Details of the Drug Combination

General Information of Drug Combination (ID: DCSM0Q6)

• Drug Combination Name: Bortezomib + MK-4827
• Indication: Large cell lung carcinoma; Status: Investigative [1]
• Component Drugs:
  Bortezomib (DMNO38U): Small molecular drug
  MK-4827 (DMLYGH4): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: NCI-H460
  Zero Interaction Potency (ZIP) Score: 2.8
  Bliss Independence Score: 0.24
  Loewe Additivity Score: 0.25
  LHighest Single Agent (HSA) Score: 2.49

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Bortezomib

Disease Entry	ICD 11	Status	REF
Leukemia	N.A.	Approved	[2]
Lung cancer	2C25.0	Approved	[2]
Lymphoproliferative syndrome	N.A.	Approved	[2]
MALT lymphoma	N.A.	Approved	[2]
Mantle cell lymphoma	2A85.5	Approved	[3]
Minimally invasive lung adenocarcinoma	N.A.	Approved	[2]
Multiple myeloma	2A83	Approved	[4]
Nodal marginal zone lymphoma	2A85.0	Approved	[2]
Plasma cell myeloma	2A83.1	Approved	[2]
Recurrent adult burkitt lymphoma	2A85.6	Approved	[2]
Non-hodgkin lymphoma	2B33.5	Phase 3	[4]
B-cell neoplasm	N.A.	Investigative	[2]
Colon cancer	2B90.Z	Investigative	[2]
Gastric cancer	2B72	Investigative	[2]

Bortezomib Interacts with 3 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Cationic trypsinogen (PRSS1)	TT2WR1T	TRY1_HUMAN	Inhibitor	[13]
Kallikrein-related peptidase (KLK)	TT5L2VC	NOUNIPROTAC	Inhibitor	[13]
Proteasome (PS)	TTU7ZMG	NOUNIPROTAC	Modulator	[14]

Bortezomib Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[15]

Bortezomib Interacts with 5 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[16]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Metabolism	[17]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Metabolism	[18]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Metabolism	[19]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Metabolism	[18]

Bortezomib Interacts with 686 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Decreases Expression	[20]
Extended synaptotagmin-2 (ESYT2)	OTWCXTX3	ESYT2_HUMAN	Decreases Expression	[7]
Alternative prion protein (PRNP)	OTE85L1Q	APRIO_HUMAN	Increases Expression	[7]
Serine/threonine-protein kinase Sgk1 (SGK1)	OT301T1U	SGK1_HUMAN	Increases Expression	[7]
Cytosolic acyl coenzyme A thioester hydrolase (ACOT7)	OT7C68YV	BACH_HUMAN	Decreases Expression	[7]
GTP-binding protein 1 (GTPBP1)	OTA9KV6C	GTPB1_HUMAN	Decreases Expression	[7]
Galectin-8 (LGALS8)	OT71LJ8T	LEG8_HUMAN	Increases Expression	[7]
26S proteasome non-ATPase regulatory subunit 12 (PSMD12)	OTWICA51	PSD12_HUMAN	Increases Expression	[7]
Leukocyte-specific transcript 1 protein (LST1)	OTUVG424	LST1_HUMAN	Decreases Expression	[7]
Agrin (AGRN)	OTWJENAZ	AGRIN_HUMAN	Decreases Expression	[7]
Krev interaction trapped protein 1 (KRIT1)	OT58AP1I	KRIT1_HUMAN	Increases Expression	[7]
Beta-1,3-N-acetylglucosaminyltransferase manic fringe (MFNG)	OTUX45ZF	MFNG_HUMAN	Decreases Expression	[7]
Pirin (PIR)	OT8ALXHU	PIR_HUMAN	Increases Expression	[7]
Pyridoxal kinase (PDXK)	OT40AJ5J	PDXK_HUMAN	Increases Expression	[7]
Stearoyl-CoA desaturase (SCD)	OTB1073G	SCD_HUMAN	Decreases Expression	[7]
Suppressor of cytokine signaling 3 (SOCS3)	OTY183WJ	SOCS3_HUMAN	Increases Expression	[7]
TRAF-type zinc finger domain-containing protein 1 (TRAFD1)	OT7AU2R3	TRAD1_HUMAN	Increases Expression	[7]
Cytoplasmic dynein 1 intermediate chain 1 (DYNC1I1)	OTFX1KCG	DC1I1_HUMAN	Increases Expression	[7]
Chromodomain-helicase-DNA-binding protein 2 (CHD2)	OTRKL6YC	CHD2_HUMAN	Increases Expression	[7]
Golgi SNAP receptor complex member 2 (GOSR2)	OTYHIYN2	GOSR2_HUMAN	Increases Expression	[7]
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10)	OTOKUXUH	ADA10_HUMAN	Decreases Expression	[7]
Apolipoprotein L1 (APOL1)	OT8QBVTY	APOL1_HUMAN	Increases Expression	[7]
Interferon-inducible protein AIM2 (AIM2)	OT86QUI8	AIM2_HUMAN	Increases Expression	[7]
Myosin regulatory light chain 12B (MYL12B)	OTXMLQOT	ML12B_HUMAN	Increases Expression	[7]
Centrosomal protein of 290 kDa (CEP290)	OTVN52VH	CE290_HUMAN	Increases Expression	[7]
Small ribosomal subunit protein uS12m (MRPS12)	OTGY4GIX	RT12_HUMAN	Decreases Expression	[7]
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT)	OT1Z1ZXE	OGT1_HUMAN	Decreases Expression	[7]
V-type proton ATPase subunit e 1 (ATP6V0E1)	OTZZIUYY	VA0E1_HUMAN	Increases Expression	[7]
ATP-binding cassette sub-family C member 4 (ABCC4)	OTO27PAL	MRP4_HUMAN	Decreases Expression	[7]
Transcription factor MafG (MAFG)	OTBQFUZH	MAFG_HUMAN	Increases Expression	[7]
Interleukin-1 receptor-associated kinase-like 2 (IRAK2)	OT6Y1QZN	IRAK2_HUMAN	Increases Expression	[7]
PHD finger protein 1 (PHF1)	OTW2PSIR	PHF1_HUMAN	Increases Expression	[7]
Synaptogyrin-2 (SYNGR2)	OTJX84RI	SNG2_HUMAN	Decreases Expression	[7]
Cytohesin-interacting protein (CYTIP)	OTRJ3ZC5	CYTIP_HUMAN	Increases Expression	[7]
Growth arrest-specific protein 7 (GAS7)	OT0M5TNY	GAS7_HUMAN	Decreases Expression	[7]
F-box-like/WD repeat-containing protein TBL1X (TBL1X)	OTXQ51E0	TBL1X_HUMAN	Increases Expression	[7]
Glycosaminoglycan xylosylkinase (FAM20B)	OTOA0UYT	XYLK_HUMAN	Decreases Expression	[7]
Suppressor of cytokine signaling 5 (SOCS5)	OTN1ABYR	SOCS5_HUMAN	Increases Expression	[7]
Protein tyrosine phosphatase type IVA 3 (PTP4A3)	OTXMMWUN	TP4A3_HUMAN	Decreases Expression	[7]
Deformed epidermal autoregulatory factor 1 homolog (DEAF1)	OTCLX3ZW	DEAF1_HUMAN	Decreases Expression	[7]
Calpain-15 (CAPN15)	OT0WE161	CAN15_HUMAN	Decreases Expression	[7]
Carbonyl reductase 3 (CBR3)	OT9G6SF0	CBR3_HUMAN	Increases Expression	[7]
Triple functional domain protein (TRIO)	OT71X1AK	TRIO_HUMAN	Decreases Expression	[7]
Cystatin-F (CST7)	OTQWZUVQ	CYTF_HUMAN	Increases Expression	[7]
ATP-dependent DNA helicase Q4 (RECQL4)	OT59LSW7	RECQ4_HUMAN	Increases Expression	[7]
Erlin-2 (ERLIN2)	OT551BVG	ERLN2_HUMAN	Decreases Expression	[7]
Pre-mRNA-processing factor 6 (PRPF6)	OT3U0ABN	PRP6_HUMAN	Decreases Expression	[7]
Lysine-specific demethylase 4B (KDM4B)	OT5P1UPY	KDM4B_HUMAN	Decreases Expression	[7]
Methyl-CpG-binding domain protein 4 (MBD4)	OTWR9YXE	MBD4_HUMAN	Increases Expression	[7]
Arginyl-tRNA--protein transferase 1 (ATE1)	OT3QNM39	ATE1_HUMAN	Increases Expression	[7]
GDH/6PGL endoplasmic bifunctional protein (H6PD)	OTO7TNDD	G6PE_HUMAN	Decreases Expression	[7]
NAD kinase (NADK)	OTYN9GX0	NADK_HUMAN	Decreases Expression	[7]
AP-2 complex subunit alpha-1 (AP2A1)	OTEFZB21	AP2A1_HUMAN	Decreases Expression	[7]
Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)	OTBMJUOC	M4K4_HUMAN	Increases Expression	[7]
Acyl-CoA 6-desaturase (FADS2)	OTUX531P	FADS2_HUMAN	Decreases Expression	[7]
Phosphatidylserine lipase ABHD16A (ABHD16A)	OTDS9K1Z	ABHGA_HUMAN	Increases Expression	[7]
G patch domain and ankyrin repeat-containing protein 1 (GPANK1)	OT1TN2KT	GPAN1_HUMAN	Increases Expression	[7]
Putative lipid scramblase CLPTM1 (CLPTM1)	OT14QP7N	CLPT1_HUMAN	Decreases Expression	[7]
Glutathione reductase, mitochondrial (GSR)	OTM2TUYM	GSHR_HUMAN	Increases Expression	[7]
HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA)	OT7KZMP2	DRA_HUMAN	Decreases Expression	[7]
Myelin basic protein (MBP)	OTFZCEDB	MBP_HUMAN	Decreases Expression	[7]
Thy-1 membrane glycoprotein (THY1)	OTVONVTB	THY1_HUMAN	Decreases Expression	[7]
HLA class II histocompatibility antigen, DP beta 1 chain (HLA-DPB1)	OTW8JHU2	DPB1_HUMAN	Decreases Expression	[7]
T-cell surface glycoprotein CD5 (CD5)	OTC5JEG5	CD5_HUMAN	Decreases Expression	[7]
Alpha-galactosidase A (GLA)	OTBSR6DT	AGAL_HUMAN	Increases Expression	[7]
HLA class II histocompatibility antigen, DO alpha chain (HLA-DOA)	OTZE5Q7R	DOA_HUMAN	Decreases Expression	[7]
Cathepsin D (CTSD)	OTQZ36F3	CATD_HUMAN	Increases Expression	[7]
Trypsin-2 (PRSS2)	OTOMVUWL	TRY2_HUMAN	Decreases Expression	[7]
Prosaposin (PSAP)	OTUOEKY7	SAP_HUMAN	Increases Expression	[7]
