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Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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Gemcitabine FDA Label
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Paclitaxel FDA Label
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Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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ClinicalTrials.gov (NCT04390763) Study of Efficacy and Safety of NIS793 (With and Without Spartalizumab) in Combination With SOC Chemotherapy in First-line Metastatic Pancreatic Ductal Adenocarcinoma (mPDAC). U.S. National Institutes of Health.
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Anterior gradient 2 downregulation in a subset of pancreatic ductal adenocarcinoma is a prognostic factor indicative of epithelial-mesenchymal transition.Lab Invest. 2015 Feb;95(2):193-206. doi: 10.1038/labinvest.2014.138. Epub 2014 Nov 24.
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Critical role for arginase 2 in obesity-associated pancreatic cancer.Nat Commun. 2017 Aug 14;8(1):242. doi: 10.1038/s41467-017-00331-y.
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Inhibition of AKT2 enhances sensitivity to gemcitabine via regulating PUMA and NF-B signaling pathway in human pancreatic ductal adenocarcinoma.Int J Mol Sci. 2012;13(1):1186-1208. doi: 10.3390/ijms13011186. Epub 2012 Jan 20.
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CBX7 suppresses cell proliferation, migration, and invasion through the inhibition of PTEN/Akt signaling in pancreatic cancer.Oncotarget. 2017 Jan 31;8(5):8010-8021. doi: 10.18632/oncotarget.14037.
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CYR61/CCN1 Regulates dCK and CTGF and Causes Gemcitabine-resistant Phenotype in Pancreatic Ductal Adenocarcinoma.Mol Cancer Ther. 2019 Apr;18(4):788-800. doi: 10.1158/1535-7163.MCT-18-0899. Epub 2019 Feb 20.
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Analysis of the origin of anaplastic pancreatic cancer and the mechanism of its dedifferentiation.J Hepatobiliary Pancreat Sci. 2017 Mar;24(3):176-184. doi: 10.1002/jhbp.429. Epub 2017 Feb 19.
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Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells.Cancer Cell. 2019 Feb 11;35(2):221-237.e8. doi: 10.1016/j.ccell.2019.01.002.
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Cadherin-1 and cadherin-3 cooperation determines the aggressiveness of pancreatic ductal adenocarcinoma.Br J Cancer. 2018 Feb 20;118(4):546-557. doi: 10.1038/bjc.2017.411. Epub 2017 Nov 21.
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Choline Kinase Alpha (CHK) as a Therapeutic Target in Pancreatic Ductal Adenocarcinoma: Expression, Predictive Value, and Sensitivity to Inhibitors.Mol Cancer Ther. 2016 Feb;15(2):323-33. doi: 10.1158/1535-7163.MCT-15-0214. Epub 2016 Jan 14.
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Prognostic impact of carbohydrate sulfotransferase 15 in patients with pancreatic ductal adenocarcinoma.Oncol Lett. 2017 Jun;13(6):4799-4805. doi: 10.3892/ol.2017.6071. Epub 2017 Apr 21.
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Calcium-activated chloride channel regulator 1 as a prognostic biomarker in pancreatic ductal adenocarcinoma.BMC Cancer. 2018 Nov 12;18(1):1096. doi: 10.1186/s12885-018-5013-2.
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Imaging of Claudin-4 in Pancreatic Ductal Adenocarcinoma Using a Radiolabelled Anti-Claudin-4 Monoclonal Antibody.Mol Imaging Biol. 2018 Apr;20(2):292-299. doi: 10.1007/s11307-017-1112-8.
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Blocking CXCLs-CXCR2 axis in tumor-stromal interactions contributes to survival in a mouse model of pancreatic ductal adenocarcinoma through reduced cell invasion/migration and a shift of immune-inflammatory microenvironment.Oncogenesis. 2019 Jan 18;8(2):8. doi: 10.1038/s41389-018-0117-8.
