General Information of Disease (ID: DISFXKOV)

Disease Name Malignant glioma
Synonyms
neuroglial tumour; neuroglial tumor; glioma; malignant neuroglial tumor; high-grade glioma; glioma, malignant; malignant glial tumor; malignant neuroglial tumour; malignant glial tumour; malignant neuroglial neoplasm; malignant glioma; high grade glioma; malignant glial neoplasm; glial cell tumour; glial cell tumor
Disease Class 2A00: Brain cancer
Definition
A grade III or grade IV glioma arising from the central nervous system. This category includes glioblastoma, anaplastic astrocytoma, anaplastic ependymoma, anaplastic oligodendroglioma, and anaplastic oligoastrocytoma.
Disease Hierarchy
DISNVYSW: Central nervous system cancer
DIS5RPEH: Glioma
DISSW7QU: High grade malignant neoplasm
DISFXKOV: Malignant glioma
ICD Code
ICD-11
ICD-11: 2A00.0
ICD-9
ICD-9: 191
Expand ICD-9
191
Disease Identifiers
MONDO ID
MONDO_0100342
MESH ID
D005910
UMLS CUI
C0555198
MedGen ID
107826
SNOMED CT ID
74532006

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 7 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Aminolevulinic acid hci DMS4BLQ Approved Small molecular drug [1]
Armodafinil DMGB035 Approved Small molecular drug [2]
DTI-015 DMXZRW0 Approved Small molecular drug [3]
Granisetron DMIUW25 Approved Small molecular drug [4]
Modafinil DMYILBE Approved Small molecular drug [5]
Ondansetron DMOTQ1I Approved Small molecular drug [6]
Temozolomide DMKECZD Approved Small molecular drug [7]
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⏷ Show the Full List of 7 Drug(s)
This Disease is Treated as An Indication in 14 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Aglatimagene besadenovec DMACVU8 Phase 3 Gene therapy [8]
CP-868596 DMZIM37 Phase 3 Small molecular drug [9]
Marizomib DME9QGW Phase 3 Small molecular drug [9]
Pelareorep DM4WCF9 Phase 3 NA [9]
VB-111 DMX04CA Phase 3 NA [9]
Ad-RTS-hIL-12 DMCNTFW Phase 2 Gene therapy [9]
AVO113 DM520FB Phase 2 NA [10]
Anti-EGFRvIII CAR transduced PBL DMDKTYU Phase 1/2 CAR T Cell Therapy [11]
Anti-MUC1 CAR-T cells DMTQIB2 Phase 1/2 CAR T Cell Therapy [12]
CAR-T cells targeting EphA2 DMN3C2I Phase 1/2 CAR T Cell Therapy [13]
NEO100 DMI7SUU Phase 1/2 NA [14]
NUV-422 DMQJQNT Phase 1/2 Small molecule [15]
Taniraleucel DMGRKDC Phase 1/2 Cell therapy [16]
PEP-CMV DMLOWQ6 Phase 1 Vaccine [17]
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⏷ Show the Full List of 14 Drug(s)
This Disease is Treated as An Indication in 2 Patented Agent(s)
Drug Name Drug ID Highest Status Drug Type REF
PMID27828716-Compound-BIO-acetoxime DMUM5L6 Patented Small molecular drug [18]
TDZD-8 DMG6Q45 Patented Small molecular drug [18]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 143 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ATG7 TTLVB9Z Limited Therapeutic [19]
BDKRB2 TTGY8IW Limited Biomarker [20]
BMI1 TTIPNSR Limited Biomarker [21]
CAT TTPS279 Limited Altered Expression [22]
CAV1 TTXUBN2 Limited Biomarker [23]
CCR4 TT7HQD0 Limited Biomarker [24]
CD70 TTNCIE0 Limited Altered Expression [25]
CLCN2 TT30NW6 Limited Biomarker [26]
CLCN3 TT8XNZ7 Limited Biomarker [26]
F2 TT6L509 Limited Therapeutic [27]
FBXW7 TT29KY7 Limited Biomarker [28]
FTH1 TT975ZT Limited Biomarker [29]
HLA-B TTGS10J Limited Biomarker [30]
IDH1 TTV2A1R Limited Genetic Variation [31]
IL12A TTRTK6Y Limited Therapeutic [32]
IL12B TTGW72V Limited Therapeutic [32]
LGALS3 TTFPQV7 Limited ModifyingMutation [33]
MYB TT8V13P Limited Biomarker [34]
MYLK TT18ETS Limited Biomarker [35]
NTRK1 TTTDVOJ Limited Genetic Variation [36]
NTRK2 TTKN7QR Limited Biomarker [37]
PPM1D TTENJAB Limited Biomarker [38]
PTEN TTXJ3W7 Limited Biomarker [39]
ROS1 TTSZ6Y3 Limited Genetic Variation [40]
SH3GL1 TTTYNAM Limited ModifyingMutation [41]
SIRT2 TTLKF5M Limited Therapeutic [42]
SLC5A5 TTW7HI9 Limited Genetic Variation [43]
SLC6A3 TTVBI8W Limited Biomarker [44]
TFRC TT8MG4S Limited Biomarker [45]
TNFSF10 TTA5MS9 Limited Biomarker [46]
TOP2A TTCGY2K Limited Biomarker [47]
GPNMB TT7315J Disputed Biomarker [48]
AKT2 TTH24WI moderate Biomarker [49]
BRAF TT0EOB8 moderate Genetic Variation [50]
FGF2 TTGKIED moderate Biomarker [51]
GJA1 TT4F7SL moderate Biomarker [52]
MMP2 TTLM12X moderate Biomarker [53]
PTGS2 TTVKILB moderate Biomarker [54]
SLC38A3 TTMAVJQ moderate Altered Expression [55]
ACKR1 TTKY2NS Strong Altered Expression [56]
ACVR1 TTJNBQA Strong Biomarker [57]
AKT3 TTO6SGY Strong Biomarker [49]
ANGPT2 TTKLQTJ Strong Biomarker [58]
ARAF TT5TURO Strong Altered Expression [59]
AREG TT76B3W Strong Biomarker [60]
ATM TTKBM7V Strong Altered Expression [61]
ATP1A1 TTWK8D0 Strong Biomarker [62]
AURKB TT9RTBL Strong Biomarker [63]
BIRC5 TTTPU1G Strong Biomarker [64]
CA9 TT2LVK8 Strong Biomarker [65]
CALCR TTLWS2O Strong Biomarker [66]
CASP6 TTKW4ML Strong Biomarker [67]
CBX7 TTBN3HC Strong Altered Expression [68]
CD2 TTJDUNO Strong Biomarker [69]
CD80 TT89Z17 Strong Biomarker [70]
CDK2 TT7HF4W Strong Biomarker [71]
CDK7 TTQYF7G Strong Biomarker [72]
CNTN2 TT2Z1WB Strong Biomarker [73]
CSF1 TT0IQER Strong Biomarker [74]
CTSB TTF2LRI Strong Biomarker [75]
CXCR3 TT1UCIJ Strong Biomarker [76]
CYP2B6 TTMH124 Strong Genetic Variation [77]
DCN TTB3XAN Strong Biomarker [78]
DEPDC1 TT8S9CM Strong Altered Expression [79]
DUSP5 TTZN92A Strong Altered Expression [80]
EEF2K TT1QFLA Strong Altered Expression [81]
EGF TTED8JB Strong Biomarker [82]
EGFL7 TT7WD0H Strong Biomarker [83]
EIF2AK4 TT9U4EP Strong Biomarker [84]
EIF4EBP2 TTNBTCW Strong Biomarker [85]
EPOR TTAUX24 Strong Biomarker [86]
ERBB2 TTR5TV4 Strong Biomarker [87]
EREG TTYSB89 Strong Biomarker [88]
FABP3 TT3TGLR Strong Biomarker [89]
FASLG TTO7014 Strong Biomarker [90]
FGFR1 TTRLW2X Strong Altered Expression [91]
FZD7 TTUQMO5 Strong Biomarker [92]
GAST TT4LRVO Strong Biomarker [93]
GDNF TTF23ML Strong Altered Expression [94]
GFAP TTI6FFX Strong Altered Expression [95]
GJB6 TTAU8SJ Strong Altered Expression [96]
GRIA2 TTWM461 Strong Altered Expression [97]
GRM3 TT8A9EF Strong Biomarker [98]
GRM4 TTICZ1O Strong Biomarker [98]
GSTP1 TT40K12 Strong Biomarker [99]
HLA-A TTHONFT Strong Biomarker [30]
HMGB1 TTWQYB7 Strong Therapeutic [100]
HOXA13 TTN26OM Strong Biomarker [101]
HRAS TT28ZON Strong Biomarker [102]
IFNB1 TT4TZ8J Strong Biomarker [103]
IL13 TT0GVCH Strong Biomarker [104]
IL13RA2 TTMPZ7V Strong Biomarker [105]
IL4R TTDWHC3 Strong Altered Expression [106]
IL7 TT8FRMO Strong Biomarker [70]
KCNJ3 TTGM19J Strong Altered Expression [107]
KDM4A TTZHPB8 Strong Altered Expression [108]
KHK TTPAFR9 Strong Altered Expression [109]
LAMP1 TTC214J Strong Altered Expression [110]
LASP1 TTZJA87 Strong Biomarker [111]
LILRB1 TTC0QRJ Strong Biomarker [112]
MBP TT2RY5P Strong Biomarker [113]
MDK TTV8UE7 Strong Biomarker [114]
MDM4 TT9OUDQ Strong Biomarker [73]
MELK TTBZOTY Strong Biomarker [115]
MKI67 TTB4UNG Strong Biomarker [116]
MRC2 TTYVR8M Strong Altered Expression [117]
MSI1 TTSM4BA Strong Altered Expression [118]
MVD TTE5J6X Strong Biomarker [119]
NEK2 TT3VZ24 Strong Altered Expression [120]
NES TTHZ752 Strong Biomarker [95]
NPTX2 TTNJ5A6 Strong Biomarker [121]
NTRK3 TTXABCW Strong Biomarker [37]
PCSK6 TT75LN9 Strong Biomarker [122]
PDE4C TT6A59G Strong Posttranslational Modification [123]
PDGFRA TT8FYO9 Strong Genetic Variation [36]
PLK1 TTH4IP0 Strong Biomarker [124]
PLTP TTZF6SN Strong Altered Expression [125]
PPIB TT6ZFQ4 Strong Altered Expression [126]
PPME1 TTXQ54R Strong Altered Expression [127]
RAF1 TTAN5W2 Strong Biomarker [128]
RBPJ TT72D4Z Strong Altered Expression [129]
SLC1A5 TTF7WRM Strong Biomarker [130]
SLC38A1 TT1YE9Z Strong Biomarker [130]
SLC38A5 TTC8YPT Strong Biomarker [130]
SLK TT8K4DE Strong Biomarker [131]
SMYD3 TTKLJYX Strong Biomarker [132]
SOD1 TTP9K3Q Strong Therapeutic [133]
SPHK1 TTOHFIY Strong Biomarker [134]
SPP1 TT8ME6I Strong Biomarker [135]
STMN1 TT7W5OT Strong Biomarker [136]
TAGLN2 TTP6BIJ Strong Biomarker [137]
TERT TTQY2EJ Strong Genetic Variation [138]
TGFB2 TTI0KH6 Strong Biomarker [139]
TK1 TTP3QRF Strong Biomarker [140]