Guanine nucleotide-binding protein G(i) subunit alpha-3 (GNAI3)	OT89UWAR	GNAI3_HUMAN	Increases Expression	[7]
Steryl-sulfatase (STS)	OTXTJQPC	STS_HUMAN	Decreases Expression	[7]
Monoacylglycerol lipase ABHD2 (ABHD2)	OTCRUOCS	ABHD2_HUMAN	Increases Expression	[7]
Gamma-enolase (ENO2)	OTRODL0T	ENOG_HUMAN	Increases Expression	[7]
Tropomyosin alpha-1 chain (TPM1)	OTD73X6R	TPM1_HUMAN	Increases Expression	[7]
Cancer/testis antigen family 45 member A6 (CT45A5)	OTIFETOM	CT456_HUMAN	Increases Expression	[7]
Schwannomin-interacting protein 1 (SCHIP1)	OTF3FR4A	SCHI1_HUMAN	Decreases Expression	[7]
Granzyme B (GZMB)	OTPPVIRS	GRAB_HUMAN	Increases Expression	[7]
Clusterin (CLU)	OTQGG0JM	CLUS_HUMAN	Increases Expression	[7]
Endoplasmic reticulum chaperone BiP (HSPA5)	OTFUIRAO	BIP_HUMAN	Increases Expression	[7]
Phenylethanolamine N-methyltransferase (PNMT)	OTGLCPE8	PNMT_HUMAN	Decreases Expression	[7]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)	OT2HZK5M	GTR3_HUMAN	Increases Expression	[7]
Ras-related protein Ral-A (RALA)	OT734R7X	RALA_HUMAN	Increases Expression	[7]
Breakpoint cluster region protein (BCR)	OTCN76C1	BCR_HUMAN	Decreases Expression	[7]
Glucose-6-phosphate 1-dehydrogenase (G6PD)	OT300SMK	G6PD_HUMAN	Decreases Expression	[7]
Steroid hormone receptor ERR1 (ESRRA)	OTTDTUSP	ERR1_HUMAN	Decreases Expression	[7]
B-cell antigen receptor complex-associated protein alpha chain (CD79A)	OTOJC8DV	CD79A_HUMAN	Decreases Expression	[7]
Granzyme A (GZMA)	OT43R33L	GRAA_HUMAN	Decreases Expression	[7]
Cytochrome b-245 light chain (CYBA)	OT16N9ZO	CY24A_HUMAN	Decreases Expression	[7]
Sodium/potassium-transporting ATPase subunit alpha-3 (ATP1A3)	OTM8EG6H	AT1A3_HUMAN	Decreases Expression	[7]
Perforin-1 (PRF1)	OTFVXD7H	PERF_HUMAN	Decreases Expression	[7]
Insulin-degrading enzyme (IDE)	OT5GQTJ5	IDE_HUMAN	Increases Expression	[7]
Ras-related C3 botulinum toxin substrate 2 (RAC2)	OTAOHFNH	RAC2_HUMAN	Decreases Expression	[7]
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)	OT18H1B0	ERF3A_HUMAN	Decreases Expression	[7]
Folate receptor alpha (FOLR1)	OT0QZ0H6	FOLR1_HUMAN	Decreases Expression	[7]
Cyclic AMP-dependent transcription factor ATF-2 (ATF2)	OTNIZPEA	ATF2_HUMAN	Increases Expression	[7]
NAD(P)H dehydrogenase 1 (NQO1)	OTZGGIVK	NQO1_HUMAN	Increases Expression	[7]
Immunoglobulin lambda-like polypeptide 1 (IGLL1)	OTRTNVOG	IGLL1_HUMAN	Decreases Expression	[7]
Mucin-1 (MUC1)	OTHQI7IY	MUC1_HUMAN	Decreases Expression	[7]
Ribosyldihydronicotinamide dehydrogenase (NQO2)	OTGDAJRZ	NQO2_HUMAN	Increases Expression	[7]
Leukosialin (SPN)	OTFW338K	LEUK_HUMAN	Decreases Expression	[7]
Transcription factor JunD (JUND)	OTNKACJD	JUND_HUMAN	Decreases Expression	[7]
Integrin beta-6 (ITGB6)	OTI3DJ7U	ITB6_HUMAN	Increases Expression	[7]
Ras-related protein Rab-5A (RAB5A)	OTFR2KM4	RAB5A_HUMAN	Decreases Expression	[7]
Integrin alpha-L (ITGAL)	OTCUQAIS	ITAL_HUMAN	Decreases Expression	[7]
B-cell lymphoma 3 protein (BCL3)	OT1M5B95	BCL3_HUMAN	Decreases Expression	[7]
5'-nucleotidase (NT5E)	OT7J5LT6	5NTD_HUMAN	Decreases Expression	[7]
Ephrin type-A receptor 1 (EPHA1)	OTGJMRZ0	EPHA1_HUMAN	Decreases Expression	[7]
CD9 antigen (CD9)	OT2184XU	CD9_HUMAN	Increases Expression	[7]
Integrin alpha-6 (ITGA6)	OT3FA39C	ITA6_HUMAN	Decreases Expression	[7]
Ribosomal protein S6 kinase beta-1 (RPS6KB1)	OTAELNGX	KS6B1_HUMAN	Increases Expression	[7]
Tyrosine-protein kinase JAK1 (JAK1)	OT0X3D17	JAK1_HUMAN	Decreases Expression	[7]
ER lumen protein-retaining receptor 1 (KDELR1)	OT8YBS5G	ERD21_HUMAN	Decreases Expression	[7]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)	OTDRV63V	GA45A_HUMAN	Increases Expression	[7]
Polypyrimidine tract-binding protein 1 (PTBP1)	OT2OBJUK	PTBP1_HUMAN	Decreases Expression	[7]
NKG2-D type II integral membrane protein (KLRK1)	OTQWXK71	NKG2D_HUMAN	Decreases Expression	[7]
CD82 antigen (CD82)	OTH8MC64	CD82_HUMAN	Decreases Expression	[7]
HLA class II histocompatibility antigen, DM beta chain (HLA-DMB)	OT17HGXJ	DMB_HUMAN	Decreases Expression	[7]
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)	OTG0TTX7	CD38_HUMAN	Decreases Expression	[7]
Ephrin type-B receptor 2 (EPHB2)	OT8VZ6C5	EPHB2_HUMAN	Decreases Expression	[7]
Flavin reductase (BLVRB)	OTHCFN2C	BLVRB_HUMAN	Increases Expression	[7]
G1/S-specific cyclin-D2 (CCND2)	OTDULQF9	CCND2_HUMAN	Decreases Expression	[7]
Homeobox protein Hox-A11 (HOXA11)	OT42C4HF	HXA11_HUMAN	Decreases Expression	[7]
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Increases Expression	[7]
Stress-induced-phosphoprotein 1 (STIP1)	OT7TXLOX	STIP1_HUMAN	Decreases Expression	[7]
Guanylate-binding protein 2 (GBP2)	OTVU4G07	GBP2_HUMAN	Increases Expression	[7]
Multidrug resistance-associated protein 1 (ABCC1)	OTGUN89S	MRP1_HUMAN	Decreases Expression	[7]
Protein phosphatase 1A (PPM1A)	OT1U770U	PPM1A_HUMAN	Increases Expression	[7]
Transcription factor 7 (TCF7)	OT1ID822	TCF7_HUMAN	Decreases Expression	[7]
Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2)	OTUE7Z91	MP2K2_HUMAN	Decreases Expression	[7]
Transgelin-2 (TAGLN2)	OTUXZGDQ	TAGL2_HUMAN	Decreases Expression	[7]
Pre-B-cell leukemia transcription factor 3 (PBX3)	OT8WMVM4	PBX3_HUMAN	Decreases Expression	[7]
Interleukin-15 (IL15)	OTQSYWQS	IL15_HUMAN	Increases Expression	[7]
Trifunctional enzyme subunit alpha, mitochondrial (HADHA)	OTO557N2	ECHA_HUMAN	Increases Expression	[7]
Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3)	OTARRES9	IF2G_HUMAN	Decreases Expression	[7]
B-cell lymphoma 6 protein (BCL6)	OTQAWWO1	BCL6_HUMAN	Increases Expression	[7]
Lysine-specific demethylase 5C (KDM5C)	OTZ6E0HY	KDM5C_HUMAN	Decreases Expression	[7]
Eukaryotic translation initiation factor 1 (EIF1)	OTB4GZ0V	EIF1_HUMAN	Increases Expression	[7]
5-hydroxytryptamine receptor 2B (HTR2B)	OTM1AD9J	5HT2B_HUMAN	Decreases Expression	[7]
Lamina-associated polypeptide 2, isoform alpha (TMPO)	OTL68EL4	LAP2A_HUMAN	Decreases Expression	[7]
ETS translocation variant 4 (ETV4)	OT8C98UZ	ETV4_HUMAN	Decreases Expression	[7]
Killer cell immunoglobulin-like receptor 2DS4 (KIR2DS4)	OT00N6UJ	KI2S4_HUMAN	Decreases Expression	[7]
26S proteasome regulatory subunit 6B (PSMC4)	OTS3XN41	PRS6B_HUMAN	Increases Expression	[7]
Lys-63-specific deubiquitinase BRCC36 (BRCC3)	OTK0ZN7Y	BRCC3_HUMAN	Decreases Expression	[7]
LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1)	OT729S0T	LIMS1_HUMAN	Increases Expression	[7]
NADP-dependent malic enzyme (ME1)	OTSVEUQE	MAOX_HUMAN	Increases Expression	[7]
MAP kinase-activated protein kinase 2 (MAPKAPK2)	OT460SBO	MAPK2_HUMAN	Decreases Expression	[7]
Large ribosomal subunit protein bL19m (MRPL19)	OTRBKF6R	RM19_HUMAN	Increases Expression	[7]
Beta-arrestin-1 (ARRB1)	OT2NJS37	ARRB1_HUMAN	Decreases Expression	[7]
Ubiquitin-conjugating enzyme E2 R1 (CDC34)	OTNBK390	UB2R1_HUMAN	Increases Expression	[7]
Choline-phosphate cytidylyltransferase A (PCYT1A)	OTMH0YLN	PCY1A_HUMAN	Increases Expression	[7]
Protein phosphatase 1F (PPM1F)	OTU0MVR7	PPM1F_HUMAN	Increases Expression	[7]
Protein numb homolog (NUMB)	OTMB586Q	NUMB_HUMAN	Increases Expression	[7]
Presenilin-1 (PSEN1)	OTKL39RT	PSN1_HUMAN	Decreases Expression	[7]
Cytosolic purine 5'-nucleotidase (NT5C2)	OTJMF66Z	5NTC_HUMAN	Increases Expression	[7]
DNA ligase 4 (LIG4)	OT40DNXU	DNLI4_HUMAN	Increases Expression	[7]
Dynamin-2 (DNM2)	OTUYU2U3	DYN2_HUMAN	Decreases Expression	[7]
Poly(A) polymerase alpha (PAPOLA)	OTPHD65D	PAPOA_HUMAN	Decreases Expression	[7]
Tyrosine-protein kinase Blk (BLK)	OT1EB8MT	BLK_HUMAN	Decreases Expression	[7]
Succinate-semialdehyde dehydrogenase, mitochondrial (ALDH5A1)	OTF3TBTK	SSDH_HUMAN	Decreases Expression	[7]
26S proteasome non-ATPase regulatory subunit 7 (PSMD7)	OT7PZZ4K	PSMD7_HUMAN	Increases Expression	[7]
N-sulphoglucosamine sulphohydrolase (SGSH)	OTLSSEOS	SPHM_HUMAN	Increases Expression	[7]
AF4/FMR2 family member 1 (AFF1)	OTT2C78E	AFF1_HUMAN	Increases Expression	[7]
