Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM53SRA)

Drug Name
Prochlorperazine Drug Info
Synonyms
CHLOPERAZINE; Capazine; Chlormeprazine; Chlorperazine; Combid; Compazine; Compro; Emelent; Eskatrol; Kronocin; Meterazin; Meterazine; Nipodal; Novamin; Prochloroperazine; Prochlorpemazine; Prochlorperazin; Prochlorperazinum; Prochlorpermazine; Prochlorpromazine; Procloperazine; Proclorperazina; Proclorperazine; Stemetil; Tementil; Temetid; Vertigon; Compazine Suppositories; Prochlorperazine Edisylate Salt; Prochlorperazine dihydrobromide; Prochlorperazine dimaleate; Prochlorperazine maleate; Prochlorperazine mesilate; Bayer A 173; P77; RP 6140; SKF 4657; Buccastem (TN); Compazine (TN); Compro (TN); Phenotil (TN); Prochlorperazinum [INN-Latin]; Proclorperazina [INN-Spanish]; Stemetil (TN); Stemzine (TN); Compazine (*Maleate*); Prochlorperazine (JAN/USP/INN); Prochlorperazine [USAN:INN:BAN:JAN]; Chloro-3 (N-methylpiperazinyl-3 propyl)-10 phenothiazine; Chloro-3 (N-methylpiperazinyl-3 propyl)-10 phenothiazine [French]; N-(gamma-(4'-Methylpiperazinyl-1')propyl)-3-chlorophenothiazine; 2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)-phenothiazine; 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-10H-phenothiazine; 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine; 2-Chloro-10-[3-(4-methyl-1-piper-azinyl)propyl]-10H-pheno-thiazine dimaleate; 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine; 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine; 3-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine; 3-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine; 6140 RP
Indication
Disease Entry ICD 11 Status REF
Nausea MD90 Approved [1]
Therapeutic Class
Antipsychotic Agents
Cross-matching ID
PubChem CID
4917
ChEBI ID
CHEBI:8435
CAS Number
CAS 58-38-8
TTD Drug ID
DM53SRA
VARIDT Drug ID
DR00592
INTEDE Drug ID
DR1345
ACDINA Drug ID
D00559

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Dopamine D2 receptor (D2R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [6]
Haloperidol DM96SE0 Delirium Approved [7]
Perphenazine DMA4MRX Schizophrenia 6A20 Approved [8]
Perazine DM2AOTZ Psychotic disorder 6A20-6A25 Approved [9]
Domperidone DMBDPY0 Gastrointestinal disease DE2Z Approved [10]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [11]
Quetiapine DM1N62C Anorexia nervosa cachexia 6B80 Approved [12]
Pimozide DMW83TP Schizophrenia 6A20 Approved [13]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [14]
Iloperidone DM6AUFY Schizophrenia 6A20 Approved [15]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [16]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [17]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [18]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [19]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [20]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [21]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [22]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [23]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [24]
Propranolol DM79NTF Angina pectoris BA40 Approved [25]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor EB (TFEB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [26]
Fluphenazine DMIT8LX Psychotic disorder 6A20-6A25 Approved [5]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [27]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [28]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [29]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [31]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [32]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [33]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glucose-6-phosphatase catalytic subunit 1 (G6PC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Fluoxetine DM3PD2C Bipolar depression Approved [36]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [37]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [38]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [39]
Leflunomide DMR8ONJ Arthritis FA20 Approved [40]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [41]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [37]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [37]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [42]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dopamine D2 receptor (D2R) TTEX248 DRD2_HUMAN Antagonist [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2D6 (CYP2D6) Main DME DECB0K3 CP2D6_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Glucose-6-phosphatase catalytic subunit 1 (G6PC1) OTJ6FM9F G6PC1_HUMAN Drug Response [4]
Transcription factor EB (TFEB) OTJUJJQY TFEB_HUMAN Protein Interaction/Cellular Processes [5]
UDP-glucuronosyltransferase 1A1 OTH1C8OJ UD11_HUMAN Drug Response [4]

References

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