TNC TTUCPMY Strong Biomarker [141]
TP53 TT12KOD Strong Genetic Variation [31]
TPO TT52XDZ Strong Genetic Variation [142]
TRIM24 TT9Q7AE Strong Biomarker [143]
TRIM28 TTQ2BKV Strong Altered Expression [144]
TRPM7 TTFPVZO Strong Biomarker [145]
APLNR TTJ8E43 Definitive Altered Expression [146]
KLK6 TTLPF4X Definitive Altered Expression [147]
PLCB1 TTLPGU7 Definitive Biomarker [148]
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⏷ Show the Full List of 143 DTT(s)
This Disease Is Related to 2 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC34A1 DT42EWA moderate Biomarker [149]
SLC27A3 DTEW95J Strong Biomarker [150]
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This Disease Is Related to 3 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
CYP27B1 DE3FYEM Strong Biomarker [77]
CYP4B1 DEMF740 Strong Biomarker [151]
DCTD DEXL3P2 Strong Biomarker [152]
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This Disease Is Related to 163 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
APOD OTT77XW8 Limited Biomarker [153]
ATRX OT77RSQW Limited Biomarker [154]
CAV2 OT1FGRQX Limited Biomarker [23]
CDKN2B OTAG24N1 Limited Biomarker [155]
CHI3L1 OT2Z7VJH Limited Biomarker [156]
CLCN5 OT9YXZSO Limited Biomarker [26]
DMXL1 OTWVL31L Limited Biomarker [153]
FABP7 OTRE2H4G Limited Biomarker [157]
FAM107A OTBG61YZ Limited Biomarker [153]
H3-3B OT9XHQ3C Limited Genetic Variation [158]
HLA-C OTV38BUJ Limited Biomarker [30]
HMGN5 OTUUAHVQ Limited Biomarker [159]
MYBL1 OTBJMC2P Limited Biomarker [128]
PCMT1 OTGYVSGU Limited Biomarker [160]
PHEX OTG7N3J7 Limited Altered Expression [161]
PHLDB1 OTIRCB6I Limited Biomarker [155]
PSD3 OTTN9B9O Limited Biomarker [153]
QKI OTTAUGLB Limited Biomarker [34]
RTEL1 OTI3PJCT Limited Genetic Variation [162]
TRIM29 OT2DNESG Limited Biomarker [163]
NF1 OTC29NHH Disputed Biomarker [164]
SUZ12 OT655XF8 Disputed Biomarker [164]
ATF5 OT03QCLM moderate Altered Expression [165]
CREB3L2 OT09MHV0 moderate Altered Expression [166]
LTBP1 OTR7Q75L moderate Altered Expression [167]
TREX1 OTQG7K12 moderate Altered Expression [168]
ADA2 OTGCV24S Strong Biomarker [169]
ADGRB1 OTJSEXRC Strong Altered Expression [170]
ADGRB3 OT1EWGRW Strong Altered Expression [171]
ADGRE2 OTUYJVYG Strong Altered Expression [172]
ADGRE5 OTTSB84Q Strong Altered Expression [172]
AJAP1 OTAAW121 Strong Altered Expression [173]
ALDH1A3 OT1C9NKQ Strong Biomarker [174]
ANKRD49 OTG9XX92 Strong Biomarker [175]
AQP4 OTA9MYD5 Strong Biomarker [176]
ATP1B2 OTYTBYVU Strong Biomarker [153]
ATP6V0A2 OTJBDX0Y Strong Altered Expression [177]
AZIN2 OT8OB7CG Strong Biomarker [178]
BAD OT63ERYM Strong Biomarker [179]
BCAN OTPVY3ZR Strong Biomarker [180]
BEX1 OTBQIF0H Strong Biomarker [181]
BEX2 OT4G5SIC Strong Biomarker [181]
BHLHE22 OTZUQY5L Strong Altered Expression [182]
BIK OTTH1T3D Strong Biomarker [183]
BRMS1L OTJIW47U Strong Altered Expression [184]
C1QL1 OTNQ0G3E Strong Biomarker [185]
CASD1 OT1YB54Z Strong Biomarker [186]
CBFA2T2 OTNOIB23 Strong Biomarker [187]
CCNO OT68CH0B Strong Biomarker [188]
CD109 OTDADBM4 Strong Biomarker [189]
CD93 OT6HZT6H Strong Altered Expression [190]
CMTM6 OT70T27A Strong Altered Expression [191]
CPEB1 OTLCXC6H Strong Genetic Variation [192]
CPEB4 OTW1SCZW Strong Genetic Variation [192]
CREB3L1 OT2JHIHM Strong Genetic Variation [193]
CTSZ OTSCX2LL Strong Altered Expression [194]
DCT OTYVNTBG Strong Biomarker [195]
DMBT1 OTVNU9D9 Strong Genetic Variation [196]
DOCK1 OTCFV3ON Strong Biomarker [197]
DSC3 OTYG47F8 Strong Biomarker [198]
ECRG4 OTHZYUXX Strong Posttranslational Modification [199]
ECT2 OTQDUCT6 Strong Altered Expression [200]
EFEMP1 OTZVUOOB Strong Biomarker [201]
EFS OT06O7XL Strong Biomarker [202]
EIF4A2 OT08H03R Strong Biomarker [85]
EIF4G1 OT2CF1E6 Strong Biomarker [85]
EMC10 OTQ6S50X Strong Genetic Variation [203]
EMP1 OTSZHUHQ Strong Biomarker [204]
EMP3 OTODMJ1D Strong Biomarker [205]
ENOPH1 OTKXMWNN Strong Biomarker [206]
EPS8 OTZ6ES6V Strong Biomarker [207]
FADD OTV7GFHH Strong Biomarker [208]
FBXO17 OTDSRA7P Strong Altered Expression [209]
FIG4 OT501PY9 Strong Biomarker [210]
GADD45A OTDRV63V Strong Biomarker [211]
GADL1 OTJM4A0R Strong Biomarker [178]
GALNT2 OTZZ5386 Strong Biomarker [212]
GIPC1 OTXLVCPJ Strong Biomarker [213]
GLS2 OT08MSHL Strong Altered Expression [107]
GNL3 OTILGYO4 Strong Altered Expression [214]
GOLPH3 OTDLGYM3 Strong Biomarker [215]
GOPC OTRBGH71 Strong Genetic Variation [40]
GOT2 OT6XBWN0 Strong Biomarker [157]
GPR26 OTBDYUOH Strong Biomarker [216]
GSC OT4DH7PR Strong Altered Expression [217]
HCLS1 OTX7WGYN Strong Altered Expression [218]
HHLA2 OTYBTVQS Strong Altered Expression [219]
HRG OTPLUFOG Strong Biomarker [220]
IDH2 OTTQA4PB Strong Genetic Variation [221]
IKBKE OT5VYOSM Strong Biomarker [222]
IL17RA OTVVI8ER Strong Altered Expression [217]
ITGA3 OTBCH21D Strong Biomarker [223]
ITGA7 OTTBTAYW Strong Altered Expression [224]
KAZALD1 OTSFOX2H Strong Biomarker [225]
KIF23 OTY850JC Strong Altered Expression [226]
KLF8 OTUC5CDB Strong Biomarker [227]
LAT OTZC1XZ1 Strong Genetic Variation [228]
LAYN OT9A9Q1X Strong Altered Expression [229]
LGI1 OTPS77HO Strong Biomarker [230]
LIG4 OT40DNXU Strong Altered Expression [231]
LLGL1 OTAIQSXZ Strong Biomarker [232]
LRRN2 OTGP2DCY Strong Biomarker [233]
MACC1 OTV3DLX0 Strong Biomarker [234]
MBD3 OTRL76H5 Strong Biomarker [235]
MCM3AP OT895FEC Strong Biomarker [210]
MEF2D OT7CEIG0 Strong Biomarker [236]
MLST8 OT8DNJSD Strong Altered Expression [237]
MMP19 OTLSTT2B Strong Biomarker [238]
MPI OTBH6ZK1 Strong Biomarker [239]
MTCP1 OT4O23TK Strong Biomarker [240]
NLGN3 OTKDEC1Q Strong Altered Expression [241]
NOB1 OTW0YNSL Strong Altered Expression [242]
NOL3 OT1K0L0D Strong Biomarker [243]
NPAS3 OT8D1ILB Strong Altered Expression [244]
NUDT21 OTZHKWAR Strong Biomarker [245]
NUMB OTMB586Q Strong Biomarker [246]
OLIG2 OTMCN6D3 Strong Biomarker [247]
PCBP2 OTXCN9CG Strong Biomarker [248]
PCDH9 OTX3BFV4 Strong Altered Expression [249]
PCGF1 OTHOU68T Strong Biomarker [250]
PDCD5 OT6T2DDL Strong Biomarker [251]
PEA15 OTKCKTSX Strong Biomarker [252]
PEG10 OTWD2278 Strong Biomarker [253]
PID1 OT5YJ7FI Strong Altered Expression [254]
PIK3R2 OTZSUQK5 Strong Biomarker [187]
PPP1R12C OT9Q86JO Strong Biomarker [187]
PPP1R13B OTC88VQO Strong Biomarker [187]
PPP1R1A OTGTAGCV Strong Biomarker [255]
PRAF2 OT1QN4LV Strong Altered Expression [256]
PVR OT3N91T7 Strong Biomarker [257]
PXN OTVMMUOF Strong Altered Expression [258]
QPRT OT6SKKLL Strong Biomarker [259]
RAB27B OTPF9D0K Strong Altered Expression [260]
RABAC1 OTGB32NG Strong Altered Expression [256]
RANBP2 OTFG5CVF Strong Biomarker [195]
RASL10A OTEXTN6I Strong Altered Expression [261]
RDH16 OTCJ915F Strong Biomarker [250]
RHPN2 OTTYWMF6 Strong Biomarker [262]
RND3 OTXMXPIH Strong Biomarker [263]
SAMSN1 OT7N88T1 Strong Altered Expression [264]
SH3GL3 OTX6BOCN Strong Biomarker [122]
SIAH1 OT29A838 Strong Altered Expression [265]
SIGLEC7 OTNDLURR Strong Altered Expression [218]
SND1 OTT734JN Strong Biomarker [53]
SOX11 OT4LG7LA Strong Genetic Variation [266]
SOX7 OTOZOFAG Strong Biomarker [267]
ST6GAL1 OT7US3NO Strong Altered Expression [268]
TAX1BP3 OTQ6IB4T Strong Biomarker [269]
TEAD2 OTM8YMYT Strong Biomarker [222]
TET3 OT76U3YF Strong Altered Expression [270]
TFG OT2KJENI Strong Biomarker [271]
TFPI2 OTZCRWOR Strong Altered Expression [272]
THY1 OTVONVTB Strong Biomarker [273]
TRABD2B OTI7B18G Strong Altered Expression [274]
TRAF4 OTJLRVMC Strong Biomarker [275]
TRAP1 OTNG0L8J Strong Altered Expression [276]
TRIM11 OTMD6IM2 Strong Biomarker [277]
TSEN54 OT7MR9LY Strong Biomarker [278]
TSPAN8 OT1F68WQ Strong Altered Expression [279]
ANGPTL1 OTXIN6V5 Definitive Biomarker [280]
LHX9 OTDPEHC4 Definitive Altered Expression [281]
LRIG1 OTY5HZN5 Definitive Biomarker [282]
MCPH1 OTYT3TT5 Definitive Biomarker [283]
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⏷ Show the Full List of 163 DOT(s)

References

1 Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol. 2006 May;7(5):392-401.