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The Histone Demethylase KDM3A, Increased in Human Pancreatic Tumors, Regulates Expression of DCLK1 and Promotes Tumorigenesis in Mice.Gastroenterology. 2019 Dec;157(6):1646-1659.e11. doi: 10.1053/j.gastro.2019.08.018. Epub 2019 Aug 20.
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Dkk1 involvement and its potential as a biomarker in pancreatic ductal adenocarcinoma.Clin Chim Acta. 2019 Jan;488:226-234. doi: 10.1016/j.cca.2018.11.023. Epub 2018 Nov 16.
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eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth.Cancer Res. 2017 Apr 15;77(8):1997-2007. doi: 10.1158/0008-5472.CAN-16-2594. Epub 2017 Apr 5.
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N1-guanyl-1, 7-diaminoheptane enhances the sensitivity of pancreatic ductal adenocarcinoma cells to gemcitabine via the inhibition of eukaryotic translation initiation factor 5A2.Exp Ther Med. 2017 Sep;14(3):2101-2107. doi: 10.3892/etm.2017.4740. Epub 2017 Jul 9.
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High Expression of FAM83B Predicts Poor Prognosis in Patients with Pancreatic Ductal Adenocarcinoma and Correlates with Cell Cycle and Cell Proliferation.J Cancer. 2017 Sep 12;8(16):3154-3165. doi: 10.7150/jca.20086. eCollection 2017.
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Emerging Roles of Fibroblast Growth Factor 10 in Cancer.Front Genet. 2018 Oct 24;9:499. doi: 10.3389/fgene.2018.00499. eCollection 2018.
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Expression status of folate receptor alpha is a predictor of survival in pancreatic ductal adenocarcinoma.Oncotarget. 2017 Jun 6;8(23):37646-37656. doi: 10.18632/oncotarget.16841.
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MiR-27a-regulated FOXO1 promotes pancreatic ductal adenocarcinoma cell progression by enhancing Wnt/-catenin signaling activity.Am J Transl Res. 2019 May 15;11(5):3069-3080. eCollection 2019.
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Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation.Cancer Res. 2016 Dec 1;76(23):7049-7058. doi: 10.1158/0008-5472.CAN-16-0715. Epub 2016 Oct 6.
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GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine.Oncogene. 2018 Dec;37(49):6368-6382. doi: 10.1038/s41388-018-0390-1. Epub 2018 Jul 30.
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High expression of GRK3 is associated with favorable prognosis in pancreatic ductal adenocarcinoma.Pathol Res Pract. 2018 Feb;214(2):228-232. doi: 10.1016/j.prp.2017.11.013. Epub 2017 Nov 20.
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Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. Oncogene. 2015 Jan 8;34(2):263-8.
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Metformin as an Adjunctive Therapy for Pancreatic Cancer: A Review of the Literature on Its Potential Therapeutic Use.Dig Dis Sci. 2018 Nov;63(11):2840-2852. doi: 10.1007/s10620-018-5233-y. Epub 2018 Aug 29.
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The involvement of insulin-like growth factor 2 binding protein 3 (IMP3) in pancreatic cancer cell migration, invasion, and adhesion.BMC Cancer. 2015 Apr 11;15:266. doi: 10.1186/s12885-015-1251-8.
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Constitutive IRAK4 Activation Underlies Poor Prognosis and Chemoresistance in Pancreatic Ductal Adenocarcinoma.Clin Cancer Res. 2017 Apr 1;23(7):1748-1759. doi: 10.1158/1078-0432.CCR-16-1121. Epub 2016 Oct 4.
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Integrin 6 acts as an unfavorable prognostic indicator and promotes cellular malignant behaviors via ERK-ETS1 pathway in pancreatic ductal adenocarcinoma (PDAC).Tumour Biol. 2016 Apr;37(4):5117-31. doi: 10.1007/s13277-015-4353-7. Epub 2015 Nov 7.
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Novel crosstalk between KLF4 and ZEB1 regulates gemcitabine resistance in pancreatic ductal adenocarcinoma.Int J Oncol. 2017 Oct;51(4):1239-1248. doi: 10.3892/ijo.2017.4099. Epub 2017 Aug 22.
