Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMV26S8)

• Drug Name: Levomilnacipran Drug Info
• Synonyms: Fetzima; UNII-UGM0326TXX; Levomilnacipran HCl; 96847-54-0; UGM0326TXX; CHEMBL99946; F-2695; (1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide; (1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide; Levomilnacipran [USAN:INN]; Milnacipram; AC1OCEN8; F 2695; Levomilnacipran (USAN/INN); ZINC506; SCHEMBL1414867; GTPL7435; GJJFMKBJSRMPLA-DZGCQCFKSA-N; CHEBI:136040; BDBM50032379; SB17447; DB08918; f2-695; D10072

Indication

Disease Entry	ICD 11	Status	REF
Fibromyalgia	MG30.01	Approved	[1] , [2]

• Cross-matching ID:
  PubChem CID: 6917779
  ChEBI ID: CHEBI:136040
  CAS Number: CAS 96847-54-0
  TTD Drug ID: DMV26S8
  VARIDT Drug ID: DR00049
  INTEDE Drug ID: DR0945
  ACDINA Drug ID: D00362

Molecule-Related Drug Atlas

Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Solid tumour/cancer	2A00-2F9Z	Approved	[5]
Estradiol	DMUNTE3	Breast cancer	2C60-2C65	Approved	[6]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[6]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[7]
Verapamil	DMA7PEW	Hypertension	BA00-BA04	Approved	[8]
Diclofenac	DMPIHLS	Osteoarthritis	FA00-FA05	Approved	[9]
Sorafenib	DMS8IFC	Hepatocellular carcinoma	2C12.02	Approved	[10]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[6]
Mycophenolate mofetil	DMPQAGE	Organ transplant rejection	NE84	Approved	[11]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[12]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Bacterial infection	1A00-1C4Z	Approved	[13]
Doxorubicin	DMVP5YE	Solid tumour/cancer	2A00-2F9Z	Approved	[14]
Methotrexate	DM2TEOL	leukaemia	2A60-2B33	Approved	[15]
Folic acid	DMEMBJC	Folate-deficiency anemia	3A02.Y	Approved	[16]
Fluorouracil	DMUM7HZ	Solid tumour/cancer	2A00-2F9Z	Approved	[15]
Cisplatin	DMRHGI9	Solid tumour/cancer	2A00-2F9Z	Approved	[15]
Progesterone	DMUY35B	Premature labour	JB00	Approved	[17]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[15]
Estradiol	DMUNTE3	Breast cancer	2C60-2C65	Approved	[18]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[19]

Drug(s) Targeting Norepinephrine transporter (NET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Pain	MG30-MG3Z	Approved	[20]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[21]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[22]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[20]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[23]
Bupropion	DM5PCS7	Smoking dependence	6C4A.2	Approved	[24]
Tapentadol hydrochloride	DMXLSH3	Acute pain	MG31	Approved	[25]
Venlafaxine	DMR6QH0	Depression	6A70-6A7Z	Approved	[24]
Trimipramine	DM1SC8M	Major depressive disorder	6A70.3	Approved	[26]
Duloxetine	DM9BI7M	Depression	6A70-6A7Z	Approved	[27]

Drug(s) Targeting Serotonin transporter (SERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Pain	MG30-MG3Z	Approved	[20]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[21]
Fluoxetine	DM3PD2C	Depression	6A70-6A7Z	Approved	[28]
Vortioxetine	DM6F1PU	Major depressive disorder	6A70.3	Approved	[29]
Sertraline	DM0FB1J	Depression	6A70-6A7Z	Approved	[30]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[23]
Bupropion	DM5PCS7	Smoking dependence	6C4A.2	Approved	[24]
Citalopram	DM2G9AE	Depression	6A70-6A7Z	Approved	[28]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[28]
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[28]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Norepinephrine transporter (NET)	TTAWNKZ	SC6A2_HUMAN	Modulator	[2]
Serotonin transporter (SERT)	TT3ROYC	SC6A4_HUMAN	Modulator	[2]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4) Main DME	DE4LYSA	CP3A4_HUMAN	Substrate	[]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Substrate	[]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Substrate	[4]
Cytochrome P450 2J2 (CYP2J2)	DERSX5P	CP2J2_HUMAN	Substrate	[]

References

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