(s) Affected By Interferon-induced GTP-binding protein Mx2 (MX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[116]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[117]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[118]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[119]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[92]

Drug(s) Affected By Tyrosine-protein kinase JAK1 (JAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[124]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[125]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[117]

Drug(s) Affected By 2'-5'-oligoadenylate synthase 2 (OAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[43]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[117]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[128]
Amantadine	DMS3YE9	Influenza A virus infection	1E30	Approved	[129]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[130]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[131]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[132]

Drug(s) Affected By Succinate dehydrogenase flavoprotein subunit, mitochondrial (SDHA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[59]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[135]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[136]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[137]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[130]

Drug(s) Affected By Interferon alpha-inducible protein 27, mitochondrial (IFI27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[93]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[45]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[125]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[138]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[139]
Selenium	DM25CGV	N. A.	N. A.	Approved	[98]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[140]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[141]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[144]

Drug(s) Affected By Signal transducer and activator of transcription 5B (STAT5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[146]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[114]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[148]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[149]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[150]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[151]

Drug(s) Affected By Interferon-induced 35 kDa protein (IFI35)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[98]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[59]

Drug(s) Affected By Interferon regulatory factor 9 (IRF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[152]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[45]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[117]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[135]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[153]

Drug(s) Affected By AMP deaminase 2 (AMPD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[154]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[59]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[155]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[156]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[157]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[157]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[158]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[159]

Drug(s) Affected By Sonic hedgehog protein (SHH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[161]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[163]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[161]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[136]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[164]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[155]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[165]

Drug(s) Affected By Secreted frizzled-related protein 5 (SFRP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[166]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[167]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[168]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[62]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[169]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[170]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[159]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[171]

Drug(s) Affected By Interferon-induced protein 44 (IFI44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[45]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[117]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[37]
Bortezomib	DMNO38U	Leukemia		Approved	[173]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[37]

Drug(s) Affected By S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (RSAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[117]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[37]

Drug(s) Affected By Interferon regulatory factor 7 (IRF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[177]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[175]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[37]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[37]

Drug(s) Affected By Kelch-like protein 31 (KLHL31)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[39]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[62]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[178]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[171]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[179]

Drug(s) Affected By Histone-lysine N-methyltransferase PRDM16 (PRDM16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[163]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[180]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[181]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[135]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[180]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[182]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[183]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[184]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[185]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[186]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[184]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[184]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[187]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[188]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[186]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[184]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Janus kinase 3 (JAK-3)	TTT7PJU	JAK3_HUMAN	Modulator	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[4]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Substrate	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
2'-5'-oligoadenylate synthase 1 (OAS1)	OT8ZLOCY	OAS1_HUMAN	Gene/Protein Processing	[5]
2'-5'-oligoadenylate synthase 2 (OAS2)	OT64CCTM	OAS2_HUMAN	Gene/Protein Processing	[5]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Regulation of Drug Effects	[6]
AMP deaminase 2 (AMPD2)	OTBS30JU	AMPD2_HUMAN	Gene/Protein Processing	[7]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Gene/Protein Processing	[8]
Cytochrome c oxidase subunit 1 (COX1)	OTG3O9BN	COX1_HUMAN	Gene/Protein Processing	[5]
Histone-lysine N-methyltransferase PRDM16 (PRDM16)	OT0BGA27	PRD16_HUMAN	Gene/Protein Processing	[5]
Interferon alpha-inducible protein 27, mitochondrial (IFI27)	OTI2XGIT	IFI27_HUMAN	Gene/Protein Processing	[5]
Interferon regulatory factor 7 (IRF7)	OTC1A2PQ	IRF7_HUMAN	Gene/Protein Processing	[9]
Interferon regulatory factor 9 (IRF9)	OTK4MYQJ	IRF9_HUMAN	Gene/Protein Processing	[5]

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