Details of Disease

General Information of Disease (ID: DISQ5AO6)

• Disease Name: Gonorrhea
• Synonyms: papular acrodermatitis of childhood; infections, Neisseria gonorrhoeae; acrodermatitis, papular infantile; acrodermatitis, infantile lichenoid; PAS; PAC; Gianotti Crosti syndrome; Crosti-gianotti syndrome; chronic gonococcal infectious disease of upper genitourinary tract; chronic gonococcal infectious disease of lower genitourinary tract; Neisseria gonorrhoeae infection; GC
• Disease Class: 1A7Z: Gonococcal infection
• Definition: A common sexually transmitted bacterial infection caused by Neisseria gonorrhoeae. It is transmitted through vaginal, oral, or anal intercourse. Infected individuals may be asymptomatic. Symptoms in males include burning sensation during urination, discharge from the penis, and painful swelling of the testes. Symptoms in females include painful urination, vaginal discharge, and vaginal bleeding between periods. If untreated, the infection may lead to pelvic inflammatory disease.
• Disease Hierarchy:
  DIS8ZVFW: Primary bacterial infectious disease
  DISK46TO: Bacterial sexually transmitted disease
  DISEM33Q: Infectious disease
  DISQ5AO6: Gonorrhea
• ICD Code: ICD-11: ICD-11: 1A7Z
• Disease Identifiers:
  MONDO ID: MONDO_0004277
  MESH ID: D006069
  UMLS CUI: C0018081
  MedGen ID: 9077
  Orphanet ID: 100642
  SNOMED CT ID: 15628003

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
GSK4348413A	DMQDJIL	Phase 1	Vaccine	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 11 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
MUC16	TTC1PS3	Limited	Biomarker	[2]
BCL6	TTC9YX5	Strong	Biomarker	[3]
BRSK1	TTV6WMQ	Strong	Genetic Variation	[4]
FDPS	TTIKWV4	Strong	Biomarker	[5]
FURIN	TTH9WF6	Strong	Altered Expression	[6]
GPR182	TTT23CG	Strong	Biomarker	[7]
KIF26B	TTQWICZ	Strong	Altered Expression	[8]
NPR2	TTNB7IF	Strong	Genetic Variation	[9]
TIGIT	TTWNL74	Strong	Biomarker	[10]
UMPS	TTAFJUD	Strong	Biomarker	[11]
ZAP70	TTUMHT8	Strong	Biomarker	[12]

This Disease Is Related to 2 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
HINT1	DEWJATF	moderate	Altered Expression	[13]
SULT2A1	DE0P6LK	Strong	Biomarker	[12]

This Disease Is Related to 51 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
C4BPA	OTHNH6Y8	Limited	Biomarker	[14]
C4BPB	OTJ70B0K	Limited	Biomarker	[14]
CIB2	OT9ZJX1I	Limited	Biomarker	[15]
CPXM2	OTDJNOTR	Limited	Biomarker	[16]
GPRASP1	OTPYQYUD	Limited	Biomarker	[17]
HDGFL2	OTWX2GHS	Limited	Altered Expression	[18]
HOXA10	OTB6GQ09	Limited	Biomarker	[19]
INTS13	OTWE6180	Limited	Biomarker	[20]
NDUFAB1	OTF906UR	Limited	Altered Expression	[21]
RAI14	OT6USGBK	Limited	Altered Expression	[22]
SARS1	OTFKXQ1O	Limited	Biomarker	[23]
SARS2	OTU4T99W	Limited	Biomarker	[23]
THEMIS	OTXODBXJ	Limited	Biomarker	[17]
TFAP2E	OTA4B1SG	Disputed	Genetic Variation	[24]
HSPH1	OTVRR73T	moderate	Biomarker	[25]
ILF2	OTWWVM9X	moderate	Biomarker	[26]
RASSF6	OT25GVWY	moderate	Biomarker	[27]
RGS3	OTYG5OXI	moderate	Altered Expression	[28]
