Details of Disease

General Information of Disease (ID: DISDH7NI)

• Disease Name: Pancreas disorder
• Synonyms: pancreatic disease; diseases, pancreatic; disease, pancreatic; pancreatic disorder; pancreas disease or disorder; pancreas disease; disorder of pancreas; disease or disorder of pancreas; disease of pancreas
• Definition: A non-neoplastic or neoplastic disorder that affects the pancreas. Representative examples of non-neoplastic disorders include pancreatitis and pancreatic insufficiency. Representative examples of neoplastic disorders include cystadenomas, carcinomas, lymphomas, and neuroendocrine neoplasms.
• Disease Hierarchy:
  DISWD40R: Disease
  DIS7JDYJ: Gastrointestinal disease
  DISRGY2N: Endocrine disease
  DISDH7NI: Pancreas disorder
• Disease Identifiers:
  MONDO ID: MONDO_0002356
  MESH ID: D010182
  UMLS CUI: C0030286
  MedGen ID: 14583
  SNOMED CT ID: 3855007

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 16 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CFTR	TTRLZHP	Limited	Biomarker	[1]
AGER	TTMO9HF	Strong	Biomarker	[2]
ALB	TTFNGC9	Strong	Biomarker	[3]
CEL	TTTRNQW	Strong	Biomarker	[4]
CPA1	TT3LJ6G	Strong	Biomarker	[5]
HMOX1	TTI6V2A	Strong	Therapeutic	[6]
IAPP	TTHN8EM	Strong	Biomarker	[7]
LEPR	TT0HD6V	Strong	Biomarker	[8]
NPTX2	TTNJ5A6	Strong	Biomarker	[9]
PPY	TTIB95A	Strong	Biomarker	[10]
SCT	TTOBVIN	Strong	Biomarker	[11]
SLC26A9	TTKRVU0	Strong	Biomarker	[12]
SLCO1B3	TTU86P0	Strong	Altered Expression	[13]
SPP1	TT8ME6I	Strong	Biomarker	[14]
UBC	TTBP3XA	Strong	Biomarker	[15]
CTSE	TTLXC4Q	Definitive	Altered Expression	[16]

This Disease Is Related to 3 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
ABCD1	DTKM9DZ	Strong	Biomarker	[17]
SLC25A13	DTDSYAQ	Strong	Genetic Variation	[18]
SLC26A2	DTFSLX5	Strong	Biomarker	[19]

This Disease Is Related to 17 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
GPC1	OTQKRSSV	Disputed	Altered Expression	[20]
AZU1	OTHXU264	Strong	Biomarker	[21]
CELA3B	OTGU8BE9	Strong	Genetic Variation	[22]
CHGB	OT7SAQT2	Strong	Biomarker	[23]
DTD1	OT63V2KK	Strong	Biomarker	[19]
GP2	OTB6TMGY	Strong	Biomarker	[24]
PKD2	OTIXBU8H	Strong	Genetic Variation	[25]
PRSS2	OTOMVUWL	Strong	Altered Expression	[26]
RPLP2	OT2YBK3W	Strong	Biomarker	[27]
RPS27A	OTIIGGZ2	Strong	Biomarker	[15]
SAV1	OTSAEV92	Strong	Genetic Variation	[28]
SBDS	OTHDCCIB	Strong	Biomarker	[29]
SPINK1	OTSUVAL2	Strong	Biomarker	[30]
STK25	OT4YPNTF	Strong	Biomarker	[31]
TIGAR	OTR7NMRJ	Strong	Biomarker	[32]
TPM2	OTA1L0P8	Strong	Biomarker	[33]
PTRH2	OTBU39Q1	Definitive	Genetic Variation	[34]

References

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• [27] Upregulation of CD39/NTPDases and P2 receptors in human pancreatic disease.Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G223-30. doi: 10.1152/ajpgi.00259.2006. Epub 2006 Aug 17.
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• [33] Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry.Cancer Res. 2004 Dec 15;64(24):9018-26. doi: 10.1158/0008-5472.CAN-04-3262.
• [34] Phenotype variability of infantile-onset multisystem neurologic, endocrine, and pancreatic disease IMNEPD. Orphanet J Rare Dis. 2016 Apr 29;11(1):52. doi: 10.1186/s13023-016-0433-z.