Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYOP45)

Drug Name
Piceatannol Drug Info
Synonyms
piceatannol; 10083-24-6; 3-Hydroxyresveratol; piceatanol; astringinin; 3,5,3',4'-Tetrahydroxystilbene; (E)-4-(3,5-dihydroxystyryl)benzene-1,2-diol; 3,3',4'5-Tetrahydroxystilbene; 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol; 3,3',4,5'-Tetrahydroxystilbene; UNII-6KS3LS0D4F; NSC 365798; NSC-365798; NSC 622471; 6KS3LS0D4F; CHEMBL69863; 3,3',4,5'-Stilbenetetrol; 4-[(E)-2-(3,5-dihydroxyphenyl)vinyl]benzene-1,2-diol; 4339-71-3; CHEBI:28814; C14H12O4; NSC365798; NSC622471; 1,2-Benzenediol, 4-(2-(3,5-dihydroxyphenyl)ethenyl)-
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
667639
ChEBI ID
CHEMBL28814
CAS Number
CAS 10083-24-6
TTD Drug ID
DMYOP45

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Affected By Amyloid-beta precursor protein (APP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [10]
Selenium DM25CGV N. A. N. A. Approved [11]
Methotrexate DM2TEOL Anterior urethra cancer Approved [12]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [13]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [14]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [15]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [16]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [17]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [18]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [19]
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Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [20]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [10]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [21]
Quercetin DM3NC4M Obesity 5B81 Approved [22]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [23]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [24]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [25]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [26]
Testosterone DM7HUNW Hot flushes GA30 Approved [27]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [28]
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Drug(s) Affected By Egl nine homolog 1 (EGLN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [6]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [30]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [31]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [32]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [33]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Ethanol DMDRQZU Chronic pain MG30 Approved [35]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [30]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
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Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Selenium DM25CGV N. A. N. A. Approved [38]
Methotrexate DM2TEOL Anterior urethra cancer Approved [39]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [40]
Epinephrine DM3KJBC Acute asthma CA23 Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [43]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [44]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [46]
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Drug(s) Affected By 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [47]
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [48]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [48]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Metyrapone DMI7FVQ Cushing disease 5A70 Approved [51]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [47]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [52]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [53]
Levetiracetam DMTGDN8 Epilepsy 8A60-8A68 Approved [50]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [54]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [54]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [55]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [56]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [57]
Etidronic acid DM1XHYJ Bone Paget disease Approved [54]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [54]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [54]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [58]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [59]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [60]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [61]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [62]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [63]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Selenium DM25CGV N. A. N. A. Approved [65]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [60]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [66]
Methotrexate DM2TEOL Anterior urethra cancer Approved [67]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [66]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [68]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [69]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [70]
Gefitinib DM15F0X Colon adenocarcinoma Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Selenium DM25CGV N. A. N. A. Approved [73]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [74]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [75]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [76]
Methotrexate DM2TEOL Anterior urethra cancer Approved [12]
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Drug(s) Affected By Transcription factor Jun (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [77]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [78]
Fructose DM43AN2 Vomiting MD90 Approved [79]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [20]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [80]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [69]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [81]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [83]
Methotrexate DM2TEOL Anterior urethra cancer Approved [84]
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Drug(s) Affected By Vitamin K-dependent protein S (PROS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Desogestrel DM27U4Y Contraception QA21 Approved [85]
Methotrexate DM2TEOL Anterior urethra cancer Approved [12]
Quercetin DM3NC4M Obesity 5B81 Approved [86]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [87]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [88]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [89]
Testosterone enanthate DMB6871 N. A. N. A. Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [91]
Folic Acid DMEMBJC Colorectal carcinoma Approved [92]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [93]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [94]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [95]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [96]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [97]