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L1CAM induces perineural invasion of pancreas cancer cells by upregulation of metalloproteinase expression.Oncogene. 2019 Jan;38(4):596-608. doi: 10.1038/s41388-018-0458-y. Epub 2018 Aug 31.
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LASP1 is a HIF1 target gene critical for metastasis of pancreatic cancer.Cancer Res. 2015 Jan 1;75(1):111-9. doi: 10.1158/0008-5472.CAN-14-2040. Epub 2014 Nov 10.
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Asparaginyl endopeptidase enhances pancreatic ductal adenocarcinoma cell invasion in an exosome-dependent manner and correlates with poor prognosis.Int J Oncol. 2018 May;52(5):1651-1660. doi: 10.3892/ijo.2018.4318. Epub 2018 Mar 15.
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The MAZ transcription factor is a downstream target of the oncoprotein Cyr61/CCN1 and promotes pancreatic cancer cell invasion via CRAF-ERK signaling.J Biol Chem. 2018 Mar 23;293(12):4334-4349. doi: 10.1074/jbc.RA117.000333. Epub 2018 Feb 6.
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Assessment of tumor characteristics based on glycoform analysis of membrane-tethered MUC1.Lab Invest. 2017 Sep;97(9):1103-1113. doi: 10.1038/labinvest.2017.53. Epub 2017 Jun 5.
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Postoperative serum CEA and CA125 levels are supplementary to perioperative CA19-9 levels in predicting operative outcomes ofpancreatic ductal adenocarcinoma.Surgery. 2017 Feb;161(2):373-384. doi: 10.1016/j.surg.2016.08.005. Epub 2016 Nov 9.
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VEGF receptor-2/neuropilin 1 trans-complex formation between endothelial and tumor cells is an independent predictor of pancreatic cancer survival.J Pathol. 2018 Nov;246(3):311-322. doi: 10.1002/path.5141. Epub 2018 Sep 4.
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Expression and prognostic value of NSD1 and SETD2 in pancreatic ductal adenocarcinoma and its precursor lesions.Pathology. 2019 Jun;51(4):392-398. doi: 10.1016/j.pathol.2019.02.005. Epub 2019 May 3.
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Preclinical Evaluation of (68)Ga-DOTA-NT-20.3: A Promising PET Imaging Probe To Discriminate Human Pancreatic Ductal Adenocarcinoma from Pancreatitis.Mol Pharm. 2019 Jun 3;16(6):2776-2784. doi: 10.1021/acs.molpharmaceut.9b00283. Epub 2019 May 3.
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P4HA1/HIF1 feedback loop drives the glycolytic and malignant phenotypes of pancreatic cancer.Biochem Biophys Res Commun. 2019 Aug 27;516(3):606-612. doi: 10.1016/j.bbrc.2019.06.096. Epub 2019 Jun 22.
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Novel p21-Activated Kinase 4 (PAK4) Allosteric Modulators Overcome Drug Resistance and Stemness in Pancreatic Ductal Adenocarcinoma.Mol Cancer Ther. 2017 Jan;16(1):76-87. doi: 10.1158/1535-7163.MCT-16-0205. Epub 2016 Nov 15.
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A PD-L2-based immune marker signature helps to predict survival in resected pancreatic ductal adenocarcinoma.J Immunother Cancer. 2019 Aug 29;7(1):233. doi: 10.1186/s40425-019-0703-0.
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PDZ-containing 1 acts as a suppressor of pancreatic cancer by regulating PTEN phosphorylation.Oncotarget. 2017 Aug 24;8(42):72893-72909. doi: 10.18632/oncotarget.20552. eCollection 2017 Sep 22.
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Upregulation of pyruvate kinase M2 expression by fatty acid synthase contributes to gemcitabine resistance in pancreatic cancer.Oncol Lett. 2018 Feb;15(2):2211-2217. doi: 10.3892/ol.2017.7598. Epub 2017 Dec 13.