Importin subunit alpha-1 (KPNA2)	OTU7FOE6	IMA1_HUMAN	Increases Expression	[7]
Diacylglycerol kinase epsilon (DGKE)	OTWS86AS	DGKE_HUMAN	Decreases Expression	[7]
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)	OTK13JKC	MP2K6_HUMAN	Decreases Expression	[7]
Rho GDP-dissociation inhibitor 1 (ARHGDIA)	OTEXWJDO	GDIR1_HUMAN	Decreases Expression	[7]
Cysteine-rich protein 2 (CRIP2)	OTVVJSYX	CRIP2_HUMAN	Decreases Expression	[7]
Serine/threonine-protein phosphatase 5 (PPP5C)	OTC3HT6Y	PPP5_HUMAN	Decreases Expression	[7]
Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1)	OT6W40XU	P5CS_HUMAN	Decreases Expression	[7]
Proteinase-activated receptor 2 (F2RL1)	OTMRMJ8N	PAR2_HUMAN	Decreases Expression	[7]
Myc-associated zinc finger protein (MAZ)	OTEHKN1M	MAZ_HUMAN	Decreases Expression	[7]
ADP-ribosylation factor-like protein 4C (ARL4C)	OTQ3QNNU	ARL4C_HUMAN	Decreases Expression	[7]
Small integral membrane protein 11 (SMIM11)	OTZPLVUC	SIM11_HUMAN	Decreases Expression	[7]
Triosephosphate isomerase (TPI1)	OT14KP4B	TPIS_HUMAN	Increases Expression	[7]
Cell division control protein 42 homolog (CDC42)	OT5QBC5M	CDC42_HUMAN	Decreases Expression	[7]
C-X-C chemokine receptor type 4 (CXCR4)	OTUFSBX2	CXCR4_HUMAN	Decreases Expression	[7]
Large ribosomal subunit protein uL24 (RPL26)	OTFNRC27	RL26_HUMAN	Increases Expression	[7]
cAMP-dependent protein kinase inhibitor alpha (PKIA)	OT8M5GVO	IPKA_HUMAN	Increases Expression	[7]
AP-1 complex subunit sigma-1A (AP1S1)	OTQ2H8DN	AP1S1_HUMAN	Decreases Expression	[7]
Small ribosomal subunit protein uS17 (RPS11)	OTILZE44	RS11_HUMAN	Increases Expression	[7]
ADP-ribosylation factor 6 (ARF6)	OTVV7KJO	ARF6_HUMAN	Increases Expression	[7]
Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A)	OT6285L4	FKB1A_HUMAN	Decreases Expression	[7]
Calcineurin subunit B type 1 (PPP3R1)	OTGQNFJQ	CANB1_HUMAN	Decreases Expression	[7]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A)	OT9297OG	2ABA_HUMAN	Increases Expression	[7]
Small ubiquitin-related modifier 1 (SUMO1)	OTJFD4P5	SUMO1_HUMAN	Increases Expression	[7]
Eukaryotic translation initiation factor 5A-1 (EIF5A)	OTQ8DJX5	IF5A1_HUMAN	Decreases Expression	[7]
DNA-dependent protein kinase catalytic subunit (PRKDC)	OTJVS4EG	PRKDC_HUMAN	Decreases Expression	[7]
Small ribosomal subunit protein uS5m (MRPS5)	OTZZR208	RT05_HUMAN	Decreases Expression	[7]
Spectrin beta chain, non-erythrocytic 1 (SPTBN1)	OTOVM4D4	SPTB2_HUMAN	Increases Expression	[7]
Large neutral amino acids transporter small subunit 1 (SLC7A5)	OT2WPVXD	LAT1_HUMAN	Decreases Expression	[7]
2-oxoglutarate dehydrogenase complex component E1 (OGDH)	OTHGTQWF	ODO1_HUMAN	Decreases Expression	[7]
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase , mitochondrial (ALDH6A1)	OT8LCZCT	MMSA_HUMAN	Decreases Expression	[7]
Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11)	OT7EVFBK	M2OM_HUMAN	Decreases Expression	[7]
Glutathione S-transferase Mu 4 (GSTM4)	OTOTF8DU	GSTM4_HUMAN	Decreases Expression	[7]
cAMP-responsive element modulator (CREM)	OTJIJ5AL	CREM_HUMAN	Increases Expression	[7]
Centromere protein C (CENPC)	OTVJ6VE9	CENPC_HUMAN	Increases Expression	[7]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Decreases Expression	[7]
Neurogenic locus notch homolog protein 2 (NOTCH2)	OTQ3Y9PA	NOTC2_HUMAN	Decreases Expression	[7]
CTD small phosphatase-like protein 2 (CTDSPL2)	OTPF8W4P	CTSL2_HUMAN	Decreases Expression	[7]
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)	OTFH9M73	PTN11_HUMAN	Decreases Expression	[7]
Early activation antigen CD69 (CD69)	OTGJHSVP	CD69_HUMAN	Increases Expression	[7]
Serine/arginine-rich splicing factor 1 (SRSF1)	OTF61HOV	SRSF1_HUMAN	Decreases Expression	[7]
Rho GTPase-activating protein 1 (ARHGAP1)	OT0H2ZBZ	RHG01_HUMAN	Decreases Expression	[7]
FACT complex subunit SSRP1 (SSRP1)	OT5TYJK9	SSRP1_HUMAN	Decreases Expression	[7]
Sodium/bile acid cotransporter 7 (SLC10A7)	OTYLAWNV	NTCP7_HUMAN	Increases Expression	[7]
Apolipoprotein B receptor (APOBR)	OT9EUZX3	APOBR_HUMAN	Decreases Expression	[7]
Nuclear factor 1 A-type (NFIA)	OTDHQ9CG	NFIA_HUMAN	Decreases Expression	[7]
Interferon-related developmental regulator 2 (IFRD2)	OT2URF18	IFRD2_HUMAN	Decreases Expression	[7]
Protein AF1q (MLLT11)	OTG5RVHC	AF1Q_HUMAN	Increases Expression	[7]
PR domain zinc finger protein 2 (PRDM2)	OT8L7CGX	PRDM2_HUMAN	Decreases Expression	[7]
Dual specificity protein phosphatase 4 (DUSP4)	OT6WAO12	DUS4_HUMAN	Decreases Expression	[7]
Oxysterols receptor LXR-alpha (NR1H3)	OT54YZ9I	NR1H3_HUMAN	Decreases Expression	[7]
Chromobox protein homolog 3 (CBX3)	OTOP9RLD	CBX3_HUMAN	Increases Expression	[7]
Phosducin-like protein (PDCL)	OTDNHIXG	PHLP_HUMAN	Increases Expression	[7]
DNA-binding protein Ikaros (IKZF1)	OTCW1FKL	IKZF1_HUMAN	Decreases Expression	[7]
Protein OS-9 (OS9)	OTB5B2TY	OS9_HUMAN	Increases Expression	[7]
Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5)	OT404F9K	FKBP5_HUMAN	Decreases Expression	[7]
Sequestosome-1 (SQSTM1)	OTGY5D5J	SQSTM_HUMAN	Increases Expression	[7]
Transformer-2 protein homolog alpha (TRA2A)	OT5NHOO3	TRA2A_HUMAN	Decreases Expression	[7]
Rap guanine nucleotide exchange factor 1 (RAPGEF1)	OTZ0TBN1	RPGF1_HUMAN	Decreases Expression	[7]
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (PDE7A)	OTVDV4IT	PDE7A_HUMAN	Decreases Expression	[7]
Nuclear transcription factor Y subunit gamma (NFYC)	OTZVVEV7	NFYC_HUMAN	Decreases Expression	[7]
Transcription factor Dp-1 (TFDP1)	OT6RZ7VT	TFDP1_HUMAN	Decreases Expression	[7]
Fas-activated serine/threonine kinase (FASTK)	OTTHFZMP	FASTK_HUMAN	Decreases Expression	[7]
Mediator of DNA damage checkpoint protein 1 (MDC1)	OTEUQH4J	MDC1_HUMAN	Decreases Expression	[7]
Structural maintenance of chromosomes protein 1A (SMC1A)	OT9ZMRK9	SMC1A_HUMAN	Decreases Expression	[7]
Neutral alpha-glucosidase AB (GANAB)	OTYLXY4M	GANAB_HUMAN	Decreases Expression	[7]
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D)	OT43TTX0	2A5D_HUMAN	Decreases Expression	[7]
Kinesin-like protein KIF22 (KIF22)	OTY6X6BL	KIF22_HUMAN	Decreases Expression	[7]
Killer cell immunoglobulin-like receptor 3DS1 (KIR3DS1)	OTJWIO4T	KI3S1_HUMAN	Decreases Expression	[7]
Killer cell immunoglobulin-like receptor 2DS3 (KIR2DS3)	OT3PSLDL	KI2S3_HUMAN	Decreases Expression	[7]
DAZ-associated protein 2 (DAZAP2)	OTNURO9F	DAZP2_HUMAN	Decreases Expression	[7]
Neutrophil cytosol factor 4 (NCF4)	OTX007YL	NCF4_HUMAN	Decreases Expression	[7]
kinase isozyme 2, mitochondrial (PDK2)	OTM436F9	PDK2_HUMAN	Decreases Expression	[7]
Leucine-rich repeat-containing protein 41 (LRRC41)	OT4YSBV5	LRC41_HUMAN	Decreases Expression	[7]
Ras suppressor protein 1 (RSU1)	OTO5GHT1	RSU1_HUMAN	Increases Expression	[7]
Scaffold attachment factor B1 (SAFB)	OTGRV2LW	SAFB1_HUMAN	Decreases Expression	[7]
NF-kappa-B inhibitor beta (NFKBIB)	OTY1ZJXH	IKBB_HUMAN	Increases Expression	[7]
NGFI-A-binding protein 2 (NAB2)	OTG4BDF3	NAB2_HUMAN	Decreases Expression	[7]
Neuronal pentraxin-1 (NPTX1)	OTKVHCV0	NPTX1_HUMAN	Decreases Expression	[7]
Coiled-coil domain-containing protein 6 (CCDC6)	OTXRQDYG	CCDC6_HUMAN	Decreases Expression	[7]
Drebrin (DBN1)	OTZVKG8A	DREB_HUMAN	Increases Expression	[7]
Solute carrier family 35 member G1 (SLC35G1)	OTKZUA8O	S35G1_HUMAN	Decreases Expression	[7]
Protein mono-ADP-ribosyltransferase PARP6 (PARP6)	OTWSXW4O	PARP6_HUMAN	Decreases Expression	[7]
Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1)	OTN7XAUD	LRRF1_HUMAN	Increases Expression	[7]
Polycomb group RING finger protein 3 (PCGF3)	OTY7TPPZ	PCGF3_HUMAN	Increases Expression	[7]
NAD kinase 2, mitochondrial (NADK2)	OT1I8GDE	NAKD2_HUMAN	Increases Expression	[7]
B-cell CLL/lymphoma 7 protein family member A (BCL7A)	OTYFUJTP	BCL7A_HUMAN	Decreases Expression	[7]
Glycerol-3-phosphate acyltransferase 3 (GPAT3)	OTJUGPK0	GPAT3_HUMAN	Increases Expression	[7]
Acylglycerol kinase, mitochondrial (AGK)	OTJGWBYT	AGK_HUMAN	Decreases Expression	[7]
