Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLP68J)

• Drug Name: [3H]CGS8216 Drug Info
• Synonyms: 2-Phenylpyrazolo(4,3-c)quinolin-3(5H)-one; Cgs 8216; CGS-8216; 77779-60-3; 2-phenylpyrazolo(4,3-c)quinolin-3(5H)-one; BRN 4257286; 2-phenyl-1,2-dihydro-3h-pyrazolo[4,3-c]quinolin-3-one; 2,5-Dihydro-2-phenyl-3H-pyrazolo(4,3-c)quinolin-3-one; 3H-Pyrazolo(4,3-c)quinolin-3-one, 2,5-dihydro-2-phenyl-; 2-phenyl-1H-pyrazolo[4,5-c]quinolin-3-one; 2,5-DIHYDRO-2-PHENYL-3H-PYRAZOLO[4,3-C]QUINOLIN-3-ONE; AC1Q6FQG; AC1Q6NJI; AC1L2XPQ; 2-phenyl-1H-pyrazolo[4,3-c]quinolin-3-one; 2-phenyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-one; GTPL4366; GTPL4156; SCHEMBL1466280

Indication

Disease Entry	ICD 11	Status	REF
Inflammation	1A00-CA43.1	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 104916
  CAS Number: CAS 77779-60-3
  TTD Drug ID: DMLP68J

Molecule-Related Drug Atlas

Drug(s) Targeting GABA(A) receptor gamma-2 (GABRG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[7]
THIOCOLCHICOSIDE	DMEPWYA	Muscle spasm	MB47.3	Approved	[8]
ZK-93423	DMFWMKZ	Epileptic seizures	8A61-8A6Z	Phase 3	[9]
GSK683699	DMTW79H	Inflammatory bowel disease	DD72	Phase 2	[8]
ELTANOLONE	DM38CIV	Premenstrual syndrome	GA34.40	Discontinued in Phase 3	[7]
U-78875	DM2WOPX	Anxiety disorder	6B00-6B0Z	Discontinued in Phase 1	[10]
CGS-9896	DM39PQI	N. A.	N. A.	Terminated	[11]
CGS-17867A	DMMZJY3	Alcohol dependence	6C40.2	Terminated	[12]
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[13]
AMENTOFLAVONE	DMLRNV2	Discovery agent	N.A.	Investigative	[14]

Drug(s) Targeting GABA(A) receptor alpha-5 (GABRA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flumazenil	DMPCG2L	Benzodiazepine overdose	PC91	Approved	[5]
GSK683699	DMTW79H	Inflammatory bowel disease	DD72	Phase 2	[15]
Basmisanil	DMQ8J0U	Alzheimer disease	8A20	Phase 2	[16]
RG-7816	DMD16JK	Autism spectrum disorder	6A02	Phase 1	[17]
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[5]
AMENTOFLAVONE	DMLRNV2	Discovery agent	N.A.	Investigative	[14]
Ro-15-3505	DM4NW3U	Discovery agent	N.A.	Investigative	[18]
isonipecotic acid	DMO1ZHE	Discovery agent	N.A.	Investigative	[5]
[3H]Ro154513	DMMBWKL	Discovery agent	N.A.	Investigative	[19]
CI-218872	DM0RH3S	Discovery agent	N.A.	Investigative	[20]

Drug(s) Targeting GABA(A) receptor gamma-3 (GABRG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolpidem	DMWOSKJ	Insomnia	7A00-7A0Z	Approved	[6]
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[16]
Clobazam - Lundbeck	DMW1OQ0	Anxiety disorder	6B00-6B0Z	Approved	[21]
Flumazenil	DMPCG2L	Benzodiazepine overdose	PC91	Approved	[6]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[22]
Thiamylal	DMHDF7B	Anaesthesia	9A78.6	Approved	[21]
Ganaxolone	DMXJMKF	Epileptic seizures	8A61-8A6Z	Approved	[16]
Mebutamate	DM0KYI4	Anxiety disorder	6B00-6B0Z	Approved	[21]
Metharbital	DM5A38V	Epilepsy	8A60-8A68	Approved	[21]
Etomidate	DMZI3WO	Anaesthesia	9A78.6	Approved	[21]

Drug(s) Targeting GABA(A) receptor alpha-2 (GABRA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flumazenil	DMPCG2L	Benzodiazepine overdose	PC91	Approved	[3]
GSK683699	DMTW79H	Inflammatory bowel disease	DD72	Phase 2	[15]
PF-4480682	DMWYJHC	Neuropathic pain	8E43.0	Discontinued in Phase 2	[23]
CGS-17867A	DMMZJY3	Alcohol dependence	6C40.2	Terminated	[12]
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[3]
AMENTOFLAVONE	DMLRNV2	Discovery agent	N.A.	Investigative	[14]
Ro-15-3505	DM4NW3U	Discovery agent	N.A.	Investigative	[18]
isonipecotic acid	DMO1ZHE	Discovery agent	N.A.	Investigative	[3]
[3H]Ro154513	DMMBWKL	Discovery agent	N.A.	Investigative	[19]
CI-218872	DM0RH3S	Discovery agent	N.A.	Investigative	[20]

