Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTW0YNSL)

DOT Name RNA-binding protein NOB1 (NOB1)
Synonyms EC 3.1.-.-; Phosphorylation regulatory protein HP-10; Protein ART-4
Gene Name NOB1
Related Disease
Epithelial ovarian cancer ( )
Adult glioblastoma ( )
Bone osteosarcoma ( )
Colon cancer ( )
Colon carcinoma ( )
Colorectal carcinoma ( )
Gastric cancer ( )
Glioblastoma multiforme ( )
Hepatocellular carcinoma ( )
Malignant glioma ( )
Non-small-cell lung cancer ( )
Obesity ( )
Osteosarcoma ( )
Pancreatic cancer ( )
Prostate cancer ( )
Prostate carcinoma ( )
Stomach cancer ( )
Thyroid gland papillary carcinoma ( )
Breast cancer ( )
Breast carcinoma ( )
Carcinoma ( )
Metastatic malignant neoplasm ( )
Squamous cell carcinoma ( )
Glioma ( )
Invasive ductal breast carcinoma ( )
Ovarian cancer ( )
Ovarian neoplasm ( )
Thyroid tumor ( )
UniProt ID
NOB1_HUMAN
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
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PDB ID
6G18; 6G4S; 6G51; 6G53; 6G5I; 6ZUO; 6ZXD; 6ZXE; 6ZXF; 7WTW; 7WTX; 7WTZ; 7WU0
EC Number
3.1.-.-
Pfam ID
PF08772 ; PF17146 ; PF15017
Sequence
MAPVEHVVADAGAFLRHAALQDIGKNIYTIREVVTEIRDKATRRRLAVLPYELRFKEPLP
EYVRLVTEFSKKTGDYPSLSATDIQVLALTYQLEAEFVGVSHLKQEPQKVKVSSSIQHPE
TPLHISGFHLPYKPKPPQETEKGHSACEPENLEFSSFMFWRNPLPNIDHELQELLIDRGE
DVPSEEEEEEENGFEDRKDDSDDDGGGWITPSNIKQIQQELEQCDVPEDVRVGCLTTDFA
MQNVLLQMGLHVLAVNGMLIREARSYILRCHGCFKTTSDMSRVFCSHCGNKTLKKVSVTV
SDDGTLHMHFSRNPKVLNPRGLRYSLPTPKGGKYAINPHLTEDQRFPQLRLSQKARQKTN
VFAPDYIAGVSPFVENDISSRSATLQVRDSTLGAGRRRLNPNASRKKFVKKR
Function May play a role in mRNA degradation (Probable). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits.
Tissue Specificity Detected in liver, lung, placenta, endothelial cells and spleen.
KEGG Pathway
Ribosome biogenesis in eukaryotes (hsa03008 )
Reactome Pathway
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226 )

Molecular Interaction Atlas (MIA) of This DOT

28 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Epithelial ovarian cancer DIS56MH2 Definitive Biomarker [1]
Adult glioblastoma DISVP4LU Strong Altered Expression [2]
Bone osteosarcoma DIST1004 Strong Biomarker [3]
Colon cancer DISVC52G Strong Biomarker [4]
Colon carcinoma DISJYKUO Strong Biomarker [4]
Colorectal carcinoma DIS5PYL0 Strong Altered Expression [5]
Gastric cancer DISXGOUK Strong Altered Expression [6]
Glioblastoma multiforme DISK8246 Strong Altered Expression [2]
Hepatocellular carcinoma DIS0J828 Strong Altered Expression [7]
Malignant glioma DISFXKOV Strong Altered Expression [8]
Non-small-cell lung cancer DIS5Y6R9 Strong Altered Expression [9]
Obesity DIS47Y1K Strong Genetic Variation [10]
Osteosarcoma DISLQ7E2 Strong Biomarker [3]
Pancreatic cancer DISJC981 Strong Altered Expression [11]
Prostate cancer DISF190Y Strong Altered Expression [12]
Prostate carcinoma DISMJPLE Strong Altered Expression [12]
Stomach cancer DISKIJSX Strong Altered Expression [6]
Thyroid gland papillary carcinoma DIS48YMM Strong Biomarker [13]
Breast cancer DIS7DPX1 moderate Biomarker [14]
Breast carcinoma DIS2UE88 moderate Biomarker [14]
Carcinoma DISH9F1N moderate Altered Expression [15]
Metastatic malignant neoplasm DIS86UK6 moderate Biomarker [16]
Squamous cell carcinoma DISQVIFL moderate Altered Expression [17]
Glioma DIS5RPEH Limited Altered Expression [11]
Invasive ductal breast carcinoma DIS43J58 Limited Biomarker [18]
Ovarian cancer DISZJHAP Limited Altered Expression [19]
Ovarian neoplasm DISEAFTY Limited Altered Expression [19]
Thyroid tumor DISLVKMD Limited Altered Expression [20]
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⏷ Show the Full List of 28 Disease(s)
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
6 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate decreases the expression of RNA-binding protein NOB1 (NOB1). [21]
Ciclosporin DMAZJFX Approved Ciclosporin increases the expression of RNA-binding protein NOB1 (NOB1). [22]
Tretinoin DM49DUI Approved Tretinoin decreases the expression of RNA-binding protein NOB1 (NOB1). [23]
Ivermectin DMDBX5F Approved Ivermectin decreases the expression of RNA-binding protein NOB1 (NOB1). [24]
Phenobarbital DMXZOCG Approved Phenobarbital affects the expression of RNA-binding protein NOB1 (NOB1). [25]
PMID28460551-Compound-2 DM4DOUB Patented PMID28460551-Compound-2 increases the expression of RNA-binding protein NOB1 (NOB1). [27]
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⏷ Show the Full List of 6 Drug(s)
3 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene decreases the methylation of RNA-binding protein NOB1 (NOB1). [26]
PMID28870136-Compound-52 DMFDERP Patented PMID28870136-Compound-52 affects the phosphorylation of RNA-binding protein NOB1 (NOB1). [28]
Coumarin DM0N8ZM Investigative Coumarin increases the phosphorylation of RNA-binding protein NOB1 (NOB1). [28]
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References

