Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMT5HA4)

• Drug Name: Ketamine Drug Info
• Synonyms: Calypsol; Cetamina; Green; Ketaject; Ketalar; Ketaminum; Ketanest; Ketoject; Ketolar; Tekam; KETAMINE HCL; Ketalar base; Ketamine Base; Special K; Special K [street name]; CLSTA 20; T385; Cetamina [INN-Spanish]; Dl-Ketamine; Ketalar (TN); Ketamine (INN); Ketamine [INN:BAN]; Ketaminum [INN-Latin]; Ketanest (TN); Ketaset (TN); Tekam (TN); Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-(9CI); Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (+-)-(9CI); Cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, (+/-)-(8CI); (+/-)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone; (+/-)-2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone; 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone; 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one; 2-(Methylamino)-2-(2-chlorophenyl)cyclohexanone; 2-(o-Chlorophenyl)-2-(methylamino)-cyclohexanone; 2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone

Indication

Disease Entry	ICD 11	Status	REF
Anaesthesia	9A78.6	Approved	[1]
Anxiety		Approved	[2]
Bipolar disorder	6A60	Approved	[2]
Depression	6A70-6A7Z	Approved	[2]
Traumatic brain injury	NA07.Z	Approved	[2]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[3]
Chronic pain	MG30	Investigative	[2]

• Therapeutic Class: Analgesics
• Cross-matching ID:
  PubChem CID: 3821
  ChEBI ID: CHEBI:6121
  CAS Number: CAS 6740-88-1
  TTD Drug ID: DMT5HA4
  VARIDT Drug ID: DR00685
  INTEDE Drug ID: DR0903

Molecule-Related Drug Atlas

Drug(s) Targeting N-methyl-D-aspartate receptor (NMDAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Glutamic Acid	DM4PUDW	Schizophrenia	6A20	Approved	[12]
Cycloserine	DMT1I52	Bacterial infection	1A00-1C4Z	Approved	[13]
Benzphetamine	DMIJATC	Obesity	5B81	Approved	[14]
Felbamate	DM1V5ZS	Epilepsy	8A60-8A68	Approved	[15]
Memantine	DMD9WSC	Alzheimer disease	8A20	Approved	[16]
Huperzine A	DMMAWLU	Alzheimer disease	8A20	Approved	[17]
Levorphanol	DMGS80V	Pain	MG30-MG3Z	Approved	[18]
Magnesium Sulfate	DMVEK07	Acute pain	MG31	Approved	[19]
Magnesium	DMU4ORS	Ischemic stroke	8B11.5Z	Approved	[20]
Orphenadrine	DMW542E	Parkinson disease	8A00.0	Approved	[21]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[23]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[24]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[26]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[27]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[28]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[29]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[23]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[30]
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[48]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[49]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[50]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[51]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[52]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[53]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[54]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[55]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[56]

Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[31]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[32]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[34]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[34]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[36]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[37]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]

Drug(s) Metabolized By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[40]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[34]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[41]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[43]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[44]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[45]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[46]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[47]

Drug(s) Affected By Zinc finger protein SNAI2 (SNAI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[62]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]

Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[69]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[70]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[63]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[71]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[72]

Drug(s) Affected By Renin (REN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[73]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[74]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[75]
Reboxetine	DM26PRD	Depression	6A70-6A7Z	Approved	[76]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[77]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[78]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[79]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[80]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[81]
Chlorthalidone	DM4DMBT	Edema	MG29	Approved	[82]

Drug(s) Affected By Angiotensinogen (AGT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[83]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[85]
Reboxetine	DM26PRD	Depression	6A70-6A7Z	Approved	[76]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[86]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[87]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[89]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[90]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[92]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[93]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[94]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[96]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[97]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[98]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[99]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[100]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[101]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[102]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[103]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[104]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[104]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[106]
Selenium	DM25CGV	N. A.	N. A.	Approved	[107]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[108]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[109]

Drug(s) Affected By Fibronectin (FN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[100]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[111]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[112]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[115]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[118]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[100]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[120]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[121]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[122]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[123]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[124]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[125]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[126]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[127]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[129]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[100]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[130]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[131]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[136]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[137]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[138]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[139]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[140]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[92]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[142]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[143]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[144]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[145]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[146]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[147]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[149]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[150]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[151]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[152]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[153]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[154]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[155]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[156]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[157]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[160]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[161]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]

Drug(s) Affected By Protein S100-A4 (S100A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[164]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[165]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[168]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[169]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[170]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[171]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[172]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[147]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[150]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[174]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]

Drug(s) Affected By TGF-beta receptor type-1 (TGFBR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[93]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[178]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[179]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[180]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[180]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]

Drug(s) Affected By TGF-beta receptor type-2 (TGFBR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[176]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[85]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[183]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[184]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[115]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[62]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]

Drug(s) Affected By Leptin (LEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[187]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[188]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[189]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[190]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[187]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[187]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[192]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[193]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[194]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[197]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[122]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[198]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[199]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[200]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[201]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[202]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[203]

Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[204]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[205]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[207]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[208]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[209]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[210]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[211]

Drug(s) Affected By Leptin receptor (LEPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[212]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[190]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[213]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[214]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[215]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[216]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[217]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[218]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[219]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[143]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[220]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[221]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[222]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[223]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[224]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[225]

Drug(s) Affected By Caspase-6 (CASP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[226]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[101]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[85]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[227]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[228]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[229]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[160]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[230]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[118]

Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[231]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[234]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[211]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[62]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[235]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[137]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[203]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[142]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[155]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[220]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[236]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[237]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[238]

Drug(s) Affected By Sodium/hydrogen exchanger 6 (SLC9A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[239]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[240]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[226]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[241]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[216]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[242]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[243]

Drug(s) Affected By Apolipoprotein E (APOE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[244]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[245]
Selenium	DM25CGV	N. A.	N. A.	Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[178]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[160]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[246]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[247]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[239]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
N-methyl-D-aspartate receptor (NMDAR)	TT9IK2Z	NOUNIPROTAC	Antagonist	[4]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[5]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Substrate	[5]
Cytochrome P450 2B6 (CYP2B6)	DEPKLMQ	CP2B6_HUMAN	Substrate	[5]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Gene/Protein Processing	[6]
Amyloid-beta precursor protein (APP)	OTKFD7R4	A4_HUMAN	Gene/Protein Processing	[7]
Angiotensinogen (AGT)	OTBZLYR3	ANGT_HUMAN	Gene/Protein Processing	[8]
Apolipoprotein E (APOE)	OTFOWL2H	APOE_HUMAN	Drug Response	[9]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Protein Interaction/Cellular Processes	[10]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[11]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Gene/Protein Processing	[6]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[10]
Caspase-6 (CASP6)	OTXLD3EC	CASP6_HUMAN	Gene/Protein Processing	[10]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Gene/Protein Processing	[10]

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