Vesicle transport protein SFT2C (SFT2D3)	OT0IEAAR	SFT2C_HUMAN	Decreases Expression	[7]
Transmembrane protein 41B (TMEM41B)	OTW0B0KS	TM41B_HUMAN	Increases Expression	[7]
Torsin-1A-interacting protein 1 (TOR1AIP1)	OTTG8MAK	TOIP1_HUMAN	Decreases Expression	[7]
Tetratricopeptide repeat protein 39A (TTC39A)	OT80PQWX	TT39A_HUMAN	Increases Expression	[7]
Protein furry homolog (FRY)	OT74IAG2	FRY_HUMAN	Increases Expression	[7]
Probable E3 ubiquitin-protein ligase HECTD2 (HECTD2)	OTDIBGQV	HECD2_HUMAN	Increases Expression	[7]
G-protein coupled receptor 157 (GPR157)	OTE7K9D7	GP157_HUMAN	Decreases Expression	[7]
Obscurin (OBSCN)	OTT14OVX	OBSCN_HUMAN	Decreases Expression	[7]
G kinase-anchoring protein 1 (GKAP1)	OTHZRJ56	GKAP1_HUMAN	Increases Expression	[7]
Protein TASOR 2 (TASOR2)	OTN4VE8H	TASO2_HUMAN	Decreases Expression	[7]
Sushi domain-containing protein 4 (SUSD4)	OTWCJTT3	SUSD4_HUMAN	Decreases Expression	[7]
Proteasome adapter and scaffold protein ECM29 (ECPAS)	OT1C0KOI	ECM29_HUMAN	Increases Expression	[7]
DENN domain-containing protein 4C (DENND4C)	OT8SYN47	DEN4C_HUMAN	Increases Expression	[7]
Pecanex-like protein 4 (PCNX4)	OTV474RQ	PCX4_HUMAN	Increases Expression	[7]
Protein SPT2 homolog (SPTY2D1)	OT1RY99Z	SPT2_HUMAN	Increases Expression	[7]
CWF19-like protein 1 (CWF19L1)	OTAMYTOW	C19L1_HUMAN	Decreases Expression	[7]
U11/U12 small nuclear ribonucleoprotein 48 kDa protein (SNRNP48)	OTSR6DEJ	SNR48_HUMAN	Increases Expression	[7]
Tyrosine-protein kinase STYK1 (STYK1)	OT61CSU7	STYK1_HUMAN	Increases Expression	[7]
SPRY domain-containing SOCS box protein 3 (SPSB3)	OTHGEE2K	SPSB3_HUMAN	Increases Expression	[7]
E3 ubiquitin-protein ligase TRIM65 (TRIM65)	OTSQTK3A	TRI65_HUMAN	Decreases Expression	[7]
Leucine-rich repeat and fibronectin type-III domain-containing protein 4 (LRFN4)	OT7RWBKE	LRFN4_HUMAN	Decreases Expression	[7]
Type-1 angiotensin II receptor-associated protein (AGTRAP)	OT02N7LD	ATRAP_HUMAN	Decreases Expression	[7]
Transmembrane protein 92 (TMEM92)	OTTKJ2C0	TMM92_HUMAN	Decreases Expression	[7]
MICOS complex subunit MIC27 (APOOL)	OTC1WT8O	MIC27_HUMAN	Increases Expression	[7]
DnaJ homolog subfamily C member 14 (DNAJC14)	OT7DPIVN	DJC14_HUMAN	Decreases Expression	[7]
TBC1 domain family member 9 (TBC1D9)	OTSSCTB5	TBCD9_HUMAN	Increases Expression	[7]
Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1)	OTMQXW7S	RAPH1_HUMAN	Increases Expression	[7]
Serine/threonine-protein kinase MARK2 (MARK2)	OTJWGLUZ	MARK2_HUMAN	Decreases Expression	[7]
Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B)	OTE8GBUR	RIR2B_HUMAN	Increases Expression	[7]
Probable C-mannosyltransferase DPY19L4 (DPY19L4)	OTQ89TXA	D19L4_HUMAN	Increases Expression	[7]
Coiled-coil domain-containing protein 186 (CCDC186)	OTONSQAD	CC186_HUMAN	Increases Expression	[7]
C-myc promoter-binding protein (DENND4A)	OT8FFZ29	MYCPP_HUMAN	Increases Expression	[7]
Cytochrome P450 2U1 (CYP2U1)	OT6RXLXS	CP2U1_HUMAN	Increases Expression	[7]
HAUS augmin-like complex subunit 6 (HAUS6)	OT7ZVR57	HAUS6_HUMAN	Increases Expression	[7]
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (PIP4P1)	OT991XS0	PP4P1_HUMAN	Decreases Expression	[7]
Kinectin (KTN1)	OTQAV541	KTN1_HUMAN	Increases Expression	[7]
Phosphatidylcholine:ceramide cholinephosphotransferase 1 (SGMS1)	OTZQE7PW	SMS1_HUMAN	Increases Expression	[7]
Sodium-independent sulfate anion transporter (SLC26A11)	OTWBV9CR	S2611_HUMAN	Increases Expression	[7]
RNA-binding protein MEX3D (MEX3D)	OTAUWRK7	MEX3D_HUMAN	Decreases Expression	[7]
Dynein axonemal assembly factor 5 (DNAAF5)	OTN0CT52	DAAF5_HUMAN	Decreases Expression	[7]
Syntaxin-12 (STX12)	OT5IBQ62	STX12_HUMAN	Increases Expression	[7]
Mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3)	OTNJX38T	M4K3_HUMAN	Increases Expression	[7]
Protein FAM219A (FAM219A)	OTAFZHY9	F219A_HUMAN	Increases Expression	[7]
Mitofusin-1 (MFN1)	OTCBXQZF	MFN1_HUMAN	Decreases Expression	[7]
Pleckstrin homology domain-containing family M member 2 (PLEKHM2)	OT4ZYV73	PKHM2_HUMAN	Decreases Expression	[7]
Mitochondrial Rho GTPase 2 (RHOT2)	OTV8WT2L	MIRO2_HUMAN	Decreases Expression	[7]
Xaa-Arg dipeptidase (PM20D2)	OTD2Y7LU	P20D2_HUMAN	Increases Expression	[7]
Solute carrier family 38 member 6 (SLC38A6)	OTIC8SHQ	S38A6_HUMAN	Increases Expression	[7]
Abl interactor 1 (ABI1)	OT5H4M62	ABI1_HUMAN	Increases Expression	[7]
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (GCNT2)	OTRUIMC4	GNT2A_HUMAN	Increases Expression	[7]
Protein FAM43A (FAM43A)	OT5RPQRE	FA43A_HUMAN	Decreases Expression	[7]
CAP-Gly domain-containing linker protein 4 (CLIP4)	OT75KVQK	CLIP4_HUMAN	Increases Expression	[7]
Putative transporter SVOPL (SVOPL)	OTJ4G2ND	SVOPL_HUMAN	Decreases Expression	[7]
Polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4)	OT6WKC13	GALT4_HUMAN	Increases Expression	[7]
Coiled-coil domain-containing protein 82 (CCDC82)	OT16EAZ7	CCD82_HUMAN	Increases Expression	[7]
SH2 domain-containing protein 3C (SH2D3C)	OTAGXO0N	SH2D3_HUMAN	Decreases Expression	[7]
Methyltransferase-like protein 27 (METTL27)	OTOF0GTU	MET27_HUMAN	Decreases Expression	[7]
ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1)	OTM3KHIE	ARFG1_HUMAN	Decreases Expression	[7]
Protein KRI1 homolog (KRI1)	OT1IGOK7	KRI1_HUMAN	Increases Expression	[7]
ATPase family gene 2 protein homolog A (AFG2A)	OTPZKWN7	AFG2A_HUMAN	Increases Expression	[7]
Equilibrative nucleobase transporter 1 (SLC43A3)	OTR60ZLA	S43A3_HUMAN	Decreases Expression	[7]
Retinol dehydrogenase 13 (RDH13)	OT48VJ65	RDH13_HUMAN	Increases Expression	[7]
Neuropilin and tolloid-like protein 2 (NETO2)	OT0YAMC0	NETO2_HUMAN	Decreases Expression	[7]
Polyhomeotic-like protein 3 (PHC3)	OTTTLIAP	PHC3_HUMAN	Increases Expression	[7]
Glutathione S-transferase C-terminal domain-containing protein (GSTCD)	OTIIINMT	GSTCD_HUMAN	Decreases Expression	[7]
Folliculin (FLCN)	OTVM78XM	FLCN_HUMAN	Increases Expression	[7]
Tubulin--tyrosine ligase (TTL)	OTSS1CK4	TTL_HUMAN	Decreases Expression	[7]
Protein NEDD1 (NEDD1)	OTBD6X77	NEDD1_HUMAN	Increases Expression	[7]
Protein FAM76A (FAM76A)	OT28WHO4	FA76A_HUMAN	Increases Expression	[7]
Proline-rich protein 7 (PRR7)	OT56XAQK	PRR7_HUMAN	Decreases Expression	[7]
Transmembrane protein 254 (TMEM254)	OTGDPU8S	TM254_HUMAN	Decreases Expression	[7]
Retinol dehydrogenase 11 (RDH11)	OTIND43N	RDH11_HUMAN	Increases Expression	[7]
POC1 centriolar protein homolog B (POC1B)	OTDIMIRZ	POC1B_HUMAN	Increases Expression	[7]
Interferon-induced protein 44 (IFI44)	OTOKSZVA	IFI44_HUMAN	Increases Expression	[7]
Large ribosomal subunit protein uL30m (MRPL30)	OT26OPYV	RM30_HUMAN	Decreases Expression	[7]
RB1-inducible coiled-coil protein 1 (RB1CC1)	OTZK8PFX	RBCC1_HUMAN	Increases Expression	[7]
Elongator complex protein 5 (ELP5)	OTW5R7YD	ELP5_HUMAN	Decreases Expression	[7]
DDB1- and CUL4-associated factor 11 (DCAF11)	OTNSGYK1	DCA11_HUMAN	Decreases Expression	[7]
Arginine/serine-rich protein PNISR (PNISR)	OTUM02FW	PNISR_HUMAN	Increases Expression	[7]
General transcription factor 3C polypeptide 2 (GTF3C2)	OTWDANLJ	TF3C2_HUMAN	Decreases Expression	[7]
Transmembrane protein 263 (TMEM263)	OTO1RSTS	TM263_HUMAN	Increases Expression	[7]
Protein THEM6 (THEM6)	OT51SVLH	THEM6_HUMAN	Decreases Expression	[7]
Pleckstrin homology-like domain family A member 1 (PHLDA1)	OTFTWMIQ	PHLA1_HUMAN	Increases Expression	[7]
Hexosaminidase D (HEXD)	OTTMQKLM	HEXD_HUMAN	Decreases Expression	[7]
E3 ubiquitin-protein ligase RNF138 (RNF138)	OTPU0CO4	RN138_HUMAN	Increases Expression	[7]
Heterogeneous nuclear ribonucleoprotein L-like (HNRNPLL)	OTA6Q5E0	HNRLL_HUMAN	Increases Expression	[7]
Uncharacterized protein C4orf3 (C4ORF3)	OT6TFN1O	CD003_HUMAN	Decreases Expression	[7]
tRNA-splicing endonuclease subunit Sen15 (TSEN15)	OT14UW31	SEN15_HUMAN	Decreases Expression	[7]
Palladin (PALLD)	OTZ2MUJZ	PALLD_HUMAN	Increases Expression	[7]