2 Armodafinil FDA Label
3 Stereotactic injection of DTI-015 into recurrent malignant gliomas: phase I/II trial. Neoplasia. 2003 Jan-Feb;5(1):9-16.
4 Granisetron FDA Label
5 Modafinil FDA Label
6 Ondansetron FDA Label
7 Temozolomide FDA Label
8 ClinicalTrials.gov (NCT00589875) Phase 2a Study of AdV-tk With Standard Radiation Therapy for Malignant Glioma (BrTK02). U.S. National Institutes of Health.
9 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
10 Clinical pipeline report, company report or official report of Activartis Biotech.
11 ClinicalTrials.gov (NCT01454596) CAR T Cell Receptor Immunotherapy Targeting EGFRvIII for Patients With Malignant Gliomas Expressing EGFRvIII. U.S. National Institutes of Health.
12 ClinicalTrials.gov (NCT02617134) CAR-T Cell Immunotherapy in MUC1 Positive Solid Tumor
13 ClinicalTrials.gov (NCT02575261) CAR-T Cell Immunotherapy for EphA2 Positive Malignant Glioma Patients
14 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
15 ClinicalTrials.gov (NCT04541225) Phase 1/2 Dose Escalation, Safety, Pharmacokinetics, and Efficacy Study of NUV-422 in Adults With Recurrent or Refractory High-grade Gliomas and Solid Tumors. U.S.National Institutes of Health.
16 ClinicalTrials.gov (NCT05218408) A Phase I/IIa Open Label Multicenter, Non-Randomized, Trial to Assess the Safety and Efficacy of CYNK-001in Combination With Recombinant Human Interleukin-2 in Adults With Recurrent Resection Eligible IDH1 Wild-type Glioblastoma. U.S.National Institutes of Health.
17 ClinicalTrials.gov (NCT03299309) PEP-CMV in Recurrent MEdulloblastoma/Malignant Glioma (PRiME). U.S. National Institutes of Health.
18 Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666.
19 Autophagy inhibition improves the efficacy of curcumin/temozolomide combination therapy in glioblastomas.Cancer Lett. 2015 Mar 28;358(2):220-231. doi: 10.1016/j.canlet.2014.12.044. Epub 2014 Dec 24.
20 Selective tumor blood-brain barrier opening with the kinin B2 receptor agonist [Phe(8)psi(CH(2)NH)Arg(9)]-BK in a F98 glioma rat model: an MRI study.Neuropeptides. 2010 Apr;44(2):177-85. doi: 10.1016/j.npep.2009.12.009. Epub 2010 Jan 18.
21 Bmi-1 promotes glioma angiogenesis by activating NF-B signaling.PLoS One. 2013;8(1):e55527. doi: 10.1371/journal.pone.0055527. Epub 2013 Jan 31.
22 Differential activation of catalase expression and activity by PPAR agonists: implications for astrocyte protection in anti-glioma therapy.Redox Biol. 2013 Jan 26;1(1):70-9. doi: 10.1016/j.redox.2012.12.006. eCollection 2013.
23 Low-frequency ultrasound irradiation increases blood-tumor barrier permeability by transcellular pathway in a rat glioma model.J Mol Neurosci. 2012 Sep;48(1):281-90. doi: 10.1007/s12031-012-9770-0. Epub 2012 Apr 20.
24 Preferential migration of regulatory T cells mediated by glioma-secreted chemokines can be blocked with chemotherapy.Cancer Immunol Immunother. 2008 Jan;57(1):123-31. doi: 10.1007/s00262-007-0336-x. Epub 2007 May 24.
25 Identification of CD70-mediated apoptosis of immune effector cells as a novel immune escape pathway of human glioblastoma.Cancer Res. 2002 May 1;62(9):2592-9.
26 Expression of voltage-gated chloride channels in human glioma cells.J Neurosci. 2003 Jul 2;23(13):5572-82. doi: 10.1523/JNEUROSCI.23-13-05572.2003.
27 The role of thrombin in gliomas.J Thromb Haemost. 2005 Sep;3(9):1917-23. doi: 10.1111/j.1538-7836.2005.01446.x. Epub 2005 Jun 24.
28 Promoter hypermethylation is not the major mechanism for inactivation of the FBXW7 beta-form in human gliomas.Genes Genet Syst. 2008 Aug;83(4):347-52. doi: 10.1266/ggs.83.347.
29 Heavy chain ferritin siRNA delivered by cationic liposomes increases sensitivity of cancer cells to chemotherapeutic agents.Cancer Res. 2011 Mar 15;71(6):2240-9. doi: 10.1158/0008-5472.CAN-10-1375. Epub 2011 Mar 8.
30 Human alloreactive CTL interactions with gliomas and with those having upregulated HLA expression from exogenous IFN-gamma or IFN-gamma gene modification.J Interferon Cytokine Res. 2003 Jul;23(7):379-93. doi: 10.1089/107999003322226032.
31 Widely metastatic IDH1-mutant glioblastoma with oligodendroglial features and atypical molecular findings: a case report and review of current challenges in molecular diagnostics.Diagn Pathol. 2019 Feb 9;14(1):16. doi: 10.1186/s13000-019-0793-5.
32 A safety and efficacy study of local delivery of interleukin-12 transgene by PPC polymer in a model of experimental glioma.Anticancer Drugs. 2008 Feb;19(2):133-42. doi: 10.1097/CAD.0b013e3282f24017.
33 Galectin-3 in preneoplastic lesions of glioma.J Neurooncol. 2013 Jan;111(2):123-32. doi: 10.1007/s11060-012-1005-2. Epub 2012 Nov 23.
34 MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism.Nat Genet. 2016 Mar;48(3):273-82. doi: 10.1038/ng.3500. Epub 2016 Feb 1.
35 Glioma migration can be blocked by nontoxic inhibitors of myosin II.Cancer Res. 1999 May 1;59(9):2076-82.
36 Deep multiomics profiling of brain tumors identifies signaling networks downstream of cancer driver genes.Nat Commun. 2019 Aug 16;10(1):3718. doi: 10.1038/s41467-019-11661-4.
37 The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma.Nat Genet. 2014 May;46(5):444-450. doi: 10.1038/ng.2938. Epub 2014 Apr 6.
38 Combination of lentivirus-mediated silencing of PPM1D and temozolomide chemotherapy eradicates malignant glioma through cell apoptosis and cell cycle arrest.Oncol Rep. 2016 Nov;36(5):2544-2552. doi: 10.3892/or.2016.5089. Epub 2016 Sep 14.
39 PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding protein.Neuro Oncol. 2018 Sep 3;20(10):1344-1355. doi: 10.1093/neuonc/noy068.
40 Novel GOPC(FIG)-ROS1 fusion in a pediatric high-grade glioma survivor.J Neurosurg Pediatr. 2017 Jul;20(1):51-55. doi: 10.3171/2017.2.PEDS16679. Epub 2017 Apr 7.
41 Autologous antibody to src-homology 3-domain GRB2-like 1 specifically increases in the sera of patients with low-grade gliomas.J Exp Clin Cancer Res. 2012 Oct 11;31(1):85. doi: 10.1186/1756-9966-31-85.
42 Ultrasound-sensitive siRNA-loaded nanobubbles formed by hetero-assembly of polymeric micelles and liposomes and their therapeutic effect in gliomas.Biomaterials. 2013 Jun;34(18):4532-43. doi: 10.1016/j.biomaterials.2013.02.067. Epub 2013 Mar 19.
43 Glial fibrillary acidic protein promoters direct adenovirus early 1A gene and human telomerase reverse transcriptase promoters direct sodium iodide symporter expression for malignant glioma radioiodine therapy.Mol Cell Biochem. 2015 Jan;399(1-2):279-89. doi: 10.1007/s11010-014-2254-5. Epub 2014 Nov 20.
44 Alteration of striatal dopaminergic function induced by glioma development: a microdialysis and immunohistological study in the rat striatum.Neurosci Lett. 2004 Jan 9;354(2):131-4. doi: 10.1016/j.neulet.2003.10.005.
45 The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer.Clin Immunol. 2006 Nov;121(2):144-58. doi: 10.1016/j.clim.2006.06.010. Epub 2006 Aug 10.
46 Potential application of temozolomide in mesenchymal stem cell-based TRAIL gene therapy against malignant glioma.Stem Cells Transl Med. 2014 Feb;3(2):172-82. doi: 10.5966/sctm.2013-0132. Epub 2014 Jan 16.
47 DNA topoisomerase II-alpha as a proliferation marker in human gliomas: correlation with PCNA expression and patient survival.Clin Neuropathol. 2008 Mar-Apr;27(2):83-90. doi: 10.5414/npp27083.
48 Glycoprotein nonmetastatic melanoma protein B, a potential molecular therapeutic target in patients with glioblastoma multiforme.Clin Cancer Res. 2006 Apr 1;12(7 Pt 1):1970-82. doi: 10.1158/1078-0432.CCR-05-2797.
49 Genomically amplified Akt3 activates DNA repair pathway and promotes glioma progression.Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3421-6. doi: 10.1073/pnas.1414573112. Epub 2015 Mar 3.
