Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT8NGED)

• DTT Name: Prostaglandin G/H synthase 1 (COX-1) DTT Info
• Gene Name: PTGS1

Molecule-Related Drug & Molecule List

15 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aminosalicylic Acid	DMENSL5	Crohn disease	DD70	Approved	[1]
Balsalazide	DM7I1T9	Inflammatory bowel disease	DD72	Approved	[2]
Bromfenac	DMKB79O	Pain	MG30-MG3Z	Approved	[3]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[4]
FENBUFEN	DMXGDFK	Arthritis	FA20	Approved	[5]
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[6]
Gamma-Homolinolenic acid	DMSXKYG	Malnutrition	5B50-5B71	Approved	[7]
Meclofenamate Sodium	DMNL98G	Arthritis	FA20	Approved	[8]
Mesalazine	DMOL5IU	Diverticulitis		Approved	[9]
Naproxen	DMZ5RGV	Bursitis		Approved	[10]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[1]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[11]
Salsalate	DM13P4C	Osteoarthritis	FA00-FA05	Approved	[12]
Suprofen	DMKXJZ7	Miosis	LA11.62	Approved	[13]
IMRECOXIB	DMVXLOD	N. A.	N. A.	Phase 4	[14]

6 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(S)-FLURBIPROFEN	DMF2O4T	Myalgia	FB56.2	Preregistration	[15]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[16]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[17]
ThermoProfen	DMPGH7N	Pain	MG30-MG3Z	Phase 3	[18]
EPICATECHIN	DMN0EMP	Duchenne dystrophy	8C70	Phase 1/2	[19]
EXO-230	DM64PM7	Diabetic neuropathy	8C0Z	Phase 1/2	[20]

1 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamate derivative 2	DMEWPQ6	N. A.	N. A.	Patented	[21]

8 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
INDOPROFEN	DM5QSKN	Gout	FA25	Withdrawn from market	[15]
Metamizole	DM79GRO	Fever	MG26	Withdrawn from market	[22]
Phenacetin	DMRQAM0	Analgesia	MB40.8	Withdrawn from market	[23]
CRx-401	DM39N7W	Type-2 diabetes	5A11	Discontinued in Phase 2	[24]
R-ketoprofen	DMHSUQ1	N. A.	N. A.	Discontinued in Phase 2	[15]
TEBUFELONE	DMMUE8P	Pain	MG30-MG3Z	Discontinued in Phase 2	[25]
ATLIPROFEN METHYL ESTER	DMS2FB3	Inflammation	1A00-CA43.1	Terminated	[1]
SC-58451	DMVGK24	N. A.	N. A.	Terminated	[26]

