Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTQ1Y3)

Drug Name

AXL-1717 Drug Info

Synonyms

BVT-51004; IGF-1 inhibitors, Axelar/Biovitrum; IGF-1 inhibitors, Karolinska/Biovitrum; Insulin-like growth factor 1 inhibitors, Axelar/Biovitrum

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 2	[1]

Cross-matching ID

PubChem CID: 72435
ChEBI ID: CHEBI:75251
CAS Number: CAS 477-47-4
TTD Drug ID: DMTQ1Y3

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Insulin-like growth factor I receptor (IGF1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Teprotumumab	DM4L59B	Graves disease	5A02.0	Approved	[4]
Mecasermin	DM1O3BY	Growth failure	LD2F.1Y	Approved	[5]
Somatomedin-1	DMZ9FAO	Hormone deficiency	5A61.1	Approved	[6]
OSI-906	DMHKZLF	Solid tumour/cancer	2A00-2F9Z	Phase 3	[7]
Rinfabate	DML9FD4	Solid tumour/cancer	2A00-2F9Z	Phase 2/3	[8]
MM-141	DM2RJ4D	Pancreatic cancer	2C10	Phase 2	[9]
TT-100	DMZE6Y9	Non-small-cell lung cancer	2C25.Y	Phase 2	[10]
AMG 479	DM0DRAZ	Breast cancer	2C60-2C65	Phase 2	[11]
VPI-2690B	DMUQZT4	Diabetic nephropathy	GB61.Z	Phase 2	[12]
R1507	DMIUS5X	Graves ophthalmopathy	9C82.3	Phase 2	[13]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[14]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[15]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[17]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[18]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[19]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[20]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[21]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[23]
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Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[24]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[25]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[14]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Selenium	DM25CGV	N. A.	N. A.	Approved	[27]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[18]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[28]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[29]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[33]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[34]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[35]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[36]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[37]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[38]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[39]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[40]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[42]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[33]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[43]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[44]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[45]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[46]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[35]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[36]
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Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[35]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[48]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[49]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[54]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[55]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Insulin-like growth factor I receptor (IGF1R)	TTHRID2	IGF1R_HUMAN	Inhibitor	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[3]
Cyclin-dependent kinase 1 (CDK1)	OTW1SC2N	CDK1_HUMAN	Gene/Protein Processing	[3]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Gene/Protein Processing	[3]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Post-Translational Modifications	[3]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Post-Translational Modifications	[3]

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References

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