1 MicroRNA-215 targets NOB1 and inhibits growth and invasion of epithelial ovarian cancer.Am J Transl Res. 2017 Feb 15;9(2):466-477. eCollection 2017.
2 MicroRNA-139-3p suppresses growth and metastasis of glioblastoma via inhibition of NIN1/RPNI2 binding protein 1 homolog.Eur Rev Med Pharmacol Sci. 2019 May;23(10):4264-4274. doi: 10.26355/eurrev_201905_17931.
3 Long non-coding RNA ZFAS1 regulates NOB1 expression through interacting with miR-646 and promotes tumorigenesis in osteosarcoma.Eur Rev Med Pharmacol Sci. 2019 Apr;23(8):3206-3216. doi: 10.26355/eurrev_201904_17679.
4 Lentivirus-mediated knockdown of NOB1 suppresses the proliferation of colon cancer cells.Z Gastroenterol. 2014 May;52(5):429-35. doi: 10.1055/s-0033-1356338. Epub 2014 May 13.
5 Low-level miR-646 in colorectal cancer inhibits cell proliferation and migration by targeting NOB1 expression.Oncol Lett. 2017 Dec;14(6):6708-6714. doi: 10.3892/ol.2017.7032. Epub 2017 Sep 22.
6 EXPRESSION MECHANISM AND CLINICAL SIGNIFICANCE OF NOB1 IN GASTRIC CANCER TISSUE AND ADJACENT NORMAL TISSUE.J Biol Regul Homeost Agents. 2015 Apr-Jun;29(2):423-30.
7 Downregulation of NIN/RPN12 binding protein inhibit the growth of human hepatocellular carcinoma cells.Mol Biol Rep. 2012 Jan;39(1):501-7. doi: 10.1007/s11033-011-0764-8. Epub 2011 May 15.
8 MicroRNA-326 functions as a tumor suppressor in glioma by targeting the Nin one binding protein (NOB1).PLoS One. 2013 Jul 15;8(7):e68469. doi: 10.1371/journal.pone.0068469. Print 2013.
9 miR?45 inhibits human nonsmall-cell lung cancer growth by dual-targeting RIOK2 and NOB1.Int J Oncol. 2018 Jul;53(1):257-265. doi: 10.3892/ijo.2018.4393. Epub 2018 May 3.
10 Diet-dependent obesity and hypercholesterolemia in the New Zealand obese mouse: identification of a quantitative trait locus for elevated serum cholesterol on the distal mouse chromosome 5.Biochem Biophys Res Commun. 2003 May 16;304(4):812-7. doi: 10.1016/s0006-291x(03)00664-8.
11 NOB1: A Potential Biomarker or Target in Cancer.Curr Drug Targets. 2019;20(10):1081-1089. doi: 10.2174/1389450120666190308145346.
12 MiR-192 suppresses the tumorigenicity of prostate cancer cells by targeting and inhibiting nin one binding protein.Int J Mol Med. 2016 Feb;37(2):485-92. doi: 10.3892/ijmm.2016.2449. Epub 2016 Jan 5.
13 MicroRNA?44 suppresses cell proliferation and invasion of papillary thyroid cancer by directly targeting NOB1.Mol Med Rep. 2019 Mar;19(3):1903-1910. doi: 10.3892/mmr.2019.9826. Epub 2019 Jan 4.
14 siRNA mediated silencing of NIN1/RPN12 binding protein 1 homolog inhibits proliferation and growth of breast cancer cells.Asian Pac J Cancer Prev. 2012;13(5):1823-7. doi: 10.7314/apjcp.2012.13.5.1823.
15 Expression and clinical significance of the nin one binding protein and p38 MAPK in prostate carcinoma.Int J Clin Exp Pathol. 2013 Oct 15;6(11):2300-11. eCollection 2013.
16 MicroRNA-326 functions as a tumor suppressor in colorectal cancer by targeting the nin one binding protein.Oncol Rep. 2015 May;33(5):2309-18. doi: 10.3892/or.2015.3840. Epub 2015 Mar 6.
17 Downregulation of NOB1 inhibits proliferation and promotes apoptosis in human oral squamous cell carcinoma.Oncol Rep. 2015 Dec;34(6):3077-87. doi: 10.3892/or.2015.4271. Epub 2015 Sep 11.
18 Clinical significance of NOB1 expression in breast infiltrating ductal carcinoma.Int J Clin Exp Pathol. 2013 Sep 15;6(10):2137-44. eCollection 2013.
19 MicroRNA-363 inhibits ovarian cancer progression by inhibiting NOB1.Oncotarget. 2017 Sep 30;8(60):101649-101658. doi: 10.18632/oncotarget.21417. eCollection 2017 Nov 24.
20 Expression of the NOB1 gene and its clinical significance in papillary thyroid carcinoma.J Int Med Res. 2013 Jun;41(3):568-72. doi: 10.1177/0300060513479862. Epub 2013 May 17.
21 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
22 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
23 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
24 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
25 Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
26 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
27 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
28 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.