106 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(-)-3-O-acetylspectaline	DMKRTBM	Discovery agent	N.A.	Investigative	[27]
(11H-Dibenzo[b,e][1,4]dioxepin-2-yl)-acetic acid	DMSUPVE	Discovery agent	N.A.	Investigative	[28]
(11H-Dibenzo[b,e][1,4]dioxepin-7-yl)-acetic acid	DM5ZTXL	Discovery agent	N.A.	Investigative	[28]
(11H-Dibenzo[b,e][1,4]dioxepin-8-yl)-acetic acid	DMBY623	Discovery agent	N.A.	Investigative	[28]
(3-Chloro-4-Propoxy-Phenyl)-Acetic Acid	DMHODXG	Discovery agent	N.A.	Investigative	[29]
(R)-2-(4-Isobutyl-phenyl)-N-phenyl-propionamide	DMAD4JY	Discovery agent	N.A.	Investigative	[15]
(Z)-2'-des-methyl sulindac sulfide	DM0OEQJ	Discovery agent	N.A.	Investigative	[30]
1,2-dihydro-3-(2,3,4-trimethoxyphenyl)naphthalene	DMST60D	Discovery agent	N.A.	Investigative	[31]
1-(4-(methylsulfonyl)phenyl)-3-p-tolylurea	DMMSQLC	Discovery agent	N.A.	Investigative	[32]
1-(4-(methylsulfonyl)phenyl)-3-phenylurea	DMH7RY0	Discovery agent	N.A.	Investigative	[32]
1-(4-aminosulfonylphenyl)-2-(2-pyridyl)acetylene	DMWA6G1	Discovery agent	N.A.	Investigative	[33]
1-(4-aminosulfonylphenyl)-2-(4-pyridyl)acetylene	DMP93E2	Discovery agent	N.A.	Investigative	[33]
2'-epi-guianin	DMNVJY0	Discovery agent	N.A.	Investigative	[34]
2,4'-Dimethoxy-5,3'-di-(2-propenyl)-biphenyl	DMWNJ84	Discovery agent	N.A.	Investigative	[35]
2-(1,1'-Biphenyl-4-Yl)Propanoic Acid	DMUE0D6	Discovery agent	N.A.	Investigative	[29]
2-(2,3,4-trimethoxyphenyl)-1H-indene	DMFU1PK	Discovery agent	N.A.	Investigative	[31]
2-(2-(2,6-dimethylphenylamino)phenyl)acetic acid	DMJ2DE4	Discovery agent	N.A.	Investigative	[36]
2-(2-methoxyphenyl)-1H-indene	DMXFYN8	Discovery agent	N.A.	Investigative	[31]
2-(2-Methylpropanoyl)-1,3,5-benzenetriol	DMPH63G	Discovery agent	N.A.	Investigative	[37]
2-(3'-Allyl-biphenyl-4-yl)-propionic acid	DMAGFUH	Discovery agent	N.A.	Investigative	[38]
2-(3'-Ethyl-biphenyl-4-yl)-propionic acid	DMPLN58	Discovery agent	N.A.	Investigative	[38]
2-(3'-Ethylsulfanyl-biphenyl-4-yl)-propionic acid	DMPGYDA	Discovery agent	N.A.	Investigative	[38]
2-(3'-Vinyl-biphenyl-4-yl)-propionic acid	DM7NGV1	Discovery agent	N.A.	Investigative	[38]
2-(3-Phenyl-propyl)-1,2-dihydro-indazol-3-one	DMIQBXD	Discovery agent	N.A.	Investigative	[39]
2-(N-(2-Ffuorophenyl)pyrrol-3-yl) acetic acid	DMRNOM6	Discovery agent	N.A.	Investigative	[40]
2-(N-(2-fluorophenyl)pyrrol-2-yl) acetic acid	DMCL9E6	Discovery agent	N.A.	Investigative	[40]
2-(p-Methylsulfonylbenzoyl)furan	DMLT635	Discovery agent	N.A.	Investigative	[41]
2-Benzyl-1,2-dihydro-indazol-3-one	DM1CB5J	Discovery agent	N.A.	Investigative	[39]
2-Bromoacetyl Group	DMIHJSA	Discovery agent	N.A.	Investigative	[42]
2-Furan-2-ylmethyl-1,2-dihydro-indazol-3-one	DMQIRY7	Discovery agent	N.A.	Investigative	[39]
2-Methyl-1,2-dihydro-indazol-3-one	DMDJHFQ	Discovery agent	N.A.	Investigative	[39]
2-Naphthalen-2-ylmethyl-1,2-dihydro-indazol-3-one	DM1EJ6W	Discovery agent	N.A.	Investigative	[39]
2-Phenethyl-1,2-dihydro-indazol-3-one	DM0WMBC	Discovery agent	N.A.	Investigative	[39]
