DDI Drug Name |
DDI Drug ID |
Severity |
Mechanism |
Comorbidity |
REF |
Remdesivir |
DMBFZ6L
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Remdesivir. |
1D6YCoronavirus Disease 2019 [1D6YCoronavirus Disease 2019]
|
[6] |
Tretinoin |
DM49DUI
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Tretinoin. |
Acne vulgaris [ED80]
|
[5] |
Isotretinoin |
DM4QTBN
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Isotretinoin. |
Acne vulgaris [ED80]
|
[5] |
Nicotinamide |
DMUPE07
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Nicotinamide. |
Acquired cutaneous blood vessel malformation [EF20]
|
[7] |
Troglitazone |
DM3VFPD
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Troglitazone. |
Acute diabete complication [5A2Y]
|
[5] |
Pioglitazone |
DMKJ485
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Pioglitazone. |
Acute diabete complication [5A2Y]
|
[5] |
Acarbose |
DMRM3AW
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Acarbose. |
Acute diabete complication [5A2Y]
|
[5] |
Thioguanine |
DM7NKEV
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Thioguanine. |
Acute myeloid leukaemia [2A60]
|
[7] |
Tagraxofusp |
DM9HQ5U
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Tagraxofusp. |
Acute myeloid leukaemia [2A60]
|
[5] |
Gilteritinib |
DMTI0ZO
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Gilteritinib. |
Acute myeloid leukaemia [2A60]
|
[5] |
Chlorzoxazone |
DMCYVDT
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Chlorzoxazone. |
Acute pain [MG31]
|
[5] |
Oxandrolone |
DMU9MYJ
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Oxandrolone. |
Alcoholic liver disease [DB94]
|
[5] |
Tacrine |
DM51FY6
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Tacrine. |
Alzheimer disease [8A20]
|
[5] |
Inotersen |
DMJ93CT
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Inotersen. |
Amyloidosis [5D00]
|
[5] |
Dronedarone |
DMA8FS5
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Dronedarone. |
Angina pectoris [BA40]
|
[5] |
Oxymetholone |
DMFXUT8
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Oxymetholone. |
Aplastic anaemia [3A70]
|
[5] |
Voriconazole |
DMAOL2S
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Voriconazole. |
Aspergillosis [1F20]
|
[5] |
Posaconazole |
DMUL5EW
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Posaconazole. |
Aspergillosis [1F20]
|
[5] |
Zafirlukast |
DMHNQOG
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Zafirlukast. |
Asthma [CA23]
|
[5] |
Aminophylline |
DML2NIB
|
Moderate |
Decreased metabolism of Interferon beta-1a caused by Aminophylline mediated inhibition of CYP450 enzyme. |
Asthma [CA23]
|
[6] |
Zileuton |
DMVRIC2
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Zileuton. |
Asthma [CA23]
|
[5] |
Clavulanate |
DM2FGRT
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Clavulanate. |
Bacterial infection [1A00-1C4Z]
|
[7] |
Erythromycin |
DM4K7GQ
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Erythromycin. |
Bacterial infection [1A00-1C4Z]
|
[5] |
Clarithromycin |
DM4M1SG
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Clarithromycin. |
Bacterial infection [1A00-1C4Z]
|
[5] |
Trovafloxacin |
DM6AN32
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Trovafloxacin. |
Bacterial infection [1A00-1C4Z]
|
[5] |
Sulfamethoxazole |
DMB08GE
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Sulfamethoxazole. |
Bacterial infection [1A00-1C4Z]
|
[5] |
Levofloxacin |
DMS60RB
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Levofloxacin. |
Bacterial infection [1A00-1C4Z]
|
[5] |
Moxifloxacin |
DMU8V4S
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Moxifloxacin. |
Bacterial infection [1A00-1C4Z]
|
[5] |
Troleandomycin |
DMUZNIG
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Troleandomycin. |
