Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3FZ6P)

• Drug Name: IODIDE Drug Info
• Synonyms: Iodide ion; 20461-54-5; Iodide-127; Iodide(1-); iodinane; trihydridoiodine; iodine anion; Iodide anion; Iodide Salt; lambda(3)-iodane; UNII-09G4I6V86Q; I-; CHEMBL185537; CHEBI:16382; 09G4I6V86Q; Colloidal iodine; Iodine ion; Iodide ion(1-); Iodine(1-); Iodine, ion (I1-); AC1L1IXU; hydriodic acid, ion(1-); CTK1A4386; CHEBI:37181; BDBM26981; XMBWDFGMSWQBCA-UHFFFAOYSA-M; Iodide (6CI,7CI,8CI,9CI); Ba 2796; DB12754; LS-193152

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 30165
  ChEBI ID: CHEBI:16382
  CAS Number: CAS 20461-54-5
  TTD Drug ID: DM3FZ6P

Molecule-Related Drug Atlas

Drug(s) Targeting Carbonic anhydrase I (CA-I)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[5]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[6]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[6]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[7]
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[6]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[8]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[9]
CG-100649	DMIKMA9	Arthritis	FA20	Phase 3	[10]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[8]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[11]

Drug(s) Targeting Carbonic anhydrase II (CA-II)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[5]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[12]
Dorzolamide	DMA17D0	Ocular hypertension	9C61.01	Approved	[13]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[14]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[15]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[15]
Cyclothiazide	DMJ4AWC	Congestive heart failure	BD10	Approved	[16]
Ethinamate	DMK57GB	Insomnia	7A00-7A0Z	Approved	[17]
Benzthiazide	DMQWZ0H	High blood pressure	BA00	Approved	[18]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[8]

Drug(s) Affected By Thyroid peroxidase (TPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[19]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[20]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[4]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[22]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[23]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[24]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[23]

Drug(s) Affected By Sodium/iodide cotransporter (SLC5A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Tazarotene	DM8SMD1	Acne vulgaris	ED80	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[29]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[30]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[31]
Romidepsin	DMT5GNL	Cutaneous T-cell lymphoma	2B01	Approved	[29]

Drug(s) Affected By Pendrin (SLC26A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[32]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[33]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[30]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[34]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[35]
CHLORIDE	DM1TJXA	Solid tumour/cancer	2A00-2F9Z	Phase 3	[36]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[37]
Formic Acid	DMNFZC6	Discovery agent	N.A.	Investigative	[38]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase I (CA-I)	TTHQPL7	CAH1_HUMAN	Inhibitor	[1]
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Pendrin (SLC26A4)	OTXUTLVS	S26A4_HUMAN	Regulation of Drug Effects	[2]
Sodium/iodide cotransporter (SLC5A5)	OTU7E9G7	SC5A5_HUMAN	Regulation of Drug Effects	[3]
Thyroid peroxidase (TPO)	OTJJLL20	PERT_HUMAN	Biotransformations	[4]

References

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