Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMX9K8F)

Drug Name
Carbachol Drug Info
Synonyms
Carbach; Carbacholin; Carbacholine; Carbacholinum; Carbacholum; Carbacol; Carbacolina; Carbacolo; Carbamiotin; Carbamoylcholine; Carbastat; Carbochol; Carbocholin; Carbocholine; Carbyl; Carcholin; Coletyl; Doryl; Jestryl; Karbachol; Lentin; Lentine; Miostat; Moryl; Rilentol; Vasoperif; CARBACHOL CHLORIDE; Carbachol hydrochloride; Carbacholine chloride; Carbacholini chloridum; Carbacholinium chloratum; Carbacholum chloratum; Carbacolo [DCIT]; Carbaminocholine chloride; Carbaminoylcholine chloride; Carbamoylcholine chloride; Carbamylcholine chloride; Choline carbamate chloride; Choline chloride carbamate; Choline chlorine carbamate; Isopto Carbachol; Karbachol [Czech]; Karbamoylcholin chlorid; Karbamoylcholin chlorid [Czech]; Lentine [French]; Mistura C; C 4382; TL 457; C-1770; Carbacholum [INN-Latin]; Carbacol [INN-Spanish]; Carbamic acid, ester with choline chloride; Carbamoylcholine-hydrochloride; Carbastat (TN); Carboptic (TN); Choline chloride, carbamate; Doryl (VAN); Doryl (pharmaceutical); Gamma-Carbamoyl choline chloride; Isopto Carbachol (TN); Miostat (TN); Carbachol [INN:BAN:JAN]; Choline, chloride carbamate(ester); Choline, chloride, carbamate; P. V. Carbachol; Carbachol (JAN/USP/INN); Choline, chloride, carbamate, hydrochloride; Ethanaminium, 2-(aminocarbonyl)oxy-N,N,N-trimethyl-, chloride; Ethanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-, chloride; Ethanaminium, 2-((aminocarbonyl)oxy)-N,N,N-trimethyl-, chloride; Ethanaminium, 2-((aminocarbonyl)oxy)-N,N,N-trimethyl-, chloride (1:1); (2-Carbamoyloxy-ethyl)-trimethyl-ammonium; (2-Carbamoyloxy-ethyl)-trimethyl-ammonium(Carbachol); (2-Carbamoyloxyethyl)trimethylammonium chloride; (2-Hydroxyethyl)trimethyl ammonium chloride carbamate; (2-Hydroxyethyl)trimethylammonium chloride carbamate; (carbachol)(2-Carbamoyloxy-ethyl)-trimethyl-ammonium; 2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminium chloride; 2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminum chloride; 2-(carbamoyloxy)-N,N,N-trimethylethanaminium chloride; 2-[(aminocarbonyl)oxy]-N,N,N-trimethylethanaminium chloride; 2-carbamoyloxyethyl(trimethyl)azanium chloride
Indication
Disease Entry ICD 11 Status REF
Glaucoma/ocular hypertension 9C61 Approved [1]
Therapeutic Class
Cardiotonic Agents
Cross-matching ID
PubChem CID
5831
ChEBI ID
CHEMBL14
CAS Number
CAS 51-83-2
TTD Drug ID
DMX9K8F
ACDINA Drug ID
D00912

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Neuronal acetylcholine receptor alpha-2 (CHRNA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rocuronium DMY9BMK Muscle spasm MB47.3 Approved [7]
Tubocurarine DMBZIVP Anaesthesia 9A78.6 Approved [7]
Cisatracurium DMUZPJ5 Muscle spasm MB47.3 Approved [7]
Vecuronium DMP0UK2 Spasm MB47.3 Approved [7]
Levallorphan DMCOLUP Narcotic depression 6A7Z Approved [2]
Mivacurium DM473VD Anaesthesia 9A78.6 Approved [7]
Pipecuronium DM5F84A Spasm MB47.3 Approved [2]
CYTISINE DMUF0BJ Tobacco dependence 6C4A.2 Phase 3 [8]
CHOLINE DM5D9YK Insomnia 7A00-7A0Z Investigative [9]
[125I]epibatidine DMZWQH3 Discovery agent N.A. Investigative [10]
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Drug(s) Affected By Aquaporin-5 (AQP5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [11]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [12]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [13]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [14]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [15]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [16]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [17]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [18]
Milchsaure DM462BT Pruritus EC90 Investigative [19]
cordycepin DM72Y01 Discovery agent N.A. Investigative [11]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 5 (CD40)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [20]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [21]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [23]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [24]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [25]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [26]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [27]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [28]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [29]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [30]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [31]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [32]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [33]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [34]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [35]
Gefitinib DM15F0X Colon adenocarcinoma Approved [36]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [37]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [38]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [39]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [30]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [40]
Paclitaxel DMLB81S Breast carcinoma Approved [41]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [42]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [29]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [4]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [20]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [32]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [33]
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Drug(s) Affected By Cytochrome c oxidase subunit 1 (COX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [43]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [44]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [45]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [46]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [47]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [49]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [50]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [51]
Nicotinamide DMUPE07 Acne vulgaris ED80 Approved [45]
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Drug(s) Affected By Protein c-Fos (FOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [52]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [53]
Verapamil DMA7PEW Angina pectoris BA40 Approved [54]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [55]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [54]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [56]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Methotrexate DM2TEOL Anterior urethra cancer Approved [58]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [59]
Quercetin DM3NC4M Obesity 5B81 Approved [60]
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Drug(s) Affected By Prostaglandin E2 receptor EP1 subtype (PTGER1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrochlorothiazide DMUSZHD Chronic heart failure BD1Z Approved [4]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Neuronal acetylcholine receptor alpha-2 (CHRNA2) TTF4E0J ACHA2_HUMAN Antagonist [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aquaporin-5 (AQP5) OT77GBY8 AQP5_HUMAN Protein Interaction/Cellular Processes [3]
Cytochrome c oxidase subunit 1 (COX1) OTG3O9BN COX1_HUMAN Drug Response [4]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Gene/Protein Processing [5]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Gene/Protein Processing [5]
Prostaglandin E2 receptor EP1 subtype (PTGER1) OTZV8W66 PE2R1_CANLF Drug Response [4]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Drug Response [4]
Tumor necrosis factor receptor superfamily member 5 (CD40) OT5YU2XB TNR5_HUMAN Gene/Protein Processing [6]

References

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27 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
28 Fenofibrate induces effective apoptosis in mantle cell lymphoma by inhibiting the TNFalpha/NF-kappaB signaling axis. Leukemia. 2010 Aug;24(8):1476-86. doi: 10.1038/leu.2010.117. Epub 2010 Jun 3.
29 Treatment with anticancer agents induces dysregulation of specific Wnt signaling pathways in human ovarian luteinized granulosa cells in vitro. Toxicol Sci. 2013 Nov;136(1):183-92. doi: 10.1093/toxsci/kft175. Epub 2013 Aug 16.
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55 Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
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57 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
58 Methotrexate induces production of IL-1 and IL-6 in the monocytic cell line U937. Arthritis Res Ther. 2014 Jan 20;16(1):R17. doi: 10.1186/ar4444.
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