Bacterial infection [1A00-1C4Z]
|
[5] |
Minocycline |
DMVN5OH
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Minocycline. |
Bacterial infection [1A00-1C4Z]
|
[5] |
Telithromycin |
DMZ4P3A
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Telithromycin. |
Bacterial infection [1A00-1C4Z]
|
[5] |
Pexidartinib |
DMS2J0Z
|
Major |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Pexidartinib. |
Bone/articular cartilage neoplasm [2F7B]
|
[8] |
Temozolomide |
DMKECZD
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Temozolomide. |
Brain cancer [2A00]
|
[5] |
Lomustine |
DMMWSUL
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Lomustine. |
Brain cancer [2A00]
|
[5] |
Lapatinib |
DM3BH1Y
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Lapatinib. |
Breast cancer [2C60-2C6Y]
|
[5] |
LY2835219 |
DM93VBZ
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and LY2835219. |
Breast cancer [2C60-2C6Y]
|
[5] |
Pralatrexate |
DMAO80I
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Pralatrexate. |
Breast cancer [2C60-2C6Y]
|
[5] |
Tucatinib |
DMBESUA
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Tucatinib. |
Breast cancer [2C60-2C6Y]
|
[5] |
Bosutinib |
DMTI8YE
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Bosutinib. |
Breast cancer [2C60-2C6Y]
|
[5] |
Trastuzumab Emtansine |
DMU1LXS
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Trastuzumab Emtansine. |
Breast cancer [2C60-2C6Y]
|
[7] |
Fluoxymesterone |
DMUHCF1
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Fluoxymesterone. |
Breast cancer [2C60-2C6Y]
|
[5] |
Atorvastatin |
DMF28YC
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Atorvastatin. |
Cardiovascular disease [BA00-BE2Z]
|
[5] |
Macitentan |
DMP79A1
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Macitentan. |
Cardiovascular disease [BA00-BE2Z]
|
[5] |
Chenodiol |
DMQ8JIK
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Chenodiol. |
Cholelithiasis [DC11]
|
[5] |
Phenylbutazone |
DMAYL0T
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Phenylbutazone. |
Chronic pain [MG30]
|
[5] |
Ketoprofen |
DMRKXPT
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Ketoprofen. |
Chronic pain [MG30]
|
[5] |
Regorafenib |
DMHSY1I
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Regorafenib. |
Colorectal cancer [2B91]
|
[5] |
Oxaliplatin |
DMQNWRD
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Oxaliplatin. |
Colorectal cancer [2B91]
|
[5] |
Intedanib |
DMSTA36
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Intedanib. |
Colorectal cancer [2B91]
|
[5] |
Oxtriphylline |
DMLHSE3
|
Moderate |
Decreased metabolism of Interferon beta-1a caused by Oxtriphylline mediated inhibition of CYP450 enzyme. |
Cough [MD12]
|
[6] |
Ivacaftor |
DMZC1HS
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Ivacaftor. |
Cystic fibrosis [CA25]
|
[5] |
Ethanol |
DMDRQZU
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Ethanol. |
Cystitis [GC00]
|
[5] |
Nefazodone |
DM4ZS8M
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Nefazodone. |
Depression [6A70-6A7Z]
|
[5] |
Duloxetine |
DM9BI7M
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Duloxetine. |
Depression [6A70-6A7Z]
|
[5] |
Milnacipran |
DMBFE74
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Milnacipran. |
Depression [6A70-6A7Z]
|
[5] |
Polatuzumab vedotin |
DMF6Y0L
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Polatuzumab vedotin. |
Diffuse large B-cell lymphoma [2A81]
|
[5] |
PMID28454500-Compound-96 |
DM2A75P
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and PMID28454500-Compound-96. |
Discovery agent [N.A.]
|
[5] |
PMID28870136-Compound-48 |
DMPIM9L
|
Moderate |
Decreased metabolism of Interferon beta-1a caused by PMID28870136-Compound-48 mediated inhibition of CYP450 enzyme. |
Discovery agent [N.A.]
