Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTOUY9)

Drug Name
Suramin Drug Info
Synonyms
Antrypol; Belganyl; Farma; Fourneau; Germanin; Moranyl; Naganil; Naganin; Naganine; Naganol; Naphuride; SVR; Suramine; SURAMIN SODIUM; Sodium suramin; Suramine sodium; Farma 939; Naganol 6 Na; Germanin (TN); SGCTO-001
Indication
Disease Entry ICD 11 Status REF
African trypanosomiasis 1F51 Phase 1 [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [2]
Therapeutic Class
Antinematodal Agents
Cross-matching ID
PubChem CID
5361
ChEBI ID
CHEMBL45906
CAS Number
CAS 145-63-1
TTD Drug ID
DMTOUY9

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Approved Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Heparanase (HPSE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PG-545 DM68D3O Ocular disease 1F00.1Z Phase 1 [11]
Neutralase DMXHWK6 Angiogenesis disorder BE2Z Discontinued in Phase 3 [12]
Drug(s) Targeting Follicle-stimulating hormone receptor (FSHR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Urofollitropin DMG9HIA Female infertility GA31.Z Approved [13]
Menotropins DM4CF18 Female infertility GA31.Z Approved [14]
Follitropin beta DM2JTS5 Female infertility GA31.Z Approved [15]
Recombinant follicle stimulating hormone DMNHOI3 Female infertility GA31.Z Investigative [16]
PRX-111 DMSPH30 Female infertility GA31.Z Investigative [17]
Long-acting FSH conjugate DMD32IN Female infertility GA31.Z Investigative [16]
FSHR NAM DMPRMOD Contraception QA21 Investigative [16]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Targeting COVID-19 RNA-directed RNA polymerase (RdRp)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [18]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [19]
Penciclovir DMOUMDV Herpes simplex labialis 1F00.01 Approved [18]
Anidulafungin DM8QM5U Aspergillosis 1F20 Approved [2]
Favipiravir DMBZ27L Influenza virus infection 1E30-1E32 Registered [20]
Galidesivir DMG9C4I Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 1 Trial [21]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [22]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [23]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [24]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [25]
Capsaicin DMGMF6V Back pain ME84.Z Approved [26]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [5]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [27]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [5]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [23]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [28]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hematopoietic prostaglandin D synthase (HPGDS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [29]
Sanguinarine DMDINFS Dental plaque DA08.4 Approved [8]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [30]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [31]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [32]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [33]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [34]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Fibroblast growth factor 5 (FGF5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [35]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [36]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [37]
Arsenic DMTL2Y1 N. A. N. A. Approved [38]
Ardeparin DMYRX8B Deep vein thrombosis BD71 Approved [39]
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [40]
Paclitaxel DMLB81S Breast carcinoma Approved [41]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [41]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [42]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibroblast growth factor 7 (FGF7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [43]
Methotrexate DM2TEOL Anterior urethra cancer Approved [44]
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [46]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [49]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [44]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [50]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [51]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By SHC-transforming protein 1 (SHC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [52]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [53]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [54]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [55]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [57]
Bortezomib DMNO38U Leukemia Approved [58]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [59]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [60]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [61]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-12 subunit beta (IL12B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [62]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [63]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [64]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [65]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [66]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Capsaicin DMGMF6V Back pain ME84.Z Approved [68]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [51]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [69]
Bryostatin-1 DM1JOXY Alzheimer disease 8A20 Phase 2 [70]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Follicle-stimulating hormone receptor (FSHR) TTZFDBT FSHR_HUMAN Antagonist [3]
Heparanase (HPSE) TTR7GJO HPSE_HUMAN Inhibitor [4]
COVID-19 RNA-directed RNA polymerase (RdRp) TTV1095 R1AB_SARS2 (4393-5324) Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Gene/Protein Processing [5]
Fibroblast growth factor 5 (FGF5) OTQXGHBY FGF5_HUMAN Gene/Protein Processing [6]
Fibroblast growth factor 7 (FGF7) OTGK6ANL FGF7_HUMAN Protein Interaction/Cellular Processes [7]
Hematopoietic prostaglandin D synthase (HPGDS) OTU8FWHU HPGDS_HUMAN Gene/Protein Processing [8]
Interleukin-12 subunit beta (IL12B) OT0JF8A3 IL12B_HUMAN Gene/Protein Processing [9]
SHC-transforming protein 1 (SHC1) OT1J5IRN SHC1_HUMAN Gene/Protein Processing [10]

References

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2 Suramin, Penciclovir and Anidulafungin bind nsp12, which governs the RNA-dependent-RNA polymerase activity of SARS-CoV-2, with higher interaction energy than Remdesivir, indicating potential in the treatment of Covid-19 infection. April.21.2020. Doi: 10.31219/osf.io/urxwh
3 Suramin: clinical uses and structure-activity relationships. Mini Rev Med Chem. 2008 Nov;8(13):1384-94.
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1728).
5 Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s. Drug Metab Dispos. 2001 Jan;29(1):30-5.
6 Increased expression of fibroblast growth factors (FGFs) and their receptor by protamine and suramin on Kaposi's sarcoma-derived cells. Anticancer Res. 1993 Jul-Aug;13(4):887-90.
7 Keratinocyte growth factor-1 expression in healthy and diseased human periodontal tissues. J Periodontal Res. 2005 Apr;40(2):118-28. doi: 10.1111/j.1600-0765.2004.00780.x.
8 Identification of new inhibitors for human hematopoietic prostaglandin D2 synthase among FDA-approved drugs and other compounds. Chem Biol Interact. 2015 Mar 5;229:91-9. doi: 10.1016/j.cbi.2015.01.014. Epub 2015 Jan 17.
9 Biological inactivation and impaired detection of IL-10 by suramin. J Immunol Methods. 2005 Apr;299(1-2):91-8. doi: 10.1016/j.jim.2005.01.008. Epub 2005 Feb 17.
10 Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction. Circ Res. 2011 Sep 2;109(6):639-48. doi: 10.1161/CIRCRESAHA.111.243592. Epub 2011 Jul 21.
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32 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
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