General Information of Drug (ID: DMWAF5Z)

Drug Name
MANGIFERIN Drug Info
Synonyms
Mangiferin; 4773-96-0; Hedysarid; Chinomin; Alpizarin; Chinonin; Aphloiol; Alpizarine; UNII-1M84LD0UMD; 1M84LD0UMD; CHEBI:6682; 2-beta-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one; (1S)-1,5-anhydro-1-(1,3,6,7-tetrahydroxy-9-oxo-9H-xanthen-2-yl)-D-glucitol; 1,3,6,7-Tetrahydroxyxanthone-C2-b-D-glucoside; Chinoinin; 9H-Xanthen-9-one, 2-.beta.-D-glucopyranosyl-1,3,6,7-tetrahydroxy-; C19H18O11; NSC 248870; 9H-Xanthen-9-one, 2-beta-D-glucopyranosyl-1,3,6,7-tetrahydroxy-; cid_5358385; Mangiferin;; Alpizarine;; Chinomin;
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5281647
ChEBI ID
CHEMBL464825
CAS Number
CAS 4773-96-0
TTD Drug ID
DMWAF5Z

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug(s) Targeting Aldose reductase (AKR1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Epalrestat DM5OGK0 Diabetic neuropathy 8C0Z Approved [9]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [10]
Fidarestat DMZL1I8 Diabetic complication 5A2Y Phase 3 [11]
Ranirestat DMD5QRS Diabetic neuropathy 8C0Z Phase 3 [12]
CONTIGOSIDE B DMX9V8K Thrombosis DB61-GB90 Phase 2/3 [13]
BNV-222 DMYFQJL Diabetic neuropathy 8C0Z Phase 2/3 [12]
BNV-222 DMYFQJL Diabetic neuropathy 8C0Z Phase 2/3 [14]
LIDORESTAT DMA0RI9 Diabetic complication 5A2Y Phase 2 [15]
QR-333 DMKVIWM Diabetic neuropathy 8C0Z Phase 2 [16]
ADMVA DM819CO Diabetic complication 5A2Y Phase 2 [12]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Oseltamivir DMGO72P Influenza 1E30-1E32 Approved [17]
Zanamivir DMFMBZ4 Influenza 1E30-1E32 Approved [17]
Peramivir DMNXY5K Influenza virus infection 1E30-1E32 Approved [18]
UX-001 DMD2O0L Hereditary inclusion body myositis 4A41.2 Phase 3 [19]
CS-8958 DM4CSDH Influenza virus infection 1E30-1E32 Phase 3 [18]
DAS-181 DM0Y8JP Influenza virus infection 1E30-1E32 Phase 2 [20]
Lactose DMO4GPK Discovery agent N.A. Phase 1 [19]
GS-3435 DMV7JC6 Influenza virus infection 1E30-1E32 Terminated [21]
BCX-140 DMBJERO Influenza virus infection 1E30-1E32 Terminated [22]
Alpha-D-Mannose DMF5DLW Discovery agent N.A. Investigative [19]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [23]
Gefitinib DM15F0X Colon adenocarcinoma Approved [24]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [25]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [26]
Etretinate DM2CZFA Keratosis ED56 Approved [27]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [28]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [29]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [30]
Quercetin DM3NC4M Obesity 5B81 Approved [31]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [32]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [33]
Haloperidol DM96SE0 Delirium Approved [34]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [35]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [36]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [37]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [38]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [39]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [40]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [41]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [42]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [44]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [45]
Panobinostat DM58WKG Chronic graft versus host disease Approved [46]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [47]
Testosterone DM7HUNW Hot flushes GA30 Approved [48]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [48]
Leflunomide DMR8ONJ Arthritis FA20 Approved [49]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [50]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [51]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [52]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [44]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [55]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [56]
Leflunomide DMR8ONJ Arthritis FA20 Approved [49]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [57]
Sanguinarine DMDINFS Dental plaque DA08.4 Approved [58]
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Drug(s) Affected By Albumin (ALB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [42]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [59]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [60]
Diazepam DM08E9O Alcohol withdrawal Approved [61]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [62]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [63]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [64]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [65]
Methotrexate DM2TEOL Anterior urethra cancer Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [68]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [69]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [70]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [71]
Cepharanthine DM9Y5JB N. A. N. A. Approved [72]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [73]
Clozapine DMFC71L Schizophrenia 6A20 Approved [74]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [75]
Trifluoperazine DMKBYWI Anxiety Approved [76]
Olanzapine DMPFN6Y Bipolar depression Approved [74]
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Drug(s) Affected By Matrilysin (MMP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [80]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [81]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [83]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [84]
Clozapine DMFC71L Schizophrenia 6A20 Approved [85]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [86]
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Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [87]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [88]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [89]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [90]