|
[6] |
Felbamate |
DM1V5ZS
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Felbamate. |
Epilepsy/seizure [8A61-8A6Z]
|
[5] |
Mephenytoin |
DM5UGDK
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Mephenytoin. |
Epilepsy/seizure [8A61-8A6Z]
|
[5] |
Valproate |
DMCFE9I
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Valproate. |
Epilepsy/seizure [8A61-8A6Z]
|
[5] |
Phenytoin |
DMNOKBV
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Phenytoin. |
Epilepsy/seizure [8A61-8A6Z]
|
[5] |
Fosphenytoin |
DMOX3LB
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Fosphenytoin. |
Epilepsy/seizure [8A61-8A6Z]
|
[5] |
Ethotoin |
DMXWOCP
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Ethotoin. |
Epilepsy/seizure [8A61-8A6Z]
|
[5] |
Carbamazepine |
DMZOLBI
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Carbamazepine. |
Epilepsy/seizure [8A61-8A6Z]
|
[5] |
Cannabidiol |
DM0659E
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Cannabidiol. |
Epileptic encephalopathy [8A62]
|
[9] |
Mefenamic acid |
DMK7HFI
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Mefenamic acid. |
Female pelvic pain [GA34]
|
[5] |
Dantrolene |
DM1D8XY
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Dantrolene. |
Fever [MG26]
|
[5] |
Itraconazole |
DMCR1MV
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Itraconazole. |
Fungal infection [1F29-1F2F]
|
[5] |
Caspofungin |
DMGQIPT
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Caspofungin. |
Fungal infection [1F29-1F2F]
|
[5] |
Terbinafine |
DMI6HUW
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Terbinafine. |
Fungal infection [1F29-1F2F]
|
[5] |
Clotrimazole |
DMMFCIH
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Clotrimazole. |
Fungal infection [1F29-1F2F]
|
[5] |
Fluconazole |
DMOWZ6B
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Fluconazole. |
Fungal infection [1F29-1F2F]
|
[5] |
Ketoconazole |
DMPZI3Q
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Ketoconazole. |
Fungal infection [1F29-1F2F]
|
[5] |
Atovaquone |
DMY4UMW
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Atovaquone. |
Fungal infection [1F29-1F2F]
|
[5] |
Sunitinib |
DMCBJSR
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Sunitinib. |
Gastrointestinal stromal tumour [2B5B]
|
[5] |
Ramipril |
DM2R68E
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Ramipril. |
Heart failure [BD10-BD1Z]
|
[5] |
Interferon alfacon-1 |
DM90WJH
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Interferon alfacon-1. |
Hepatitis virus infection [1E50-1E51]
|
[5] |
Lamivudine |
DMI347A
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Lamivudine. |
Hepatitis virus infection [1E50-1E51]
|
[5] |
177Lu-DOTATATE |
DMT8GVU
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and 177Lu-DOTATATE. |
Hepatitis virus infection [1E50-1E51]
|
[5] |
Isoniazid |
DM5JVS3
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Isoniazid. |
HIV-infected patients with tuberculosis [1B10-1B14]
|
[5] |
Rifampin |
DMA8J1G
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Rifampin. |
HIV-infected patients with tuberculosis [1B10-1B14]
|
[7] |
Brentuximab vedotin |
DMWLC57
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Brentuximab vedotin. |
Hodgkin lymphoma [2B30]
|
[7] |
Stavudine |
DM6DEK9
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Stavudine. |
Human immunodeficiency virus disease [1C60-1C62]
|
[5] |
Nevirapine |
DM6HX9B
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Nevirapine. |
Human immunodeficiency virus disease [1C60-1C62]
|
[5] |
Tipranavir |
DM8HJX6
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Tipranavir. |
Human immunodeficiency virus disease [1C60-1C62]
|
[5] |
Emtricitabine |
DMBMUWZ
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Emtricitabine. |
Human immunodeficiency virus disease [1C60-1C62]
|
[5] |
Efavirenz |
DMC0GSJ
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Efavirenz. |
Human immunodeficiency virus disease [1C60-1C62]
|
[5] |
Zalcitabine |
DMH7MUV
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Zalcitabine. |
Human immunodeficiency virus disease [1C60-1C62]
|
[5] |
Didanosine |
DMI2QPE
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Didanosine. |
