Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMP2BFG)

Drug Name
Anacetrapib Drug Info
Synonyms MK0859; Anacetrapib (USAN); MK-0859
Indication
Disease Entry ICD 11 Status REF
Arteriosclerosis BD40 Phase 3 [1]
Hyperlipidaemia 5C80 Phase 2 [1]
Cross-matching ID
PubChem CID
11556427
CAS Number
CAS 875446-37-0
TTD Drug ID
DMP2BFG
INTEDE Drug ID
DR1884

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Approved Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Cholesteryl ester transfer protein (CETP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Evacetrapib DMCDZ15 Cardiovascular disease BA00-BE2Z Phase 3 [5]
Dalcetrapib DMKNCVM Acute coronary syndrome BA41 Phase 3 [6]
JTT-302 DMGLVBI Lipid metabolism disorder 5C52.Z Phase 2 [5]
DRL-17822 DMGD3XT Arteriosclerosis BD40 Phase 2 [5]
TA-8995 DMAZHT0 Cardiovascular disease BA00-BE2Z Phase 2 [7]
BAY-60-5521 DMXIDWE Arteriosclerosis BD40 Phase 1 [8]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [9]
CETi-1 DMUG5OB Arteriosclerosis BD40 Discontinued in Phase 2 [10]
CP-800569 DMZ0YU7 Arteriosclerosis BD40 Discontinued in Phase 1 [11]
R7232 DMETAP8 Dyslipidemia 5C80-5C81 Discontinued in Phase 1 [6]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [12]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [13]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [14]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [15]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [16]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [17]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [18]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [19]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [13]
Verapamil DMA7PEW Angina pectoris BA40 Approved [20]
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Drug(s) Affected By Glucocorticoid receptor (NR3C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [21]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [22]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [23]
Selenium DM25CGV N. A. N. A. Approved [24]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [25]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Quercetin DM3NC4M Obesity 5B81 Approved [27]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [28]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [30]
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Drug(s) Affected By Cytochrome b-245 heavy chain (CYBB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [31]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [33]
Ethanol DMDRQZU Chronic pain MG30 Approved [34]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [35]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [36]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [32]
Dalcetrapib DMKNCVM Acute coronary syndrome BA41 Phase 3 [4]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [37]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [38]
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Drug(s) Affected By Mineralocorticoid receptor (NR3C2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [39]
Testosterone DM7HUNW Hot flushes GA30 Approved [40]
Triamcinolone DM98IXF Acute adrenal insufficiency Approved [41]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [42]
Betamethasone DMAHJEF Acute adrenal insufficiency Approved [41]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [41]
Budesonide DMJIBAW Allergic rhinitis CA08.0 Approved [41]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [45]
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Drug(s) Affected By Cytochrome P450 11B1, mitochondrial (CYP11B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [46]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [47]
Quercetin DM3NC4M Obesity 5B81 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Ethanol DMDRQZU Chronic pain MG30 Approved [49]
Potassium Chloride DMMTAJC Hypokalemia 5C77 Approved [50]
Mitotane DMU1GX0 Adrenocortical carcinoma 2D11.Z Approved [51]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [52]
Dalcetrapib DMKNCVM Acute coronary syndrome BA41 Phase 3 [4]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [38]
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Drug(s) Affected By Cyclic AMP-responsive element-binding protein 1 (CREB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [53]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [54]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [55]
Selenium DM25CGV N. A. N. A. Approved [24]
Methotrexate DM2TEOL Anterior urethra cancer Approved [56]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [58]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [59]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [60]
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Drug(s) Affected By Cytochrome P450 11B2, mitochondrial (CYP11B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [61]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [47]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [62]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Potassium Chloride DMMTAJC Hypokalemia 5C77 Approved [50]
Dutasteride DMQ4TJK Benign prostatic hyperplasia GA90 Approved [63]
Mitotane DMU1GX0 Adrenocortical carcinoma 2D11.Z Approved [64]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [62]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [65]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [66]
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Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [71]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [72]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [73]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [74]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [75]
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Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [52]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [76]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [77]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [79]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [80]
Methotrexate DM2TEOL Anterior urethra cancer Approved [81]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [82]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [83]
Quercetin DM3NC4M Obesity 5B81 Approved [84]
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Drug(s) Affected By Nuclear receptor subfamily 4 group A member 2 (NR4A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [85]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [86]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [87]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [88]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [89]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [91]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [92]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [93]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [94]
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Drug(s) Affected By Steroidogenic acute regulatory protein, mitochondrial (STAR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etretinate DM2CZFA Keratosis ED56 Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [33]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [97]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
Ethanol DMDRQZU Chronic pain MG30 Approved [100]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [101]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [102]
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Drug(s) Affected By NADPH oxidase 5 (NOX5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [103]
Isoflavone DM7U58J N. A. N. A. Phase 4 [104]
Dalcetrapib DMKNCVM Acute coronary syndrome BA41 Phase 3 [4]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [105]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [4]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [106]
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Drug(s) Affected By NADPH oxidase 4 (NOX4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [108]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [109]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Capsaicin DMGMF6V Back pain ME84.Z Approved [110]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [111]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [112]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [113]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [114]
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Drug(s) Affected By NADPH oxidase 1 (NOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [115]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [115]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [116]
Arsenic DMTL2Y1 N. A. N. A. Approved [117]
Dalcetrapib DMKNCVM Acute coronary syndrome BA41 Phase 3 [4]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [118]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [4]
Acteoside DM0YHKB Nephritis GB40 Terminated [119]
U0126 DM31OGF Discovery agent N.A. Investigative [120]
Nickel chloride DMI12Y8 Discovery agent N.A. Investigative [121]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cholesteryl ester transfer protein (CETP) TTFQAYR CETP_HUMAN Inhibitor [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cyclic AMP-responsive element-binding protein 1 (CREB1) OT1MDLA1 CREB1_HUMAN Post-Translational Modifications [4]
Cytochrome b-245 heavy chain (CYBB) OTGSG868 CY24B_HUMAN Gene/Protein Processing [4]
Cytochrome P450 11B1, mitochondrial (CYP11B1) OTKKL894 C11B1_HUMAN Gene/Protein Processing [4]
Cytochrome P450 11B2, mitochondrial (CYP11B2) OTIOLWYN C11B2_HUMAN Gene/Protein Processing [4]
Glucocorticoid receptor (NR3C1) OTCI2YDI GCR_HUMAN Gene/Protein Processing [4]
Mineralocorticoid receptor (NR3C2) OT0F2V2Z MCR_HUMAN Gene/Protein Processing [4]
NADPH oxidase 1 (NOX1) OTZPJQCC NOX1_HUMAN Gene/Protein Processing [4]
NADPH oxidase 4 (NOX4) OTTYQ097 NOX4_HUMAN Gene/Protein Processing [4]
NADPH oxidase 5 (NOX5) OTHTH59G NOX5_HUMAN Gene/Protein Processing [4]
Nuclear receptor subfamily 4 group A member 2 (NR4A2) OT3F9IR2 NR4A2_HUMAN Gene/Protein Processing [4]

References

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