Drug(s) Targeting GABA(A) receptor alpha-1 (GABRA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[24]
Zolpidem	DMWOSKJ	Insomnia	7A00-7A0Z	Approved	[25]
Methoxyflurane	DML0RAE	Anaesthesia	9A78.6	Approved	[24]
Nitrazepam	DMEGIQ6	Epilepsy	8A60-8A68	Approved	[24]
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[7]
Clobazam - Lundbeck	DMW1OQ0	Anxiety disorder	6B00-6B0Z	Approved	[24]
Hexobarbital	DMQ314B	Anaesthesia	9A78.6	Approved	[24]
THIOCOLCHICOSIDE	DMEPWYA	Muscle spasm	MB47.3	Approved	[8]
Meprobamate	DMHM93Y	Anxiety		Approved	[24]
Zaleplon	DMGFWSM	Insomnia	7A00-7A0Z	Approved	[21]

Drug(s) Targeting GABA(A) receptor alpha-3 (GABRA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flumazenil	DMPCG2L	Benzodiazepine overdose	PC91	Approved	[4]
GSK683699	DMTW79H	Inflammatory bowel disease	DD72	Phase 2	[15]
Adipiplon	DM821BS	Sleep-wake disorder	7A00-7B2Z	Phase 2	[26]
NS-2710	DMMUR6V	Anxiety disorder	6B00-6B0Z	Phase 2	[27]
AZD6280	DMFAZLU	Anxiety disorder	6B00-6B0Z	Discontinued in Phase 1	[28]
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[4]
AMENTOFLAVONE	DMLRNV2	Discovery agent	N.A.	Investigative	[14]
Ro-15-3505	DM4NW3U	Discovery agent	N.A.	Investigative	[18]
isonipecotic acid	DMO1ZHE	Discovery agent	N.A.	Investigative	[4]
[3H]Ro154513	DMMBWKL	Discovery agent	N.A.	Investigative	[19]

Drug(s) Targeting Gamma-aminobutyric acid receptor (GAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[24]
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[29]
THIOCOLCHICOSIDE	DMEPWYA	Muscle spasm	MB47.3	Approved	[8]
Clonazepam	DMTO13J	Absence epilepsy		Approved	[30]
Piperazine	DMTY9LU	Ascariasis	1F62	Approved	[31]
Alpidem	DMN7Y9K	Anxiety disorder	6B00-6B0Z	Approved	[32]
Moxidectin	DMYGHX5	Onchocerciasis	1F6A	Approved	[33]
DP-VPA	DMGOXPQ	Bipolar disorder	6A60	Approved	[34]
ANDROSTERONE	DMITJAK	N. A.	N. A.	Phase 3	[29]
ZK-93423	DMFWMKZ	Epileptic seizures	8A61-8A6Z	Phase 3	[9]

Drug(s) Targeting GABA(A) receptor beta-2 (GABRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[7]
THIOCOLCHICOSIDE	DMEPWYA	Muscle spasm	MB47.3	Approved	[8]
Ethchlorvynol	DM53IP1	Insomnia	7A00-7A0Z	Approved	[24]
ZK-93423	DMFWMKZ	Epileptic seizures	8A61-8A6Z	Phase 3	[9]
GSK683699	DMTW79H	Inflammatory bowel disease	DD72	Phase 2	[8]
ELTANOLONE	DM38CIV	Premenstrual syndrome	GA34.40	Discontinued in Phase 3	[7]
U-78875	DM2WOPX	Anxiety disorder	6B00-6B0Z	Discontinued in Phase 1	[35]
CGS-9896	DM39PQI	N. A.	N. A.	Terminated	[11]
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[36]
AMENTOFLAVONE	DMLRNV2	Discovery agent	N.A.	Investigative	[14]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
GABA(A) receptor alpha-1 (GABRA1)	TT1MPAY	GBRA1_HUMAN	Inhibitor	[2]
GABA(A) receptor alpha-2 (GABRA2)	TTBMV1G	GBRA2_HUMAN	Modulator (allosteric modulator)	[3]
GABA(A) receptor alpha-3 (GABRA3)	TT37EDJ	GBRA3_HUMAN	Modulator (allosteric modulator)	[4]
GABA(A) receptor alpha-5 (GABRA5)	TTNZPQ1	GBRA5_HUMAN	Modulator (allosteric modulator)	[5]
GABA(A) receptor beta-2 (GABRB2)	TTZA1NY	GBRB2_HUMAN	Inhibitor	[1]
GABA(A) receptor gamma-2 (GABRG2)	TT06RH5	GBRG2_HUMAN	Inhibitor	[2]
GABA(A) receptor gamma-3 (GABRG3)	TTEX6LM	GBRG3_HUMAN	Modulator (allosteric modulator)	[6]
Gamma-aminobutyric acid receptor (GAR)	TTNJYV2	NOUNIPROTAC	Inhibitor	[2]

References

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