Human immunodeficiency virus disease [1C60-1C62]
|
[5] |
Rilpivirine |
DMJ0QOW
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Rilpivirine. |
Human immunodeficiency virus disease [1C60-1C62]
|
[5] |
Abacavir |
DMMN36E
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Abacavir. |
Human immunodeficiency virus disease [1C60-1C62]
|
[5] |
Darunavir |
DMN3GCH
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Darunavir. |
Human immunodeficiency virus disease [1C60-1C62]
|
[5] |
Maraviroc |
DMTL94F
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Maraviroc. |
Human immunodeficiency virus disease [1C60-1C62]
|
[5] |
Simvastatin |
DM30SGU
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Simvastatin. |
Hyper-lipoproteinaemia [5C80]
|
[5] |
Fluvastatin |
DM4MDJY
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Fluvastatin. |
Hyper-lipoproteinaemia [5C80]
|
[5] |
Pravastatin |
DM6A0X7
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Pravastatin. |
Hyper-lipoproteinaemia [5C80]
|
[5] |
Lovastatin |
DM9OZWQ
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Lovastatin. |
Hyper-lipoproteinaemia [5C80]
|
[5] |
Fenofibrate |
DMFKXDY
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Fenofibrate. |
Hyper-lipoproteinaemia [5C80]
|
[5] |
Mipomersen |
DMGSRN1
|
Major |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Mipomersen. |
Hyper-lipoproteinaemia [5C80]
|
[10] |
Rosuvastatin |
DMMIQ7G
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Rosuvastatin. |
Hyper-lipoproteinaemia [5C80]
|
[5] |
Teriflunomide |
DMQ2FKJ
|
Major |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Teriflunomide. |
Hyper-lipoproteinaemia [5C80]
|
[11] |
BMS-201038 |
DMQTAGO
|
Major |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and BMS-201038. |
Hyper-lipoproteinaemia [5C80]
|
[12] |
Cerivastatin |
DMXCM7H
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Cerivastatin. |
Hyper-lipoproteinaemia [5C80]
|
[5] |
Moexipril |
DM26E4B
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Moexipril. |
Hypertension [BA00-BA04]
|
[5] |
Captopril |
DM458UM
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Captopril. |
Hypertension [BA00-BA04]
|
[5] |
Trandolapril |
DM4L6EU
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Trandolapril. |
Hypertension [BA00-BA04]
|
[5] |
Methyldopa |
DM5I621
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Methyldopa. |
Hypertension [BA00-BA04]
|
[5] |
Fosinopril |
DM9NJ52
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Fosinopril. |
Hypertension [BA00-BA04]
|
[5] |
Labetalol |
DMK8U72
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Labetalol. |
Hypertension [BA00-BA04]
|
[5] |
Perindopril |
DMOPZDT
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Perindopril. |
Hypertension [BA00-BA04]
|
[5] |
Quinapril |
DMR8H31
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Quinapril. |
Hypertension [BA00-BA04]
|
[5] |
Lisinopril |
DMUOK4C
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Lisinopril. |
Hypertension [BA00-BA04]
|
[5] |
Tolvaptan |
DMIWFRL
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Tolvaptan. |
Hypo-osmolality/hyponatraemia [5C72]
|
[5] |
Pirfenidone |
DM6VZFQ
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Pirfenidone. |
Idiopathic interstitial pneumonitis [CB03]
|
[5] |
Vitamin B3 |
DMQVRZH
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Vitamin B3. |
Inborn lipid metabolism error [5C52]
|
[5] |
Givosiran |
DM5PFIJ
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Givosiran. |
Inborn porphyrin/heme metabolism error [5C58]
|
[5] |
Febuxostat |
DMDEXQ0
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Febuxostat. |
Inborn purine/pyrimidine/nucleotide metabolism error [5C55]
|
[5] |
Meclofenamic acid |
DM05FXR
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Meclofenamic acid. |
Inflammatory spondyloarthritis [FA92]
|
[7] |
Polyethylene glycol |
DM4I1JP
|
Moderate |
Increased risk of lowers seizure threshold by the combination of Interferon beta-1a and Polyethylene glycol. |
Irritable bowel syndrome [DD91]
|
[13] |
Methotrexate |
DM2TEOL
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Methotrexate. |
Leukaemia [2A60-2B33]
|
[9] |
DTI-015 |
DMXZRW0
