Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMT5HA4)

Drug Name
Ketamine Drug Info
Synonyms
Calypsol; Cetamina; Green; Ketaject; Ketalar; Ketaminum; Ketanest; Ketoject; Ketolar; Tekam; KETAMINE HCL; Ketalar base; Ketamine Base; Special K; Special K [street name]; CLSTA 20; T385; Cetamina [INN-Spanish]; Dl-Ketamine; Ketalar (TN); Ketamine (INN); Ketamine [INN:BAN]; Ketaminum [INN-Latin]; Ketanest (TN); Ketaset (TN); Tekam (TN); Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-(9CI); Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (+-)-(9CI); Cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, (+/-)-(8CI); (+/-)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone; (+/-)-2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone; 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone; 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one; 2-(Methylamino)-2-(2-chlorophenyl)cyclohexanone; 2-(o-Chlorophenyl)-2-(methylamino)-cyclohexanone; 2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone
Indication
Disease Entry ICD 11 Status REF
Anaesthesia 9A78.6 Approved [1]
Anxiety Approved [2]
Bipolar disorder 6A60 Approved [2]
Depression 6A70-6A7Z Approved [2]
Traumatic brain injury NA07.Z Approved [2]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [3]
Chronic pain MG30 Investigative [2]
Therapeutic Class
Analgesics
Cross-matching ID
PubChem CID
3821
ChEBI ID
CHEMBL742
CAS Number
CAS 6740-88-1
TTD Drug ID
DMT5HA4
VARIDT Drug ID
DR00685
INTEDE Drug ID
DR0903

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting N-methyl-D-aspartate receptor (NMDAR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-Glutamic Acid DM4PUDW Schizophrenia 6A20 Approved [10]
Cycloserine DMT1I52 Bacterial infection 1A00-1C4Z Approved [11]
Benzphetamine DMIJATC Obesity 5B81 Approved [12]
Felbamate DM1V5ZS Epilepsy 8A60-8A68 Approved [13]
Memantine DMD9WSC Alzheimer disease 8A20 Approved [14]
Huperzine A DMMAWLU Alzheimer disease 8A20 Approved [15]
Levorphanol DMGS80V Pain MG30-MG3Z Approved [16]
Magnesium Sulfate DMVEK07 Acute pain MG31 Approved [17]
Magnesium DMU4ORS Ischemic stroke 8B11.5Z Approved [18]
Orphenadrine DMW542E Parkinson disease 8A00.0 Approved [19]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [20]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [21]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [22]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [23]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [24]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [25]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [26]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [27]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [21]
Verapamil DMA7PEW Angina pectoris BA40 Approved [28]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [29]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [30]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [31]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [32]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [33]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [32]
Verapamil DMA7PEW Angina pectoris BA40 Approved [34]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [35]
Estrone DM5T6US Acne vulgaris ED80 Approved [36]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [37]
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Drug(s) Metabolized By Cytochrome P450 2B6 (CYP2B6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [38]
Verapamil DMA7PEW Angina pectoris BA40 Approved [32]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [39]
Estrone DM5T6US Acne vulgaris ED80 Approved [31]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [41]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [42]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [43]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [44]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [45]
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Drug(s) Affected By Zinc finger protein SNAI2 (SNAI2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [46]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [48]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [50]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [54]
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Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [55]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [46]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [47]
Quercetin DM3NC4M Obesity 5B81 Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [58]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [59]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [60]
Sanguinarine DMDINFS Dental plaque DA08.4 Approved [61]
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Drug(s) Affected By Renin (REN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [62]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [63]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [64]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [65]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [66]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [67]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [68]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [69]
Epinephrine DM3KJBC Acute asthma CA23 Approved [70]
Chlorthalidone DM4DMBT Edema MG29 Approved [71]
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Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [72]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [73]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [74]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [75]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [77]
Prednisone DM2HG4X Acute asthma CA23 Approved [78]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [79]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [80]
Methotrexate DM2TEOL Anterior urethra cancer Approved [81]
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Drug(s) Affected By Amyloid-beta precursor protein (APP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Selenium DM25CGV N. A. N. A. Approved [83]
Methotrexate DM2TEOL Anterior urethra cancer Approved [81]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [84]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [85]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [86]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [87]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [88]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [89]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [90]
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Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [91]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [46]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [92]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [93]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [94]
Quercetin DM3NC4M Obesity 5B81 Approved [95]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [96]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [97]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [98]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
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Drug(s) Affected By Protein S100-A4 (S100A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [99]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [48]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [100]
Panobinostat DM58WKG Chronic graft versus host disease Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [101]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [102]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [103]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [104]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [105]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
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Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [107]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [108]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [109]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [110]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [111]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [112]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [113]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [114]
Methotrexate DM2TEOL Anterior urethra cancer Approved [115]
Quercetin DM3NC4M Obesity 5B81 Approved [95]
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Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [116]
Quercetin DM3NC4M Obesity 5B81 Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Panobinostat DM58WKG Chronic graft versus host disease Approved [118]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [119]
Pirfenidone DM6VZFQ Idiopathic pulmonary fibrosis CB03.4 Approved [120]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [121]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [122]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
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Drug(s) Affected By Sodium/hydrogen exchanger 6 (SLC9A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [117]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [123]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [124]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [125]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [126]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [127]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [128]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [129]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
N-methyl-D-aspartate receptor (NMDAR) TT9IK2Z NOUNIPROTAC Antagonist [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [5]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [5]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Actin, aortic smooth muscle (ACTA2) OTEDLG8E ACTA_HUMAN Gene/Protein Processing [6]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Gene/Protein Processing [7]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Gene/Protein Processing [6]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Gene/Protein Processing [8]
Protein S100-A4 (S100A4) OTLRGFSQ S10A4_HUMAN Gene/Protein Processing [6]
Renin (REN) OT52GZR2 RENI_HUMAN Gene/Protein Processing [9]
Sodium/hydrogen exchanger 6 (SLC9A6) OT5N47TC SL9A6_HUMAN Gene/Protein Processing [7]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Gene/Protein Processing [6]
Twist-related protein 1 OTB3H60O TWST1_HUMAN Gene/Protein Processing [6]
Vimentin OTGZLW4J VIME_HUMAN Gene/Protein Processing [6]

References

1 FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 076092.
2 Ketamine FDA Label
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52 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
53 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
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