2-Phenyl-1,2-dihydro-indazol-3-one	DM28CLZ	Discovery agent	N.A.	Investigative	[39]
2-[4-(1H-Indol-5-yl)-phenyl]-propionic acid	DMUHECR	Discovery agent	N.A.	Investigative	[38]
3 beta-O-acetyloleanolic acid	DM1L5IJ	Discovery agent	N.A.	Investigative	[43]
3-(4-Methanesulfonyl-phenyl)-1-phenyl-propynone	DMSR2O3	Discovery agent	N.A.	Investigative	[44]
4'-Methoxy-5,3'-dipropyl-biphenyl-2ol	DM5FRV2	Discovery agent	N.A.	Investigative	[35]
4,5-Bis(4-chlorophenyl)-1,2-selenazole	DMIO254	Discovery agent	N.A.	Investigative	[45]
4,5-Bis(4-chlorophenyl)isothiazole	DMENLFY	Discovery agent	N.A.	Investigative	[46]
4,5-Bis(4-methoxyphenyl)-1,2-selenazole	DMKHD1M	Discovery agent	N.A.	Investigative	[45]
4,5-Bis(4-methoxyphenyl)-3H-1,2-dithiol-3-one	DMI39QT	Discovery agent	N.A.	Investigative	[46]
4,5-Bis(4-methoxyphenyl)-3H-1,2-dithiole-3-thione	DMPW145	Discovery agent	N.A.	Investigative	[46]
4,5-Bis(4-methoxyphenyl)isothiazole	DM90DV6	Discovery agent	N.A.	Investigative	[46]
4-(4-Chlorophenyl)-5-(4-methoxyphenyl)isothiazole	DMODVGN	Discovery agent	N.A.	Investigative	[46]
4-(4-Chlorophenyl)-5-p-tolyl-1,2-selenazole	DMZBEYO	Discovery agent	N.A.	Investigative	[45]
4-(4-Chlorophenyl)-5-p-tolyl-3H-1,2-dithiol-3-one	DMVDF9Q	Discovery agent	N.A.	Investigative	[46]
4-(4-Chlorophenyl)-5-p-tolylisothiazole	DMMK9RC	Discovery agent	N.A.	Investigative	[46]
4-(5-(4-Hydroxyphenyl)isothiazol-4-yl)phenol	DMK1ZF2	Discovery agent	N.A.	Investigative	[46]
4-amino-N-(2-chlorophenyl)benzenesulfonamide	DM6PQ5V	Discovery agent	N.A.	Investigative	[47]
4-amino-N-(4-chlorophenyl)benzenesulfonamide	DMCUSD4	Discovery agent	N.A.	Investigative	[47]
4-amino-N-p-tolylbenzenesulfonamide	DMLW651	Discovery agent	N.A.	Investigative	[47]
5,3'-Dipropyl-biphenyl-2,4'-diol	DMJRXLD	Discovery agent	N.A.	Investigative	[35]
5-(2-1H-indenyl)-1,3-benzodioxole	DM149IX	Discovery agent	N.A.	Investigative	[31]
5-(2-Imidazol-1-yl-ethyl)-7,8-dihydro-quinoline	DMCP5U8	Discovery agent	N.A.	Investigative	[48]
5-(4-Chlorophenyl)-4-(4-methoxyphenyl)isothiazole	DMSTG03	Discovery agent	N.A.	Investigative	[46]
5-(4-Chlorophenyl)-4-p-tolyl-1,2-selenazole	DMY0P86	Discovery agent	N.A.	Investigative	[45]
5-(4-Chlorophenyl)-4-p-tolyl-3H-1,2-dithiol-3-one	DMFYEL8	Discovery agent	N.A.	Investigative	[46]
5-(4-Chlorophenyl)-4-p-tolylisothiazole	DMA1N75	Discovery agent	N.A.	Investigative	[46]
5-(4-Methoxyphenyl)-4-p-tolyl-1,2-selenazole	DMEV8WS	Discovery agent	N.A.	Investigative	[45]
5-(4-Methoxyphenyl)-4-p-tolylisothiazole	DMJSTCK	Discovery agent	N.A.	Investigative	[46]
5-Ethyl-3,4-diphenyl-isoxazole	DMRIGXA	Discovery agent	N.A.	Investigative	[49]
5-Methyl-3,4-diphenyl-isoxazole	DM0G2N5	Discovery agent	N.A.	Investigative	[49]
5-Phenyl-pentanoic acid benzyl-hydroxy-amide	DM3B6A8	Discovery agent	N.A.	Investigative	[50]
Acetic acid 2-hept-2-ynylsulfanyl-phenyl ester	DM97DJL	Discovery agent	N.A.	Investigative	[51]
Acetic acid 2-hept-3-ynylsulfanyl-phenyl ester	DMD89A1	Discovery agent	N.A.	Investigative	[51]