50 TERT expression is susceptible to BRAF and ETS-factor inhibition in BRAF(V600E)/TERT promoter double-mutated glioma.Acta Neuropathol Commun. 2019 Aug 7;7(1):128. doi: 10.1186/s40478-019-0775-6.
51 Adenovirus-mediated delivery of bFGF small interfering RNA reduces STAT3 phosphorylation and induces the depolarization of mitochondria and apoptosis in glioma cells U251.J Exp Clin Cancer Res. 2011 Sep 9;30(1):80. doi: 10.1186/1756-9966-30-80.
52 Adjuvant therapeutic potential of tonabersat in the standard treatment of glioblastoma: Apreclinical F98 glioblastoma rat model study.PLoS One. 2019 Oct 21;14(10):e0224130. doi: 10.1371/journal.pone.0224130. eCollection 2019.
53 miR-361-5p inhibits glioma migration and invasion by targeting SND1.Onco Targets Ther. 2018 Aug 28;11:5239-5252. doi: 10.2147/OTT.S171539. eCollection 2018.
54 Evaluation of human glioma using in-vivo proton magnetic resonance spectroscopy combined with expression of cyclooxygenase-2: a preliminary clinical trial.Neuroreport. 2017 May 3;28(7):414-420. doi: 10.1097/WNR.0000000000000771.
55 Selective decrease of SN1(SNAT3) mRNA expression in human and rat glioma cells adapted to grow in acidic medium. Neurochem Int. 2006 May-Jun;48(6-7):547-52.
56 Herpes simplex virus 1 recombinant virions exhibiting the amino terminal fragment of urokinase-type plasminogen activator can enter cells via the cognate receptor.Gene Ther. 2006 Apr;13(7):621-9. doi: 10.1038/sj.gt.3302685.
57 Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations.Nat Genet. 2014 May;46(5):451-6. doi: 10.1038/ng.2936. Epub 2014 Apr 6.
58 Assessment of blood volume, vessel size, and the expression of angiogenic factors in two rat glioma models: a longitudinal in vivo and ex vivo study.NMR Biomed. 2008 Nov;21(10):1043-56. doi: 10.1002/nbm.1278.
59 RAF expression in human astrocytic tumors.Int J Mol Med. 2009 Jan;23(1):17-31.
60 Increased expression of schwannoma-derived growth factor (SDGF) mRNA in rat tumor cells: involvement of SDGF in the growth promotion of rat gliomas.Int J Cancer. 1996 May 3;66(3):352-7. doi: 10.1002/(SICI)1097-0215(19960503)66:3<352::AID-IJC15>3.0.CO;2-D.
61 Lack of correlation between ATM protein expression and tumour cell radiosensitivity.Int J Radiat Biol. 1998 Aug;74(2):217-24. doi: 10.1080/095530098141591.
62 The sodium pump 1 subunit regulates bufalin sensitivity of human glioblastoma cells through the p53 signaling pathway.Cell Biol Toxicol. 2019 Dec;35(6):521-539. doi: 10.1007/s10565-019-09462-y. Epub 2019 Feb 9.
63 Aurora kinase B/C inhibition impairs malignant glioma growth in vivo.J Neurooncol. 2012 Jul;108(3):349-60. doi: 10.1007/s11060-012-0835-2. Epub 2012 Mar 1.
64 Intracranial stereotaxic cannulation for development of orthotopic glioblastoma allograft in Sprague-Dawley rats and histoimmunopathological characterization of the brain tumor.Neurochem Res. 2007 Dec;32(12):2235-42. doi: 10.1007/s11064-007-9450-6. Epub 2007 Aug 15.
65 Targeting CAIX with [(64)Cu]XYIMSR-06 Small Molecular Radiotracer Enables Noninvasive PET Imaging of Malignant Glioma in U87 MG Tumor Cell Xenograft Mice.Mol Pharm. 2019 Apr 1;16(4):1532-1540. doi: 10.1021/acs.molpharmaceut.8b01210. Epub 2019 Mar 12.
66 Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas.BMC Cancer. 2019 Feb 18;19(1):157. doi: 10.1186/s12885-019-5369-y.
67 Combination of caspase transfer using the human telomerase reverse transcriptase promoter and conventional therapies for malignant glioma cells.Int J Oncol. 2004 Jul;25(1):57-63.
68 CBX7 is a glioma prognostic marker and induces G1/S arrest via the silencing of CCNE1. Oncotarget. 2017 Apr 18;8(16):26637-26647.
69 Influence of multiple delays in brain tumor and immune system interaction with T11 target structure as a potent stimulator.Math Biosci. 2018 Aug;302:116-130. doi: 10.1016/j.mbs.2018.06.001. Epub 2018 Jun 15.
70 Regression of intracerebral rat glioma isografts by therapeutic subcutaneous immunization with interferon-gamma, interleukin-7, or B7-1-transfected tumor cells.Cancer Gene Ther. 1999 Jan-Feb;6(1):37-44. doi: 10.1038/sj.cgt.7700023.
71 Adenoviral p16/CDKN2 gene transfer to malignant glioma: role of p16 in growth, invasion, and senescence.Oncol Rep. 2003 Sep-Oct;10(5):1121-6.
72 Cyclin-dependent kinase 7 is a therapeutic target in high-grade glioma.Oncogenesis. 2017 May 15;6(5):e336. doi: 10.1038/oncsis.2017.33.
73 Refined mapping of 1q32 amplicons in malignant gliomas confirms MDM4 as the main amplification target.Int J Cancer. 2003 May 10;104(6):752-7. doi: 10.1002/ijc.11023.
74 Antiangiogenic drugs synergize with a membrane macrophage colony-stimulating factor-based tumor vaccine to therapeutically treat rats with an established malignant intracranial glioma.J Immunol. 2005 Mar 1;174(5):2533-43. doi: 10.4049/jimmunol.174.5.2533.
75 Cytosolic activation of cathepsins mediates parvovirus H-1-induced killing of cisplatin and TRAIL-resistant glioma cells.J Virol. 2007 Apr;81(8):4186-98. doi: 10.1128/JVI.02601-06. Epub 2007 Feb 7.
76 Chemokine receptor CXCR3 promotes growth of glioma.Carcinogenesis. 2011 Feb;32(2):129-37. doi: 10.1093/carcin/bgq224. Epub 2010 Nov 3.
77 Towards a complete picture of splice variants of the gene for 25-hydroxyvitamin D31alpha-hydroxylase in brain and skin cancer.J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):527-32. doi: 10.1016/j.jsbmb.2004.03.062.
78 Inhibition of experimental rat glioma growth by decorin gene transfer is associated with decreased microglial infiltration.J Neuroimmunol. 1999 Sep 1;99(1):13-8. doi: 10.1016/s0165-5728(99)00062-4.
79 Functional analysis of the DEPDC1 oncoantigen in malignant glioma and brain tumor initiating cells.J Neurooncol. 2017 Jun;133(2):297-307. doi: 10.1007/s11060-017-2457-1. Epub 2017 May 29.
80 P68 RNA helicase promotes invasion of glioma cells through negatively regulating DUSP5.Cancer Sci. 2019 Jan;110(1):107-117. doi: 10.1111/cas.13858. Epub 2018 Dec 3.
81 Inhibition of elongation factor-2 kinase augments the antitumor activity of Temozolomide against glioma.PLoS One. 2013 Nov 26;8(11):e81345. doi: 10.1371/journal.pone.0081345. eCollection 2013.
82 Epidermal growth factor receptor promotes glioma progression by regulating xCT and GluN2B-containing N-methyl-d-aspartate-sensitive glutamate receptor signaling.Cancer Sci. 2018 Dec;109(12):3874-3882. doi: 10.1111/cas.13826. Epub 2018 Nov 5.
83 EGFL7: Master regulator of cancer pathogenesis, angiogenesis and an emerging mediator of bone homeostasis.J Cell Physiol. 2018 Nov;233(11):8526-8537. doi: 10.1002/jcp.26792. Epub 2018 Jun 19.
84 GCN2 is essential for CD8(+) T cell survival and function in murine models of malignant glioma.Cancer Immunol Immunother. 2020 Jan;69(1):81-94. doi: 10.1007/s00262-019-02441-6. Epub 2019 Dec 16.
85 Inhibition of eIF4F complex loading inhibits the survival of malignant glioma.Oncol Rep. 2018 Oct;40(4):2399-2407. doi: 10.3892/or.2018.6587. Epub 2018 Jul 20.
86 Targeting the erythropoietin receptor on glioma cells reduces tumour growth.Exp Cell Res. 2011 Oct 1;317(16):2321-32. doi: 10.1016/j.yexcr.2011.06.011. Epub 2011 Jun 30.
87 Replication-competent herpes simplex virus retargeted to HER2 as therapy for high-grade glioma.Mol Ther. 2012 May;20(5):994-1001. doi: 10.1038/mt.2012.22. Epub 2012 Feb 21.
88 High epiregulin expression in human U87 glioma cells relies on IRE1 and promotes autocrine growth through EGF receptor.BMC Cancer. 2013 Dec 13;13:597. doi: 10.1186/1471-2407-13-597.
89 Novel target for peptide-based imaging and treatment of brain tumors.Mol Cancer Ther. 2014 Apr;13(4):996-1007. doi: 10.1158/1535-7163.MCT-13-0684. Epub 2014 Feb 3.
90 CD95-mediated apoptosis of human glioma cells: modulation by epidermal growth factor receptor activity.Brain Pathol. 2002 Jan;12(1):12-20. doi: 10.1111/j.1750-3639.2002.tb00418.x.
91 FGFR1 Expression and Role in Migration in Low and High Grade Pediatric Gliomas.Front Oncol. 2019 Mar 13;9:103. doi: 10.3389/fonc.2019.00103. eCollection 2019.
92 MicroRNA-206 attenuates glioma cell proliferation, migration, and invasion by blocking the WNT/-catenin pathway via direct targeting of Frizzled 7 mRNA.Am J Transl Res. 2019 Jul 15;11(7):4584-4601. eCollection 2019.
93 Characterization of gastrin-induced cytostatic effect on cell proliferation in experimental malignant gliomas.Neurosurgery. 2003 Apr;52(4):881-90; discussion 890-1. doi: 10.1227/01.neu.0000053366.00088.80.
94 Egr-1 and RNA POL II facilitate glioma cell GDNF transcription induced by histone hyperacetylation in promoter II.Oncotarget. 2017 Jul 11;8(28):45105-45116. doi: 10.18632/oncotarget.15126.
95 In vitro neurosphere formation correlates with poor survival in glioma.IUBMB Life. 2019 Feb;71(2):244-253. doi: 10.1002/iub.1964. Epub 2018 Nov 4.