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and DTI-015. |
Liver cancer [2C12]
|
[5] |
Testosterone |
DM7HUNW
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Testosterone. |
Low bone mass disorder [FB83]
|
[7] |
Crizotinib |
DM4F29C
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Crizotinib. |
Lung cancer [2C25]
|
[5] |
Erlotinib |
DMCMBHA
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Erlotinib. |
Lung cancer [2C25]
|
[5] |
Lurbinectedin |
DMEFRTZ
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Lurbinectedin. |
Lung cancer [2C25]
|
[5] |
Alectinib |
DMP1I6Y
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Alectinib. |
Lung cancer [2C25]
|
[5] |
BIBW 2992 |
DMTKD7Q
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and BIBW 2992. |
Lung cancer [2C25]
|
[5] |
Pralsetinib |
DMWU0I2
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Pralsetinib. |
Lung cancer [2C25]
|
[5] |
Capmatinib |
DMYCXKL
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Capmatinib. |
Lung cancer [2C25]
|
[5] |
Selpercatinib |
DMZR15V
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Selpercatinib. |
Lung cancer [2C25]
|
[5] |
Sulphadoxine |
DMZI2UF
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Sulphadoxine. |
Malaria [1F40-1F45]
|
[5] |
Inotuzumab ozogamicin |
DMAC130
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Inotuzumab ozogamicin. |
Malignant haematopoietic neoplasm [2B33]
|
[5] |
Idelalisib |
DM602WT
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Idelalisib. |
Mature B-cell leukaemia [2A82]
|
[14] |
IPI-145 |
DMWA24P
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and IPI-145. |
Mature B-cell leukaemia [2A82]
|
[5] |
Clofarabine |
DMCVJ86
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Clofarabine. |
Mature B-cell lymphoma [2A85]
|
[15] |
Blinatumomab |
DMGECIJ
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Blinatumomab. |
Mature B-cell lymphoma [2A85]
|
[5] |
Vincristine |
DMINOX3
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Vincristine. |
Mature B-cell lymphoma [2A85]
|
[5] |
Mercaptopurine |
DMTM2IK
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Mercaptopurine. |
Mature B-cell lymphoma [2A85]
|
[5] |
Ponatinib |
DMYGJQO
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Ponatinib. |
Mature B-cell lymphoma [2A85]
|
[5] |
Cytarabine |
DMZD5QR
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Cytarabine. |
Mature B-cell lymphoma [2A85]
|
[5] |
Arry-162 |
DM1P6FR
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Arry-162. |
Melanoma [2C30]
|
[5] |
Vemurafenib |
DM62UG5
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Vemurafenib. |
Melanoma [2C30]
|
[5] |
Ipilimumab |
DMJTIYK
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Ipilimumab. |
Melanoma [2C30]
|
[5] |
Dacarbazine |
DMNPZL4
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Dacarbazine. |
Melanoma [2C30]
|
[5] |
Interferon alfa-2B |
DMWCQP4
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Interferon alfa-2B. |
Melanoma [2C30]
|
[5] |
Danazol |
DML8KTN
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Danazol. |
Menstrual cycle bleeding disorder [GA20]
|
[5] |
Exjade |
DMHPRWG
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Exjade. |
Mineral absorption/transport disorder [5C64]
|
[5] |
Riluzole |
DMECBWN
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Riluzole. |
Motor neuron disease [8B60]
|
[5] |
Carfilzomib |
DM48K0X
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Carfilzomib. |
Multiple myeloma [2A83]
|
[5] |
Panobinostat |
DM58WKG
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Panobinostat. |
Multiple myeloma [2A83]
|
[5] |
Lenalidomide |
DM6Q7U4
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Lenalidomide. |
Multiple myeloma [2A83]
|
[5] |
Elotuzumab |
DMEYHG9
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Elotuzumab. |
Multiple myeloma [2A83]
|
[5] |
Bortezomib |
DMNO38U
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Bortezomib. |
Multiple myeloma [2A83]
|
[5] |
Pyrazinamide |
DM4IF32
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Pyrazinamide. |
Mycobacterium infection [1B10-1B21]
|
[5] |
Bexarotene |
DMOBIKY
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Bexarotene. |
