Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMURH4X)

Drug Name
Oxypurinol Drug Info
Synonyms Oxypurinol (intravenous)
Indication
Disease Entry ICD 11 Status REF
Heart failure BD10-BD13 Phase 2/3 [1]
Cross-matching ID
PubChem CID
135398752
ChEBI ID
CHEBI:28315
CAS Number
CAS 2465-59-0
TTD Drug ID
DMURH4X
VARIDT Drug ID
DR00123

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Xanthine dehydrogenase/oxidase (XDH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Allopurinol DMLPAOB Gout FA25 Approved [7]
Febuxostat DMDEXQ0 Hyperuricaemia 5C55.Y Approved [8]
Fosdenopterin DMR0TYK Molybdenum cofactor deficiency 5B5K.A Approved [9]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [10]
BAICALEIN DM4C7E6 Influenza virus infection 1E30-1E32 Phase 2 [11]
Topiroxostat DMA04DE Gout FA25 Phase 2 [12]
TMX-049 DME8PFQ Diabetic nephropathy GB61.Z Phase 2 [13]
LC-350189 DMHT3CB Gout FA25 Phase 1 [14]
Azaindole derivative 5 DMD2BL3 N. A. N. A. Patented [15]
Fused heterocyclic compound 3 DM2QVHY N. A. N. A. Patented [15]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Urate anion exchanger 1 (SLC22A12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
uric acid DMA1MKT Discovery agent N.A. Investigative [16]
Orotate DMMB29S Discovery agent N.A. Investigative [17]
Drug(s) Affected By Solute carrier family 22 member 12 (SLC22A12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [18]
Benzbromarone DMC3YUA Gout FA25 Approved [19]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [20]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [18]
Arsenic DMTL2Y1 N. A. N. A. Approved [21]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [22]
Erythropoietin DM3R8YL Periventricular leukomalacia Investigative [19]
[3H]estrone-3-sulphate DMGPF0N Discovery agent N.A. Investigative [23]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [24]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [25]
Fructose DM43AN2 Vomiting MD90 Approved [26]
Ketoprofen DMRKXPT Bursitis Approved [26]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [27]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [28]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [29]
Gefitinib DM15F0X Colon adenocarcinoma Approved [30]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [31]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [32]
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Drug(s) Affected By C-X-C motif chemokine 10 (CXCL10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [33]
Quercetin DM3NC4M Obesity 5B81 Approved [34]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [35]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [36]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [37]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [38]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [39]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [41]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [20]
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Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [42]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [43]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [44]
Verapamil DMA7PEW Angina pectoris BA40 Approved [45]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [46]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Selenium DM25CGV N. A. N. A. Approved [48]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [49]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [50]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [52]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [53]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [54]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [44]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [55]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [46]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [56]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [58]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [56]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [59]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [60]
Gefitinib DM15F0X Colon adenocarcinoma Approved [61]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [32]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [62]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [63]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [49]
Methotrexate DM2TEOL Anterior urethra cancer Approved [64]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [65]
Quercetin DM3NC4M Obesity 5B81 Approved [34]
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Drug(s) Affected By Protein DEK (DEK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [66]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [67]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [68]
Testosterone DM7HUNW Hot flushes GA30 Approved [69]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [72]
Folic Acid DMEMBJC Colorectal carcinoma Approved [73]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [74]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Xanthine dehydrogenase/oxidase (XDH) TT7RJY8 XDH_HUMAN Inhibitor [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Urate anion exchanger 1 (SLC22A12) DT2WLAD S22AC_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Gene/Protein Processing [4]
C-X-C motif chemokine 10 (CXCL10) OTTLQ6S0 CXL10_HUMAN Gene/Protein Processing [5]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Gene/Protein Processing [5]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [5]
Protein DEK (DEK) OTYCJ5H6 DEK_HUMAN Regulation of Drug Effects [6]
Solute carrier family 22 member 12 (SLC22A12) OT72ZAWS S22AC_HUMAN Regulation of Drug Effects [3]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Gene/Protein Processing [4]

References

1 ClinicalTrials.gov (NCT00063687) Oxypurinol Compared With Placebo for Class III-IV NYHA Congestive Heart Failure. U.S. National Institutes of Health.
2 Oxypurinol as an inhibitor of xanthine oxidase-catalyzed production of superoxide radical. Biochem Pharmacol. 1988 Jan 15;37(2):349-52.
3 Involvement of uric acid transporter in increased renal clearance of the xanthine oxidase inhibitor oxypurinol induced by a uricosuric agent, benzbromarone. Drug Metab Dispos. 2005 Dec;33(12):1791-5.
4 Allopurinol induces innate immune responses through mitogen-activated protein kinase signaling pathways in HL-60 cells. J Appl Toxicol. 2016 Sep;36(9):1120-8. doi: 10.1002/jat.3272. Epub 2015 Dec 7.
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23 Lack of interaction of the fluorosurfactant C6O4 with human renal transporters: In vitro/in silico analysis. Toxicology. 2022 Jun 30;476:153257. doi: 10.1016/j.tox.2022.153257. Epub 2022 Jul 12.
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41 Regulation of inflammatory responses in tumor necrosis factor-activated and rheumatoid arthritis synovial macrophages by JAK inhibitors. Arthritis Rheum. 2012 Dec;64(12):3856-66. doi: 10.1002/art.37691.
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43 Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
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