96 Connexin 30 expression inhibits growth of human malignant gliomas but protects them against radiation therapy.Neuro Oncol. 2015 Mar;17(3):392-406. doi: 10.1093/neuonc/nou215. Epub 2014 Aug 25.
97 Underediting of glutamate receptor GluR-B mRNA in malignant gliomas.Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14687-92. doi: 10.1073/pnas.251531398. Epub 2001 Nov 20.
98 Targeting metabotropic glutamate receptors in the treatment of primary brain tumors.Curr Opin Pharmacol. 2018 Feb;38:59-64. doi: 10.1016/j.coph.2018.02.005. Epub 2018 Mar 8.
99 In vitro drug response and molecular markers associated with drug resistance in malignant gliomas. Clin Cancer Res. 2006 Aug 1;12(15):4523-32. doi: 10.1158/1078-0432.CCR-05-1830.
100 Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases.Nature. 2000 May 18;405(6784):354-60. doi: 10.1038/35012626.
101 HOXA13 is a potential GBM diagnostic marker and promotes glioma invasion by activating the Wnt and TGF- pathways.Oncotarget. 2015 Sep 29;6(29):27778-93. doi: 10.18632/oncotarget.4813.
102 Ras-Induced miR-146a and 193a Target Jmjd6 to Regulate Melanoma Progression.Front Genet. 2018 Dec 18;9:675. doi: 10.3389/fgene.2018.00675. eCollection 2018.
103 Antitumorigenic effect of interferon- by inhibition of undifferentiated glioblastoma cells.Int J Oncol. 2015 Nov;47(5):1647-54. doi: 10.3892/ijo.2015.3165. Epub 2015 Sep 14.
104 Cintredekin besudotox in treatment of malignant glioma.Expert Opin Biol Ther. 2008 Jun;8(6):805-12. doi: 10.1517/14712598.8.6.805.
105 Induction of cytotoxic T lymphocytes specific to malignant glioma using T2 cells pulsed with HLA-A2-restricted interleukin-13 receptor alpha 2 peptide in vitro.Acta Biochim Biophys Sin (Shanghai). 2007 Sep;39(9):641-8. doi: 10.1111/j.1745-7270.2007.00331.x.
106 Decreasing expression of the interleukin-13 receptor IL-13Ralpha2 in treated recurrent malignant gliomas.Neurol Med Chir (Tokyo). 2010;50(8):617-21. doi: 10.2176/nmc.50.617.
107 Relative expression of mRNAS coding for glutaminase isoforms in CNS tissues and CNS tumors.Neurochem Res. 2008 May;33(5):808-13. doi: 10.1007/s11064-007-9507-6. Epub 2007 Oct 17.
108 Downregulation of KDM4A Suppresses the Survival of Glioma Cells by Promoting Autophagy.J Mol Neurosci. 2016 Oct;60(2):137-44. doi: 10.1007/s12031-016-0796-6. Epub 2016 Aug 11.
109 Ketohexokinase is involved in fructose utilization and promotes tumor progression in glioma.Biochem Biophys Res Commun. 2018 Sep 10;503(3):1298-1306. doi: 10.1016/j.bbrc.2018.07.040. Epub 2018 Jul 19.
110 LAMP-1 gene is overexpressed in high grade glioma.APMIS. 2018 Aug;126(8):657-662. doi: 10.1111/apm.12856. Epub 2018 Jun 19.
111 LIM and SH3 protein 1 induces glioma growth and invasion through PI3K/AKT signaling and epithelial-mesenchymal transition.Biomed Pharmacother. 2019 Aug;116:109013. doi: 10.1016/j.biopha.2019.109013. Epub 2019 May 27.
112 miR-7 inhibits glioblastoma growth by simultaneously interfering with the PI3K/ATK and Raf/MEK/ERK pathways.Int J Oncol. 2014 May;44(5):1571-80. doi: 10.3892/ijo.2014.2322. Epub 2014 Mar 5.
113 Adenovirus-mediated overexpression of Fas induces apoptosis of gliomas.Cancer Gene Ther. 2000 Feb;7(2):224-32. doi: 10.1038/sj.cgt.7700110.
114 Stimulation of the midkine/ALK axis renders glioma cells resistant to cannabinoid antitumoral action. Cell Death Differ. 2011 Jun;18(6):959-73. doi: 10.1038/cdd.2010.170. Epub 2011 Jan 14.
115 Tumor-specific activation of the C-JUN/MELK pathway regulates glioma stem cell growth in a p53-dependent manner.Stem Cells. 2013 May;31(5):870-81. doi: 10.1002/stem.1322.
116 Evaluation of biocompatibility and anti-glioma efficacy of doxorubicin and irinotecan drug-eluting bead suspensions in alginate.Clin Transl Oncol. 2012 Jan;14(1):50-9. doi: 10.1007/s12094-012-0761-y.
117 Downregulation of uPARAP mediates cytoskeletal rearrangements and decreases invasion and migration properties in glioma cells.J Neurooncol. 2011 Jun;103(2):267-76. doi: 10.1007/s11060-010-0398-z. Epub 2010 Sep 16.
118 Musashi1 enhances chemotherapy resistance of pediatric glioblastoma cells in vitro.Pediatr Res. 2020 Mar;87(4):669-676. doi: 10.1038/s41390-019-0628-9. Epub 2019 Nov 22.
119 HMGA1 expression in human gliomas and its correlation with tumor proliferation, invasion and angiogenesis.J Neurooncol. 2012 Feb;106(3):543-9. doi: 10.1007/s11060-011-0710-6. Epub 2011 Oct 8.
120 Overexpression of NIMA-related kinase 2 is associated with poor prognoses in malignant glioma.J Neurooncol. 2017 May;132(3):409-417. doi: 10.1007/s11060-017-2401-4. Epub 2017 Mar 21.
121 Relationship between survival and edema in malignant gliomas: role of vascular endothelial growth factor and neuronal pentraxin 2.Clin Cancer Res. 2007 May 1;13(9):2592-8. doi: 10.1158/1078-0432.CCR-06-2772.
122 Identification and functional validation of CDH11, PCSK6 and SH3GL3 as novel glioma invasion-associated candidate genes.Neuropathol Appl Neurobiol. 2012 Apr;38(2):201-12. doi: 10.1111/j.1365-2990.2011.01207.x.
123 Integrated analysis using methylation and gene expression microarrays reveals PDE4C as a prognostic biomarker in human glioma.Oncol Rep. 2014 Jul;32(1):250-60. doi: 10.3892/or.2014.3176. Epub 2014 May 15.
124 Clinicopathological significance of Polo-like kinase 1 (PLK1) expression in human malignant glioma.Acta Histochem. 2012 Sep;114(5):503-9. doi: 10.1016/j.acthis.2011.09.004. Epub 2011 Oct 13.
125 Lipoprotein lipase and phospholipid transfer protein overexpression in human glioma cells and their effect on cell growth, apoptosis, and migration.Acta Biochim Biophys Sin (Shanghai). 2017 Jan;49(1):62-73. doi: 10.1093/abbs/gmw117. Epub 2016 Nov 17.
126 Cyclophilin B supports Myc and mutant p53-dependent survival of glioblastoma multiforme cells.Cancer Res. 2014 Jan 15;74(2):484-96. doi: 10.1158/0008-5472.CAN-13-0771. Epub 2013 Nov 22.
127 PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma.Cancer Res. 2009 Apr 1;69(7):2870-7. doi: 10.1158/0008-5472.CAN-08-2760. Epub 2009 Mar 17.
128 Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas.Nat Genet. 2013 Jun;45(6):602-12. doi: 10.1038/ng.2611. Epub 2013 Apr 14.
129 CBF1 is clinically prognostic and serves as a target to block cellular invasion and chemoresistance of EMT-like glioblastoma cells.Br J Cancer. 2017 Jun 27;117(1):102-112. doi: 10.1038/bjc.2017.157. Epub 2017 Jun 1.
130 Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas. Neuroreport. 2004 Mar 22;15(4):575-8.
131 Ste20-like kinase is upregulated in glioma and induces glioma invasion.Neoplasma. 2018;65(2):185-191. doi: 10.4149/neo_2018_170318N193.
132 SET and MYND domain-containing protein 3 is overexpressed in human glioma and contributes to tumorigenicity.Oncol Rep. 2015 Nov;34(5):2722-30. doi: 10.3892/or.2015.4239. Epub 2015 Sep 1.
133 Overexpression of copper zinc superoxide dismutase suppresses human glioma cell growth.Cancer Res. 2002 Feb 15;62(4):1205-12.
134 Modulation of P-glycoprotein function by sphingosine kinase-1 in brain endothelial cells.J Neurochem. 2007 Mar;100(5):1203-10. doi: 10.1111/j.1471-4159.2006.04295.x.
135 Association of Notch-1, osteopontin and stem-like cells in ENU-glioma malignant process.Oncotarget. 2018 Jul 31;9(59):31330-31341. doi: 10.18632/oncotarget.25808. eCollection 2018 Jul 31.
136 The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas. J Natl Cancer Inst. 2007 Apr 18;99(8):639-52. doi: 10.1093/jnci/djk135.
137 TAGLN2 is a candidate prognostic biomarker promoting tumorigenesis in human gliomas.J Exp Clin Cancer Res. 2017 Nov 6;36(1):155. doi: 10.1186/s13046-017-0619-9.
138 High incidence of TERT mutation in brain tumor cell lines.Brain Tumor Pathol. 2016 Jul;33(3):222-7. doi: 10.1007/s10014-016-0257-5. Epub 2016 Mar 9.
139 Metformin inhibits proliferation and migration of glioblastoma cells independently of TGF-2.Cell Cycle. 2016 Jul 2;15(13):1755-66. doi: 10.1080/15384101.2016.1186316. Epub 2016 May 10.
140 Plant thymidine kinase 1: a novel efficient suicide gene for malignant glioma therapy.Neuro Oncol. 2010 Jun;12(6):549-58. doi: 10.1093/neuonc/nop067. Epub 2010 Feb 13.
141 Tenascin-C expression contributes to pediatric brainstem glioma tumor phenotype and represents a novel biomarker of disease.Acta Neuropathol Commun. 2019 May 15;7(1):75. doi: 10.1186/s40478-019-0727-1.
142 Telomerase reverse transcriptase promoter-driven expression of iodine pump genes for targeted radioiodine therapy of malignant glioma cells.Chin J Cancer. 2011 Aug;30(8):574-80. doi: 10.5732/cjc.010.10580.
143 TRIM24 promotes glioma progression and enhances chemoresistance through activation of the PI3K/Akt signaling pathway.Oncogene. 2015 Jan 29;34(5):600-10. doi: 10.1038/onc.2013.593. Epub 2014 Jan 27.