Cepharanthine DM9Y5JB N. A. N. A. Approved [98]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [99]
Clozapine DMFC71L Schizophrenia 6A20 Approved [100]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [101]
Trifluoperazine DMKBYWI Anxiety Approved [102]
Olanzapine DMPFN6Y Bipolar depression Approved [100]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [103]
Gefitinib DM15F0X Colon adenocarcinoma Approved [104]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [105]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [106]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [107]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [108]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [107]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [109]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [110]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
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Drug(s) Affected By Tyrosine-protein kinase JAK1 (JAK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Quercetin DM3NC4M Obesity 5B81 Approved [86]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [112]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [88]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [113]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [32]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [114]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [91]
Clozapine DMFC71L Schizophrenia 6A20 Approved [115]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [116]
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Drug(s) Affected By Biotin--protein ligase (HLCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [117]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [118]
Quercetin DM3NC4M Obesity 5B81 Approved [5]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [88]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [118]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [119]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [36]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [120]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [117]
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Drug(s) Affected By Eotaxin (CCL11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prednisone DM2HG4X Acute asthma CA23 Approved [121]
Methotrexate DM2TEOL Anterior urethra cancer Approved [12]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [122]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [123]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [124]
Ethanol DMDRQZU Chronic pain MG30 Approved [125]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [126]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [127]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [128]
Tacrolimus DMZ7XNQ Graft-versus-host disease 4B24 Approved [129]
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Drug(s) Affected By Type II iodothyronine deiodinase (DIO2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [103]
Quercetin DM3NC4M Obesity 5B81 Approved [130]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [131]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [132]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [39]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [91]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [133]
Ergocalciferol DMHO0AR Hypoparathyroidism 5A50 Approved [134]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [116]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [93]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Interferon regulatory factor 3 (IRF3) TTYR7OH IRF3_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2) OT02MSKN 3BHS2_HUMAN Gene/Protein Processing [2]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Protein Interaction/Cellular Processes [3]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [4]
Biotin--protein ligase (HLCS) OTPDUX30 BPL1_HUMAN Gene/Protein Processing [5]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Gene/Protein Processing [6]
Egl nine homolog 1 (EGLN1) OT5QODDK EGLN1_HUMAN Gene/Protein Processing [6]
Eotaxin (CCL11) OT3BIFPK CCL11_HUMAN Gene/Protein Processing [7]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Gene/Protein Processing [8]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Gene/Protein Processing [9]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [4]

References

1 Inhibition of lipopolysaccharide-induced interferon regulatory factor 3 activation and protection from septic shock by hydroxystilbenes. Shock. 2004 May;21(5):470-5.
2 Inhibition of CYP17A1 activity by resveratrol, piceatannol, and synthetic resveratrol analogs. Prostate. 2014 Jun;74(8):839-51.
3 Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides. J Biol Chem. 2005 Nov 11;280(45):37377-82.
4 Induction of autophagy, apoptosis and aquisition of resistance in response to piceatannol toxicity in MOLT-4 human leukemia cells. Toxicol In Vitro. 2019 Sep;59:12-25. doi: 10.1016/j.tiv.2019.03.040. Epub 2019 Mar 30.
5 Resveratrol compounds inhibit human holocarboxylase synthetase and cause a lean phenotype in Drosophila melanogaster. J Nutr Biochem. 2015 Nov;26(11):1379-84. doi: 10.1016/j.jnutbio.2015.07.004. Epub 2015 Jul 26.
6 Involvement of SIRT1 in hypoxic down-regulation of c-Myc and beta-catenin and hypoxic preconditioning effect of polyphenols. Toxicol Appl Pharmacol. 2012 Mar 1;259(2):210-8.
7 Control of eotaxin-1 expression and release by resveratrol and its metabolites in culture human pulmonary artery endothelial cells. Am J Cardiovasc Dis. 2011;1(1):16-30. Epub 2011 Apr 26.
8 Resveratrol-induced modification of polyamine metabolism is accompanied by induction of c-Fos. Carcinogenesis. 2003 Mar;24(3):469-74. doi: 10.1093/carcin/24.3.469.
9 Stable cellular models of nuclear receptor PXR for high-throughput evaluation of small molecules. Toxicol In Vitro. 2018 Oct;52:222-234.
10 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
11 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
12 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
13 Simvastatin protects neurons from cytotoxicity by up-regulating Bcl-2 mRNA and protein. J Neurochem. 2007 Apr;101(1):77-86. doi: 10.1111/j.1471-4159.2006.04375.x. Epub 2007 Jan 4.
14 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
15 Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease. J Struct Biol. 2000 Jun;130(2-3):209-16. doi: 10.1006/jsbi.2000.4285.
16 Increased processing of APLP2 and APP with concomitant formation of APP intracellular domains in BDNF and retinoic acid-differentiated human neuroblastoma cells. J Neurochem. 2005 Nov;95(4):1059-68. doi: 10.1111/j.1471-4159.2005.03440.x. Epub 2005 Sep 7.
