Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM563PZ)

Drug Name
Corosolic acid Drug Info
Synonyms
A,5xi,18; A)-2,3-dihydroxyurs-12-en-28-oic acid; AC1Q5QHO; AC1L4WCO; SCHEMBL1157257; KB-333790; LS-193275; (2a,3b)-2,3-dihydroxy-urs-12-en-28-oic acid; (1S,2R,4aS,6aR,6aS,6bR,10R,11R,12aR,14bR)-10,11-dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
6918774
ChEBI ID
CHEBI:67895
CAS Number
CAS 4547-24-4
TTD Drug ID
DM563PZ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
GLYCYRRHIZIN DM8M2N3 Influenza virus infection 1E30-1E32 Phase 3 [4]
BVT.2733 DM6RUKX Lupus 4A40 Phase 3 [5]
INCB13739 DMLQ3PO Type-2 diabetes 5A11 Phase 2a [6]
URSOLIC ACID DM4SOAW Metabolic syndrome x 5C50-5D2Z Phase 2 [1]
JTT-654 DM50M2R Type-2 diabetes 5A11 Phase 2 [7]
RG-4929 DMT4QRD Metabolic disorder 5C50-5D2Z Phase 2 [7]
BMS-770767 DMTVGY7 Hypercholesterolaemia 5C80.0 Phase 2 [7]
UE-2343 DMIERPK Alzheimer disease 8A20 Phase 2 [8]
AZD-4017 DML9M5S Ocular hypertension 9C61.01 Phase 2 [7]
Xanamem DM580GT Alzheimer disease 8A20 Phase 1/2 [9]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [10]
Gefitinib DM15F0X Colon adenocarcinoma Approved [11]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [12]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [13]
Etretinate DM2CZFA Keratosis ED56 Approved [14]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [15]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [16]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [17]
Quercetin DM3NC4M Obesity 5B81 Approved [18]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [19]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [20]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [21]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [23]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [24]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [25]
Verapamil DMA7PEW Angina pectoris BA40 Approved [26]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [27]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [28]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [29]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [30]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [31]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [13]
Methotrexate DM2TEOL Anterior urethra cancer Approved [32]
Epinephrine DM3KJBC Acute asthma CA23 Approved [33]
Quercetin DM3NC4M Obesity 5B81 Approved [34]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [35]
Fructose DM43AN2 Vomiting MD90 Approved [36]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [30]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [37]
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Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [24]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [38]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [39]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [40]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [41]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [42]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [43]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [44]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [46]
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Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [47]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [48]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [49]
Quercetin DM3NC4M Obesity 5B81 Approved [34]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [51]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [52]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [53]
Testosterone DM7HUNW Hot flushes GA30 Approved [54]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [55]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [56]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [57]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [58]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [59]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [60]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [61]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [62]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [63]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [64]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [38]
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Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [39]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [29]
Selenium DM25CGV N. A. N. A. Approved [65]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [66]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [67]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [46]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [70]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [20]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [38]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [25]
Verapamil DMA7PEW Angina pectoris BA40 Approved [26]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [30]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [71]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [72]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [48]
Meloxicam DM2AR7L Arthritis FA20 Approved [73]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [74]
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Drug(s) Affected By Diablo IAP-binding mitochondrial protein (DIABLO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [13]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [34]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [78]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [79]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [80]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [81]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [82]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) TTN7BL9 DHI1_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [2]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [2]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [2]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [2]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Protein Interaction/Cellular Processes [3]
Diablo IAP-binding mitochondrial protein (DIABLO) OTHJ9MCZ DBLOH_HUMAN Gene/Protein Processing [2]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Gene/Protein Processing [2]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Gene/Protein Processing [2]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Gene/Protein Processing [2]

References

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64 mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Biol Chem. 2004 Nov;385(11):1099-103. doi: 10.1515/BC.2004.143.
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69 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
70 Glucosamine regulation of LPS-mediated inflammation in human bronchial epithelial cells. Eur J Pharmacol. 2010 Jun 10;635(1-3):219-26. doi: 10.1016/j.ejphar.2010.02.044. Epub 2010 Mar 20.
71 Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells. Ann N Y Acad Sci. 2005 May;1042:531-7. doi: 10.1196/annals.1338.065.
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