Mycosis fungoides [2B01]
|
[5] |
Fedratinib |
DM4ZBK6
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Fedratinib. |
Myeloproliferative neoplasm [2A20]
|
[5] |
Nilotinib |
DM7HXWT
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Nilotinib. |
Myeloproliferative neoplasm [2A20]
|
[5] |
Imatinib |
DM7RJXL
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Imatinib. |
Myeloproliferative neoplasm [2A20]
|
[5] |
Bupropion |
DM5PCS7
|
Major |
Increased risk of lowers seizure threshold by the combination of Interferon beta-1a and Bupropion. |
Nicotine use disorder [6C4A]
|
[5] |
Entrectinib |
DMMPTLH
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Entrectinib. |
Non-small cell lung cancer [2C25]
|
[5] |
Orlistat |
DMRJSP8
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Orlistat. |
Obesity [5B80-5B81]
|
[5] |
Rofecoxib |
DM3P5DA
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Rofecoxib. |
Osteoarthritis [FA00-FA05]
|
[5] |
Valdecoxib |
DMAY7H4
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Valdecoxib. |
Osteoarthritis [FA00-FA05]
|
[5] |
Diclofenac |
DMPIHLS
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Diclofenac. |
Osteoarthritis [FA00-FA05]
|
[7] |
Naproxen |
DMZ5RGV
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Naproxen. |
Osteoarthritis [FA00-FA05]
|
[5] |
Etodolac |
DM6WJO9
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Etodolac. |
Pain [MG30-MG3Z]
|
[5] |
Ibuprofen |
DM8VCBE
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Ibuprofen. |
Pain [MG30-MG3Z]
|
[5] |
Tramadol |
DMRQD04
|
Major |
Increased risk of lowers seizure threshold by the combination of Interferon beta-1a and Tramadol. |
Pain [MG30-MG3Z]
|
[16] |
Piroxicam |
DMTK234
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Piroxicam. |
Pain [MG30-MG3Z]
|
[5] |
Acetaminophen |
DMUIE76
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Acetaminophen. |
Pain [MG30-MG3Z]
|
[5] |
Tolcapone |
DM8MNVO
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Tolcapone. |
Parkinsonism [8A00]
|
[5] |
Ropinirole |
DMA6S1D
|
Moderate |
Decreased metabolism of Interferon beta-1a caused by Ropinirole mediated inhibition of CYP450 enzyme. |
Parkinsonism [8A00]
|
[17] |
Lindane |
DMB8CNL
|
Moderate |
Increased risk of lowers seizure threshold by the combination of Interferon beta-1a and Lindane. |
Pediculosis [1G00]
|
[18] |
Ketorolac |
DMI4EL5
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Ketorolac. |
Postoperative inflammation [1A00-CA43]
|
[5] |
Bromfenac |
DMKB79O
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Bromfenac. |
Postoperative inflammation [1A00-CA43]
|
[5] |
ABIRATERONE |
DM8V75C
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and ABIRATERONE. |
Prostate cancer [2C82]
|
[5] |
Nilutamide |
DMFN07X
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Nilutamide. |
Prostate cancer [2C82]
|
[5] |
Flutamide |
DMK0O7U
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Flutamide. |
Prostate cancer [2C82]
|
[5] |
Infliximab |
DMH7OIA
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Infliximab. |
Psoriasis [EA90]
|
[5] |
Ambrisentan |
DMD1QXW
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Ambrisentan. |
Pulmonary hypertension [BB01]
|
[5] |
Bosentan |
DMIOGBU
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Bosentan. |
Pulmonary hypertension [BB01]
|
[5] |
Axitinib |
DMGVH6N
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Axitinib. |
Renal cell carcinoma [2C90]
|
[5] |
Sorafenib |
DMS8IFC
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Sorafenib. |
Renal cell carcinoma [2C90]
|
[5] |
Sulfadiazine |
DMTW3R8
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Sulfadiazine. |
Rheumatic fever [1B40]
|
[5] |
Meloxicam |
DM2AR7L
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Meloxicam. |
Rheumatoid arthritis [FA20]
|
[5] |
Sulindac |
DM2QHZU
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Sulindac. |
Rheumatoid arthritis [FA20]
|
[5] |
Celecoxib |
DM6LOQU
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Celecoxib. |
Rheumatoid arthritis [FA20]
|
[5] |
Tocilizumab |
DM7J6OR
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Tocilizumab. |
Rheumatoid arthritis [FA20]
|
[5] |