Protein N-lysine methyltransferase METTL21A (METTL21A)	OTXJTNXY	MT21A_HUMAN	Increases Expression	[7]
Histone acetyltransferase KAT6B (KAT6B)	OTMUDTAH	KAT6B_HUMAN	Decreases Expression	[7]
E3 ubiquitin-protein ligase rififylin (RFFL)	OT85MGDH	RFFL_HUMAN	Increases Expression	[7]
Aquaporin-3 (AQP3)	OT2J7JPD	AQP3_HUMAN	Increases Expression	[7]
Proteasome inhibitor PI31 subunit (PSMF1)	OTX84WLQ	PSMF1_HUMAN	Decreases Expression	[7]
Protein FAM168A (FAM168A)	OTDXQCS5	F168A_HUMAN	Increases Expression	[7]
Protein NDRG1 (NDRG1)	OTVO66BO	NDRG1_HUMAN	Increases Expression	[7]
TRAF family member-associated NF-kappa-B activator (TANK)	OTZSGFIK	TANK_HUMAN	Increases Expression	[7]
Ras-related protein Rab-8B (RAB8B)	OTBPUHV9	RAB8B_HUMAN	Decreases Expression	[7]
GTP-binding protein Rit1 (RIT1)	OTVNOGOH	RIT1_HUMAN	Increases Expression	[7]
Phosphorylase b kinase regulatory subunit beta (PHKB)	OTKXZZIU	KPBB_HUMAN	Increases Expression	[7]
BLOC-2 complex member HPS3 (HPS3)	OTAKROK7	HPS3_HUMAN	Decreases Expression	[7]
F-box/WD repeat-containing protein 7 (FBXW7)	OTJXE4OT	FBXW7_HUMAN	Decreases Expression	[7]
Polyamine deacetylase HDAC10 (HDAC10)	OTHCKKUQ	HDA10_HUMAN	Decreases Expression	[7]
NXPE family member 3 (NXPE3)	OTLVZ8W2	NXPE3_HUMAN	Increases Expression	[7]
Transmembrane protein 230 (TMEM230)	OTAFALFV	TM230_HUMAN	Decreases Expression	[7]
SOSS complex subunit B2 (NABP1)	OTFTNFHW	SOSB2_HUMAN	Increases Expression	[7]
Ankyrin repeat domain-containing protein 9 (ANKRD9)	OT7VGO6G	ANKR9_HUMAN	Increases Expression	[7]
ADP-ribosylation factor-like protein 8A (ARL8A)	OTEYM6FA	ARL8A_HUMAN	Increases Expression	[7]
m7GpppX diphosphatase (DCPS)	OT1FZVC9	DCPS_HUMAN	Decreases Expression	[7]
Protein FAM241B (FAM241B)	OTLISLRC	F241B_HUMAN	Increases Expression	[7]
R3H domain-containing protein 4 (R3HDM4)	OTE0Q78Q	R3HD4_HUMAN	Decreases Expression	[7]
E3 ubiquitin-protein ligase CHFR (CHFR)	OTRAD2TT	CHFR_HUMAN	Decreases Expression	[7]
ATP-dependent DNA helicase DDX11 (DDX11)	OT1WR3MD	DDX11_HUMAN	Decreases Expression	[7]
Kelch domain-containing protein 7B (KLHDC7B)	OT2H5BNX	KLD7B_HUMAN	Increases Expression	[7]
H/ACA ribonucleoprotein complex non-core subunit NAF1 (NAF1)	OTMJKJAK	NAF1_HUMAN	Increases Expression	[7]
Histone-lysine N-methyltransferase EHMT2 (EHMT2)	OTC4DWB6	EHMT2_HUMAN	Decreases Expression	[7]
Uncharacterized protein C9orf85 (C9ORF85)	OTJWBPL3	CI085_HUMAN	Increases Expression	[7]
Pannexin-2 (PANX2)	OTAQ2S8R	PANX2_HUMAN	Increases Expression	[7]
Ribosomal protein S6 kinase delta-1 (RPS6KC1)	OT2LRTG4	KS6C1_HUMAN	Increases Expression	[7]
Structural maintenance of chromosomes protein 6 (SMC6)	OT3IBHQD	SMC6_HUMAN	Increases Expression	[7]
Protein orai-2 (ORAI2)	OTYISRYH	ORAI2_HUMAN	Decreases Expression	[7]
E3 ubiquitin-protein ligase RING2 (RNF2)	OTFPLOIN	RING2_HUMAN	Increases Expression	[7]
Krueppel-like factor 6 (KLF6)	OTQY9S7F	KLF6_HUMAN	Increases Expression	[7]
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (SDHC)	OTC8G2MX	C560_HUMAN	Decreases Expression	[7]
Sigma non-opioid intracellular receptor 1 (SIGMAR1)	OTDORW5C	SGMR1_HUMAN	Decreases Expression	[7]
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1A)	OTVTB5R5	PI51A_HUMAN	Decreases Expression	[7]
Apolipoprotein L4 (APOL4)	OTTOH86V	APOL4_HUMAN	Decreases Expression	[7]
Protein NipSnap homolog 1 (NIPSNAP1)	OTKXKUT8	NIPS1_HUMAN	Decreases Expression	[7]
Protein FAM118B (FAM118B)	OTRLY4B0	F118B_HUMAN	Increases Expression	[7]
Target of rapamycin complex 2 subunit MAPKAP1 (MAPKAP1)	OTYKB9G3	SIN1_HUMAN	Decreases Expression	[7]
TM2 domain-containing protein 3 (TM2D3)	OT6MS96W	TM2D3_HUMAN	Increases Expression	[7]
Ferroptosis suppressor protein 1 (AIFM2)	OT57XWXO	FSP1_HUMAN	Increases Expression	[7]
Tubulin-specific chaperone D (TBCD)	OTS4JKNQ	TBCD_HUMAN	Decreases Expression	[7]
Iron-sulfur cluster assembly 1 homolog, mitochondrial (ISCA1)	OTU230MC	ISCA1_HUMAN	Increases Expression	[7]
Bublin coiled-coil protein (BBLN)	OTUMVEWE	BBLN_HUMAN	Decreases Expression	[7]
Coiled-coil domain-containing protein 32 (CCDC32)	OTPPUFIF	CCD32_HUMAN	Increases Expression	[7]
Kinesin-like protein KIFC1 (KIFC1)	OTNQDS00	KIFC1_HUMAN	Decreases Expression	[7]
Katanin p60 ATPase-containing subunit A-like 1 (KATNAL1)	OTBUZ7KA	KATL1_HUMAN	Increases Expression	[7]
Protein C1orf43 (C1ORF43)	OTT9CVZR	CA043_HUMAN	Decreases Expression	[7]
TM2 domain-containing protein 2 (TM2D2)	OTB51WEY	TM2D2_HUMAN	Increases Expression	[7]
Sphingosine-1-phosphate phosphatase 1 (SGPP1)	OT9X54CQ	SGPP1_HUMAN	Increases Expression	[7]
FSD1-like protein (FSD1L)	OTBQ48RF	FSD1L_HUMAN	Increases Expression	[7]
C-type lectin domain family 7 member A (CLEC7A)	OTRTBH27	CLC7A_HUMAN	Increases Expression	[7]
Serrate RNA effector molecule homolog (SRRT)	OTMYPSWV	SRRT_HUMAN	Decreases Expression	[7]
Protein kinase C and casein kinase substrate in neurons protein 1 (PACSIN1)	OT07Z2RQ	PACN1_HUMAN	Increases Expression	[7]
Sterile alpha motif domain-containing protein 10 (SAMD10)	OTBKWB5C	SAM10_HUMAN	Decreases Expression	[7]
ATP-binding cassette sub-family A member 2 (ABCA2)	OTVSYK0X	ABCA2_HUMAN	Decreases Expression	[7]
INO80 complex subunit B (INO80B)	OTSHV8JF	IN80B_HUMAN	Decreases Expression	[7]
Uncharacterized protein C6orf62 (C6ORF62)	OTGK4G35	CF062_HUMAN	Increases Expression	[7]
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1)	OT4U7SBG	GBRL1_HUMAN	Increases Expression	[7]
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1)	OTL4VJC5	NUCKS_HUMAN	Decreases Expression	[7]
Oxysterol-binding protein-related protein 2 (OSBPL2)	OTCK671N	OSBL2_HUMAN	Increases Expression	[7]
Dual specificity protein phosphatase 15 (DUSP15)	OTS6PQYL	DUS15_HUMAN	Decreases Expression	[7]
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (KCTD10)	OT5HFZXU	BACD3_HUMAN	Increases Expression	[7]
UPF0696 protein C11orf68 (C11ORF68)	OTOKOGZ6	CK068_HUMAN	Decreases Expression	[7]
Differentially expressed in FDCP 6 homolog (DEF6)	OTIRBYVK	DEFI6_HUMAN	Decreases Expression	[7]
Sentrin-specific protease 3 (SENP3)	OTFQDOMC	SENP3_HUMAN	Decreases Expression	[7]
ESF1 homolog (ESF1)	OTHEDM0A	ESF1_HUMAN	Increases Expression	[7]
RNA polymerase II-associated protein 3 (RPAP3)	OTCW17LF	RPAP3_HUMAN	Increases Expression	[7]
Sin3 histone deacetylase corepressor complex component SDS3 (SUDS3)	OTZ1AARI	SDS3_HUMAN	Increases Expression	[7]
Caspase activity and apoptosis inhibitor 1 (CAAP1)	OTD2DN1Z	CAAP1_HUMAN	Increases Expression	[7]
Kinesin-like protein KIF9 (KIF9)	OT7W6VI1	KIF9_HUMAN	Decreases Expression	[7]
E3 ubiquitin-protein ligase SMURF2 (SMURF2)	OT3TRVL7	SMUF2_HUMAN	Increases Expression	[7]
Transcription factor IIIB 50 kDa subunit (BRF2)	OT2C6TH2	BRF2_HUMAN	Increases Expression	[7]
Retinoid-inducible serine carboxypeptidase (SCPEP1)	OT43LYEZ	RISC_HUMAN	Increases Expression	[7]
POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1)	OT0X9WGR	PATZ1_HUMAN	Decreases Expression	[7]
DNA dC->dU-editing enzyme APOBEC-3G (APOBEC3G)	OT410VP5	ABC3G_HUMAN	Increases Expression	[7]
DnaJ homolog subfamily C member 4 (DNAJC4)	OT4BUBQU	DNJC4_HUMAN	Decreases Expression	[7]
DNA-directed DNA/RNA polymerase mu (POLM)	OT0SRIP4	DPOLM_HUMAN	Decreases Expression	[7]
Carbohydrate sulfotransferase 11 (CHST11)	OTNJJ5Q1	CHSTB_HUMAN	Decreases Expression	[7]
Uncharacterized protein C14orf132 (C14ORF132)	OTBVC3AO	CN132_HUMAN	Decreases Expression	[7]
Putative RNA-binding protein Luc7-like 1 (LUC7L)	OT77JDB7	LUC7L_HUMAN	Increases Expression	[7]
Prefoldin subunit 4 (PFDN4)	OT5NRHER	PFD4_HUMAN	Increases Expression	[7]
Solute carrier family 35 member C2 (SLC35C2)	OT9H15XZ	S35C2_HUMAN	Decreases Expression	[7]
Gephyrin (GPHN)	OTAKK1SV	GEPH_HUMAN	Decreases Expression	[7]
Endophilin-B2 (SH3GLB2)	OTF7BB9S	SHLB2_HUMAN	Decreases Expression	[7]
Muscleblind-like protein 1 (MBNL1)	OTOV7J85	MBNL1_HUMAN	Decreases Expression	[7]
