Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSPJG2)

Drug Name
Ropivacaine Drug Info
Synonyms
Naropin; ROPIVACAINE HCl; Ropivacaine hydrochloride; Ropivacaine monohydrochloride; Naropin (TN); Ropivacaine monohydrochloride, (S)-isomer; (2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide; (2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride
Indication
Disease Entry ICD 11 Status REF
Anaesthesia 9A78.6 Approved [1]
Appendicitis DB10 Approved [2]
Therapeutic Class
Anesthetics
Cross-matching ID
PubChem CID
175805
ChEBI ID
CHEBI:8890
CAS Number
CAS 84057-95-4
TTD Drug ID
DMSPJG2
INTEDE Drug ID
DR1442

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Voltage-gated sodium channel alpha Nav1.8 (SCN10A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rilpivirine DMJ0QOW Human immunodeficiency virus infection 1C62 Approved [12]
Bupivacaine DM4PRFC Anaesthesia 9A78.6 Approved [3]
Tiapride DMN6CAG Alcohol dependence 6C40.2 Approved [13]
Tetracaine DM9J6C2 Spinal anesthesia MB40.3 Approved [14]
Proparacaine DMLS39E Anaesthesia 9A78.6 Approved [3]
Conatumumab DM2UOSN Colorectal cancer 2B91.Z Phase 2 [15]
VX-150 DMGDB21 Neuropathic pain 8E43.0 Phase 2 [16]
DSP-2230 DM0WTMD Neuropathic pain 8E43.0 Phase 1 [17]
PF-01247324 DM93LMS Pain MG30-MG3Z Phase 1 [18]
VX-128 DMC8J0G Pain MG30-MG3Z Phase 1 [16]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [19]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [20]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [21]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [22]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [23]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [24]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [25]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [26]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [20]
Verapamil DMA7PEW Angina pectoris BA40 Approved [27]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [28]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [29]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [30]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [31]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [32]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [33]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [25]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [34]
Verapamil DMA7PEW Angina pectoris BA40 Approved [35]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [36]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [37]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [38]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [23]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [27]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [40]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [41]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [42]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [43]
Propranolol DM79NTF Angina pectoris BA40 Approved [44]
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Drug(s) Metabolized By Cytochrome P450 2B6 (CYP2B6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [45]
Verapamil DMA7PEW Angina pectoris BA40 Approved [5]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [46]
Estrone DM5T6US Acne vulgaris ED80 Approved [47]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [49]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [50]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [51]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [52]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [53]
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Drug(s) Affected By Apoptosis-inducing factor 1, mitochondrial (AIFM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [54]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [55]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [56]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [57]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [59]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [60]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [61]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [62]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [63]
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Drug(s) Affected By L-lactate dehydrogenase A chain (LDHA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [64]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [65]
Etretinate DM2CZFA Keratosis ED56 Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [69]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [70]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [71]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [72]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [73]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [74]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [75]
Gefitinib DM15F0X Colon adenocarcinoma Approved [76]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [77]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [77]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [79]
Selenium DM25CGV N. A. N. A. Approved [80]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [81]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [82]
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Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [83]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [84]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [85]
Verapamil DMA7PEW Angina pectoris BA40 Approved [86]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [75]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [87]
Selenium DM25CGV N. A. N. A. Approved [88]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [89]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [90]
Methotrexate DM2TEOL Anterior urethra cancer Approved [91]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [92]
Gefitinib DM15F0X Colon adenocarcinoma Approved [93]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [94]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [56]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [95]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [96]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [95]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [97]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [98]
Methotrexate DM2TEOL Anterior urethra cancer Approved [99]
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Drug(s) Affected By Caspase-1 (CASP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [74]
Gefitinib DM15F0X Colon adenocarcinoma Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [79]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [101]
Quercetin DM3NC4M Obesity 5B81 Approved [102]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [104]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [105]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [106]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [107]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [108]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [109]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [110]
Gefitinib DM15F0X Colon adenocarcinoma Approved [111]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [112]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [113]
Selenium DM25CGV N. A. N. A. Approved [114]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [115]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [116]
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Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [117]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [118]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [119]
Gefitinib DM15F0X Colon adenocarcinoma Approved [120]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [121]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [116]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [122]
Quercetin DM3NC4M Obesity 5B81 Approved [123]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [124]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [125]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [126]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [127]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [128]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [129]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [130]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [131]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [132]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [133]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [134]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [135]
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Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [136]
Methotrexate DM2TEOL Anterior urethra cancer Approved [137]
Quercetin DM3NC4M Obesity 5B81 Approved [138]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [139]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [140]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [141]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [142]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [143]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [144]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [145]
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Drug(s) Affected By Potassium voltage-gated channel subfamily KQT member 1 (KCNQ1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Propranolol DM79NTF Angina pectoris BA40 Approved [146]
Atenolol DMNKG1Z Angina pectoris BA40 Approved [146]
