Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5FL14)

Drug Name
Amifostine Drug Info
Synonyms Ethiofos; Ethyol; Gammaphos; WR-1064; WR-2721; WR-2721C; YM-08310
Indication
Disease Entry ICD 11 Status REF
Mucositis CA00 Approved [1]
Cross-matching ID
PubChem CID
2141
ChEBI ID
CHEBI:2636
CAS Number
CAS 20537-88-6
TTD Drug ID
DM5FL14
INTEDE Drug ID
DR0085

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Metabolized By Alkaline phosphatase (ALPL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fospropofol DM8J5XT N. A. N. A. Approved [6]
Drug(s) Affected By Etoposide-induced protein 2.4 homolog (EI24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [7]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [8]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [9]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [10]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [11]
Menthol DMG2KW7 Back pain ME84.Z Approved [12]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [13]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [14]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [13]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [15]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [16]
Methotrexate DM2TEOL Anterior urethra cancer Approved [17]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [18]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [20]
Paclitaxel DMLB81S Breast carcinoma Approved [21]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [22]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [23]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [24]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [25]
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Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [26]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [27]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [28]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [29]
Selenium DM25CGV N. A. N. A. Approved [30]
Etretinate DM2CZFA Keratosis ED56 Approved [31]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [32]
Methotrexate DM2TEOL Anterior urethra cancer Approved [33]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [34]
Quercetin DM3NC4M Obesity 5B81 Approved [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [36]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [37]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [38]
Gefitinib DM15F0X Colon adenocarcinoma Approved [39]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [40]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [41]
Etretinate DM2CZFA Keratosis ED56 Approved [31]
Prednisone DM2HG4X Acute asthma CA23 Approved [42]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [43]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [44]
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Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Flucytosine DM13VTW Cryptococcal meningitis Approved [46]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [46]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Methotrexate DM2TEOL Anterior urethra cancer Approved [33]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [48]
Quercetin DM3NC4M Obesity 5B81 Approved [7]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [18]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [50]
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Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [51]
Selenium DM25CGV N. A. N. A. Approved [52]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [32]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [53]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [54]
Quercetin DM3NC4M Obesity 5B81 Approved [7]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [55]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [56]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [57]
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Drug(s) Affected By Quinone oxidoreductase PIG3 (TP53I3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [58]
Methotrexate DM2TEOL Anterior urethra cancer Approved [33]
Quercetin DM3NC4M Obesity 5B81 Approved [59]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Testosterone DM7HUNW Hot flushes GA30 Approved [61]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [62]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [63]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [63]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Toxic reactive metabolite (TRM) TT0C9DV NOUNIPROTAC Modulator [1]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Alkaline phosphatase (ALPL) Main DME DEVEFKM PPBT_HUMAN Substrate [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [3]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Post-Translational Modifications [3]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [4]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Gene/Protein Processing [4]
Etoposide-induced protein 2.4 homolog (EI24) OTD4NOYS EI24_HUMAN Gene/Protein Processing [4]
Quinone oxidoreductase PIG3 (TP53I3) OTSCM68G QORX_HUMAN Gene/Protein Processing [4]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Protein Interaction/Cellular Processes [5]

References

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