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Expression and clinical significance of placenta-specific 1 in pancreatic ductal adenocarcinoma.Tumour Biol. 2017 Jun;39(6):1010428317699131. doi: 10.1177/1010428317699131.
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Simultaneous high expression of PLD1 and Sp1 predicts a poor prognosis for pancreatic ductal adenocarcinoma patients.Oncotarget. 2016 Nov 29;7(48):78557-78565. doi: 10.18632/oncotarget.12447.
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The FOXO3/PGC-1 signaling axis is essential for cancer stem cell properties of pancreatic ductal adenocarcinoma.J Biol Chem. 2017 Jun 30;292(26):10813-10823. doi: 10.1074/jbc.M116.772111. Epub 2017 May 15.
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Phosphatase PPM1A is a novel prognostic marker in pancreatic ductal adenocarcinoma.Hum Pathol. 2016 Sep;55:151-8. doi: 10.1016/j.humpath.2016.05.002. Epub 2016 May 16.
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Dual-Modality Immuno-PET and Near-Infrared Fluorescence Imaging of Pancreatic Cancer Using an Anti-Prostate Stem Cell Antigen Cys-Diabody.J Nucl Med. 2018 Sep;59(9):1398-1405. doi: 10.2967/jnumed.117.207332. Epub 2018 Mar 30.
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Prognostic and diagnostic value of REG4 serum and tissue expression in pancreatic ductal adenocarcinoma.Tumour Biol. 2018 Mar;40(3):1010428318761494. doi: 10.1177/1010428318761494.
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Inhibition of mTORC2 component RICTOR impairs tumor growth in pancreatic cancer models.Oncotarget. 2017 Apr 11;8(15):24491-24505. doi: 10.18632/oncotarget.15524.
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Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors.Nat Med. 2017 Jan;23(1):60-68. doi: 10.1038/nm.4219. Epub 2016 Nov 21.
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Multiplex Enrichment and Detection of Rare KRAS Mutations in Liquid Biopsy Samples using Digital Droplet Pre-Amplification.Anal Chem. 2019 Jun 18;91(12):7516-7523. doi: 10.1021/acs.analchem.8b01605. Epub 2019 May 24.
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Functional role of BTB and CNC Homology 1 gene in pancreatic cancer and its association with survival in patients treated with gemcitabine.Theranostics. 2018 May 23;8(12):3366-3379. doi: 10.7150/thno.23978. eCollection 2018.
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miR-367 promotes epithelial-to-mesenchymal transition and invasion of pancreatic ductal adenocarcinoma cells by targeting the Smad7-TGF- signalling pathway.Br J Cancer. 2015 Apr 14;112(8):1367-75. doi: 10.1038/bjc.2015.102. Epub 2015 Mar 17.
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The impact of SPARC expression on the survival of pancreatic ductal adenocarcinoma patients after curative resection.J Cancer. 2019 Jan 1;10(3):627-633. doi: 10.7150/jca.28660. eCollection 2019.
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Cilia loss sensitizes cells to transformation by activating the mevalonate pathway.J Exp Med. 2018 Jan 2;215(1):177-195. doi: 10.1084/jem.20170399. Epub 2017 Dec 13.
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SOX9 inhibits -TrCP-mediated protein degradation to promote nuclear GLI1 expression and cancer stem cell properties.J Cell Sci. 2015 Mar 15;128(6):1123-38. doi: 10.1242/jcs.162164. Epub 2015 Jan 27.
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STK33 Promotes Growth and Progression of Pancreatic Cancer as a Critical Downstream Mediator of HIF1.Cancer Res. 2017 Dec 15;77(24):6851-6862. doi: 10.1158/0008-5472.CAN-17-0067. Epub 2017 Oct 16.
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Role of transgelin-2 in diabetes-associated pancreatic ductal adenocarcinoma.Oncotarget. 2017 Jul 25;8(30):49592-49604. doi: 10.18632/oncotarget.17519.
