Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMI5DW1)

Drug Name
Hesperidin Drug Info
Synonyms
hesperidin; 520-26-3; Cirantin; Hesperidoside; Hesper bitabs; Hesperetin-rutinosid; Hesperidine; UNII-E750O06Y6O; CCRIS 3940; (S)-(-)-Hesperidin; EINECS 208-288-1; NSC 44184; BRN 0075140; Hesperidin, (2S)-; Hesperetin 7-rutinoside; MLS001304066; (2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-2,3-dihydrochromen-4-one; CHEBI:28775; USAF CF-3; Hesperidin, (S)-(-)-; Hesperitin-7-rhamnoglucoside; E750O06Y6O; C28H34O15; HESPERIDINE
Indication
Disease Entry ICD 11 Status REF
Vascular purpura 3B60 Approved [1]
Cross-matching ID
PubChem CID
10621
ChEBI ID
CHEBI:28775
CAS Number
CAS 520-26-3
TTD Drug ID
DMI5DW1
VARIDT Drug ID
DR00632

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Preclinical Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Voltage-gated calcium channel alpha Cav2.2 (CACNA1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
LOMERIZINE DME0TC8 Migraine 8A80 Approved [7]
Ziconotide DMSLJP4 Pain MG30-MG3Z Approved [8]
Cilnidipine DM1975O High blood pressure BA00 Phase 3 [9]
Ralfinamide DMUNMY0 Neuropathic pain 8E43.0 Phase 3 [10]
CNV-2197944 DMLT7JV Pain MG30-MG3Z Phase 2 [11]
Ritanserin DM0X36Y Anxiety disorder 6B00-6B0Z Discontinued in Phase 3 [12]
CNSB-004 DMHAI0M Pain MG30-MG3Z Preclinical [13]
TH-9229 DMG1MPD Reperfusion injury ND56.Z Terminated [14]
PD-157667 DM61NFD N. A. N. A. Terminated [15]
PD-0204318 DMGKVPH Pain MG30-MG3Z Terminated [16]
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Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [17]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [18]
Gefitinib DM15F0X Colon adenocarcinoma Approved [19]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [20]
Selenium DM25CGV N. A. N. A. Approved [21]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [22]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [23]
Methotrexate DM2TEOL Anterior urethra cancer Approved [24]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [25]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [26]
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Drug(s) Affected By Glucose-6-phosphate 1-dehydrogenase (G6PD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [27]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [28]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [29]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [18]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [30]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [31]
Quercetin DM3NC4M Obesity 5B81 Approved [32]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [33]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [34]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [35]
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Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [36]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [37]
Selenium DM25CGV N. A. N. A. Approved [38]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [39]
Methotrexate DM2TEOL Anterior urethra cancer Approved [40]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [41]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [42]
Quercetin DM3NC4M Obesity 5B81 Approved [43]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [44]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [45]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [46]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [47]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [48]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [49]
Gefitinib DM15F0X Colon adenocarcinoma Approved [50]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [51]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [52]
Selenium DM25CGV N. A. N. A. Approved [53]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [54]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [55]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [56]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [57]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [58]
Gefitinib DM15F0X Colon adenocarcinoma Approved [59]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [51]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Etretinate DM2CZFA Keratosis ED56 Approved [61]
Prednisone DM2HG4X Acute asthma CA23 Approved [62]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [63]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [64]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [65]
Gefitinib DM15F0X Colon adenocarcinoma Approved [50]
Prednisone DM2HG4X Acute asthma CA23 Approved [62]
Methotrexate DM2TEOL Anterior urethra cancer Approved [66]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [67]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [68]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Fluoxetine DM3PD2C Bipolar depression Approved [70]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [71]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
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Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [37]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [73]
Gefitinib DM15F0X Colon adenocarcinoma Approved [74]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [75]
Methotrexate DM2TEOL Anterior urethra cancer Approved [76]
Quercetin DM3NC4M Obesity 5B81 Approved [77]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [44]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Panobinostat DM58WKG Chronic graft versus host disease Approved [80]
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Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 5 (MAP2K5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [45]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [82]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [83]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [84]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [85]
Arsenic DMTL2Y1 N. A. N. A. Approved [86]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [27]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [87]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [84]
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Drug(s) Affected By Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [88]
Methotrexate DM2TEOL Anterior urethra cancer Approved [76]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [89]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [90]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [91]
Leflunomide DMR8ONJ Arthritis FA20 Approved [92]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [83]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [93]
Menthol DMG2KW7 Back pain ME84.Z Approved [94]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [95]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 25 (TNFRSF25)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [88]
Methotrexate DM2TEOL Anterior urethra cancer Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [45]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [96]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [97]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [91]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [99]
Menthol DMG2KW7 Back pain ME84.Z Approved [94]
Capsaicin DMGMF6V Back pain ME84.Z Approved [100]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) TT4FDG6 CAC1B_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Gene/Protein Processing [3]
Cyclin-dependent kinase 6 (CDK6) OTR95N0X CDK6_HUMAN Gene/Protein Processing [3]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [3]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Gene/Protein Processing [3]
Dual specificity mitogen-activated protein kinase kinase 5 (MAP2K5) OT6T408U MP2K5_HUMAN Post-Translational Modifications [3]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [3]
Glucose-6-phosphate 1-dehydrogenase (G6PD) OT300SMK G6PD_HUMAN Gene/Protein Processing [4]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Protein Interaction/Cellular Processes [5]
Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) OTVZ7I3A TNR25_HUMAN Gene/Protein Processing [6]
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD) OTBOSJHO TRADD_HUMAN Gene/Protein Processing [6]

References

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57 Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
58 Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
59 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
60 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
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67 Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells. Melanoma Res. 2008 Apr;18(2):85-94. doi: 10.1097/CMR.0b013e3282f60097.
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71 Induction mechanism of apoptosis by troglitazone through peroxisome proliferator-activated receptor-gamma in gastric carcinoma cells. Anticancer Res. 2003 Jan-Feb;23(1A):267-73.
72 Down-regulation of CD44 contributes to the differentiation of HL-60 cells induced by ATRA or HMBA. Cell Mol Immunol. 2007 Feb;4(1):59-63.
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