ADGRF1	OTRAOBYH	Strong	Biomarker	[29]
AHCYL1	OTX8L3M5	Strong	Altered Expression	[30]
ARPP21	OTWXZN5I	Strong	Biomarker	[31]
CKAP5	OTEMFY7X	Strong	Biomarker	[32]
CUL4B	OT2QX4DO	Strong	Biomarker	[33]
DMTN	OTDTKPBW	Strong	Genetic Variation	[34]
EMP1	OTSZHUHQ	Strong	Altered Expression	[35]
FOXL2	OTFRQUYL	Strong	Genetic Variation	[36]
GKN1	OT7ZYFQ9	Strong	Biomarker	[37]
GSC	OT4DH7PR	Strong	Biomarker	[5]
HLA-F	OT76CM19	Strong	Altered Expression	[38]
INPPL1	OTCDAVBQ	Strong	Altered Expression	[39]
IRF4	OT1DHQ1P	Strong	Altered Expression	[40]
KIF2A	OT2WQ6QD	Strong	Altered Expression	[41]
LZTFL1	OTIEIOEW	Strong	Altered Expression	[42]
MATN1	OTBRTCTQ	Strong	Biomarker	[43]
MAX	OTKZ0YKM	Strong	Biomarker	[44]
MCRS1	OT8K2X8P	Strong	Biomarker	[45]
MPZL2	OTKFNDUI	Strong	Biomarker	[46]
MTA2	OTCCYIQJ	Strong	Biomarker	[47]
NID2	OTHC33FF	Strong	Altered Expression	[48]
NPVF	OTIMUS0X	Strong	Biomarker	[49]
PPFIA3	OTNPZ6HT	Strong	Posttranslational Modification	[50]
PRDM4	OTD9PAZJ	Strong	Biomarker	[51]
PWWP3A	OTXQVL4U	Strong	Altered Expression	[40]
RAP1B	OTHEIIMM	Strong	Altered Expression	[52]
RD3	OT2L9Y6M	Strong	Biomarker	[53]
SPACA9	OTVRFX49	Strong	Biomarker	[54]
SPG21	OTMKJSYS	Strong	Biomarker	[54]
TEAD4	OTJS0T2B	Strong	Biomarker	[55]
TMEM8B	OTJZWPS6	Strong	Altered Expression	[56]
TNMD	OTHLVA9G	Strong	Biomarker	[57]
TSC22D3	OT03UM03	Strong	Altered Expression	[58]

References

• [1] Clinical pipeline report, company report or official report of GlaxoSmithKline
• [2] Clinicopathological features and prognosis in elderly gastric cancer patients: a retrospective cohort study.Onco Targets Ther. 2018 Mar 12;11:1353-1362. doi: 10.2147/OTT.S152471. eCollection 2018.
• [3] Germinal center-derived lymphomas: The darkest side of humoral immunity.Immunol Rev. 2019 Mar;288(1):214-239. doi: 10.1111/imr.12755.
• [4] Putative Tumor Suppressor Genes EGR1 and BRSK1 Are Mutated in Gastric and Colorectal Cancers.Oncology. 2016;91(5):289-294. doi: 10.1159/000450616. Epub 2016 Sep 28.
• [5] Glucocorticoids decrease the numbers and activation of mast cells by inducing the transactivation receptors of AGEs.J Leukoc Biol. 2019 Jan;105(1):131-142. doi: 10.1002/JLB.3A0917-364RR. Epub 2018 Sep 10.
• [6] Expression of the gonococcal global regulatory protein Fur and genes encompassing the Fur and iron regulon during in vitro and in vivo infection in women.J Bacteriol. 2008 May;190(9):3129-39. doi: 10.1128/JB.01830-07. Epub 2008 Feb 29.
• [7] Analysis of the potential for point-of-care test to enable individualised treatment of infections caused by antimicrobial-resistant and susceptible strains of Neisseria gonorrhoeae: a modelling study.BMJ Open. 2017 Jun 14;7(6):e015447. doi: 10.1136/bmjopen-2016-015447.
• [8] KIF26B, a novel oncogene, promotes proliferation and metastasis by activating the VEGF pathway in gastric cancer. Oncogene. 2017 Oct 5;36(40):5609-5619.
• [9] BCL-6 mutations are associated with immunoglobulin variable heavy chain mutations in B-cell chronic lymphocytic leukemia.Cancer Res. 2000 Oct 15;60(20):5644-8.