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Trefoil factor family 1 expression in the invasion front is a poor prognostic factor associated with lymph node metastasis in pancreatic cancer.Pancreatology. 2017 Sep-Oct;17(5):782-787. doi: 10.1016/j.pan.2017.07.188. Epub 2017 Jul 26.
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Thymidine kinase 1 silencing retards proliferative activity of pancreatic cancer cell via E2F1-TK1-P21 axis.Cell Prolif. 2018 Jun;51(3):e12428. doi: 10.1111/cpr.12428. Epub 2017 Dec 20.
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Tenascin C, Fibronectin, and Tumor-Stroma Ratio in Pancreatic Ductal Adenocarcinoma.Pancreas. 2019 Jan;48(1):43-48. doi: 10.1097/MPA.0000000000001195.
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Trophoblast glycoprotein promotes pancreatic ductal adenocarcinoma cell metastasis through Wnt/planar cell polarity signaling.Mol Med Rep. 2015 Jul;12(1):503-9. doi: 10.3892/mmr.2015.3412. Epub 2015 Mar 4.
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LncRNA PVT1 triggers Cyto-protective autophagy and promotes pancreatic ductal adenocarcinoma development via the miR-20a-5p/ULK1 Axis.Mol Cancer. 2018 Jul 12;17(1):98. doi: 10.1186/s12943-018-0845-6.
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High expression of WNT7A predicts poor prognosis and promote tumor metastasis in pancreatic ductal adenocarcinoma.Sci Rep. 2018 Oct 25;8(1):15792. doi: 10.1038/s41598-018-34094-3.
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Germline BRCA2 K3326X and CHEK2 I157T mutations increase risk for sporadic pancreatic ductal adenocarcinoma.Int J Cancer. 2019 Aug 1;145(3):686-693. doi: 10.1002/ijc.32127. Epub 2019 Feb 7.
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Screening and validating the core biomarkers in patients with pancreatic ductal adenocarcinoma.Math Biosci Eng. 2019 Nov 6;17(1):910-927. doi: 10.3934/mbe.2020048.
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111 Integrin is Induced in a Subset of Cancer-Associated Fibroblasts in Desmoplastic Tumor Stroma and Mediates In Vitro Cell Migration.Cancers (Basel). 2019 Jun 1;11(6):765. doi: 10.3390/cancers11060765.
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MCOLN1 Promotes Proliferation and Predicts Poor Survival of Patients with Pancreatic Ductal Adenocarcinoma.Dis Markers. 2019 Aug 5;2019:9436047. doi: 10.1155/2019/9436047. eCollection 2019.
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PDX1, a key factor in pancreatic embryogenesis, can exhibit antimetastatic activity in pancreatic ductal adenocarcinoma.Cancer Manag Res. 2019 Jul 26;11:7077-7087. doi: 10.2147/CMAR.S209940. eCollection 2019.
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ADAM8 expression is associated with increased invasiveness and reduced patient survival in pancreatic cancer.J Cell Mol Med. 2007 Sep-Oct;11(5):1162-74. doi: 10.1111/j.1582-4934.2007.00082.x.
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Activation of p16 gene silenced by DNA methylation in cancer cells by phosphoramidate derivatives of 2'-deoxyzebularine.J Med Chem. 2008 Dec 11;51(23):7593-601. doi: 10.1021/jm8005965.
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AZGP1 is a tumor suppressor in pancreatic cancer inducing mesenchymal-to-epithelial transdifferentiation by inhibiting TGF--mediated ERK signaling.Oncogene. 2010 Sep 16;29(37):5146-58. doi: 10.1038/onc.2010.258. Epub 2010 Jun 28.
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Identification of human complement factor B as a novel biomarker candidate for pancreatic ductal adenocarcinoma.J Proteome Res. 2014 Nov 7;13(11):4878-88. doi: 10.1021/pr5002719. Epub 2014 Aug 8.
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DEPTOR has growth suppression activity against pancreatic cancer cells.Oncotarget. 2014 Dec 30;5(24):12811-9. doi: 10.18632/oncotarget.2659.