Quercetin DM3NC4M Obesity 5B81 Approved [91]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [92]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [93]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [94]
Panobinostat DM58WKG Chronic graft versus host disease Approved [46]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [95]
Quercetin DM3NC4M Obesity 5B81 Approved [96]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [97]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Panobinostat DM58WKG Chronic graft versus host disease Approved [46]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [97]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [51]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [98]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [99]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [87]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [26]
Methotrexate DM2TEOL Anterior urethra cancer Approved [101]
Epinephrine DM3KJBC Acute asthma CA23 Approved [102]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [104]
Fructose DM43AN2 Vomiting MD90 Approved [105]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [87]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [106]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [107]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [108]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [109]
Paclitaxel DMLB81S Breast carcinoma Approved [110]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [111]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [59]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [113]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [114]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [115]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [113]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [116]
Selenium DM25CGV N. A. N. A. Approved [117]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [118]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [119]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [120]
Quercetin DM3NC4M Obesity 5B81 Approved [91]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [121]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [122]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [123]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [124]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [125]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [26]
Selenium DM25CGV N. A. N. A. Approved [117]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [126]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [127]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [128]
Quercetin DM3NC4M Obesity 5B81 Approved [129]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [130]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [131]
Quercetin DM3NC4M Obesity 5B81 Approved [91]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [132]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [93]
Testosterone DM7HUNW Hot flushes GA30 Approved [48]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [48]
Leflunomide DMR8ONJ Arthritis FA20 Approved [49]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [133]
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Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [134]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [135]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [136]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [137]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [138]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [139]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [140]
Testosterone DM7HUNW Hot flushes GA30 Approved [141]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [142]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aldose reductase (AKR1B1) TTFBNVI ALDR_HUMAN Inhibitor [2]
Influenza Neuraminidase (Influ NA) TT50QJ3 NRAM_I33A0 Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Albumin (ALB) OTVMM513 ALBU_HUMAN Protein Interaction/Cellular Processes [3]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [4]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [5]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [6]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Gene/Protein Processing [7]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Drug Response [7]
E3 ubiquitin-protein ligase XIAP OT24GP9B XIAP_HUMAN Gene/Protein Processing [6]
Matrilysin (MMP7) OTVT3SEJ MMP7_HUMAN Gene/Protein Processing [7]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Protein Interaction/Cellular Processes [8]
Mitogen-activated protein kinase kinase kinase 14 (MAP3K14) OTT3DOOL M3K14_HUMAN Post-Translational Modifications [5]

References

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3 Characterization of the mangiferin-human serum albumin complex by spectroscopic and molecular modeling approaches. J Pharm Biomed Anal. 2009 Apr 5;49(3):753-9. doi: 10.1016/j.jpba.2008.12.017. Epub 2008 Dec 24.
4 In vitro modulation of ABCB1/P-glycoprotein expression by polyphenols from Mangifera indica. Chem Biol Interact. 2010 Aug 5;186(3):287-94. doi: 10.1016/j.cbi.2010.05.012. Epub 2010 Jun 1.
5 Mangiferin induces apoptosis in multiple myeloma cell lines by suppressing the activation of nuclear factor kappa B-inducing kinase. Chem Biol Interact. 2016 May 5;251:26-33. doi: 10.1016/j.cbi.2016.03.018. Epub 2016 Mar 17.
6 Mangiferin induces apoptosis by suppressing Bcl-xL and XIAP expressions and nuclear entry of NF-B in HL-60 cells. Arch Pharm Res. 2011 Mar;34(3):469-75. doi: 10.1007/s12272-011-0316-8. Epub 2011 May 6.
7 Mangiferin exerts antitumor activity in breast cancer cells by regulating matrix metalloproteinases, epithelial to mesenchymal transition, and -catenin signaling pathway. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):180-90. doi: 10.1016/j.taap.2013.05.011. Epub 2013 May 22.
8 Norathyriol suppresses skin cancers induced by solar ultraviolet radiation by targeting ERK kinases. Cancer Res. 2012 Jan 1;72(1):260-70. doi: 10.1158/0008-5472.CAN-11-2596. Epub 2011 Nov 14.