• [10] Co-inhibition of TIGIT, PD1, and Tim3 reverses dysfunction of Wilms tumor protein-1 (WT1)-specific CD8+ T lymphocytes after dendritic cell vaccination in gastric cancer.Am J Cancer Res. 2018 Aug 1;8(8):1564-1575. eCollection 2018.
• [11] Impact of intratumoral expression levels of fluoropyrimidine-metabolizing enzymes on treatment outcomes of adjuvant S-1 therapy in gastric cancer.PLoS One. 2015 Mar 20;10(3):e0120324. doi: 10.1371/journal.pone.0120324. eCollection 2015.
• [12] Single and Repeated Use of the Emergency Department for Chlamydia and Gonorrhea Care.Sex Transm Dis. 2020 Jan;47(1):14-18. doi: 10.1097/OLQ.0000000000001087.
• [13] Clinical significance of expression of Hint1 and potential epigenetic mechanism in gastric cancer.Int J Oncol. 2011 Jun;38(6):1557-64. doi: 10.3892/ijo.2011.994. Epub 2011 Apr 4.
• [14] C4BP-IgM protein as a therapeutic approach to treat Neisseria gonorrhoeae infections.JCI Insight. 2019 Dec 5;4(23):e131886. doi: 10.1172/jci.insight.131886.
• [15] Expression of p21(Wafl/Cip1), p57(Kip2) and HER2/neu in patients with gallbladder cancer.Anticancer Res. 2007 May-Jun;27(3B):1679-84.
• [16] Overexpression of CPXM2 predicts an unfavorable prognosis and promotes the proliferation and migration of gastric cancer.Oncol Rep. 2019 Oct;42(4):1283-1294. doi: 10.3892/or.2019.7254. Epub 2019 Jul 30.
• [17] Summary and Trends of the Russian Gonococcal Antimicrobial Surveillance Programme, 2005 to 2016.J Clin Microbiol. 2019 May 24;57(6):e02024-18. doi: 10.1128/JCM.02024-18. Print 2019 Jun.
• [18] Analysis of key genes and signaling pathways involved in Helicobacter pylori-associated gastric cancer based on The Cancer Genome Atlas database and RNA sequencing data.Helicobacter. 2018 Oct;23(5):e12530. doi: 10.1111/hel.12530. Epub 2018 Sep 2.
• [19] HOXA10 induces BCL2 expression, inhibits apoptosis, and promotes cell proliferation in gastric cancer.Cancer Med. 2019 Sep;8(12):5651-5661. doi: 10.1002/cam4.2440. Epub 2019 Jul 30.
• [20] Fine map of the Gct1 spontaneous ovarian granulosa cell tumor locus.Mamm Genome. 2013 Feb;24(1-2):63-71. doi: 10.1007/s00335-012-9439-6. Epub 2012 Nov 18.
• [21] Structure of the Recombinant Neisseria gonorrhoeae Adhesin Complex Protein (rNg-ACP) and Generation of Murine Antibodies with Bactericidal Activity against Gonococci.mSphere. 2018 Oct 10;3(5):e00331-18. doi: 10.1128/mSphere.00331-18.
• [22] High Expression of Retinoic Acid Induced 14 (RAI14) in Gastric Cancer and Its Prognostic Value.Med Sci Monit. 2018 Apr 14;24:2244-2251. doi: 10.12659/msm.910133.
• [23] Surface enhanced Raman spectroscopy of Chlamydia trachomatis and Neisseria gonorrhoeae for diagnostics, and extra-cellular metabolomics and biochemical monitoring.Sci Rep. 2018 Mar 26;8(1):5163. doi: 10.1038/s41598-018-23562-5.
• [24] Efficacy of decitabine-loaded gelatinases-stimuli nanoparticles in overcoming cancer drug resistance is mediated via its enhanced demethylating activity to transcription factor AP-2 epsilon.Oncotarget. 2017 Sep 26;8(70):114495-114505. doi: 10.18632/oncotarget.21274. eCollection 2017 Dec 29.
• [25] Nuclear heat shock protein 110 expression is associated with poor prognosis and hyperthermo-chemotherapy resistance in gastric cancer patients with peritoneal metastasis.World J Gastroenterol. 2017 Nov 14;23(42):7541-7550. doi: 10.3748/wjg.v23.i42.7541.
