Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSAJO8)

Drug Name
ODQ Drug Info
Synonyms
1h-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one; 41443-28-1; ODQ; [1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one; UNII-S57V2NMV38; S57V2NMV38; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one; ODQ, 98%; SR-01000075519; 1-H-[1,2,4]Oxadiazolo-[4,3,2]quinoxalin-1-ine; 1H-ODQ; Tocris-0880; AC1L1BIQ; Lopac-O-3636; AC1Q6H5T; Lopac0_000953; SCHEMBL210817; CHEMBL598952; GTPL5234; DTXSID2036796; CTK1D6485; CHEBI:91215; MolPort-003-959-081; HMS3649K18; HMS3262P08; HMS3266N10; KS-000013GE; ZINC2569341; BCP06748; Tox21_500953; GL1507; 1963AH; MFCD00792620; BS0137
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
1456
ChEBI ID
CHEBI:91215
CAS Number
CAS 41443-28-1
TTD Drug ID
DMSAJO8

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Soluble guanylyl cyclase (GUCY2D)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Riociguat DMXBLMP Chronic thromboembolic pulmonary hypertension Approved [5]
Vericiguat DM7MDBE Heart failure BD10-BD13 Approved [6]
FK-409 DMKVXYS Angina pectoris BA40 Phase 2 [7]
BAY412272 DM0M59T Discovery agent N.A. Investigative [8]
NS 2028 DML0N7D Discovery agent N.A. Investigative [9]
Drug(s) Affected By Osteocalcin (BGLAP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [10]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [11]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [12]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [13]
Quercetin DM3NC4M Obesity 5B81 Approved [14]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [15]
Pamidronate DMB4AVP Bone Paget disease Approved [16]
Falecalcitrol DMBI9ZJ Hyperparathyroidism 5A51 Approved [17]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [18]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [19]
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Drug(s) Affected By Collagen alpha-2(I) chain (COL1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [20]
Panobinostat DM58WKG Chronic graft versus host disease Approved [21]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [22]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [23]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [24]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Testosterone enanthate DMB6871 N. A. N. A. Approved [26]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [27]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [28]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [29]
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Drug(s) Affected By Osteopontin (SPP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [30]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [31]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [32]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [33]
Quercetin DM3NC4M Obesity 5B81 Approved [34]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [35]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [36]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [37]
Panobinostat DM58WKG Chronic graft versus host disease Approved [21]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [38]
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Drug(s) Affected By Integrin-binding sialoprotein (IBSP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [39]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [40]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [41]
Calcidiol DMN4CV5 Hypophosphatemia Approved [40]
Magnesium DMU4ORS Ischemic stroke 8B11.5Z Approved [42]
Vitamin C DMXJ7O8 Adenocarcinoma 2D40 Approved [43]
Camptothecin DM6CHNJ Solid tumour/cancer 2A00-2F9Z Phase 3 [44]
GSK2816126 DMJDVW4 Solid tumour/cancer 2A00-2F9Z Phase 1 [45]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [46]
EUGENOL DM7US1H Discovery agent N.A. Patented [47]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [48]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [49]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [50]
Gefitinib DM15F0X Colon adenocarcinoma Approved [51]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [52]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [53]
Etretinate DM2CZFA Keratosis ED56 Approved [54]
Prednisone DM2HG4X Acute asthma CA23 Approved [55]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [56]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [57]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [58]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [59]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [60]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [61]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [62]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [63]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [64]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [65]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [66]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [67]
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Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [68]
Flucytosine DM13VTW Cryptococcal meningitis Approved [69]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [69]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Methotrexate DM2TEOL Anterior urethra cancer Approved [71]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [72]
Quercetin DM3NC4M Obesity 5B81 Approved [14]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [73]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [74]
Amifostine DM5FL14 Mucositis CA00 Approved [75]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [76]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [67]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [77]
Verapamil DMA7PEW Angina pectoris BA40 Approved [78]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [79]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [80]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [52]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [81]
Meloxicam DM2AR7L Arthritis FA20 Approved [82]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [56]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Soluble guanylyl cyclase (GUCY2D) TTWNFC2 GUC2D_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [3]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [3]
Collagen alpha-2(I) chain (COL1A2) OTY7G382 CO1A2_HUMAN Gene/Protein Processing [4]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [3]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Gene/Protein Processing [3]
E3 ubiquitin-protein ligase XIAP OT24GP9B XIAP_HUMAN Drug Response [3]
Integrin-binding sialoprotein (IBSP) OT29944Y SIAL_HUMAN Gene/Protein Processing [4]
Osteocalcin (BGLAP) OTK1YLWQ OSTCN_HUMAN Gene/Protein Processing [4]
Osteopontin (SPP1) OTJGC23Y OSTP_HUMAN Gene/Protein Processing [4]

References

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32 Chronic senescent human mesenchymal stem cells as possible contributor to the wound healing disorder after exposure to the alkylating agent sulfur mustard. Arch Toxicol. 2021 Feb;95(2):727-747. doi: 10.1007/s00204-020-02946-5. Epub 2021 Jan 25.
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37 Gene microarray analysis of human renal cell carcinoma: the effects of HDAC inhibition and retinoid treatment. Cancer Biol Ther. 2008 Oct;7(10):1607-18.
38 Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq. Arch Toxicol. 2018 Aug;92(8):2517-2531.
39 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
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49 Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
50 Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
51 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
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68 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
69 Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells. Oncogene. 2005 Feb 10;24(7):1231-43. doi: 10.1038/sj.onc.1208290.
70 In vitro antioxidant and antigenotoxic potentials of 3,5-O-di-galloylquinic acid extracted from Myrtus communis leaves and modulation of cell gene expression by H2O2. J Appl Toxicol. 2012 May;32(5):333-41.
71 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
72 HMG-CoA reductase inhibitors, statins, induce phosphorylation of Mdm2 and attenuate the p53 response to DNA damage. FASEB J. 2005 Mar;19(3):476-8. doi: 10.1096/fj.04-2745fje. Epub 2004 Dec 29.
73 Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line. Toxicol Appl Pharmacol. 2006 Oct 1;216(1):89-97. doi: 10.1016/j.taap.2006.04.015. Epub 2006 May 19.
74 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
75 Amifostine impairs p53-mediated apoptosis of human myeloid leukemia cells. Mol Cancer Ther. 2003 Sep;2(9):893-900.
76 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
77 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
78 Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. Toxicol In Vitro. 2018 Oct;52:306-313. doi: 10.1016/j.tiv.2018.07.001. Epub 2018 Jul 9.
79 Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
80 Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells. Ann N Y Acad Sci. 2005 May;1042:531-7. doi: 10.1196/annals.1338.065.
81 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
82 Combining kallistatin gene therapy and meloxicam to treat hepatocellular carcinoma in mice. Cancer Sci. 2009 Nov;100(11):2226-33. doi: 10.1111/j.1349-7006.2009.01306.x. Epub 2009 Aug 4.