Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8HJX6)

Drug Name
Tipranavir Drug Info
Synonyms
Aptivus; TPV; PNU 140690; U 140690; Aptivus (Boehringer Ingelheim); Aptivus (TN); Aptivus(TM); PNU-140690; PNU-140690E; Tipranavir (INN); U-140690; N-[3-[(1R)-1-[(2R)-6-hydroxy-4-oxo-2-phenethyl-2-propyl-3H-pyran-5-yl]propyl]phenyl]-5-(trifluoromethyl)pyridine-2-sulfonamide; N-(3-{(1R)-1-[(6R)-4-HYDROXY-2-OXO-6-PHENETHYL-6-PROPYL-5,6-DIHYDRO-2H-PYRAN-3-YL]PROPYL}PHENYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINESULFONAMIDE
Indication
Disease Entry ICD 11 Status REF
Human immunodeficiency virus infection 1C62 Approved [1]
Therapeutic Class
Anti-HIV Agents
Cross-matching ID
PubChem CID
54682461
ChEBI ID
CHEBI:63628
CAS Number
CAS 174484-41-4
TTD Drug ID
DM8HJX6
VARIDT Drug ID
DR00962
INTEDE Drug ID
DR1601

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Human immunodeficiency virus Protease (HIV PR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Saquinavir DMG814N Human immunodeficiency virus infection 1C62 Approved [6]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [7]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [8]
Atazanavir DMSYRBX Human immunodeficiency virus infection 1C62 Approved [9]
Amprenavir DMLMXE0 Human immunodeficiency virus infection 1C62 Approved [10]
Darunavir DMN3GCH Human immunodeficiency virus infection 1C62 Approved [11]
Fosamprenavir DM4W9B3 Human immunodeficiency virus infection 1C62 Approved [12]
BI 201335 DM3MXT8 Hepatitis C virus infection 1E51.1 Phase 3 [13]
BMS 650032 DMQI43G Hepatitis C virus infection 1E51.1 Phase 2 [14]
Danoprevir DM20MDU Hepatitis C virus infection 1E51.1 Phase 2 [15]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [16]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [17]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [18]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [19]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [20]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [21]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [22]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [23]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [17]
Verapamil DMA7PEW Angina pectoris BA40 Approved [24]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [25]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [26]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [27]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [20]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [24]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [28]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [29]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [30]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [31]
Propranolol DM79NTF Angina pectoris BA40 Approved [32]
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Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [33]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [34]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [35]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [36]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [37]
Verapamil DMA7PEW Angina pectoris BA40 Approved [38]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [39]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [41]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [42]
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Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [43]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [4]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [4]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [44]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [43]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [4]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [5]
Gefitinib DM15F0X Colon adenocarcinoma Approved [43]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [45]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [43]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphatidylcholine translocator ABCB4 (ABCB4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [46]
Verapamil DMA7PEW Angina pectoris BA40 Approved [47]
Methysergide DM1EF73 Migraine 8A80 Approved [5]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [48]
Methotrexate DM2TEOL Anterior urethra cancer Approved [49]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [5]
Quercetin DM3NC4M Obesity 5B81 Approved [50]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [51]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [52]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [53]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Human immunodeficiency virus Protease (HIV PR) TT5FNQT POL_HV1B1 Modulator [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [3]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [3]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [4]
Phosphatidylcholine translocator ABCB4 (ABCB4) OTE6PY83 MDR3_HUMAN Gene/Protein Processing [5]

References

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