Details of the Drug-Related molecule(s) Interaction Atlas

GGTI-298 Drug Info

GGTI298; GGTI-298; Ggti 298; 180977-44-0; CHEMBL282748; N-4-[2(R)-Amino-3-mercaptopropyl]amino-2-naphthylbenzoyl-(L)-Leucine methyl ester, TFA; (S)-methyl 2-(4-((R)-2-amino-3-mercaptopropylamino)-2-(naphthalen-1-yl)benzamido)-4-methylpentanoate; SCHEMBL4283635; CHEBI:124997; EX-A2390; ZINC1488051; BCP24854; BDBM50076138; AKOS032945065; CS-6098; NCGC00165800-01; HY-100876; BRD-K19669037-019-01-3; 2-[4-((R)-2-Amino-3-mercapto-propylamino)-2-naphthalen-1-yl-benzoylamino]-4-methyl-pentanoic acid (S)-methyl ester

Cross-matching ID

PubChem CID

9811606

ChEBI ID

CHEBI:124997

CAS Number

CAS 180977-44-0

TTD Drug ID

DM1CG0J

General Information of Drug (ID: DM1CG0J)

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Approved Drug(s)

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Drug(s) Targeting Geranylgeranyl transferase I (GGTase-I)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-778123	DMWSC5L	Lymphoma	2A80-2A86	Phase 1	[5]
L-745631	DM4UP7R	Solid tumour/cancer	2A00-2F9Z	Terminated	[6]
PD-83176	DMSIMKZ	Discovery agent	N.A.	Investigative	[7]
A-313326	DML4P6O	Discovery agent	N.A.	Investigative	[8]
J-109,390	DM9SFGB	Discovery agent	N.A.	Investigative	[9]
L-269,289	DMV6018	Discovery agent	N.A.	Investigative	[9]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[10]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[11]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[12]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[13]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[14]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[15]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[16]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[18]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
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Drug(s) Affected By Tissue factor (F3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[20]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[21]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[23]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Fructose	DM43AN2	Vomiting	MD90	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[21]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[28]
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Drug(s) Affected By Krueppel-like factor 2 (KLF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[30]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[31]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[36]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[37]
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Drug(s) Affected By Transferrin receptor protein 1 (TFRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[38]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[44]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[46]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[47]
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Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[51]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[42]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[54]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
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Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[57]
Indomethacin	DMSC4A7	Bursitis		Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[60]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[61]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[64]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[65]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[66]
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Drug(s) Affected By Transforming protein RhoA (RHOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[61]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[72]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[73]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[74]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Geranylgeranyl transferase I (GGTase-I)	TTX20QP	PGTB1_HUMAN	Inhibitor	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Gene/Protein Processing	[2]
Krueppel-like factor 2 (KLF2)	OTIP1UFX	KLF2_HUMAN	Gene/Protein Processing	[2]
Nitric oxide synthase, inducible (NOS2)	OTKKIOJ1	NOS2_HUMAN	Gene/Protein Processing	[3]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Gene/Protein Processing	[3]
Tissue factor (F3)	OT3MSU3B	TF_HUMAN	Gene/Protein Processing	[2]
Transferrin receptor protein 1 (TFRC)	OT8ZPBDL	TFR1_HUMAN	Gene/Protein Processing	[3]
Transforming protein RhoA (RHOA)	OT6YOJ9N	RHOA_HUMAN	Protein Interaction/Cellular Processes	[4]

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References

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