• [26] Expression and Clinical Significance of ILF2 in Gastric Cancer.Dis Markers. 2017;2017:4387081. doi: 10.1155/2017/4387081. Epub 2017 Jul 31.
• [27] miR-181a-5p promotes the progression of gastric cancer via RASSF6-mediated MAPK signalling activation.Cancer Lett. 2017 Mar 28;389:11-22. doi: 10.1016/j.canlet.2016.12.033. Epub 2016 Dec 30.
• [28] Regulator of G-protein signaling 3 targeted by miR-126 correlates with poor prognosis in gastric cancer patients.Anticancer Drugs. 2017 Feb;28(2):161-169. doi: 10.1097/CAD.0000000000000446.
• [29] Clinicopathological and prognostic significance of aberrant G protein-couple receptor 110 (GPR110) expression in gastric cancer.Pathol Res Pract. 2019 Mar;215(3):539-545. doi: 10.1016/j.prp.2018.12.004. Epub 2018 Dec 6.
• [30] Low IRBIT Levels Are Associated With Chemo-resistance in Gastric Cancer Patients.Anticancer Res. 2019 Aug;39(8):4111-4116. doi: 10.21873/anticanres.13569.
• [31] Evaluation of the Digene Hybrid Capture II Assay with the Rapid Capture System for detection of Chlamydia trachomatis and Neisseria gonorrhoeae.J Clin Microbiol. 2002 Oct;40(10):3558-64. doi: 10.1128/JCM.40.10.3558-3564.2002.
• [32] Gentamicin as an alternative to ceftriaxone in the treatment of gonorrhoea: the G-TOG non-inferiority RCT.Health Technol Assess. 2019 May;23(20):1-104. doi: 10.3310/hta23200.
• [33] miR?81 and miR?89 suppress cell proliferation and invasion by targeting CUL4B via the Wnt/catenin pathway in gastric cancer.Int J Oncol. 2019 Feb;54(2):733-743. doi: 10.3892/ijo.2018.4646. Epub 2018 Nov 26.
• [34] A Single Dose of 5-MeO-DMT Stimulates Cell Proliferation, Neuronal Survivability, Morphological and Functional Changes in Adult Mice Ventral Dentate Gyrus.Front Mol Neurosci. 2018 Sep 4;11:312. doi: 10.3389/fnmol.2018.00312. eCollection 2018.
• [35] Down-regulation of EMP1 is associated with epithelial hyperplasia and metaplasia in nasal polyps.Histopathology. 2013 Nov;63(5):686-95. doi: 10.1111/his.12211. Epub 2013 Aug 29.
• [36] FOXL2: a central transcription factor of the ovary.J Mol Endocrinol. 2013 Dec 19;52(1):R17-33. doi: 10.1530/JME-13-0159. Print 2014 Feb.
• [37] GKN1 expression in gastric cancer cells is negatively regulated by miR-544a.Biochimie. 2019 Dec;167:42-48. doi: 10.1016/j.biochi.2019.09.005. Epub 2019 Sep 8.
• [38] Lesion HLA-F expression is irrelevant to prognosis for patients with gastric cancer.Hum Immunol. 2013 Jul;74(7):828-32. doi: 10.1016/j.humimm.2013.03.002. Epub 2013 Mar 27.
• [39] Circulating SHIP2 mRNA as a novel biomarker in the diagnosis and prognosis of gastric cancer.Eur Rev Med Pharmacol Sci. 2017 Nov;21(22):5129-5134. doi: 10.26355/eurrev_201711_13829.
• [40] BCL3 rearrangement, amplification and expression in diffuse large B-cell lymphoma.Eur J Haematol. 2011 Dec;87(6):480-5. doi: 10.1111/j.1600-0609.2011.01684.x. Epub 2011 Aug 19.
• [41] KIF2A Overexpression and Its Association with Clinicopathologic Characteristics and Poor Prognoses in Patients with Gastric Cancer.Dis Markers. 2016;2016:7484516. doi: 10.1155/2016/7484516. Epub 2016 Sep 28.
• [42] LZTFL1 suppresses gastric cancer cell migration and invasion through regulating nuclear translocation of -catenin.J Cancer Res Clin Oncol. 2014 Dec;140(12):1997-2008. doi: 10.1007/s00432-014-1753-9. Epub 2014 Jul 9.
