Details of Disease

General Information of Disease (ID: DISQ5KRA)

• Disease Name: Aortic aneurysm
• Synonyms: ruptured thoracic aortic aneurysm; thoracic aortic aneurysm which HAS ruptured; aortic aneurysm; ruptured abdominal aortic aneurysm; abdominal aortic aneurysm, ruptured; thoracic aortic aneurysm, ruptured; thoracoabdominal aortic aneurysm, ruptured; ruptured thoracic aneurysm; aortic aneurysm (disease); ruptured thoracoabdominal aortic aneurysm; aortic aneurysm of unspecified site, ruptured; ruptured aortic aneurysm
• Disease Class: BD50: Aneurysm/dissection
• Definition: A ruptured aneurysm located in the wall of the proximal portion of the descending aorta proceeding from the arch of the aorta.
• Disease Hierarchy:
  DISKXISV: Aortic disorder
  DISQ5KRA: Aortic aneurysm
• ICD Code:
  ICD-11: ICD-11: BD50
  Expand ICD-11: 'BD50
  Expand ICD-10: 'I71; 'I71.0; 'I71.8; 'I71.9
• Disease Identifiers:
  MONDO ID: MONDO_0005160
  MESH ID: D001014
  UMLS CUI: C0003486
  MedGen ID: 362
  HPO ID: HP:0004942
  SNOMED CT ID: 67362008

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
CRD-007	DMBRJYC	Phase 2	NA	[1]

This Disease is Treated as An Indication in 2 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
VDA-1124	DMN62VE	Investigative	NA	[2]
WAY-644	DMNCZEQ	Investigative	NA	[3]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 21 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CTSK	TTDZN01	Limited	Biomarker	[4]
SMAD3	TTHQZV7	Limited	Biomarker	[5]
TGFBR2	TTZE3P7	Limited	Genetic Variation	[6]
HBEGF	TT15SL0	Disputed	Biomarker	[7]
MMP9	TT6X50U	moderate	Genetic Variation	[8]
ADAMTS5	TTXSU2Y	Strong	Biomarker	[9]
AOC3	TT7HC21	Strong	Biomarker	[10]
APOE	TTKS9CB	Strong	Biomarker	[11]
CASP4	TT6KIOT	Strong	Altered Expression	[12]
CTSA	TT5NILS	Strong	Biomarker	[13]
F10	TTCIHJA	Strong	Biomarker	[14]
FCGRT	TTKLPHO	Strong	Genetic Variation	[15]
GAA	TTLPC70	Strong	Biomarker	[16]
LOX	TTQHNAM	Strong	Biomarker	[17]
LYVE1	TTG8DNU	Strong	Genetic Variation	[18]
MMP17	TTVSZKN	Strong	Altered Expression	[19]
PDGFD	TTSN0GA	Strong	Biomarker	[20]
RTN4	TT7GXMU	Strong	Altered Expression	[21]
SERPINE1	TTTO43N	Strong	Altered Expression	[22]
SMAD6	TTON5JB	Strong	Genetic Variation	[23]
AGT	TT5C0UB	Definitive	Biomarker	[24]

This Disease Is Related to 2 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC25A37	DTLBGTZ	Strong	Biomarker	[11]
SLC2A10	DT3BI6S	Strong	Altered Expression	[25]

This Disease Is Related to 33 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
FBLN5	OTLVNZ8U	Limited	Biomarker	[26]
OSR1	OTB19LEQ	Disputed	Biomarker	[27]
TBX20	OTMPU2XQ	moderate	Biomarker	[28]
ACTA2	OTEDLG8E	Strong	Genetic Variation	[29]
ADAMTS7	OTVKZ1DV	Strong	Biomarker	[30]
ARHGAP18	OTYMJP6H	Strong	Altered Expression	[31]
ARIH1	OTO3XDR2	Strong	Biomarker	[32]
BICD1	OT78IYPF	Strong	Biomarker	[33]
BTBD8	OT3A3RD7	Strong	Biomarker	[34]
COL3A1	OTT1EMLM	Strong	Biomarker	[35]
COQ8B	OTBY50BD	Strong	Genetic Variation	[36]
COX2	OTTMVBJJ	Strong	Altered Expression	[37]
EFEMP2	OT0I2B4J	Strong	Genetic Variation	[38]
ELN	OTFSO7PG	Strong	Altered Expression	[11]
FBN1	OTYCJT63	Strong	Genetic Variation	[39]
FOXO4	OT90X9LN	Strong	Altered Expression	[40]
KLF15	OTGMQMVR	Strong	Genetic Variation	[41]
KRTDAP	OTPGRZLY	Strong	Biomarker	[33]
LOXL1	OTA0NEJU	Strong	Altered Expression	[42]
MBD4	OTWR9YXE	Strong	Biomarker	[43]
MED18	OT6M6CQ8	Strong	Biomarker	[44]
MYH10	OTXN2WXS	Strong	Biomarker	[26]
MYH11	OTVNVWY3	Strong	Biomarker	[45]
PPP1R42	OTN1HRBN	Strong	Biomarker	[18]
RBBP8	OTRHJ3GI	Strong	Genetic Variation	[46]
RBM8A	OT5SR6G0	Strong	Genetic Variation	[18]
RGS1	OTGXJYMG	Strong	Biomarker	[47]
RNASE13	OT5GGAGZ	Strong	Genetic Variation	[48]
SKI	OT4KJ8F6	Strong	Biomarker	[49]
SPATC1L	OTED6WB8	Strong	Genetic Variation	[48]
TRIP13	OTFM3TI9	Strong	Biomarker	[50]
TSHZ1	OTYQ9ECW	Strong	Genetic Variation	[51]
TSPYL2	OTGGW2EF	Strong	Biomarker	[52]

References

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