144 TRIM28 is overexpressed in glioma and associated with tumor progression. Onco Targets Ther. 2018 Oct 10;11:6447-6458.
145 TRPM7 channel inhibition mediates midazolam-induced proliferation loss in human malignant glioma.Tumour Biol. 2016 Nov;37(11):14721-14731. doi: 10.1007/s13277-016-5317-2. Epub 2016 Sep 14.
146 Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis.Dev Biol. 2007 May 15;305(2):599-614. doi: 10.1016/j.ydbio.2007.03.004. Epub 2007 Mar 12.
147 Prognostic impact of CD68 and kallikrein 6 in human glioma.Anticancer Res. 2009 Aug;29(8):3269-79.
148 Nuclear phospholipase C isoenzyme imbalance leads to pathologies in brain, hematologic, neuromuscular, and fertility disorders.J Lipid Res. 2019 Feb;60(2):312-317. doi: 10.1194/jlr.R089763. Epub 2018 Oct 4.
149 Gefitinib inhibits sodium phosphate co-transporter III isoform 1 in a model of human malignant glioma.Anticancer Res. 2014 Nov;34(11):6527-35.
150 Acyl-CoA synthetase VL3 knockdown inhibits human glioma cell proliferation and tumorigenicity.Cancer Res. 2009 Dec 15;69(24):9175-82. doi: 10.1158/0008-5472.CAN-08-4689.
151 A chimeric fusion protein of cytochrome CYP4B1 and green fluorescent protein for detection of pro-drug activating gene delivery and for gene therapy in malignant glioma.Adv Exp Med Biol. 1998;451:393-403. doi: 10.1007/978-1-4615-5357-1_61.
152 Gene Expression and Methylation Analyses Suggest DCTD as a Prognostic Factor in Malignant Glioma.Sci Rep. 2017 Sep 14;7(1):11568. doi: 10.1038/s41598-017-11962-y.
153 Identification of novel genes associated with astrocytoma progression using suppression subtractive hybridization and real-time reverse transcription-polymerase chain reaction.Int J Cancer. 2006 Nov 15;119(10):2330-8. doi: 10.1002/ijc.22108.
154 G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma.Nat Commun. 2019 Feb 26;10(1):943. doi: 10.1038/s41467-019-08905-8.
155 Genome-wide association study identifies five susceptibility loci for glioma.Nat Genet. 2009 Aug;41(8):899-904. doi: 10.1038/ng.407. Epub 2009 Jul 5.
156 PPIC, EMP3 and CHI3L1 Are Novel Prognostic Markers for High Grade Glioma.Int J Mol Sci. 2016 Oct 28;17(11):1808. doi: 10.3390/ijms17111808.
157 Interaction of brain fatty acid-binding protein with the polyunsaturated fatty acid environment as a potential determinant of poor prognosis in malignant glioma.Prog Lipid Res. 2013 Oct;52(4):562-70. doi: 10.1016/j.plipres.2013.08.004. Epub 2013 Aug 24.
158 Extraneural Metastases From a High-Grade Glioma (HGG) With an H3F3A G34R Mutation.Front Oncol. 2019 May 8;9:373. doi: 10.3389/fonc.2019.00373. eCollection 2019.
159 Neonatal exposure to estradiol/bisphenol A alters promoter methylation and expression of Nsbp1 and Hpcal1 genes and transcriptional programs of Dnmt3a/b and Mbd2/4 in the rat prostate gland throughout life.Endocrinology. 2012 Jan;153(1):42-55. doi: 10.1210/en.2011-1308. Epub 2011 Nov 22.
160 Expression and activity of l-isoaspartyl methyltransferase decrease in stage progression of human astrocytic tumors.Brain Res Mol Brain Res. 2005 Apr 27;135(1-2):93-103. doi: 10.1016/j.molbrainres.2004.12.008.
161 PEX-producing human neural stem cells inhibit tumor growth in a mouse glioma model.Clin Cancer Res. 2005 Aug 15;11(16):5965-70. doi: 10.1158/1078-0432.CCR-05-0371.
162 RTEL1: functions of a disease-associated helicase.Trends Cell Biol. 2014 Jul;24(7):416-25. doi: 10.1016/j.tcb.2014.01.004. Epub 2014 Feb 25.
163 ATDC contributes to sustaining the growth and invasion of glioma cells through regulating Wnt/-catenin signaling.Chem Biol Interact. 2019 May 25;305:148-155. doi: 10.1016/j.cbi.2019.03.033. Epub 2019 Mar 29.
164 PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. Nature. 2014 Oct 9;514(7521):247-51.
165 miR-141-3p functions as a tumor suppressor modulating activating transcription factor 5 in glioma.Biochem Biophys Res Commun. 2017 Sep 2;490(4):1260-1267. doi: 10.1016/j.bbrc.2017.05.179. Epub 2017 Jun 7.
166 A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications.Nat Med. 2010 Jun;16(6):671-7. doi: 10.1038/nm.2158. Epub 2010 May 23.
167 Modulation of TGF?activity by latent TGFbinding protein 1 in human osteoarthritis fibroblastlike synoviocytes.Mol Med Rep. 2018 Jan;17(1):1893-1900. doi: 10.3892/mmr.2017.8086. Epub 2017 Nov 15.
168 Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs. Biochim Biophys Acta. 2013 Aug;1833(8):1832-43. doi: 10.1016/j.bbamcr.2013.03.029. Epub 2013 Apr 8.
169 CECR1-mediated cross talk between macrophages and vascular mural cells promotes neovascularization in malignant glioma.Oncogene. 2017 Sep 21;36(38):5356-5368. doi: 10.1038/onc.2017.145. Epub 2017 May 22.
170 The integrin inhibitor cilengitide enhances the anti-glioma efficacy of vasculostatin-expressing oncolytic virus.Cancer Gene Ther. 2013 Aug;20(8):437-44. doi: 10.1038/cgt.2013.38. Epub 2013 Jul 5.
171 Expression of brain-specific angiogenesis inhibitor 3 (BAI3) in normal brain and implications for BAI3 in ischemia-induced brain angiogenesis and malignant glioma.FEBS Lett. 2004 Jul 2;569(1-3):307-16. doi: 10.1016/j.febslet.2004.06.011.
172 Novel report of expression and function of CD97 in malignant gliomas: correlation with Wilms tumor 1 expression and glioma cell invasiveness.J Neurosurg. 2012 Apr;116(4):843-53. doi: 10.3171/2011.11.JNS111455. Epub 2012 Feb 7.
173 Adherens junctional associated protein-1: a novel 1p36 tumor suppressor candidate in gliomas (Review).Int J Oncol. 2014 Jul;45(1):13-7. doi: 10.3892/ijo.2014.2425. Epub 2014 May 8.
174 ALDH1A3 induces mesenchymal differentiation and serves as a predictor for survival in glioblastoma.Cell Death Dis. 2018 Dec 11;9(12):1190. doi: 10.1038/s41419-018-1232-3.
175 Up-regulation of ANKDR49, a poor prognostic factor, regulates cell proliferation of gliomas.Biosci Rep. 2017 Aug 4;37(4):BSR20170800. doi: 10.1042/BSR20170800. Print 2017 Aug 31.
176 AQP4 Aggregation State Is a Determinant for Glioma Cell Fate.Cancer Res. 2019 May 1;79(9):2182-2194. doi: 10.1158/0008-5472.CAN-18-2015. Epub 2019 Mar 15.
177 Regeneration and tolerance factor: a novel mediator of glioblastoma-associated immunosuppression.Cancer Res. 2006 Apr 1;66(7):3852-8. doi: 10.1158/0008-5472.CAN-05-3062.
178 DWI for Monitoring the Acute Response of Malignant Gliomas to Photodynamic Therapy.AJNR Am J Neuroradiol. 2019 Dec;40(12):2045-2051. doi: 10.3174/ajnr.A6300. Epub 2019 Nov 21.
179 pERK, pAkt and pBad: a possible role in cell proliferation and sustained cellular survival during tumorigenesis and tumor progression in ENU induced transplacental glioma rat model.Neurochem Res. 2006 Sep;31(9):1163-70. doi: 10.1007/s11064-006-9142-7. Epub 2006 Aug 31.
180 Novel tumor-specific isoforms of BEHAB/brevican identified in human malignant gliomas.Cancer Res. 2005 Aug 1;65(15):6726-33. doi: 10.1158/0008-5472.CAN-05-0585.
181 Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma.Cancer Res. 2006 Jul 1;66(13):6665-74. doi: 10.1158/0008-5472.CAN-05-4453.
182 Mitochondrial dysfunction in gliomas.Semin Pediatr Neurol. 2013 Sep;20(3):216-27. doi: 10.1016/j.spen.2013.09.003.
183 Adenoviral natural born killer gene therapy for malignant glioma.Hum Gene Ther. 2003 Sep 1;14(13):1235-46. doi: 10.1089/104303403767740777.
184 Decreased BRMS1L expression is correlated with glioma grade and predicts poor survival in glioblastoma via an invasive phenotype.Cancer Biomark. 2018;22(2):311-316. doi: 10.3233/CBM-171019.
185 Expression of mRNAs of urocortin and corticotropin-releasing factor receptors in malignant glioma cell lines.Anticancer Res. 2012 Dec;32(12):5299-307.
186 Enhanced repair of a cisplatin-damaged reporter chloramphenicol-O-acetyltransferase gene and altered activities of DNA polymerases alpha and beta, and DNA ligase in cells of a human malignant glioma following in vivo cisplatin therapy.J Cell Biochem. 1994 Jan;54(1):11-9. doi: 10.1002/jcb.240540103.
187 Loss of merlin-p85 protein complex in NF2-related tumors.Int J Oncol. 1998 May;12(5):1073-8. doi: 10.3892/ijo.12.5.1073.
188 Procarbazine and CCNU Chemotherapy for Recurrent Glioblastoma with MGMT Promoter Methylation.J Korean Med Sci. 2018 May 10;33(24):e167. doi: 10.3346/jkms.2018.33.e167. eCollection 2018 Jun 11.
189 Revealing the glioma cancer stem cell interactome, one niche at a time.J Pathol. 2018 Mar;244(3):260-264. doi: 10.1002/path.5024. Epub 2018 Feb 2.
190 CD93 promotes 1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis.J Clin Invest. 2018 Aug 1;128(8):3280-3297. doi: 10.1172/JCI97459. Epub 2018 Jun 25.
191 CMTM6 overexpression is associated with molecular and clinical characteristics of malignancy and predicts poor prognosis in gliomas.EBioMedicine. 2018 Sep;35:233-243. doi: 10.1016/j.ebiom.2018.08.012. Epub 2018 Aug 18.
