Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMP2BFG)

Drug Name
Anacetrapib Drug Info
Synonyms MK0859; Anacetrapib (USAN); MK-0859
Indication
Disease Entry ICD 11 Status REF
Arteriosclerosis BD40 Phase 3 [1]
Hyperlipidaemia 5C80 Phase 2 [1]
Cross-matching ID
PubChem CID
11556427
ChEBI ID
CHEMBL1800807
CAS Number
CAS 875446-37-0
TTD Drug ID
DMP2BFG
INTEDE Drug ID
DR1884

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Approved Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Cholesteryl ester transfer protein (CETP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Evacetrapib DMCDZ15 Cardiovascular disease BA00-BE2Z Phase 3 [5]
Dalcetrapib DMKNCVM Acute coronary syndrome BA41 Phase 3 [6]
JTT-302 DMGLVBI Lipid metabolism disorder 5C52.Z Phase 2 [5]
DRL-17822 DMGD3XT Arteriosclerosis BD40 Phase 2 [5]
TA-8995 DMAZHT0 Cardiovascular disease BA00-BE2Z Phase 2 [7]
BAY-60-5521 DMXIDWE Arteriosclerosis BD40 Phase 1 [8]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [9]
CETi-1 DMUG5OB Arteriosclerosis BD40 Discontinued in Phase 2 [10]
CP-800569 DMZ0YU7 Arteriosclerosis BD40 Discontinued in Phase 1 [11]
R7232 DMETAP8 Dyslipidemia 5C80-5C81 Discontinued in Phase 1 [6]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [12]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [13]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [14]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [15]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [16]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [17]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [18]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [19]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [13]
Verapamil DMA7PEW Angina pectoris BA40 Approved [20]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome b-245 heavy chain (CYBB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [21]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [23]
Ethanol DMDRQZU Chronic pain MG30 Approved [24]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [25]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [26]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [22]
Dalcetrapib DMKNCVM Acute coronary syndrome BA41 Phase 3 [4]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [27]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [28]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor subfamily 4 group A member 2 (NR4A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [29]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [30]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [32]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [33]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [34]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [36]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [37]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [38]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Steroidogenic acute regulatory protein, mitochondrial (STAR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etretinate DM2CZFA Keratosis ED56 Approved [39]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [40]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [23]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [41]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [42]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Ethanol DMDRQZU Chronic pain MG30 Approved [45]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [46]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NADPH oxidase 5 (NOX5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [49]
Isoflavone DM7U58J N. A. N. A. Phase 4 [50]
Dalcetrapib DMKNCVM Acute coronary syndrome BA41 Phase 3 [4]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [51]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [4]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [52]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By NADPH oxidase 1 (NOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [53]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [53]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [54]
Arsenic DMTL2Y1 N. A. N. A. Approved [55]
Dalcetrapib DMKNCVM Acute coronary syndrome BA41 Phase 3 [4]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [56]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [4]
Acteoside DM0YHKB Nephritis GB40 Terminated [57]
U0126 DM31OGF Discovery agent N.A. Investigative [58]
Nickel chloride DMI12Y8 Discovery agent N.A. Investigative [59]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cholesteryl ester transfer protein (CETP) TTFQAYR CETP_HUMAN Inhibitor [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cytochrome b-245 heavy chain (CYBB) OTGSG868 CY24B_HUMAN Gene/Protein Processing [4]
NADPH oxidase 1 (NOX1) OTZPJQCC NOX1_HUMAN Gene/Protein Processing [4]
NADPH oxidase 5 (NOX5) OTHTH59G NOX5_HUMAN Gene/Protein Processing [4]
Nuclear receptor subfamily 4 group A member 2 (NR4A2) OT3F9IR2 NR4A2_HUMAN Gene/Protein Processing [4]
Steroidogenic acute regulatory protein, mitochondrial (STAR) OTFEZ5AI STAR_HUMAN Gene/Protein Processing [4]

References

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