CDC42 small effector protein 2 (CDC42SE2)	OT8SG9I1	C42S2_HUMAN	Decreases Expression	[7]
RNA-binding protein PNO1 (PNO1)	OT010GIS	PNO1_HUMAN	Increases Expression	[7]
DDB1- and CUL4-associated factor 13 (DCAF13)	OTQQ0QXT	DCA13_HUMAN	Increases Expression	[7]
FGFR1 oncogene partner 2 (FGFR1OP2)	OTAHO1ZC	FGOP2_HUMAN	Increases Expression	[7]
DNA-directed RNA polymerase III subunit RPC5 (POLR3E)	OT69PWBM	RPC5_HUMAN	Increases Expression	[7]
Anoctamin-10 (ANO10)	OTG3BNOU	ANO10_HUMAN	Increases Expression	[7]
BSD domain-containing protein 1 (BSDC1)	OT853CP9	BSDC1_HUMAN	Increases Expression	[7]
G patch domain-containing protein 2-like (GPATCH2L)	OTETUZ64	GPT2L_HUMAN	Increases Expression	[7]
Ceroid-lipofuscinosis neuronal protein 6 (CLN6)	OT91IAYT	CLN6_HUMAN	Decreases Expression	[7]
AFG2-interacting ribosome maturation factor (AIRIM)	OTGG814L	AIRIM_HUMAN	Increases Expression	[7]
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2)	OTE69HV8	B3GN2_HUMAN	Decreases Expression	[7]
Opioid growth factor receptor (OGFR)	OTROS6RJ	OGFR_HUMAN	Decreases Expression	[7]
E3 ubiquitin-protein ligase KCMF1 (KCMF1)	OTVTKFAU	KCMF1_HUMAN	Increases Expression	[7]
Stromal interaction molecule 2 (STIM2)	OTYNXAW0	STIM2_HUMAN	Decreases Expression	[7]
Inhibitor of Bruton tyrosine kinase (IBTK)	OTB2GM4G	IBTK_HUMAN	Increases Expression	[7]
Phosphatidylinositol 4-kinase beta (PI4KB)	OTI9UQSU	PI4KB_HUMAN	Decreases Expression	[7]
E3 ubiquitin-protein ligase RNF14 (RNF14)	OTWX0D0H	RNF14_HUMAN	Increases Expression	[7]
Fibulin-5 (FBLN5)	OTLVNZ8U	FBLN5_HUMAN	Decreases Expression	[7]
Beta-1,4-galactosyltransferase 6 (B4GALT6)	OTBM8F2U	B4GT6_HUMAN	Increases Expression	[7]
LIM domain-containing protein 1 (LIMD1)	OTN1CG6R	LIMD1_HUMAN	Increases Expression	[7]
Protein NDRG3 (NDRG3)	OTJTJCHD	NDRG3_HUMAN	Decreases Expression	[7]
LIM domain and actin-binding protein 1 (LIMA1)	OTONPC9R	LIMA1_HUMAN	Increases Expression	[7]
AF4/FMR2 family member 4 (AFF4)	OTTL5Y8R	AFF4_HUMAN	Increases Expression	[7]
NADH-cytochrome b5 reductase 1 (CYB5R1)	OTMDHMLA	NB5R1_HUMAN	Increases Expression	[7]
Methyl-CpG-binding domain protein 1 (MBD1)	OTD19VO6	MBD1_HUMAN	Decreases Expression	[7]
Oxidative stress-induced growth inhibitor 1 (OSGIN1)	OT9KIVZW	OSGI1_HUMAN	Increases Expression	[7]
Cell division cycle protein 23 homolog (CDC23)	OTC4O83E	CDC23_HUMAN	Increases Expression	[7]
Anaphase-promoting complex subunit 5 (ANAPC5)	OTGTJNNR	APC5_HUMAN	Decreases Expression	[7]
Calcipressin-3 (RCAN3)	OTTS3CQA	RCAN3_HUMAN	Decreases Expression	[7]
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (ASAP1)	OT4DLRYY	ASAP1_HUMAN	Decreases Expression	[7]
Tetratricopeptide repeat protein 7A (TTC7A)	OTDHLPQM	TTC7A_HUMAN	Decreases Expression	[7]
Nucleosome assembly protein 1-like 2 (NAP1L2)	OT8QI4GF	NP1L2_HUMAN	Increases Expression	[7]
Protein PHTF1 (PHTF1)	OTYCZ84A	PHTF1_HUMAN	Increases Expression	[7]
26S proteasome non-ATPase regulatory subunit 13 (PSMD13)	OTNQ351N	PSD13_HUMAN	Increases Expression	[7]
Cytosolic carboxypeptidase 1 (AGTPBP1)	OTR92JFR	CBPC1_HUMAN	Increases Expression	[7]
Serine/threonine-protein kinase ICK (CILK1)	OTWOYEYP	CILK1_HUMAN	Increases Expression	[7]
Structural maintenance of chromosomes protein 3 (SMC3)	OTWGFRHD	SMC3_HUMAN	Increases Expression	[7]
Myotubularin-related protein 6 (MTMR6)	OTQPAWI3	MTMR6_HUMAN	Increases Expression	[7]
Phospholipase A-2-activating protein (PLAA)	OTZ7NJGA	PLAP_HUMAN	Increases Expression	[7]
Phenylalanine--tRNA ligase alpha subunit (FARSA)	OT3U1P20	SYFA_HUMAN	Decreases Expression	[7]
Nck-associated protein 1 (NCKAP1)	OTEZQXXJ	NCKP1_HUMAN	Increases Expression	[7]
Kelch-like protein 20 (KLHL20)	OTC0SFS9	KLH20_HUMAN	Increases Expression	[7]
ARF GTPase-activating protein GIT1 (GIT1)	OTHO92S5	GIT1_HUMAN	Decreases Expression	[7]
RING finger protein 11 (RNF11)	OTFBJSKQ	RNF11_HUMAN	Increases Expression	[7]
Transformation/transcription domain-associated protein (TRRAP)	OT68OI2Y	TRRAP_HUMAN	Decreases Expression	[7]
Carbohydrate sulfotransferase 2 (CHST2)	OTV11IZF	CHST2_HUMAN	Decreases Expression	[7]
G-protein-signaling modulator 3 (GPSM3)	OT2MO458	GPSM3_HUMAN	Decreases Expression	[7]
U6 snRNA-associated Sm-like protein LSm4 (LSM4)	OTLKJB3A	LSM4_HUMAN	Decreases Expression	[7]
DNA-directed RNA polymerase III subunit RPC8 (POLR3H)	OT7GM7MX	RPC8_HUMAN	Decreases Expression	[7]
NEDD8 ultimate buster 1 (NUB1)	OTWA6RTX	NUB1_HUMAN	Increases Expression	[7]
Selenoprotein K (SELENOK)	OTKM7N7P	SELK_HUMAN	Increases Expression	[7]
Nuclear receptor coactivator 3 (NCOA3)	OTBX300Z	NCOA3_HUMAN	Increases Expression	[7]
Numb-like protein (NUMBL)	OTWMTMMH	NUMBL_HUMAN	Increases Expression	[7]
ATPase MORC2 (MORC2)	OT52A8BJ	MORC2_HUMAN	Increases Expression	[7]
Aldo-keto reductase family 1 member B10 (AKR1B10)	OTOA4HTH	AK1BA_HUMAN	Increases Expression	[21]
Aldo-keto reductase family 1 member B1 (AKR1B1)	OTRX72TH	ALDR_HUMAN	Increases Expression	[21]
Prostaglandin G/H synthase 2 (PTGS2)	OT75U9M4	PGH2_HUMAN	Increases Expression	[21]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Increases Expression	[21]
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Affects Expression	[21]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Increases Expression	[21]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Increases Expression	[21]
Toll-like receptor 4 (TLR4)	OTP7ML3S	TLR4_HUMAN	Increases Expression	[22]
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)	OTBPCU2O	TR10A_HUMAN	Decreases Expression	[23]
NF-kappa-B inhibitor epsilon (NFKBIE)	OTLAYEL9	IKBE_HUMAN	Increases Stability	[24]
Myc box-dependent-interacting protein 1 (BIN1)	OTK8O0X8	BIN1_HUMAN	Increases Expression	[12]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)	OTA1CPBV	TR10B_HUMAN	Increases Expression	[25]
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB)	OT9RDS3H	IKKB_HUMAN	Decreases Expression	[10]
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK)	OTLF4ZB1	IKKA_HUMAN	Increases Expression	[10]
Apoptosis regulatory protein Siva (SIVA1)	OTDT0XZK	SIVA_HUMAN	Decreases Expression	[12]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[26]
High affinity copper uptake protein 1 (SLC31A1)	OTXLRTUB	COPT1_HUMAN	Decreases Degradation	[27]
CASP8 and FADD-like apoptosis regulator (CFLAR)	OTX14BAS	CFLAR_HUMAN	Decreases Expression	[12]
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1)	OTDTF5BU	SUV91_HUMAN	Decreases Expression	[12]
Serine protease HTRA2, mitochondrial (HTRA2)	OTC7616F	HTRA2_HUMAN	Affects Localization	[28]
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Increases Activity	[29]
Nuclear protein 1 (NUPR1)	OT4FU8C0	NUPR1_HUMAN	Increases Expression	[30]
Toll-like receptor 2 (TLR2)	OTGO5P4R	TLR2_HUMAN	Increases Expression	[10]
DENN domain-containing protein 4B (DENND4B)	OTFEO8KG	DEN4B_HUMAN	Increases Expression	[31]
Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)	OTL9I7LO	GA45B_HUMAN	Increases Expression	[31]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)	OTYG179K	PR15A_HUMAN	Increases Expression	[31]
Natural cytotoxicity triggering receptor 1 (NCR1)	OT6MZKQY	NCTR1_HUMAN	Decreases Expression	[32]
Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G)	OT8V1J4M	GA45G_HUMAN	Increases Expression	[26]
BAG family molecular chaperone regulator 3 (BAG3)	OTVXYUDQ	BAG3_HUMAN	Increases Expression	[31]
Apoptosis-inducing factor 1, mitochondrial (AIFM1)	OTKPWB7Q	AIFM1_HUMAN	Affects Localization	[28]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Decreases Expression	[33]
Insulin-like growth factor II (IGF2)	OTJ4O6MW	IGF2_HUMAN	Decreases Response To Substance	[34]
Prelamin-A/C (LMNA)	OT3SG7ZR	LMNA_HUMAN	Increases Cleavage	[35]
RAF proto-oncogene serine/threonine-protein kinase (RAF1)	OT51LSFO	RAF1_HUMAN	Decreases Expression	[36]
Receptor tyrosine-protein kinase erbB-2 (ERBB2)	OTOAUNCK	ERBB2_HUMAN	Decreases Phosphorylation	[37]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Activity	[38]