192 Somatic CPEB4 and CPEB1 genes mutations spectrum on the prognostic predictive accuracy in patients with high-grade glioma and their clinical significance.J Neurol Sci. 2016 Apr 15;363:80-3. doi: 10.1016/j.jns.2016.02.032. Epub 2016 Feb 16.
193 CREB3L1 and PTN expressions correlate with prognosis of brain glioma patients.Biosci Rep. 2018 May 22;38(3):BSR20170100. doi: 10.1042/BSR20170100. Print 2018 May 29.
194 Localization patterns of cathepsins K and X and their predictive value in glioblastoma.Radiol Oncol. 2018 Oct 18;52(4):433-442. doi: 10.2478/raon-2018-0040.
195 Molecular and functional analysis of tyrosinase-related protein (TRP)-2 as a cytotoxic T lymphocyte target in patients with malignant glioma.J Immunother. 2003 Jul-Aug;26(4):301-12. doi: 10.1097/00002371-200307000-00002.
196 DMBT1 polymorphisms: relationship to malignant glioma tumorigenesis.Cancer Res. 2002 Mar 15;62(6):1790-6.
197 ELMO1 and Dock180, a bipartite Rac1 guanine nucleotide exchange factor, promote human glioma cell invasion.Cancer Res. 2007 Aug 1;67(15):7203-11. doi: 10.1158/0008-5472.CAN-07-0473.
198 Combining Diffusion Tensor Metrics and DSC Perfusion Imaging: Can It Improve the Diagnostic Accuracy in Differentiating Tumefactive Demyelination from High-Grade Glioma?.AJNR Am J Neuroradiol. 2017 Apr;38(4):685-690. doi: 10.3174/ajnr.A5089. Epub 2017 Feb 16.
199 ECRG4 is a candidate tumor suppressor gene frequently hypermethylated in colorectal carcinoma and glioma.BMC Cancer. 2009 Dec 17;9:447. doi: 10.1186/1471-2407-9-447.
200 Epithelial cell transformation sequence 2 is a potential biomarker of unfavorable survival in human gliomas.Neurol India. 2014 Jul-Aug;62(4):406-9. doi: 10.4103/0028-3886.141278.
201 Tumor-derived fibulin-3 activates pro-invasive NF-B signaling in glioblastoma cells and their microenvironment.Oncogene. 2017 Aug 24;36(34):4875-4886. doi: 10.1038/onc.2017.109. Epub 2017 Apr 17.
202 MGMT as a potential stratification marker in relapsed high-grade glioma of children: the HIT-GBM experience.Pediatr Blood Cancer. 2010 Feb;54(2):228-37. doi: 10.1002/pbc.22323.
203 hHSS1: a novel secreted factor and suppressor of glioma growth located at chromosome 19q13.33.J Neurooncol. 2011 Apr;102(2):197-211. doi: 10.1007/s11060-010-0314-6. Epub 2010 Jul 31.
204 Epithelial membrane protein 1 promotes glioblastoma progression through the PI3K/AKT/mTOR signaling pathway.Oncol Rep. 2019 Aug;42(2):605-614. doi: 10.3892/or.2019.7204. Epub 2019 Jun 19.
205 Whole-Genome Expression Microarray Combined with Machine Learning to Identify Prognostic Biomarkers for High-Grade Glioma.J Mol Neurosci. 2018 Apr;64(4):491-500. doi: 10.1007/s12031-018-1049-7. Epub 2018 Mar 3.
206 Enolase-phosphatase 1 as a novel potential malignant glioma indicator promotes cell proliferation and migration.Oncol Rep. 2018 Oct;40(4):2233-2241. doi: 10.3892/or.2018.6592. Epub 2018 Jul 24.
207 Eps8 promotes cellular growth of human malignant gliomas.Oncol Rep. 2013 Feb;29(2):697-703. doi: 10.3892/or.2012.2160. Epub 2012 Nov 29.
208 A novel treatment of human malignant gliomas in vitro and in vivo: FADD gene transfer under the control of the human telomerase reverse transcriptase gene promoter.Int J Oncol. 2001 Nov;19(5):1015-20. doi: 10.3892/ijo.19.5.1015.
209 Clinical significance of FBXO17 gene expression in high-grade glioma.BMC Cancer. 2018 Jul 31;18(1):773. doi: 10.1186/s12885-018-4680-3.
210 Decreased expression of germinal center-associated nuclear protein is involved in chromosomal instability in malignant gliomas.Cancer Sci. 2009 Nov;100(11):2069-76. doi: 10.1111/j.1349-7006.2009.01293.x. Epub 2009 Jul 21.
211 MiR-148a increases glioma cell migration and invasion by downregulating GADD45A in human gliomas with IDH1 R132H mutations.Oncotarget. 2017 Apr 11;8(15):25345-25361. doi: 10.18632/oncotarget.15867.
212 regulation of the invasion and metastasis of human glioma cells by polypeptide N-acetylgalactosaminyltransferase 2.Mol Med Rep. 2011 Nov-Dec;4(6):1299-305. doi: 10.3892/mmr.2011.569. Epub 2011 Aug 22.
213 miRNA-124-3p/neuropilin-1(NRP-1) axis plays an important role in mediating glioblastoma growth and angiogenesis.Int J Cancer. 2018 Aug 1;143(3):635-644. doi: 10.1002/ijc.31329. Epub 2018 Mar 2.
214 Differential expression of nucleostemin, a stem cell marker, and its variants in different types of brain tumors.Mol Carcinog. 2010 Sep;49(9):818-25. doi: 10.1002/mc.20658.
215 Golgi Phosphoprotein 3 Inhibits the Apoptosis of Human Glioma Cells in Part by Downregulating N-myc Downstream Regulated Gene 1.Med Sci Monit. 2016 Oct 4;22:3535-3543. doi: 10.12659/msm.900349.
216 The 10q25.3-26.1 G protein-coupled receptor gene GPR26 is epigenetically silenced in human gliomas.Int J Oncol. 2009 Nov;35(5):1123-31. doi: 10.3892/ijo_00000428.
217 Preferential expression of functional IL-17R in glioma stem cells: potential role in self-renewal.Oncotarget. 2016 Feb 2;7(5):6121-35. doi: 10.18632/oncotarget.6847.
218 ProBDNF and its receptors are upregulated in glioma and inhibit the growth of glioma cells in vitro.Neuro Oncol. 2013 Aug;15(8):990-1007. doi: 10.1093/neuonc/not039. Epub 2013 Apr 10.
219 HHLA2 is a novel prognostic predictor and potential therapeutic target in malignant glioma.Oncol Rep. 2019 Dec;42(6):2309-2322. doi: 10.3892/or.2019.7343. Epub 2019 Oct 1.
220 Histidine-rich glycoprotein can prevent development of mouse experimental glioblastoma.PLoS One. 2009 Dec 31;4(12):e8536. doi: 10.1371/journal.pone.0008536.
221 Comparison of (18)F-GE-180 and dynamic (18)F-FET PET in high grade glioma: a double-tracer pilot study.Eur J Nucl Med Mol Imaging. 2019 Mar;46(3):580-590. doi: 10.1007/s00259-018-4166-1. Epub 2018 Sep 22.
222 IKBKE regulates cell proliferation and epithelial-mesenchymal transition of human malignant glioma via the Hippo pathway.Oncotarget. 2017 Jul 25;8(30):49502-49514. doi: 10.18632/oncotarget.17738.
223 Tetraspanin 8-rictor-integrin 3 complex is required for glioma cell migration.Int J Mol Sci. 2015 Mar 9;16(3):5363-74. doi: 10.3390/ijms16035363.
224 Integrin 7 Is a Functional Marker and Potential Therapeutic Target in Glioblastoma.Cell Stem Cell. 2017 Jul 6;21(1):35-50.e9. doi: 10.1016/j.stem.2017.04.009. Epub 2017 Jun 9.
225 Epigenetic silencing of KAZALD1 confers a better prognosis and is associated with malignant transformation/progression in glioma.Oncol Rep. 2013 Nov;30(5):2089-96. doi: 10.3892/or.2013.2706. Epub 2013 Aug 29.
226 KIF23 is an independent prognostic biomarker in glioma, transcriptionally regulated by TCF-4.Oncotarget. 2016 Apr 26;7(17):24646-55. doi: 10.18632/oncotarget.8261.
227 Krppel-like factor 8 (KLF8) is expressed in gliomas of different WHO grades and is essential for tumor cell proliferation.PLoS One. 2012;7(1):e30429. doi: 10.1371/journal.pone.0030429. Epub 2012 Jan 19.
228 Neurosarcoidosis Mimics High-Grade Glioma in Dynamic 18F-FET PET Due to LAT Expression.Clin Nucl Med. 2018 Nov;43(11):840-841. doi: 10.1097/RLU.0000000000002266.
229 Layilin enhances the invasive ability of malignant glioma cells via SNAI1 signaling.Brain Res. 2019 Sep 15;1719:140-147. doi: 10.1016/j.brainres.2019.05.034. Epub 2019 May 27.
230 LGI1: a gene involved in epileptogenesis and glioma progression?.Neurogenetics. 2005 May;6(2):59-66. doi: 10.1007/s10048-005-0216-5. Epub 2005 Apr 13.
231 Adenovirus-based strategies overcome temozolomide resistance by silencing the O6-methylguanine-DNA methyltransferase promoter.Cancer Res. 2007 Dec 15;67(24):11499-504. doi: 10.1158/0008-5472.CAN-07-5312.
232 Hugl-1 inhibits glioma cell growth in intracranial model.J Neurooncol. 2015 Oct;125(1):113-21. doi: 10.1007/s11060-015-1901-3. Epub 2015 Sep 4.
233 GAC1, a new member of the leucine-rich repeat superfamily on chromosome band 1q32.1, is amplified and overexpressed in malignant gliomas.Oncogene. 1998 Jun 11;16(23):2997-3002. doi: 10.1038/sj.onc.1201828.
234 Impact of MACC1 on human malignant glioma progression and patients' unfavorable prognosis.Neuro Oncol. 2013 Dec;15(12):1696-709. doi: 10.1093/neuonc/not136. Epub 2013 Nov 11.
235 Regulatory landscape and clinical implication of MBD3 in human malignant glioma.Oncotarget. 2016 Dec 6;7(49):81698-81714. doi: 10.18632/oncotarget.13173.
236 Myocyte enhancer factor 2D promotes tumorigenicity in malignant glioma cells.Tumour Biol. 2016 Jan;37(1):601-10. doi: 10.1007/s13277-015-3791-6. Epub 2015 Aug 4.
237 Epidermal growth factor receptor gene expression in high grade gliomas.Folia Neuropathol. 2011;49(1):28-38.
238 Expression of matrix metalloproteinases MMP-1, MMP-11 and MMP-19 is correlated with the WHO-grading of human malignant gliomas.Neurosci Res. 2008 Jan;60(1):40-9. doi: 10.1016/j.neures.2007.09.009. Epub 2007 Sep 29.
