Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8I94Y)

Drug Name
Venetoclax Drug Info
Synonyms Venclexta
Indication
Disease Entry ICD 11 Status REF
Chronic lymphocytic leukaemia 2A82.0 Approved [1]
Cross-matching ID
PubChem CID
49846579
ChEBI ID
CHEBI:133021
CAS Number
CAS 1257044-40-8
TTD Drug ID
DM8I94Y
VARIDT Drug ID
DR00008

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTP
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [9]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [10]
Methotrexate DM2TEOL Anterior urethra cancer Approved [11]
Folic Acid DMEMBJC Colorectal carcinoma Approved [12]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [11]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [11]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [13]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [11]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [14]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [15]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [16]
Gefitinib DM15F0X Colon adenocarcinoma Approved [17]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [18]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [19]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [20]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [21]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [20]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [23]
Methotrexate DM2TEOL Anterior urethra cancer Approved [24]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [25]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [26]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [27]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [28]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [29]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [16]
Verapamil DMA7PEW Angina pectoris BA40 Approved [30]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [31]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [32]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [33]
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Drug(s) Affected By Receptor-type tyrosine-protein kinase FLT3 (FLT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quizartinib DM8Y4JS Acute myeloid leukaemia 2A60 Approved [34]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [35]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [36]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [39]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [40]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [41]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [42]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [43]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [44]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [45]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [46]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [47]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [48]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [49]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [50]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [51]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [52]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [53]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [25]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [53]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [16]
Verapamil DMA7PEW Angina pectoris BA40 Approved [30]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [55]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [56]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Meloxicam DM2AR7L Arthritis FA20 Approved [58]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [21]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [19]
Selenium DM25CGV N. A. N. A. Approved [61]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [62]
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [64]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [65]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [67]
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Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [32]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [68]
Methotrexate DM2TEOL Anterior urethra cancer Approved [69]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [70]
Quercetin DM3NC4M Obesity 5B81 Approved [71]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [72]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [73]
Ethacrynic acid DM60QMR Edema MG29 Approved [74]
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Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [19]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [78]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [80]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [72]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [81]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [82]
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Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [83]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [84]
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Quercetin DM3NC4M Obesity 5B81 Approved [85]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [86]
Levamisole DM5EN79 Parasitic infection 1D0Y-1G2Z Approved [87]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [88]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [89]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [90]
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Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [91]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [91]
Gefitinib DM15F0X Colon adenocarcinoma Approved [92]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [29]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [93]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [94]
Methotrexate DM2TEOL Anterior urethra cancer Approved [95]
Quercetin DM3NC4M Obesity 5B81 Approved [96]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [97]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [98]
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Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [99]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [19]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [100]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [101]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [102]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [72]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [103]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [104]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [105]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Protein Interaction/Cellular Processes [3]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [4]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Protein Interaction/Cellular Processes [3]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Drug Response [5]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [3]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Protein Interaction/Cellular Processes [6]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [7]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Gene/Protein Processing [8]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Gene/Protein Processing [3]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [7]

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Venclexta FDA label
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49 Induction of mitochondrial manganese superoxide dismutase confers resistance to apoptosis in acute myeloblastic leukaemia cells exposed to etoposide. Br J Haematol. 2000 Mar;108(3):574-81. doi: 10.1046/j.1365-2141.2000.01852.x.
50 Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro. Tumour Biol. 2010 Dec;31(6):613-22. doi: 10.1007/s13277-010-0077-x. Epub 2010 Jul 11.
51 Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis. J Cell Physiol. 2000 Jan;182(1):24-32. doi: 10.1002/(SICI)1097-4652(200001)182:1<24::AID-JCP3>3.0.CO;2-6.
52 mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Biol Chem. 2004 Nov;385(11):1099-103. doi: 10.1515/BC.2004.143.
53 Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
54 Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
55 Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells. Ann N Y Acad Sci. 2005 May;1042:531-7. doi: 10.1196/annals.1338.065.
56 BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
57 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
58 Combining kallistatin gene therapy and meloxicam to treat hepatocellular carcinoma in mice. Cancer Sci. 2009 Nov;100(11):2226-33. doi: 10.1111/j.1349-7006.2009.01306.x. Epub 2009 Aug 4.
59 Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
60 Expression of the retinoic acid-metabolizing enzyme CYP26A1 limits programmed cell death. Mol Pharmacol. 2005 May;67(5):1808-17. doi: 10.1124/mol.104.005769. Epub 2005 Feb 9.
61 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
62 Role of BAX in the apoptotic response to anticancer agents. Science. 2000 Nov 3;290(5493):989-92. doi: 10.1126/science.290.5493.989.
63 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
64 Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells. Oncogene. 2005 Feb 10;24(7):1231-43. doi: 10.1038/sj.onc.1208290.
65 Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice. Int J Cancer. 2008 Aug 15;123(4):951-7. doi: 10.1002/ijc.23593.
66 Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
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