Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTOUY9)

Drug Name
Suramin Drug Info
Synonyms
Antrypol; Belganyl; Farma; Fourneau; Germanin; Moranyl; Naganil; Naganin; Naganine; Naganol; Naphuride; SVR; Suramine; SURAMIN SODIUM; Sodium suramin; Suramine sodium; Farma 939; Naganol 6 Na; Germanin (TN); SGCTO-001
Indication
Disease Entry ICD 11 Status REF
African trypanosomiasis 1F51 Phase 1 [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [2]
Therapeutic Class
Antinematodal Agents
Cross-matching ID
PubChem CID
5361
ChEBI ID
CHEBI:45906
CAS Number
CAS 145-63-1
TTD Drug ID
DMTOUY9

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Approved Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Heparanase (HPSE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PG-545 DM68D3O Ocular disease 1F00.1Z Phase 1 [11]
Neutralase DMXHWK6 Angiogenesis disorder BE2Z Discontinued in Phase 3 [12]
Drug(s) Targeting Follicle-stimulating hormone receptor (FSHR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Urofollitropin DMG9HIA Female infertility GA31.Z Approved [13]
Menotropins DM4CF18 Female infertility GA31.Z Approved [14]
Follitropin beta DM2JTS5 Female infertility GA31.Z Approved [15]
Recombinant follicle stimulating hormone DMNHOI3 Female infertility GA31.Z Investigative [16]
PRX-111 DMSPH30 Female infertility GA31.Z Investigative [17]
Long-acting FSH conjugate DMD32IN Female infertility GA31.Z Investigative [16]
FSHR NAM DMPRMOD Contraception QA21 Investigative [16]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Targeting COVID-19 RNA-directed RNA polymerase (RdRp)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [18]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [19]
Penciclovir DMOUMDV Herpes simplex labialis 1F00.01 Approved [18]
Anidulafungin DM8QM5U Aspergillosis 1F20 Approved [2]
Favipiravir DMBZ27L Influenza virus infection 1E30-1E32 Registered [20]
Galidesivir DMG9C4I Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 1 Trial [21]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [22]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [22]
Etoricoxib DM6A4NW Rheumatoid arthritis FA20 Approved [22]
Capsaicin DMGMF6V Back pain ME84.Z Approved [23]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [24]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [25]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [26]
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [27]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [28]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [29]
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Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [30]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [31]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [32]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [33]
Capsaicin DMGMF6V Back pain ME84.Z Approved [23]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [5]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [25]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [5]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [31]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [29]
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Drug(s) Affected By Hematopoietic prostaglandin D synthase (HPGDS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [34]
Sanguinarine DMDINFS Dental plaque DA08.4 Approved [8]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [35]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [36]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [37]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [38]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [39]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [40]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [41]
Fructose DM43AN2 Vomiting MD90 Approved [29]
Ketoprofen DMRKXPT Bursitis Approved [29]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [42]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [43]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [44]
Gefitinib DM15F0X Colon adenocarcinoma Approved [45]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [46]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
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Drug(s) Affected By Fibroblast growth factor 2 (FGF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [48]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [49]
Diazepam DM08E9O Alcohol withdrawal Approved [50]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [51]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [52]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [55]
Isradipine DMA5XGH Hypertension BA00-BA04 Approved [56]
Valdecoxib DMAY7H4 Osteoarthritis FA00-FA05 Approved [57]
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Drug(s) Affected By Fibroblast growth factor 5 (FGF5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [58]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [59]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [60]
Arsenic DMTL2Y1 N. A. N. A. Approved [61]
Ardeparin DMYRX8B Deep vein thrombosis BD71 Approved [62]
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [63]
Paclitaxel DMLB81S Breast carcinoma Approved [64]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [64]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [65]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [35]
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Drug(s) Affected By Fibroblast growth factor 7 (FGF7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [49]
Methotrexate DM2TEOL Anterior urethra cancer Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [68]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [66]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [72]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [73]
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Drug(s) Affected By Interleukin-10 (IL10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [74]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [75]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [76]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [78]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Bisoprolol DM3UZ95 Hypertension BA00-BA04 Approved [80]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [81]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [82]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [83]
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Drug(s) Affected By SHC-transforming protein 1 (SHC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [84]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [85]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [55]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [88]
Bortezomib DMNO38U Leukemia Approved [89]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [91]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [92]
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Drug(s) Affected By Interleukin-12 subunit beta (IL12B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [75]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [81]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [83]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [93]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [94]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [95]
Capsaicin DMGMF6V Back pain ME84.Z Approved [96]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [73]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [97]
Bryostatin-1 DM1JOXY Alzheimer disease 8A20 Phase 2 [98]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Follicle-stimulating hormone receptor (FSHR) TTZFDBT FSHR_HUMAN Antagonist [3]
Heparanase (HPSE) TTR7GJO HPSE_HUMAN Inhibitor [4]
COVID-19 RNA-directed RNA polymerase (RdRp) TTV1095 R1AB_SARS2 (4393-5324) Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Gene/Protein Processing [5]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Gene/Protein Processing [5]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Gene/Protein Processing [6]
Fibroblast growth factor 5 (FGF5) OTQXGHBY FGF5_HUMAN Gene/Protein Processing [6]
Fibroblast growth factor 7 (FGF7) OTGK6ANL FGF7_HUMAN Protein Interaction/Cellular Processes [7]
Hematopoietic prostaglandin D synthase (HPGDS) OTU8FWHU HPGDS_HUMAN Gene/Protein Processing [8]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Gene/Protein Processing [9]
Interleukin-12 subunit beta (IL12B) OT0JF8A3 IL12B_HUMAN Gene/Protein Processing [9]
SHC-transforming protein 1 (SHC1) OT1J5IRN SHC1_HUMAN Gene/Protein Processing [10]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Gene/Protein Processing [9]