17 Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq. Arch Toxicol. 2018 Aug;92(8):2517-2531.
18 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
19 Synergistic effects of iron and aluminum on stress-related gene expression in primary human neural cells. J Alzheimers Dis. 2005 Nov;8(2):117-27; discussion 209-15. doi: 10.3233/jad-2005-8204.
20 Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
21 Sulindac suppresses beta-catenin expression in human cancer cells. Eur J Pharmacol. 2008 Mar 31;583(1):26-31. doi: 10.1016/j.ejphar.2007.12.034. Epub 2008 Feb 5.
22 Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
23 Multifaceted suppression of aggressive behavior of thyroid carcinoma by all-trans retinoic acid induced re-differentiation. Mol Cell Endocrinol. 2012 Jan 2;348(1):260-9. doi: 10.1016/j.mce.2011.09.002. Epub 2011 Sep 6.
24 Arsenic trioxide and 2-methoxyestradiol reduce beta-catenin accumulation after proteasome inhibition and enhance the sensitivity of myeloma cells to Bortezomib. Leuk Res. 2008 Nov;32(11):1674-83. doi: 10.1016/j.leukres.2008.03.039. Epub 2008 May 15.
25 Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A. Oncogene. 2006 Oct 19;25(49):6447-56. doi: 10.1038/sj.onc.1209658. Epub 2006 Jul 31.
26 Benzene metabolite hydroquinone induces apoptosis of bone marrow mononuclear cells through inhibition of -catenin signaling. Toxicol In Vitro. 2018 Feb;46:361-369. doi: 10.1016/j.tiv.2017.08.018. Epub 2017 Sep 5.
27 Anti-androgen 2-hydroxyflutamide modulates cadherin, catenin and androgen receptor phosphorylation in androgen-sensitive LNCaP and androgen-independent PC3 prostate cancer cell lines acting via PI3K/Akt and MAPK/ERK1/2 pathways. Toxicol In Vitro. 2017 Apr;40:324-335. doi: 10.1016/j.tiv.2017.01.019. Epub 2017 Feb 2.
28 Anthelmintic Niclosamide Disrupts the Interplay of p65 and FOXM1/-catenin and Eradicates Leukemia Stem Cells in Chronic Myelogenous Leukemia. Clin Cancer Res. 2017 Feb 1;23(3):789-803. doi: 10.1158/1078-0432.CCR-16-0226. Epub 2016 Aug 4.
29 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
30 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
31 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
32 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
33 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
34 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
35 Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. J Appl Toxicol. 2014 Jan;34(1):66-75.
36 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
37 Neuroprotective effects of glucomoringin-isothiocyanate against H(2)O(2)-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells. Neurotoxicology. 2019 Dec;75:89-104. doi: 10.1016/j.neuro.2019.09.008. Epub 2019 Sep 12.
38 Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
39 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
40 P450 3A-catalyzed O-dealkylation of lapatinib induces mitochondrial stress and activates Nrf2. Chem Res Toxicol. 2016 May 16;29(5):784-96.
41 Epinephrine upregulates superoxide dismutase in human coronary artery endothelial cells. Free Radic Biol Med. 2001 Jan 15;30(2):148-53.
42 Cissus quadrangularis ethanol extract upregulates superoxide dismutase, glutathione peroxidase and endothelial nitric oxide synthase expression in hydrogen peroxide-injured human ECV304 cells. J Ethnopharmacol. 2012 Sep 28;143(2):664-72.
43 Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
44 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
45 Manganese superoxide dismutase is a promising target for enhancing chemosensitivity of basal-like breast carcinoma. Antioxid Redox Signal. 2014 May 20;20(15):2326-46. doi: 10.1089/ars.2013.5295. Epub 2013 Nov 14.
46 Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
47 Cinnamic acid based thiazolidinediones inhibit human P450c17 and 3beta-hydroxysteroid dehydrogenase and improve insulin sensitivity independent of PPARgamma agonist activity. J Mol Endocrinol. 2004 Apr;32(2):425-36.
48 Effects of anticonvulsants on human p450c17 (17alpha-hydroxylase/17,20 lyase) and 3beta-hydroxysteroid dehydrogenase type 2. Epilepsia. 2005 Mar;46(3):444-8.
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