Galectin-2 (LGALS2)	OTY08TMQ	LEG2_HUMAN	Decreases Expression	[12]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)	OTM0GDTP	IF2A_HUMAN	Increases Phosphorylation	[39]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Decreases Expression	[40]
Intercellular adhesion molecule 1 (ICAM1)	OTTOIX77	ICAM1_HUMAN	Decreases Expression	[10]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Decreases Expression	[10]
Cyclin-dependent kinase 1 (CDK1)	OTW1SC2N	CDK1_HUMAN	Decreases Activity	[8]
Integrin alpha-V (ITGAV)	OTAM7JTR	ITAV_HUMAN	Increases Expression	[10]
Cathepsin B (CTSB)	OTP9G5QB	CATB_HUMAN	Increases Localization	[29]
Heat shock protein HSP 90-alpha (HSP90AA1)	OTLG1WPK	HS90A_HUMAN	Decreases Expression	[10]
Heat shock protein HSP 90-beta (HSP90AB1)	OTR69EG7	HS90B_HUMAN	Increases Expression	[22]
Growth-regulated alpha protein (CXCL1)	OT3WCTZV	GROA_HUMAN	Increases Expression	[31]
Heme oxygenase 1 (HMOX1)	OTC1W6UX	HMOX1_HUMAN	Increases Expression	[31]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[41]
Heat shock 70 kDa protein 1A (HSPA1A)	OTKGIE76	HS71A_HUMAN	Increases Expression	[22]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Expression	[31]
C-C motif chemokine 3 (CCL3)	OTW2H3ND	CCL3_HUMAN	Decreases Expression	[42]
Cytochrome c oxidase subunit 8A, mitochondrial (COX8A)	OTU0NR39	COX8A_HUMAN	Decreases Expression	[38]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Expression	[43]
Osteopontin (SPP1)	OTJGC23Y	OSTP_HUMAN	Decreases Expression	[10]
Growth hormone receptor (GHR)	OT8WUWMU	GHR_HUMAN	Increases Expression	[22]
Parathyroid hormone-related protein (PTHLH)	OTI1JF13	PTHR_HUMAN	Decreases Expression	[42]
Interferon-induced transmembrane protein 1 (IFITM1)	OTECO1G8	IFM1_HUMAN	Decreases Expression	[12]
Protein Cripto (CRIPTO)	OT46DZXJ	TDGF1_HUMAN	Increases Expression	[22]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Decreases Expression	[10]
Tissue factor (F3)	OT3MSU3B	TF_HUMAN	Increases Expression	[44]
G2/mitotic-specific cyclin-B1 (CCNB1)	OT19S7E5	CCNB1_HUMAN	Increases Expression	[45]
Interleukin-1 receptor type 1 (IL1R1)	OTTU8959	IL1R1_HUMAN	Increases Expression	[22]
Transcription factor 4 (TCF4)	OTB9ASTK	ITF2_HUMAN	Increases Expression	[22]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Decreases Phosphorylation	[46]
Interleukin-7 receptor subunit alpha (IL7R)	OTBMFLQQ	IL7RA_HUMAN	Increases Expression	[10]
Heat shock 70 kDa protein 6 (HSPA6)	OTH4S7WB	HSP76_HUMAN	Increases Expression	[31]
Transcription factor JunB (JUNB)	OTG2JXV5	JUNB_HUMAN	Decreases Expression	[47]
CCAAT/enhancer-binding protein beta (CEBPB)	OTM9MQIA	CEBPB_HUMAN	Decreases Expression	[10]
Early growth response protein 1 (EGR1)	OTCP6XGZ	EGR1_HUMAN	Increases Expression	[10]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3)	OTC1UOHP	ATF3_HUMAN	Increases Expression	[26]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4)	OTRFV19J	ATF4_HUMAN	Increases Expression	[31]
Nuclear factor NF-kappa-B p105 subunit (NFKB1)	OTNRRD8I	NFKB1_HUMAN	Decreases Expression	[48]
Interleukin-10 (IL10)	OTIRFRXC	IL10_HUMAN	Affects Expression	[23]
Cyclin-dependent kinase 2 (CDK2)	OTB5DYYZ	CDK2_HUMAN	Decreases Activity	[8]
Tumor necrosis factor receptor superfamily member 6 (FAS)	OTP9XG86	TNR6_HUMAN	Decreases Expression	[10]
DnaJ homolog subfamily B member 1 (DNAJB1)	OTCOSEVH	DNJB1_HUMAN	Increases Expression	[31]
NF-kappa-B inhibitor alpha (NFKBIA)	OTFT924M	IKBA_HUMAN	Increases Expression	[22]
Pentraxin-related protein PTX3 (PTX3)	OTPXHRKU	PTX3_HUMAN	Decreases Expression	[10]
CD27 antigen (CD27)	OTH7NA58	CD27_HUMAN	Increases Expression	[22]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Decreases Activity	[36]
Calreticulin (CALR)	OTYD2TR1	CALR_HUMAN	Increases Expression	[20]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Decreases Activity	[36]
Tyrosine-protein phosphatase non-receptor type 6 (PTPN6)	OT33XNZM	PTN6_HUMAN	Decreases Expression	[12]
SHC-transforming protein 1 (SHC1)	OT1J5IRN	SHC1_HUMAN	Decreases Expression	[10]
Nitric oxide synthase 1 (NOS1)	OT7M8XVG	NOS1_HUMAN	Increases Expression	[20]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Decreases Activity	[36]
DNA replication licensing factor MCM7 (MCM7)	OT6FXC6K	MCM7_HUMAN	Decreases Expression	[12]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Increases Expression	[49]
Replication protein A 14 kDa subunit (RPA3)	OT8JAQGL	RFA3_HUMAN	Decreases Expression	[12]
Pro-adrenomedullin (ADM)	OT7T0TA4	ADML_HUMAN	Decreases Expression	[10]
Insulin receptor substrate 1 (IRS1)	OTNO82CU	IRS1_HUMAN	Decreases Degradation	[50]
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Increases Expression	[12]
Alpha-synuclein (SNCA)	OTPWC1MR	SYUA_HUMAN	Increases Expression	[22]
Breast cancer type 1 susceptibility protein (BRCA1)	OT5BN6VH	BRCA1_HUMAN	Decreases Expression	[51]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[26]
Small ribosomal subunit protein eS19 (RPS19)	OTBKGP48	RS19_HUMAN	Increases Expression	[31]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Activity	[39]
Caspase-2 (CASP2)	OTUDYSPP	CASP2_HUMAN	Increases Cleavage	[31]
Mitogen-activated protein kinase 8 (MAPK8)	OTEREYS5	MK08_HUMAN	Increases Phosphorylation	[52]
Mitogen-activated protein kinase 9 (MAPK9)	OTCEVJ9E	MK09_HUMAN	Increases Phosphorylation	[52]
Proliferation marker protein Ki-67 (MKI67)	OTA8N1QI	KI67_HUMAN	Decreases Expression	[53]
Cyclin-dependent kinase inhibitor 1B (CDKN1B)	OTNY5LLZ	CDN1B_HUMAN	Increases Expression	[8]
Tumor necrosis factor ligand superfamily member 6 (FASLG)	OTZARCHH	TNFL6_HUMAN	Increases Expression	[54]
Caspase-4 (CASP4)	OTVQTV1L	CASP4_HUMAN	Increases Activity	[39]
Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A)	OT5QQB5L	IDH3A_HUMAN	Decreases Expression	[38]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10)	OT4PXBTA	TNF10_HUMAN	Decreases Expression	[55]
Small ribosomal subunit protein mS29 (DAP3)	OTNPEZYM	RT29_HUMAN	Increases Expression	[12]
Breast cancer type 2 susceptibility protein (BRCA2)	OTF1XSV1	BRCA2_HUMAN	Decreases Expression	[51]
Interleukin-1 receptor-associated kinase 1 (IRAK1)	OT133G8J	IRAK1_HUMAN	Decreases Expression	[10]
DNA mismatch repair protein Msh6 (MSH6)	OT46FP09	MSH6_HUMAN	Decreases Expression	[12]
Caspase-7 (CASP7)	OTAPJ040	CASP7_HUMAN	Increases Activity	[56]
Caspase-6 (CASP6)	OTXLD3EC	CASP6_HUMAN	Increases Cleavage	[41]
Hepatocyte nuclear factor 3-alpha (FOXA1)	OTEBY0TD	FOXA1_HUMAN	Decreases Expression	[10]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Increases Cleavage	[26]
Histone deacetylase 4 (HDAC4)	OTQNGD32	HDAC4_HUMAN	Decreases Expression	[12]
NACHT, LRR and PYD domains-containing protein 12 (NLRP12)	OTGR132Z	NAL12_HUMAN	Increases Expression	[10]
Beta-2-microglobulin (B2M)	OTDWN6NX	B2MG_HUMAN	Decreases Expression	[57]
C-C motif chemokine 8 (CCL8)	OTCTWYN8	CCL8_HUMAN	Affects Expression	[23]
Cytochrome c (CYCS)	OTBFALJD	CYC_HUMAN	Affects Localization	[28]
Heat shock factor protein 1 (HSF1)	OTYNJ4KP	HSF1_HUMAN	Increases Expression	[22]
Nuclear factor NF-kappa-B p100 subunit (NFKB2)	OTS231V7	NFKB2_HUMAN	Decreases Expression	[48]
E3 ubiquitin-protein ligase Mdm2 (MDM2)	OTOVXARF	MDM2_HUMAN	Increases Cleavage	[58]
Dystonin (DST)	OTHZBM4X	DYST_HUMAN	Increases Expression	[12]
Heat shock factor protein 2 (HSF2)	OTXNJIJ9	HSF2_HUMAN	Increases Expression	[59]
DNA repair protein RAD51 homolog 1 (RAD51)	OTNVWGC1	RAD51_HUMAN	Decreases Expression	[51]
Fragile X messenger ribonucleoprotein 1 (FMR1)	OTWEV0T5	FMR1_HUMAN	Decreases Expression	[12]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Increases Expression	[60]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Decreases Expression	[29]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Increases Cleavage	[41]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)	OT4SO7J4	BNIP3_HUMAN	Increases Expression	[35]