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DPEP1 inhibits tumor cell invasiveness, enhances chemosensitivity and predicts clinical outcome in pancreatic ductal adenocarcinoma.PLoS One. 2012;7(2):e31507. doi: 10.1371/journal.pone.0031507. Epub 2012 Feb 20.
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Molecular determinants of retinoic acid sensitivity in pancreatic cancer.Clin Cancer Res. 2012 Jan 1;18(1):280-9. doi: 10.1158/1078-0432.CCR-11-2165. Epub 2011 Oct 18.
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Emergence of heterogeneous nuclear ribonucleoprotein A2/B1 vs loss of E-cadherin: their reciprocal immunoexpression profiles in human pancreatic cancer.Ann Diagn Pathol. 2013 Feb;17(1):14-7. doi: 10.1016/j.anndiagpath.2012.04.004. Epub 2012 May 22.
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Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitor NMS-P715.Mol Cancer Ther. 2014 Feb;13(2):307-315. doi: 10.1158/1535-7163.MCT-13-0324. Epub 2013 Nov 26.
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Co-expression of KLK6 and KLK10 as prognostic factors for survival in pancreatic ductal adenocarcinoma.Br J Cancer. 2008 Nov 4;99(9):1484-92. doi: 10.1038/sj.bjc.6604717. Epub 2008 Oct 14.
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Abnormal expression of Nek2 in pancreatic ductal adenocarcinoma: a novel marker for prognosis.Int J Clin Exp Pathol. 2014 Apr 15;7(5):2462-9. eCollection 2014.
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Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer.Cancer Cell. 2013 Mar 18;23(3):406-20. doi: 10.1016/j.ccr.2013.01.023. Epub 2013 Feb 28.
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Downregulation of RPL15 may predict poor survival and associate with tumor progression in pancreatic ductal adenocarcinoma.Oncotarget. 2015 Nov 10;6(35):37028-42. doi: 10.18632/oncotarget.5939.
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SUMO-specific protease 1 regulates pancreatic cancer cell proliferation and invasion by targeting MMP-9.Tumour Biol. 2014 Dec;35(12):12729-35. doi: 10.1007/s13277-014-2598-1. Epub 2014 Sep 13.
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Spatiotemporal proteomic analyses during pancreas cancer progression identifies serine/threonine stress kinase 4 (STK4) as a novel candidate biomarker for early stage disease.Mol Cell Proteomics. 2014 Dec;13(12):3484-96. doi: 10.1074/mcp.M113.036517. Epub 2014 Sep 15.
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AQP1 and AQP3 Expression are Associated With Severe Symptoms and Poor-prognosis of the Pancreatic Ductal Adenocarcinoma.Appl Immunohistochem Mol Morphol. 2019 Jan;27(1):40-47. doi: 10.1097/PAI.0000000000000523.
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CD13(hi) Neutrophil-like myeloid-derived suppressor cells exert immune suppression through Arginase 1 expression in pancreatic ductal adenocarcinoma.Oncoimmunology. 2017 Jan 9;6(2):e1258504. doi: 10.1080/2162402X.2016.1258504. eCollection 2017.
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Targeting cholecystokinin-2 receptor for pancreatic cancer chemoprevention.Mol Carcinog. 2019 Oct;58(10):1908-1918. doi: 10.1002/mc.23084. Epub 2019 Jul 16.
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Increased CDC20 expression is associated with pancreatic ductal adenocarcinoma differentiation and progression.J Hematol Oncol. 2012 Apr 4;5:15. doi: 10.1186/1756-8722-5-15.
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MicroRNA-148a is down-regulated in human pancreatic ductal adenocarcinomas and regulates cell survival by targeting CDC25B.Lab Invest. 2011 Oct;91(10):1472-9. doi: 10.1038/labinvest.2011.99. Epub 2011 Jun 27.
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CDK5 Inhibitor Downregulates Mcl-1 and Sensitizes Pancreatic Cancer Cell Lines to Navitoclax.Mol Pharmacol. 2019 Oct;96(4):419-429. doi: 10.1124/mol.119.116855.
