Details of Disease

General Information of Disease (ID: DISVKEHV)

• Disease Name: Pancytopenia
• Disease Class: 3A70: Aplastic anaemia
• Definition: A finding of low numbers of red and white blood cells and platelets in the peripheral blood.
• Disease Hierarchy:
  DISI8W45: Anaemia
  DISVKEHV: Pancytopenia
• ICD Code:
  ICD-11: ICD-11: 3A70.Z
  Expand ICD-11: '3A70.Z
• Disease Identifiers:
  MONDO ID: MONDO_0001529
  MESH ID: D010198
  UMLS CUI: C0030312
  MedGen ID: 18281
  HPO ID: HP:0001876
  SNOMED CT ID: 127034005

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Hyaluronate sodium	DMX8M26	Approved	Small molecular drug	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 25 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
GPI	TT19JIZ	Limited	Biomarker	[2]
THPO	TTCG5PE	Limited	Altered Expression	[3]
PRKAR1A	TTNAHEX	moderate	Biomarker	[4]
SF3B1	TTL2WUI	moderate	Genetic Variation	[5]
BRCA2	TTUARD6	Strong	Biomarker	[6]
BRIP1	TTZV7LJ	Strong	Biomarker	[7]
CSNK1A1	TTFQEMX	Strong	Biomarker	[8]
DCPS	TTLSW9V	Strong	Biomarker	[9]
DGKZ	TTSBBXL	Strong	Biomarker	[10]
DOT1L	TTSZ8T1	Strong	Biomarker	[11]
DUT	TTH6MBO	Strong	Biomarker	[12]
EPO	TTQG4NR	Strong	Biomarker	[13]
FANCA	TTV5HJS	Strong	Genetic Variation	[14]
FANCF	TTNZKFJ	Strong	Biomarker	[7]
HOXA11	TTEX4ZA	Strong	Genetic Variation	[15]
IDS	TTNY2AP	Strong	Biomarker	[16]
LIPA	TTS8T1M	Strong	Altered Expression	[17]
MPL	TTIHYA4	Strong	Biomarker	[18]
RUNX1	TTWIN3H	Strong	Biomarker	[19]
SLC46A1	TTY8Z2E	Strong	Biomarker	[20]
TBXAS1	TTKNWZ4	Strong	Genetic Variation	[21]
TCL1A	TTUKRDV	Strong	Genetic Variation	[22]
TERT	TTQY2EJ	Strong	Genetic Variation	[23]
TPP1	TTOVYPT	Strong	Genetic Variation	[24]
DHFR	TTYZVDJ	Definitive	Biomarker	[25]

This Disease Is Related to 3 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
ADH5	DEIOH6A	Strong	Genetic Variation	[26]
G6PC3	DEE1B8O	Strong	Genetic Variation	[27]
PGM3	DER0EN5	Strong	Genetic Variation	[28]

This Disease Is Related to 50 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
SBDS	OTHDCCIB	Limited	Genetic Variation	[29]
FANCM	OTNJG99Z	moderate	Biomarker	[7]
MECOM	OTP983W8	moderate	Genetic Variation	[30]
PRF1	OTFVXD7H	moderate	Altered Expression	[31]
RAD51C	OTUD6SY5	moderate	Biomarker	[7]
RPL27A	OTQQHPL0	moderate	Biomarker	[32]
ACD	OTC54EPO	Strong	Genetic Variation	[24]
CARTPT	OTTE4V9S	Strong	Altered Expression	[33]
CD48	OT83ZNPP	Strong	Biomarker	[2]
CDC73	OT6JASZ1	Strong	Biomarker	[34]
CTC1	OTRJY7QD	Strong	Genetic Variation	[35]
DERL1	OTJUS74N	Strong	Genetic Variation	[36]
DKC1	OTX7DJR6	Strong	Genetic Variation	[23]
DNAJC21	OT8C14QA	Strong	Biomarker	[37]
DOCK4	OTH3XY8B	Strong	Biomarker	[38]
E4F1	OTL5ESAC	Strong	Genetic Variation	[39]
FAAP20	OTDI1MIV	Strong	Biomarker	[40]
FANCB	OTMZTXB5	Strong	Biomarker	[7]
FANCC	OTTIDM3P	Strong	Biomarker	[41]
FANCE	OTKRPBW1	Strong	Biomarker	[7]
FANCG	OT7MC8TZ	Strong	Genetic Variation	[14]
FANCI	OTW8E3SC	Strong	Biomarker	[7]
FANCL	OTJC7QPQ	Strong	Biomarker	[7]
FLT3LG	OTU0YGC4	Strong	Biomarker	[42]
FUT1	OTODG57A	Strong	Biomarker	[43]
GATA2	OTBP2QQ2	Strong	Genetic Variation	[44]
LIG4	OT40DNXU	Strong	Biomarker	[45]
MAD2L2	OT24ZO59	Strong	Altered Expression	[46]
MOCOS	OT0TL3Q5	Strong	Biomarker	[47]
MPIG6B	OTVNKQWA	Strong	Genetic Variation	[48]
MYSM1	OTO73N00	Strong	Biomarker	[49]
NABP2	OTQU8081	Strong	Biomarker	[50]
PALB2	OT6DNDBG	Strong	Biomarker	[6]
PARN	OTTG4PE3	Strong	Genetic Variation	[51]
PRB1	OTV0SYMD	Strong	Biomarker	[52]
RHOJ	OTWI65OA	Strong	Biomarker	[53]
RPS14	OTB90KV5	Strong	Biomarker	[54]
RTEL1	OTI3PJCT	Strong	Biomarker	[55]
SAA2	OTYAVJWG	Strong	Genetic Variation	[55]
SAMD9	OTDG48P0	Strong	Biomarker	[56]
SAMD9L	OTKEJUCI	Strong	Genetic Variation	[56]
SLURP1	OT89YD2E	Strong	Biomarker	[9]
SLX4	OTF6236I	Strong	Biomarker	[7]
SPSB1	OTGY26U4	Strong	Biomarker	[50]
SRI	OT4R3EAC	Strong	Biomarker	[52]
TCN2	OT41D0L3	Strong	Biomarker	[57]
TSN	OTOFAQ2Z	Strong	Biomarker	[58]
NHEJ1	OTYOO05J	Definitive	Genetic Variation	[59]
RASA3	OT9C54MN	Definitive	Biomarker	[60]
RECQL4	OT59LSW7	Definitive	Biomarker	[61]

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