Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM92VRP)

Drug Name
Batimastat Drug Info
Synonyms
batimastat; 130370-60-4; BB-94; Batimastat (BB-94); BB 94; UNII-BK349F52C9; BB94; Batimastat(BB-94); C23H31N3O4S2; CHEMBL279786; BK349F52C9; Butanediamide, N4-hydroxy-N1-(2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl)-2-(2-methylpropyl)-3-((2-thienylthio)methyl)-, (2R-(1(S*),2R*,3S*))-; 4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE; (2S,3R)-5-Methyl-3-(((alphaS)-alpha-(methylcarbamoyl)phenethyl)carbamoyl)-2-((2-thienylthio)methyl)hexanohydroxamic acid
Indication
Disease Entry ICD 11 Status REF
Idiopathic pulmonary fibrosis CB03.4 Preclinical [1]
Cross-matching ID
PubChem CID
5362422
CAS Number
CAS 130370-60-4
TTD Drug ID
DM92VRP

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Patented Agent(s)
Discontinued Drug(s)
Investigative Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Matrix metalloproteinase-3 (MMP-3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID29130358-Compound-Figure10(2a) DMFWXPS N. A. N. A. Patented [5]
GM6001 DM7V9CT Corneal ulcer 9A76 Discontinued in Phase 2 [6]
RS-130830 DMOTANY Hepatitis C virus infection 1E51.1 Discontinued in Phase 2 [7]
PG-530742 DMELXBQ Myocardial infarction BA41-BA43 Discontinued in Phase 2 [8]
SC-44463 DMBPNKT N. A. N. A. Terminated [9]
BB-1101 DM7GH5Z Multiple sclerosis 8A40 Terminated [10]
L-696418 DMV785R N. A. N. A. Terminated [11]
RO-319790 DML3NEU Rheumatoid arthritis FA20 Terminated [12]
MMI270 DM38N2K Discovery agent N.A. Investigative [13]
IK-862 DMJA4UE Discovery agent N.A. Investigative [14]
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Drug(s) Affected By Protransforming growth factor alpha (TGFA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [15]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [15]
Methotrexate DM2TEOL Anterior urethra cancer Approved [16]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [17]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [19]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [20]
Leflunomide DMR8ONJ Arthritis FA20 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [22]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [23]
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Drug(s) Affected By Furin (FURIN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [24]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [25]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [26]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [29]
Arsenic DMTL2Y1 N. A. N. A. Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [31]
Paclitaxel DMLB81S Breast carcinoma Approved [32]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [33]
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Drug(s) Affected By Amphiregulin (AREG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [34]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [35]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [36]
Methotrexate DM2TEOL Anterior urethra cancer Approved [16]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Estrone DM5T6US Acne vulgaris ED80 Approved [39]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [40]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [41]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [42]
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Drug(s) Affected By Metalloproteinase inhibitor 2 (TIMP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [44]
Selenium DM25CGV N. A. N. A. Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [46]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [47]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [48]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [26]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [20]
Tetracaine DM9J6C2 Spinal anesthesia MB40.3 Approved [49]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [50]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [51]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [52]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [53]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [55]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [56]
Gefitinib DM15F0X Colon adenocarcinoma Approved [57]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [58]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [59]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [60]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [51]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [61]
Paclitaxel DMLB81S Breast carcinoma Approved [62]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [63]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [50]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [64]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [65]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [53]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Matrix metalloproteinase-3 (MMP-3) TTUZ2L5 MMP3_HUMAN Modulator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Amphiregulin (AREG) OTJFOR67 AREG_HUMAN Protein Interaction/Cellular Processes [3]
Furin (FURIN) OTM2665Z FURIN_HUMAN Gene/Protein Processing [4]
Metalloproteinase inhibitor 2 (TIMP2) OT8S1RRP TIMP2_HUMAN Gene/Protein Processing [4]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Gene/Protein Processing [3]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Gene/Protein Processing [3]
Protransforming growth factor alpha (TGFA) OTPD1LL9 TGFA_HUMAN Protein Interaction/Cellular Processes [3]

References

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32 cDNA microarray analysis of isogenic paclitaxel- and doxorubicin-resistant breast tumor cell lines reveals distinct drug-specific genetic signatures of resistance. Breast Cancer Res Treat. 2006 Mar;96(1):17-39. doi: 10.1007/s10549-005-9026-6. Epub 2005 Dec 2.
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