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Carcinoembryonic antigen cell adhesion molecule 6 (CEACAM6) in Pancreatic Ductal Adenocarcinoma (PDA): An integrative analysis of a novel therapeutic target.Sci Rep. 2019 Dec 4;9(1):18347. doi: 10.1038/s41598-019-54545-9.
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dCK Expression and Gene Polymorphism With Gemcitabine Chemosensitivity in Patients With Pancreatic Ductal Adenocarcinoma: A Strobe-Compliant Observational Study.Medicine (Baltimore). 2016 Mar;95(10):e2936. doi: 10.1097/MD.0000000000002936.
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Expression of DEK in pancreatic cancer and its correlation with clinicopathological features and prognosis.J Cancer. 2019 Jan 29;10(4):911-917. doi: 10.7150/jca.27405. eCollection 2019.
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Overexpressions of DLL4 and CD105 are Associated with Poor Prognosis of Patients with Pancreatic Ductal Adenocarcinoma.Pathol Oncol Res. 2015 Sep;21(4):1141-7. doi: 10.1007/s12253-015-9937-4. Epub 2015 May 19.
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Licocoumarone induces BxPC-3 pancreatic adenocarcinoma cell death by inhibiting DYRK1A. Chem Biol Interact. 2020 Jan 25;316:108913. doi: 10.1016/j.cbi.2019.108913. Epub 2019 Dec 12.
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Neovascular Prostate-Specific Membrane Antigen Expression Is Associated with Improved Overall Survival under Palliative Chemotherapy in Patients with Pancreatic Ductal Adenocarcinoma.Biomed Res Int. 2017;2017:2847303. doi: 10.1155/2017/2847303. Epub 2017 Oct 25.
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Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism.Cell Commun Signal. 2019 Aug 30;17(1):111. doi: 10.1186/s12964-019-0425-4.
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Host IDO2 Gene Status Influences Tumor Progression and Radiotherapy Response in KRAS-Driven Sporadic Pancreatic Cancers.Clin Cancer Res. 2019 Jan 15;25(2):724-734. doi: 10.1158/1078-0432.CCR-18-0814. Epub 2018 Sep 28.
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BAG3 deletion suppresses stem cell-like features of pancreatic ductal adenocarcinoma via translational suppression of ISG15.Biochim Biophys Acta Mol Cell Res. 2019 May;1866(5):819-827. doi: 10.1016/j.bbamcr.2019.02.008. Epub 2019 Feb 14.
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Correlation of clinicopathological features and leucine-rich repeat-containing G-protein-coupled receptor 5 expression in pancreatic ductal adenocarcinoma.Pathol Res Pract. 2019 Nov;215(11):152623. doi: 10.1016/j.prp.2019.152623. Epub 2019 Sep 5.
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Deficiency in hormone-sensitive lipase accelerates the development of pancreatic cancer in conditional KrasG12D mice.BMC Cancer. 2018 Aug 7;18(1):797. doi: 10.1186/s12885-018-4713-y.
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Differentially Expressed microRNAs in MIA PaCa-2 and PANC-1 Pancreas Ductal Adenocarcinoma Cell Lines are Involved in Cancer Stem Cell Regulation.Int J Mol Sci. 2019 Sep 10;20(18):4473. doi: 10.3390/ijms20184473.
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Phase I Study of Lentiviral-Transduced Chimeric Antigen Receptor-Modified T Cells Recognizing Mesothelin in Advanced Solid Cancers.Mol Ther. 2019 Nov 6;27(11):1919-1929. doi: 10.1016/j.ymthe.2019.07.015. Epub 2019 Jul 30.
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Stem cell marker nestin is critical for TGF-1-mediated tumor progression in pancreatic cancer.Mol Cancer Res. 2013 Jul;11(7):768-79. doi: 10.1158/1541-7786.MCR-12-0511. Epub 2013 Apr 3.
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