• [43] Utilizing complement evasion strategies to design complement-based antibacterial immunotherapeutics: Lessons from the pathogenic Neisseriae.Immunobiology. 2016 Oct;221(10):1110-23. doi: 10.1016/j.imbio.2016.05.016. Epub 2016 Jun 1.
• [44] Evaluation of the BD MAX?Vaginal Panel for the detection of vaginal infections in a sexual health service in the UK.Int J STD AIDS. 2019 Mar;30(4):411-414. doi: 10.1177/0956462418815284. Epub 2019 Jan 8.
• [45] Effects of MCRS1 on proliferation, migration, invasion, and epithelial mesenchymal transition of gastric cancer cells by interacting with Pkmyt1 protein kinase.Cell Signal. 2019 Jul;59:171-181. doi: 10.1016/j.cellsig.2019.04.002. Epub 2019 Apr 3.
• [46] Il n'y a pas d'amour heureux pour Casanova: Chemical- and bio-analysis of his Memoirs.Electrophoresis. 2019 Dec;40(23-24):3050-3056. doi: 10.1002/elps.201800505. Epub 2019 Apr 15.
• [47] Video-based education versus nurse-led education for partner notification in Thai women with sexually transmitted infections: a randomized controlled trial.Int J STD AIDS. 2018 Nov;29(11):1076-1083. doi: 10.1177/0956462418775507. Epub 2018 May 22.
• [48] NID2 can serve as a potential prognosis prediction biomarker and promotes the invasion and migration of gastric cancer.Pathol Res Pract. 2019 Oct;215(10):152553. doi: 10.1016/j.prp.2019.152553. Epub 2019 Jul 23.
• [49] RFRP-3, the mammalian ortholog of GnIH, induces cell cycle arrest at G2/M in porcine ovarian granulosa cells.Peptides. 2018 Mar;101:106-111. doi: 10.1016/j.peptides.2018.01.006. Epub 2018 Jan 11.
• [50] Detection of OSR2, VAV3, and PPFIA3 Methylation in the Serum of Patients with Gastric Cancer.Dis Markers. 2016;2016:5780538. doi: 10.1155/2016/5780538. Epub 2016 Apr 7.
• [51] Identification of recurrence-related genes by integrating microRNA and gene expression profiling of gastric cancer.Int J Oncol. 2012 Dec;41(6):2166-74. doi: 10.3892/ijo.2012.1637. Epub 2012 Sep 24.
• [52] Expression of RAP1B is associated with poor prognosis and promotes an aggressive phenotype in gastric cancer.Oncol Rep. 2015 Nov;34(5):2385-94. doi: 10.3892/or.2015.4234. Epub 2015 Sep 1.
• [53] Retinal Degeneration Protein 3 (RD3) in normal human tissues: Novel insights.Sci Rep. 2017 Oct 13;7(1):13154. doi: 10.1038/s41598-017-13337-9.
• [54] Increase in Gonorrhea Incidence Associated With Enhanced Partner Notification Strategy.Sex Transm Dis. 2019 Nov;46(11):706-712. doi: 10.1097/OLQ.0000000000001060.
• [55] Verteporfin targeting YAP1/TAZ-TEAD transcriptional activity inhibits the tumorigenic properties of gastric cancer stem cells.Int J Cancer. 2020 Apr 15;146(8):2255-2267. doi: 10.1002/ijc.32667. Epub 2019 Sep 30.
• [56] DNA promoter and histone H3 methylation downregulate NGX6 in gastric cancer cells.Med Oncol. 2014 Jan;31(1):817. doi: 10.1007/s12032-013-0817-z. Epub 2013 Dec 14.
• [57] Gonococcal Antimicrobial Susceptibility and the Prevalence of bla(TEM-1) and bla(TEM-135) Genes in Neisseria gonorrhoeae Isolates from Thailand.Jpn J Infect Dis. 2017 Mar 24;70(2):213-215. doi: 10.7883/yoken.JJID.2016.209. Epub 2016 Aug 31.
• [58] Predicting PTSD: pre-existing vulnerabilities in glucocorticoid-signaling and implications for preventive interventions.Brain Behav Immun. 2013 May;30:12-21. doi: 10.1016/j.bbi.2012.08.015. Epub 2012 Sep 5.