Details of the Drug-Related molecule(s) Interaction Atlas

HSDB-41 Drug Info

Aceton; Aceton [German, Dutch, Polish]; Acetone (natural); Acetone; Acetone [NF]; Chevron acetone; Dimethyl formaldehyde; Dimethyl ketone; Dimethylformaldehyde; Dimethylketal; Ketone propane; Ketone, dimethyl; Ketone, dimethyl-; Methyl ketone; Pyroacetic acid; Pyroacetic ether; RCRA waste number U002; UN1090; acetone; beta-Ketopropane; dimethylketone; propan-2-one; propanone; .beta.-Ketopropane; 2-propanone; 67-64-1; CCRIS 5953; Caswell No. 004; EINECS 200-662-2; FEMA No. 3326; HSDB 41; MFCD00008765; NSC 135802; UNII-1364PS73AF

Cross-matching ID

PubChem CID

180

ChEBI ID

CHEBI:15347

CAS Number

CAS 67-64-1

TTD Drug ID

DMR8VJA

INTEDE Drug ID

DR2231

General Information of Drug (ID: DMR8VJA)

Molecule-Related Drug Atlas

Molecule Type:

DME

DOT

Drug Status:

Approved Drug(s)

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Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[6]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[7]
Haloperidol	DM96SE0	Delirium		Approved	[8]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[9]
Selenium	DM25CGV	N. A.	N. A.	Approved	[10]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[11]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[12]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[13]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[14]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[15]
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Drug(s) Affected By Fibronectin (FN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[13]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[18]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[21]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[24]
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Drug(s) Affected By Integrin alpha-5 (ITGA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[25]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[13]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[4]
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Drug(s) Affected By Fibroblast growth factor receptor 2 (FGFR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[25]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[36]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[36]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[37]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[40]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[42]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[43]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[44]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[45]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[46]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[48]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[49]
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Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fomepizole	DM6VOWQ	Athylene glycol or methanol poisoning	NE61	Approved	[50]
Ademetionine	DMYQDBO	Hepatic fibrosis	DB93.0	Approved	[51]
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[8]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[52]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[54]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[8]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[56]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Acetone carboxylase (ACX)	DE3YZC9	D5ASJ5_RHOCB	Substrate	[1]
Acetone carboxylase (ACX)	DEFUSL7	ACXB_XANP2	Substrate	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Catalase (CAT)	OTHEBX9R	CATA_HUMAN	Gene/Protein Processing	[2]
Cytochrome P450 2E1 (CYP2E1)	OTHQ17JG	CP2E1_HUMAN	Regulation of Drug Effects	[3]
Fibroblast growth factor receptor 2 (FGFR2)	OTLOPACK	FGFR2_HUMAN	Gene/Protein Processing	[4]
Fibronectin (FN1)	OTB5ZN4Q	FINC_HUMAN	Gene/Protein Processing	[5]
G1/S-specific cyclin-D1 (CCND1)	OT8HPTKJ	CCND1_HUMAN	Gene/Protein Processing	[4]
Integrin alpha-5 (ITGA5)	OT3RCI67	ITA5_HUMAN	Gene/Protein Processing	[4]

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