Acetic acid 2-heptylselanyl-phenyl ester	DM50BTA	Discovery agent	N.A.	Investigative	[51]
Acetic acid 2-heptylsulfanyl-phenyl ester	DMLPRIG	Discovery agent	N.A.	Investigative	[51]
Acetic acid 2-hex-2-ynylsulfanyl-phenyl ester	DMFQE1C	Discovery agent	N.A.	Investigative	[51]
Acetic acid 2-hexylsulfanyl-phenyl ester	DMAKNUH	Discovery agent	N.A.	Investigative	[51]
Acetic acid 2-pentylsulfanyl-phenyl ester	DMFKRIH	Discovery agent	N.A.	Investigative	[51]
Acetic Acid Salicyloyl-Amino-Ester	DMLTNHY	Discovery agent	N.A.	Investigative	[29]
Alpha-D-Mannose	DMF5DLW	Discovery agent	N.A.	Investigative	[42]
Arachidonic Acid	DMUOQZD	Discovery agent	N.A.	Investigative	[42]
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[42]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[42]
Beta-D-Mannose	DMHIG9K	Discovery agent	N.A.	Investigative	[42]
CATECHIN	DMY38SB	Discovery agent	N.A.	Investigative	[19]
DEMETHOXYCURCUMIN	DMO5UGV	Discovery agent	N.A.	Investigative	[16]
FR122047	DMAYTWN	Discovery agent	N.A.	Investigative	[52]
Heme	DMGC287	Discovery agent	N.A.	Investigative	[29]
HONOKIOL	DMJWT3X	Discovery agent	N.A.	Investigative	[35]
Hyperforin	DM2L3PE	Discovery agent	N.A.	Investigative	[53]
IODOINDOMETHACIN	DM3BL0G	Discovery agent	N.A.	Investigative	[54]
IODOSUPROFEN	DMOE8LT	Discovery agent	N.A.	Investigative	[54]
METHYLHONOKIOL	DM9YE6K	Discovery agent	N.A.	Investigative	[35]
N-(1H-indazol-5-yl)acetamide	DMIMJNU	Discovery agent	N.A.	Investigative	[55]
N-(3-(phenylthio)pyridin-4-yl)methanesulfonamide	DMSJX1H	Discovery agent	N.A.	Investigative	[56]
N-(3-phenoxy-4-pyridinyl)ethanesulfonamide	DMXF46V	Discovery agent	N.A.	Investigative	[57]
N-(3-phenoxy-4-pyridinyl)propanesulfonamide	DMN1DPJ	Discovery agent	N.A.	Investigative	[57]
N-(3-phenoxypyridin-4-yl)methanesulfonamide	DM7CM3F	Discovery agent	N.A.	Investigative	[56]
N-(3-phenylamino-4-pyridinyl)methanesulfonamide	DMJB7SE	Discovery agent	N.A.	Investigative	[56]
Nitroflurbiprofen	DMWCV48	Discovery agent	N.A.	Investigative	[58]
O-Acetylserine	DMAEHFT	Discovery agent	N.A.	Investigative	[42]
Oxametacin	DMWVLG1	Discovery agent	N.A.	Investigative	[59]
P-(2'-Iodo-5'-Thenoyl)Hydrotropic Acid	DMJ0W43	Discovery agent	N.A.	Investigative	[29]
Phenazone	DMCE985	Discovery agent	N.A.	Investigative	[60]
PHENIDONE	DMJD8XN	Discovery agent	N.A.	Investigative	[39]
Prifelone	DMLI4RF	Discovery agent	N.A.	Investigative	[61]
Primary alcohol metabolite of celecoxib	DMA8GI6	Discovery agent	N.A.	Investigative	[62]
Protoporphyrin Ix Containing Co	DMJ8TP3	Discovery agent	N.A.	Investigative	[42]
RESORCINOL	DMM37C0	Discovery agent	N.A.	Investigative	[19]
Resveratrol Potassium3-Sulfate	DMN1RLA	Discovery agent	N.A.	Investigative	[63]
Resveratrol Potassium4,-Sulfate	DMMFP57	Discovery agent	N.A.	Investigative	[63]
SC-560	DMT1GJL	Discovery agent	N.A.	Investigative	[64]
TRL-382	DMU3E1M	Neuropathic pain	8E43.0	Investigative	[65]

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