9 Long-term effect of epalrestat, an aldose reductase inhibitor, on the development of incipient diabetic nephropathy in Type 2 diabetic patients. J Diabetes Complications. 2001 Sep-Oct;15(5):241-4.
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11 Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled double-blind parallel group study. Diabetes Care. 2001 Oct;24(10):1776-82.
12 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2768).
13 Effect of Polygonum hydropiper sulfated flavonoids on lens aldose reductase and related enzymes. J Nat Prod. 1996 Apr;59(4):443-5.
14 ClinicalTrials.gov (NCT02332005) 12-Month Efficacy and Safety of Diepalrestat in Adults With Diabetic Peripheral Neuropathy, a DB, Placebo-Controlled Study (DE-DPN). U.S. National Institutes of Health.
15 Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors ... J Med Chem. 2005 May 5;48(9):3141-52.
16 A multicenter, double-blind, safety study of QR-333 for the treatment of symptomatic diabetic peripheral neuropathy. A preliminary report. J Diabetes Complications. 2005 Sep-Oct;19(5):247-53.
17 Current and future antiviral therapy of severe seasonal and avian influenza. Antiviral Res. 2008 Apr;78(1):91-102.
18 Developing new antiviral agents for influenza treatment: what does the future hold Clin Infect Dis. 2009 Jan 1;48 Suppl 1:S3-13.
19 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
20 Inhibition of neuraminidase inhibitor-resistant influenza virus by DAS181, a novel sialidase fusion protein. PLoS One. 2009 Nov 6;4(11):e7838.
21 US patent application no. 2010,0081,713, Compositions and methods for treating viral infections.
22 CN patent application no. 104447481, Benzoic acid thiourea anti-influenza virus compounds as well as preparation method and use thereof.
23 mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
24 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
25 Assessment of the cytotoxic, genotoxic, and apoptotic potential of flurbiprofen in HeLa and HepG2 cell lines. J Biochem Mol Toxicol. 2021 Jun;35(6):1-11. doi: 10.1002/jbt.22770. Epub 2021 Mar 11.
26 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
27 Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
28 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
29 Apoptotic induction by simvastatin in human lung cancer A549 cells via Akt signaling dependent down-regulation of survivin. Invest New Drugs. 2011 Oct;29(5):945-52. doi: 10.1007/s10637-010-9450-2. Epub 2010 May 13.
30 Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells. Oncogene. 2005 Sep 15;24(41):6213-21. doi: 10.1038/sj.onc.1208774.
31 Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. Cancer Invest. 2009 Jul;27(6):604-12. doi: 10.1080/07357900802337191.
32 Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin. Apoptosis. 2006 Sep;11(9):1503-12. doi: 10.1007/s10495-006-8896-3.
33 Tea polyphenols ameliorates neural redox imbalance and mitochondrial dysfunction via mechanisms linking the key circadian regular Bmal1. Food Chem Toxicol. 2017 Dec;110:189-199. doi: 10.1016/j.fct.2017.10.031. Epub 2017 Oct 20.
34 Haloperidol, but not olanzapine, may affect expression of PER1 and CRY1 genes in human glioblastoma cell line. Biol Rhythm Res. 2016 Nov 1;47(6):865-871. doi: 10.1080/09291016.2016.1202379. Epub 2016 Jul 1.
35 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
36 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
37 Peripheral CLOCK regulates target-tissue glucocorticoid receptor transcriptional activity in a circadian fashion in man. PLoS One. 2011;6(9):e25612. doi: 10.1371/journal.pone.0025612. Epub 2011 Sep 28.
38 SGK1, a potential regulator of c-fms related breast cancer aggressiveness. Clin Exp Metastasis. 2004;21(6):477-83.
39 Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
40 Chronic treatment with prednisolone represses the circadian oscillation of clock gene expression in mouse peripheral tissues. Mol Endocrinol. 2006 Mar;20(3):573-83. doi: 10.1210/me.2005-0165. Epub 2005 Nov 3.
41 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
42 Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
43 Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling. Free Radic Biol Med. 2012 Jul 1;53(1):44-50. doi: 10.1016/j.freeradbiomed.2012.04.031. Epub 2012 May 9.
44 Ciprofloxacin mediates cancer stem cell phenotypes in lung cancer cells through caveolin-1-dependent mechanism. Chem Biol Interact. 2016 Apr 25;250:1-11.
45 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
46 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
47 Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. Environ Toxicol. 2016 Mar;31(3):314-28.
48 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
49 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
50 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
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