239 Mannose phosphate isomerase regulates fibroblast growth factor receptor family signaling and glioma radiosensitivity. PLoS One. 2014 Oct 14;9(10):e110345.
240 miR-126 Suppresses Invasion and Migration of Malignant Glioma by Targeting Mature T Cell Proliferation 1 (MTCP1).Med Sci Monit. 2018 Sep 20;24:6630-6637. doi: 10.12659/MSM.910292.
241 Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma.Nature. 2017 Sep 28;549(7673):533-537. doi: 10.1038/nature24014. Epub 2017 Sep 20.
242 MicroRNA-326 functions as a tumor suppressor in glioma by targeting the Nin one binding protein (NOB1).PLoS One. 2013 Jul 15;8(7):e68469. doi: 10.1371/journal.pone.0068469. Print 2013.
243 DNA content and chromosomal composition of malignant human gliomas.Neurol Clin. 1985 Nov;3(4):769-84.
244 NPAS3 demonstrates features of a tumor suppressive role in driving the progression of Astrocytomas.Am J Pathol. 2011 Jul;179(1):462-76. doi: 10.1016/j.ajpath.2011.03.044. Epub 2011 May 19.
245 Nudt21 regulates the alternative polyadenylation of Pak1 and is predictive in the prognosis of glioblastoma patients.Oncogene. 2019 May;38(21):4154-4168. doi: 10.1038/s41388-019-0714-9. Epub 2019 Jan 31.
246 NUMB does not impair growth and differentiation status of experimental gliomas.Exp Cell Res. 2011 Dec 10;317(20):2864-73. doi: 10.1016/j.yexcr.2011.09.002. Epub 2011 Sep 12.
247 Harnessing OLIG2 function in tumorigenicity and plasticity to target malignant gliomas.Cell Cycle. 2017 Sep 17;16(18):1654-1660. doi: 10.1080/15384101.2017.1361062. Epub 2017 Aug 14.
248 Interplay between PCBP2 and miRNA modulates ARHGDIA expression and function in glioma migration and invasion.Oncotarget. 2016 Apr 12;7(15):19483-98. doi: 10.18632/oncotarget.6869.
249 Dual inhibition of PCDH9 expression by miR-215-5p up-regulation in gliomas.Oncotarget. 2017 Feb 7;8(6):10287-10297. doi: 10.18632/oncotarget.14396.
250 NSPc1 promotes cancer stem cell self-renewal by repressing the synthesis of all-trans retinoic acid via targeting RDH16 in malignant glioma.Oncogene. 2017 Aug 17;36(33):4706-4718. doi: 10.1038/onc.2017.34. Epub 2017 Apr 10.
251 PDCD5 promotes cisplatin-induced apoptosis of glioma cells via activating mitochondrial apoptotic pathway.Cancer Biol Ther. 2012 Jul;13(9):822-30. doi: 10.4161/cbt.20565. Epub 2012 Jun 12.
252 Integrin 51 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade glioma.Cell Death Differ. 2016 Apr;23(4):640-53. doi: 10.1038/cdd.2015.131. Epub 2015 Oct 16.
253 Prediction of relapse and prognosis by expression levels of long noncoding RNA PEG10 in glioma patients.Medicine (Baltimore). 2019 Nov;98(45):e17583. doi: 10.1097/MD.0000000000017583.
254 PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas.Clin Cancer Res. 2014 Feb 15;20(4):827-36. doi: 10.1158/1078-0432.CCR-13-2053. Epub 2013 Dec 3.
255 Proteasome inhibitors induce p53/p21-independent apoptosis in human glioma cells.Cell Physiol Biochem. 1999;9(3):117-25. doi: 10.1159/000016308.
256 Subcellular distribution and expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in malignant glioma: Influence on cell survival and migration.Cancer Sci. 2010 Jul;101(7):1624-31. doi: 10.1111/j.1349-7006.2010.01570.x. Epub 2010 Mar 19.
257 Validation of an Immunohistochemistry Assay for Detection of CD155, the Poliovirus Receptor, in Malignant Gliomas.Arch Pathol Lab Med. 2017 Dec;141(12):1697-1704. doi: 10.5858/arpa.2016-0580-OA. Epub 2017 Aug 22.
258 Overexpression of Paxillin Correlates with Tumor Progression and Predicts Poor Survival in Glioblastoma.CNS Neurosci Ther. 2017 Jan;23(1):69-75. doi: 10.1111/cns.12606. Epub 2016 Sep 17.
259 Structural Insights into the Quaternary Catalytic Mechanism of Hexameric Human Quinolinate Phosphoribosyltransferase, a Key Enzyme in de novo NAD Biosynthesis.Sci Rep. 2016 Jan 25;6:19681. doi: 10.1038/srep19681.
260 Hypomethylated Rab27b is a progression-associated prognostic biomarker of glioma regulating MMP-9 to promote invasion.Oncol Rep. 2015 Sep;34(3):1503-9. doi: 10.3892/or.2015.4125. Epub 2015 Jul 13.
261 DNA hypermethylation and histone modifications downregulate the candidate tumor suppressor gene RRP22 on 22q12 in human gliomas.Brain Pathol. 2012 Jan;22(1):17-25. doi: 10.1111/j.1750-3639.2011.00507.x. Epub 2011 Aug 16.
262 RHPN2 drives mesenchymal transformation in malignant glioma by triggering RhoA activation.Cancer Res. 2013 Aug 15;73(16):5140-50. doi: 10.1158/0008-5472.CAN-13-1168-T. Epub 2013 Jun 17.
263 Inference of Low and High-Grade Glioma Gene Regulatory Networks Delineates the Role of Rnd3 in Establishing Multiple Hallmarks of Cancer.PLoS Genet. 2015 Jul 1;11(7):e1005325. doi: 10.1371/journal.pgen.1005325. eCollection 2015 Jul.
264 SAMSN1 is highly expressed and associated with a poor survival in glioblastoma multiforme.PLoS One. 2013 Nov 22;8(11):e81905. doi: 10.1371/journal.pone.0081905. eCollection 2013.
265 Ubiquitin ligase Siah1 promotes the migration and invasion of human glioma cells by regulating HIF-1 signaling under hypoxia.Oncol Rep. 2015 Mar;33(3):1185-90. doi: 10.3892/or.2014.3695. Epub 2014 Dec 23.
266 Sox11 expression in astrocytic gliomas: correlation with nestin/c-Met/IDH1-R132H expression phenotypes, p-Stat-3 and survival.Br J Cancer. 2013 May 28;108(10):2142-52. doi: 10.1038/bjc.2013.176. Epub 2013 Apr 25.
267 Sox7 promotes high-grade glioma by increasing VEGFR2-mediated vascular abnormality.J Exp Med. 2018 Mar 5;215(3):963-983. doi: 10.1084/jem.20170123. Epub 2018 Feb 14.
268 Alpha2,6-sialylation of cell-surface N-glycans inhibits glioma formation in vivo.Cancer Res. 2001 Sep 15;61(18):6822-9.
269 Tax-interacting protein 1 coordinates the spatiotemporal activation of Rho GTPases and regulates the infiltrative growth of human glioblastoma.Oncogene. 2014 Mar 20;33(12):1558-69. doi: 10.1038/onc.2013.97. Epub 2013 Apr 8.
270 Integrin 6 signaling induces STAT3-TET3-mediated hydroxymethylation of genes critical for maintenance of glioma stem cells.Oncogene. 2020 Mar;39(10):2156-2169. doi: 10.1038/s41388-019-1134-6. Epub 2019 Dec 9.
271 Characterization and transduction of a retroviral vector encoding human interleukin-4 and herpes simplex virus-thymidine kinase for glioma tumor vaccine therapy.Cancer Gene Ther. 2000 Mar;7(3):486-94. doi: 10.1038/sj.cgt.7700140.
272 Knockdown of TFPI-2 promotes migration and invasion of glioma cells.Neurosci Lett. 2011 Jun 15;497(1):49-54. doi: 10.1016/j.neulet.2011.04.027. Epub 2011 Apr 20.
273 Percentage of mesenchymal stem cells in high-grade glioma tumor samples correlates with patient survival.Neuro Oncol. 2017 May 1;19(5):660-668. doi: 10.1093/neuonc/now239.
274 microRNA response elementregulated TIKI2 expression suppresses the tumorigencity of malignant gliomas.Mol Med Rep. 2014 Oct;10(4):2079-86. doi: 10.3892/mmr.2014.2412. Epub 2014 Jul 22.
275 miR-29s function as tumor suppressors in gliomas by targeting TRAF4 and predict patient prognosis.Cell Death Dis. 2018 Oct 22;9(11):1078. doi: 10.1038/s41419-018-1092-x.
276 Expression of TRAP1 predicts poor survival of malignant glioma patients.J Mol Neurosci. 2015 Jan;55(1):62-68. doi: 10.1007/s12031-014-0413-5. Epub 2014 Sep 5.
277 TRIM11, a direct target of miR-24-3p, promotes cell proliferation and inhibits apoptosis in colon cancer.Oncotarget. 2016 Dec 27;7(52):86755-86765. doi: 10.18632/oncotarget.13550.
278 Overexpression of the orphan receptor Nur77 and its translocation induced by PCH4 may inhibit malignant glioma cell growth and induce cell apoptosis.J Surg Oncol. 2011 Apr;103(5):442-50. doi: 10.1002/jso.21809. Epub 2011 Jan 18.
279 Over-expression of tetraspanin 8 in malignant glioma regulates tumor cell progression.Biochem Biophys Res Commun. 2015 Mar 13;458(3):476-482. doi: 10.1016/j.bbrc.2015.01.128. Epub 2015 Feb 11.
280 Construction of a ganciclovir-sensitive lentiviral vector to assess the influence of angiopoietin-3 and soluble Tie2 on glioma growth.J Neurooncol. 2010 Aug;99(1):1-11. doi: 10.1007/s11060-009-0095-y. Epub 2009 Dec 18.
281 Aberrant methylation and reduced expression of LHX9 in malignant gliomas of childhood.Neoplasia. 2009 Jul;11(7):700-11. doi: 10.1593/neo.09406.
282 Lrig1 is a haploinsufficient tumor suppressor gene in malignant glioma.Oncogenesis. 2018 Feb 2;7(2):13. doi: 10.1038/s41389-017-0012-8.
283 Expression analysis of the autosomal recessive primary microcephaly genes MCPH1 (microcephalin) and MCPH5 (ASPM, abnormal spindle-like, microcephaly associated) in human malignant gliomas.Oncol Rep. 2008 Aug;20(2):301-8.