Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBKVJY)

Drug Name
PMEA Drug Info
Synonyms
ADEFOVIR; 106941-25-7; PMEA; ((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid; 9-(2-Phosphonylmethoxyethyl)adenine; GS-0393; GS 0393; GS 393; 9-(2-(Phosphonomethoxy)ethyl)adenine; N-(2-Phosphonylmethoxyethyl)adenine; DRG-0156; UNII-6GQP90I798; C8H12N5O4P; HSDB 8079; CHEMBL484; 2-(6-aminopurin-9-yl)ethoxymethylphosphonic acid; BRN 3561094; {[2-(6-Amino-9h-Purin-9-Yl)ethoxy]methyl}phosphonic Acid; N-(2-Phophonomethoxyethyl-2,6-diaminopurine); Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]-; 6GQP90I798
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
60172
ChEBI ID
CHEBI:2469
CAS Number
CAS 106941-25-7
TTD Drug ID
DMBKVJY

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Herpes simplex virus DNA polymerase UL30 (HSV UL30)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [7]
Aciclovir DMYLOVR Genital herpes 1A94 Approved [8]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [9]
Valaciclovir DMHKS94 Genital herpes 1A94 Approved [10]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [8]
Valganciclovir DMS2IUH Virus infection 1A24-1D9Z Approved [11]
Penciclovir DMOUMDV Herpes simplex labialis 1F00.01 Approved [12]
Famciclovir DMJHLSD Meniere disease AB31.0 Approved [13]
Valacyclovir Hydrochloride DM5I1CE Herpes simplex virus infection 1F00 Approved [8]
Foscavir DM9KJLZ Cytomegalovirus retinitis 9B72.00 Approved [11]
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Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [14]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [15]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [16]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [17]
Capsaicin DMGMF6V Back pain ME84.Z Approved [18]
Zafirlukast DMHNQOG Asthma CA23 Approved [19]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [16]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [20]
Fluconazole DMOWZ6B Cryptococcal meningitis Approved [17]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [16]
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Drug(s) Affected By Methylmalonyl-CoA mutase, mitochondrial (MMUT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [21]
Selenium DM25CGV N. A. N. A. Approved [22]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [4]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [23]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [24]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [25]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [26]
Gentamicin DMKINJO Bacteremia 1A73 Approved [27]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [28]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [4]
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Drug(s) Affected By Organic anion transporter 3 (SLC22A8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valsartan DMREUQ6 Chronic heart failure BD1Z Approved [29]
Methotrexate DM2TEOL Anterior urethra cancer Approved [30]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [5]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [31]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [32]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [32]
Cefdinir DMJ7A0H Bacterial infection 1A00-1C4Z Approved [33]
Cefaclor DMJXDGC Bacterial infection 1A00-1C4Z Approved [33]
Famotidine DMRL3AB Gastric ulcer DA60 Approved [34]
Tetracycline DMZA017 Acne vulgaris ED80 Approved [35]
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Drug(s) Affected By Solute carrier family 22 member 6 (SLC22A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [30]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [36]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [36]
Quercetin DM3NC4M Obesity 5B81 Approved [37]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [36]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [36]
Succinic acid DMDWICP Malnutrition 5B50-5B71 Approved [38]
Mefenamic acid DMK7HFI Dysmenorrhea GA34.3 Approved [36]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [39]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [36]
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Drug(s) Affected By ATP-binding cassette sub-family C member 4 (ABCC4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [40]
Quercetin DM3NC4M Obesity 5B81 Approved [41]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [42]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [44]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [45]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [46]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [24]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Herpes simplex virus DNA polymerase UL30 (HSV UL30) TTIU7X1 DPOL_HHV11 Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ATP-binding cassette sub-family C member 4 (ABCC4) OTO27PAL MRP4_HUMAN Regulation of Drug Effects [2]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Gene/Protein Processing [3]
Methylmalonyl-CoA mutase, mitochondrial (MMUT) OTBBBV70 MUTA_HUMAN Gene/Protein Processing [4]
Organic anion transporter 3 (SLC22A8) OT8BY933 S22A8_HUMAN Drug Response [5]
Solute carrier family 22 member 6 (SLC22A6) OTKRCBVM S22A6_HUMAN Drug Response [6]

References

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22 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
23 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
24 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
25 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
26 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
27 Stop codon read-through of a methylmalonic aciduria mutation. Mol Genet Metab. 2009 Aug;97(4):244-9. doi: 10.1016/j.ymgme.2009.04.004. Epub 2009 Apr 12.
28 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
29 Uric acid accumulation in the kidney triggers mast cell degranulation and aggravates renal oxidative stress. Toxicology. 2023 Jan 1;483:153387. doi: 10.1016/j.tox.2022.153387. Epub 2022 Dec 1.
30 P-gp, MRP2 and OAT1/OAT3 mediate the drug-drug interaction between resveratrol and methotrexate. Toxicol Appl Pharmacol. 2016 Sep 1;306:27-35. doi: 10.1016/j.taap.2016.06.030. Epub 2016 Jul 1.
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32 A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters. J Pharmacol Exp Ther. 2005 Oct;315(1):337-45.
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36 Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther. 2002 Nov;303(2):534-9.
37 Potent Inhibitors of Organic Anion Transporters 1 and 3 From Natural Compounds and Their Protective Effect on Aristolochic Acid Nephropathy. Toxicol Sci. 2020 Jun 1;175(2):279-291. doi: 10.1093/toxsci/kfaa033.
38 Lack of efflux of diglycolic acid from proximal tubule cells leads to its accumulation and to toxicity of diethylene glycol. Toxicol Lett. 2023 Apr 15;379:48-55. doi: 10.1016/j.toxlet.2023.03.007. Epub 2023 Mar 22.
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