Quinidine DMLPICK N. A. N. A. Approved [65]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Bupivacaine DM4PRFC Anaesthesia 9A78.6 Approved [147]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [145]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Mepivacaine DMH2NMY Analgesia MB40.8 Approved [147]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [149]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [149]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [150]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [151]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [92]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [152]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [153]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [154]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [56]
Meloxicam DM2AR7L Arthritis FA20 Approved [155]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [156]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [157]
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Drug(s) Affected By Gasdermin-D (GSDMD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [158]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [159]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [106]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [160]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [161]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [162]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [159]
Paclitaxel DMLB81S Breast carcinoma Approved [163]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [164]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [165]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [135]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [92]
Verapamil DMA7PEW Angina pectoris BA40 Approved [166]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [167]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [153]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [168]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [169]
Meloxicam DM2AR7L Arthritis FA20 Approved [170]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [96]
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Drug(s) Affected By Sequestosome-1 (SQSTM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [118]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [119]
Gefitinib DM15F0X Colon adenocarcinoma Approved [171]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [172]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [173]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [174]
Methotrexate DM2TEOL Anterior urethra cancer Approved [91]
Quercetin DM3NC4M Obesity 5B81 Approved [175]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [139]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
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Drug(s) Affected By Interleukin-18 (IL18)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [74]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [169]
Methotrexate DM2TEOL Anterior urethra cancer Approved [176]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [177]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [106]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [178]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [180]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [181]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [180]
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Drug(s) Affected By Beclin-1 (BECN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [182]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [92]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [121]
Methotrexate DM2TEOL Anterior urethra cancer Approved [91]
Quercetin DM3NC4M Obesity 5B81 Approved [183]
Fluoxetine DM3PD2C Bipolar depression Approved [184]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [186]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [187]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [188]
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Drug(s) Affected By NACHT, LRR and PYD domains-containing protein 3 (NLRP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [74]
Selenium DM25CGV N. A. N. A. Approved [80]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [189]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [177]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [106]
Testosterone DM7HUNW Hot flushes GA30 Approved [190]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [191]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [192]
Ethanol DMDRQZU Chronic pain MG30 Approved [193]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [194]
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Drug(s) Affected By Sulfotransferase 1A1 (SULT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [195]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [196]
Minoxidil DMA2Z4F Alopecia ED70 Approved [197]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [198]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [197]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [199]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [55]
Methotrexate DM2TEOL Anterior urethra cancer Approved [200]
Quercetin DM3NC4M Obesity 5B81 Approved [175]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [189]
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Drug(s) Affected By Histamine H1 receptor (HRH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Desloratadine DM56YN7 Allergic rhinitis CA08.0 Approved [201]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [201]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [65]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [202]
Methotrexate DM2TEOL Anterior urethra cancer Approved [176]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [203]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [63]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Clozapine DMFC71L Schizophrenia 6A20 Approved [204]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [205]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [165]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [206]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [207]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [208]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [65]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [92]
Verapamil DMA7PEW Angina pectoris BA40 Approved [166]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [152]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [209]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [110]
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Drug(s) Affected By Sulfotransferase 1E1 (SULT1E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [199]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [199]
Methotrexate DM2TEOL Anterior urethra cancer Approved [200]
Estrone DM5T6US Acne vulgaris ED80 Approved [210]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [199]
Dienestrol DMBSXI0 Atrophic vaginitis GA30.2 Approved [210]
Ethanol DMDRQZU Chronic pain MG30 Approved [211]
Folic Acid DMEMBJC Colorectal carcinoma Approved [212]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [213]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [214]
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Drug(s) Affected By Sulfotransferase 1A3 (SULT1A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [195]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [215]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ethanol DMDRQZU Chronic pain MG30 Approved [211]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [216]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [217]
Vitamin C DMXJ7O8 Adenocarcinoma 2D40 Approved [218]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [198]
Epinephrine DM3KJBC Acute asthma CA23 Approved [197]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [197]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Clusterin (CLU)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [219]
Selenium DM25CGV N. A. N. A. Approved [114]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [219]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [220]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [221]
Panobinostat DM58WKG Chronic graft versus host disease Approved [222]
Levamisole DM5EN79 Parasitic infection 1D0Y-1G2Z Approved [223]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [224]
Testosterone DM7HUNW Hot flushes GA30 Approved [190]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [219]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Voltage-gated sodium channel alpha Nav1.8 (SCN10A) TT90XZ8 SCNAA_HUMAN Modulator [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [4]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [5]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [6]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [7]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Drug Response [8]
Apoptosis-inducing factor 1, mitochondrial (AIFM1) OTKPWB7Q AIFM1_HUMAN Gene/Protein Processing [9]
Beclin-1 (BECN1) OT4X293M BECN1_HUMAN Gene/Protein Processing [7]
Caspase-1 (CASP1) OTZ3YQFU CASP1_HUMAN Protein Interaction/Cellular Processes [10]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [11]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [11]
Clusterin (CLU) OTQGG0JM CLUS_HUMAN Drug Response [8]
Gasdermin-D (GSDMD) OTH39BKI GSDMD_HUMAN Protein Interaction/Cellular Processes [10]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Gene/Protein Processing [10]

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