References

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2 Suramin, Penciclovir and Anidulafungin bind nsp12, which governs the RNA-dependent-RNA polymerase activity of SARS-CoV-2, with higher interaction energy than Remdesivir, indicating potential in the treatment of Covid-19 infection. April.21.2020. Doi: 10.31219/osf.io/urxwh
3 Suramin: clinical uses and structure-activity relationships. Mini Rev Med Chem. 2008 Nov;8(13):1384-94.
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1728).
5 Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s. Drug Metab Dispos. 2001 Jan;29(1):30-5.
6 Increased expression of fibroblast growth factors (FGFs) and their receptor by protamine and suramin on Kaposi's sarcoma-derived cells. Anticancer Res. 1993 Jul-Aug;13(4):887-90.
7 Keratinocyte growth factor-1 expression in healthy and diseased human periodontal tissues. J Periodontal Res. 2005 Apr;40(2):118-28. doi: 10.1111/j.1600-0765.2004.00780.x.
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9 Biological inactivation and impaired detection of IL-10 by suramin. J Immunol Methods. 2005 Apr;299(1-2):91-8. doi: 10.1016/j.jim.2005.01.008. Epub 2005 Feb 17.
10 Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction. Circ Res. 2011 Sep 2;109(6):639-48. doi: 10.1161/CIRCRESAHA.111.243592. Epub 2011 Jul 21.
11 PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models. Br J Cancer. 2011 Feb 15;104(4):635-42.
12 Heparanase neutralizes the anticoagulation properties of heparin and low-molecular-weight heparin. J Thromb Haemost. 2006 Mar;4(3):560-5.
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39 Sulforaphane-induced apoptosis in human leukemia HL-60 cells through extrinsic and intrinsic signal pathways and altering associated genes expression assayed by cDNA microarray. Environ Toxicol. 2017 Jan;32(1):311-328.
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47 Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
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54 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
55 Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
56 Proliferation of cultured human gingival fibroblasts caused by isradipine, a dihydropyridine-derivative calcium antagonist. Eur J Med Res. 2004 Jun 30;9(6):313-5.
57 The effect of valdecoxib on the production of growth factors evoked by hypoxia and bacterial lipopolysaccharide in HMEC-1 cells. Adv Clin Exp Med. 2013 Nov-Dec;22(6):795-800.
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59 Role of phenytoin in wound healing: microarray analysis of early transcriptional responses in human dermal fibroblasts. Biochem Biophys Res Commun. 2004 Feb 13;314(3):661-6. doi: 10.1016/j.bbrc.2003.12.146.
60 Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
61 Arsenic alters transcriptional responses to Pseudomonas aeruginosa infection and decreases antimicrobial defense of human airway epithelial cells. Toxicol Appl Pharmacol. 2017 Sep 15;331:154-163.
62 Activation of fibroblast growth factor (FGF) receptors by recombinant human FGF-5. Oncogene. 1993 May;8(5):1311-6.
63 Influence of common and rare genetic variation on warfarin dose among African-Americans and European-Americans using the exome array. Pharmacogenomics. 2017 Jul;18(11):1059-1073. doi: 10.2217/pgs-2017-0046. Epub 2017 Jul 7.
64 Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
65 A high concentration of genistein down-regulates activin A, Smad3 and other TGF-beta pathway genes in human uterine leiomyoma cells. Exp Mol Med. 2012 Apr 30;44(4):281-92.
66 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
67 Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
68 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
69 Thyroid hormone responsive genes in cultured human fibroblasts. J Clin Endocrinol Metab. 2005 Feb;90(2):936-43.
70 Regulation of keratinocyte growth factor and scatter factor in cyclosporin-induced gingival overgrowth. J Oral Pathol Med. 2004 Aug;33(7):391-7. doi: 10.1111/j.1600-0714.2004.00223.x.
71 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
72 Keratinocyte growth factor is upregulated by the hyperplasia-inducing drug nifedipine. Cytokine. 2000 Oct;12(10):1566-9. doi: 10.1006/cyto.2000.0756.
73 The effect of DNA methylation inhibitor 5-Aza-2'-deoxycytidine on human endometrial stromal cells. Hum Reprod. 2010 Nov;25(11):2859-69.
74 Cytokine mRNA profiles in cultured human skin component cells exposed to various chemicals: a simulation model of epicutaneous stimuli induced by skin barrier perturbation in comparison with that due to exposure to haptens or irritant. J Dermatol Sci. 2001 Jun;26(2):85-93. doi: 10.1016/s0923-1811(00)00165-1.
75 Regulatory role of nitric oxide on monocyte-derived dendritic cell functions. J Interferon Cytokine Res. 2003 Aug;23(8):423-31. doi: 10.1089/107999003322277838.
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