Oxaprozin |
DM9UB0P
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Oxaprozin. |
Rheumatoid arthritis [FA20]
|
[5] |
Flurbiprofen |
DMGN4BY
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Flurbiprofen. |
Rheumatoid arthritis [FA20]
|
[5] |
Sulfasalazine |
DMICA9H
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Sulfasalazine. |
Rheumatoid arthritis [FA20]
|
[5] |
Fenoprofen |
DML5VQ0
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Fenoprofen. |
Rheumatoid arthritis [FA20]
|
[5] |
Sarilumab |
DMOGNXY
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Sarilumab. |
Rheumatoid arthritis [FA20]
|
[5] |
Leflunomide |
DMR8ONJ
|
Major |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Leflunomide. |
Rheumatoid arthritis [FA20]
|
[11] |
Indomethacin |
DMSC4A7
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Indomethacin. |
Rheumatoid arthritis [FA20]
|
[5] |
Pimozide |
DMW83TP
|
Moderate |
Decreased metabolism of Interferon beta-1a caused by Pimozide mediated inhibition of CYP450 enzyme. |
Schizophrenia [6A20]
|
[19] |
Gefitinib |
DM15F0X
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Gefitinib. |
Solid tumour/cancer [2A00-2F9Z]
|
[5] |
Larotrectinib |
DM26CQR
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Larotrectinib. |
Solid tumour/cancer [2A00-2F9Z]
|
[5] |
PDX-101 |
DM6OC53
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and PDX-101. |
Solid tumour/cancer [2A00-2F9Z]
|
[5] |
LEE011 |
DMMX75K
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and LEE011. |
Solid tumour/cancer [2A00-2F9Z]
|
[5] |
Epirubicin |
DMPDW6T
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Epirubicin. |
Solid tumour/cancer [2A00-2F9Z]
|
[6] |
Methyltestosterone |
DMWLFGO
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Methyltestosterone. |
Solid tumour/cancer [2A00-2F9Z]
|
[5] |
Disulfiram |
DMCL2OK
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Disulfiram. |
Substance abuse [6C40]
|
[5] |
Naltrexone |
DMUL45H
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Naltrexone. |
Substance abuse [6C40]
|
[5] |
Zithromax |
DMN4H2O
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Zithromax. |
Syphilis [1A61-1A6Z]
|
[5] |
Fostamatinib |
DM6AUHV
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Fostamatinib. |
Thrombocytopenia [3B64]
|
[5] |
Eltrombopag |
DMOGFIX
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Eltrombopag. |
Thrombocytopenia [3B64]
|
[5] |
Lenvatinib |
DMB1IU4
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Lenvatinib. |
Thyroid cancer [2D10]
|
[5] |
Methimazole |
DM25FL8
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Methimazole. |
Thyrotoxicosis [5A02]
|
[5] |
Propylthiouracil |
DM6D7N8
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Propylthiouracil. |
Thyrotoxicosis [5A02]
|
[5] |
Tizanidine |
DMR2IQ4
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Tizanidine. |
Tonus and reflex abnormality [MB47]
|
[5] |
Trimetrexate |
DMDEA85
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Trimetrexate. |
Toxoplasmosis [1F57]
|
[5] |
Azathioprine |
DMMZSXQ
|
Moderate |
Additive immunosuppressive effects by the combination of Interferon beta-1a and Azathioprine. |
Transplant rejection [NE84]
|
[6] |
Aminosalicylic acid |
DMENSL5
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Aminosalicylic acid. |
Tuberculosis [1B10-1B12]
|
[5] |
Ethambutol |
DMR87LC
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Ethambutol. |
Tuberculosis [1B10-1B12]
|
[5] |
Nitrofurantoin |
DM7PQIK
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Nitrofurantoin. |
Urinary tract infection [GC08]
|
[5] |
Sulfamethizole |
DMGCHDS
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Sulfamethizole. |
Urinary tract infection [GC08]
|
[5] |
Sulfisoxazole |
DMXLT8C
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Sulfisoxazole. |
Urinary tract infection [GC08]
|
[5] |
Elagolix |
DMB2C0E
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Elagolix. |
Uterine fibroid [2E86]
|
[5] |
Amiodarone |
DMUTEX3
|
Moderate |
Increased risk of hepatotoxicity by the combination of Interferon beta-1a and Amiodarone. |
Ventricular tachyarrhythmia [BC71]
|
[5] |
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