Baculoviral IAP repeat-containing protein 1 (NAIP)	OTLA925F	BIRC1_HUMAN	Affects Expression	[48]
Chromatin assembly factor 1 subunit A (CHAF1A)	OTXSSY4H	CAF1A_HUMAN	Decreases Expression	[12]
S-phase kinase-associated protein 2 (SKP2)	OTD5B41X	SKP2_HUMAN	Decreases Expression	[61]
Serine-protein kinase ATM (ATM)	OTQVOHLT	ATM_HUMAN	Increases Cleavage	[58]
Bcl-2-interacting killer (BIK)	OTTH1T3D	BIK_HUMAN	Increases Activity	[29]
Interleukin-18 receptor 1 (IL18R1)	OT83XMPQ	IL18R_HUMAN	Increases Expression	[22]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Increases Expression	[62]
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Decreases Expression	[24]
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)	OTC41R1E	RIPK1_HUMAN	Decreases Expression	[10]
Cullin-1 (CUL1)	OTXPE1UZ	CUL1_HUMAN	Increases Expression	[22]
Cullin-3 (CUL3)	OTDNOAPM	CUL3_HUMAN	Decreases Expression	[12]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)	OTXEE550	APR_HUMAN	Decreases Expression	[48]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Increases Cleavage	[58]
Transcription elongation factor A protein-like 1 (TCEAL1)	OTAPG2L5	TCAL1_HUMAN	Increases Expression	[22]
Interferon regulatory factor 4 (IRF4)	OT1DHQ1P	IRF4_HUMAN	Decreases Expression	[47]
Nuclear factor erythroid 2-related factor 2 (NFE2L2)	OT0HENJ5	NF2L2_HUMAN	Increases Activity	[38]
Hsp90 co-chaperone Cdc37 (CDC37)	OTYDT4A7	CDC37_HUMAN	Increases Expression	[22]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Increases Expression	[63]
Hypoxia-inducible factor 1-alpha (HIF1A)	OTADSC03	HIF1A_HUMAN	Increases Expression	[64]
Carbonic anhydrase 9 (CA9)	OTNA51XT	CAH9_HUMAN	Decreases Expression	[64]
TIR domain-containing adapter molecule 2 (TICAM2)	OTK7GIJ5	TCAM2_HUMAN	Increases Expression	[10]
Cell division cycle and apoptosis regulator protein 1 (CCAR1)	OTUXLQZZ	CCAR1_HUMAN	Increases Expression	[65]
Ectodysplasin-A receptor-associated adapter protein (EDARADD)	OT0G52MC	EDAD_HUMAN	Increases Expression	[22]
DNA-binding death effector domain-containing protein 2 (DEDD2)	OT0WXRWT	DEDD2_HUMAN	Increases Expression	[12]
Heat shock protein 105 kDa (HSPH1)	OTVRR73T	HS105_HUMAN	Increases Expression	[26]
CREB-binding protein (CREBBP)	OTPA4QGM	CBP_HUMAN	Decreases Expression	[48]
Histone acetyltransferase KAT2B (KAT2B)	OTWQITWK	KAT2B_HUMAN	Decreases Expression	[10]
Bcl-2-like protein 2 (BCL2L2)	OTMKVO0J	B2CL2_HUMAN	Increases Expression	[66]
N-alpha-acetyltransferase 80 (NAA80)	OTLWR71Z	NAA80_HUMAN	Decreases Expression	[12]
MOB kinase activator 3A (MOB3A)	OTILIOXF	MOB3A_HUMAN	Decreases Expression	[12]
Baculoviral IAP repeat-containing protein 7 (BIRC7)	OTITCGHB	BIRC7_HUMAN	Decreases Expression	[67]
NACHT, LRR and PYD domains-containing protein 3 (NLRP3)	OTZM6MHU	NLRP3_HUMAN	Decreases Expression	[12]
Bcl-2-binding component 3, isoforms 3/4 (BBC3)	OTUAXDAY	BBC3B_HUMAN	Increases Expression	[68]
Tribbles homolog 3 (TRIB3)	OTG5OS7X	TRIB3_HUMAN	Increases Expression	[20]
Cell growth regulator with EF hand domain protein 1 (CGREF1)	OTBZQX97	CGRE1_HUMAN	Increases Expression	[22]
Myeloid differentiation primary response protein MyD88 (MYD88)	OTB4D6FL	MYD88_HUMAN	Decreases Expression	[10]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)	OTJGE772	CHAC1_HUMAN	Increases Expression	[31]
Fanconi anemia group D2 protein (FANCD2)	OTVEB5LF	FACD2_HUMAN	Decreases Expression	[69]
Eukaryotic translation initiation factor 2A (EIF2A)	OTWXELQP	EIF2A_HUMAN	Decreases Phosphorylation	[70]
DNA replication factor Cdt1 (CDT1)	OTVY53VG	CDT1_HUMAN	Decreases Expression	[12]
Interleukin-23 subunit alpha (IL23A)	OTYO99HC	IL23A_HUMAN	Increases Expression	[22]
Transcription factor 7-like 2 (TCF7L2)	OTVWPZ8B	TF7L2_HUMAN	Increases Expression	[22]
Diablo IAP-binding mitochondrial protein (DIABLO)	OTHJ9MCZ	DBLOH_HUMAN	Increases Expression	[48]
Sphingosine kinase 1 (SPHK1)	OTWYPBVD	SPHK1_HUMAN	Decreases Expression	[71]
Anaphase-promoting complex subunit 11 (ANAPC11)	OTK2SJXR	APC11_HUMAN	Decreases Expression	[12]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)	OT0DZGY4	E2AK3_HUMAN	Increases Phosphorylation	[31]
Lipid transferase CIDEB (CIDEB)	OT873IYM	CIDEB_HUMAN	Decreases Expression	[12]
Adenine DNA glycosylase (MUTYH)	OTXTKI7Q	MUTYH_HUMAN	Decreases Expression	[12]
Cell cycle progression protein 1 (CCPG1)	OT0IHDKL	CCPG1_HUMAN	Increases Expression	[10]
FAS-associated factor 1 (FAF1)	OTGAMLM4	FAF1_HUMAN	Increases Expression	[22]
Transcription factor 19 (TCF19)	OT7NKLF9	TCF19_HUMAN	Decreases Expression	[12]
Cyclic AMP-dependent transcription factor ATF-5 (ATF5)	OT03QCLM	ATF5_HUMAN	Increases Expression	[26]
Rho-related BTB domain-containing protein 2 (RHOBTB2)	OT2DATFX	RHBT2_HUMAN	Increases Response To Substance	[72]
Beclin-1 (BECN1)	OT4X293M	BECN1_HUMAN	Decreases Response To Substance	[73]
Palmitoyl thioesterase CPT1C (CPT1C)	OT8F1MBF	CPT1C_HUMAN	Increases Response To Substance	[72]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (ATP2A1)	OT959A3A	AT2A1_HUMAN	Affects Response To Substance	[74]
Histone deacetylase 6 (HDAC6)	OT9W9MXQ	HDAC6_HUMAN	Decreases Response To Substance	[75]
Serine/threonine-protein kinase 4 (STK4)	OTBRYNNH	STK4_HUMAN	Increases Response To Substance	[76]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Increases Response To Substance	[72]
Transcription factor SOX-8 (SOX8)	OTEJXYZM	SOX8_HUMAN	Increases Response To Substance	[72]
DNA repair endonuclease XPF (ERCC4)	OTFIOPG1	XPF_HUMAN	Increases Response To Substance	[72]
Polyunsaturated fatty acid lipoxygenase ALOX12 (ALOX12)	OTFL5KR5	LOX12_HUMAN	Increases Response To Substance	[72]
Heat shock protein beta-1 (HSPB1)	OTHFZ8ED	HSPB1_HUMAN	Decreases Response To Substance	[77]
Peroxisome proliferator-activated receptor delta (PPARD)	OTI4WTOP	PPARD_HUMAN	Increases Response To Substance	[72]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Increases Response To Substance	[72]
Unconventional myosin-Va (MYO5A)	OTMWLP3E	MYO5A_HUMAN	Increases Response To Substance	[72]
Proteasome subunit beta type-5 (PSMB5)	OTOZXAS6	PSB5_HUMAN	Decreases Response To Substance	[78]
Retinoblastoma-associated protein (RB1)	OTQJUJMZ	RB_HUMAN	Increases Response To Substance	[79]
Mannose-binding protein C (MBL2)	OTS63HG5	MBL2_HUMAN	Increases Response To Substance	[72]
Nucleophosmin (NPM1)	OTTBYYT0	NPM_HUMAN	Increases Response To Substance	[80]
BRCA1-associated RING domain protein 1 (BARD1)	OTTC0Z9Y	BARD1_HUMAN	Increases Response To Substance	[79]
General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3)	OTVAW3P1	ERCC3_HUMAN	Increases Response To Substance	[72]
Insulin-like growth factor 1 receptor (IGF1R)	OTXJIF13	IGF1R_HUMAN	Increases Response To Substance	[72]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)	OTY9R6FZ	ERN1_HUMAN	Decreases Response To Substance	[39]

Indication(s) of MK-4827

Disease Entry	ICD 11	Status	REF
Ovarian cancer	2C73	Phase 3	[5]
Breast cancer	2C60-2C65	Phase 2	[6]
Ewing sarcoma	2B52	Phase 1	[6]

MK-4827 Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Poly [ADP-ribose] polymerase (PARP)	TTEBCY8	NOUNIPROTAC	Modulator	[81]

MK-4827 Interacts with 3 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 1A1 (CYP1A1)	DE6OQ3W	CP1A1_HUMAN	Metabolism	[82]
Carboxylesterase 1 (CES1)	DEB30C5	EST1_HUMAN	Metabolism	[83]
Beta-glucuronidase (GUSB)	DEP54UE	BGLR_HUMAN	Metabolism	[83]

MK-4827 Interacts with 1 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Increases Expression	[84]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Adenocarcinoma	DCZ7PRA	CAOV3	Investigative	[1]
Adenocarcinoma	DCBEMGI	OVCAR3	Investigative	[1]
Adenocarcinoma	DCXG1XH	NCIH2122	Investigative	[1]
Adenocarcinoma	DC2KTZ8	NCIH23	Investigative	[1]
Adenocarcinoma	DCXLGL9	NCIH520	Investigative	[1]
Adenocarcinoma	DC9UUY5	COLO320DM	Investigative	[1]
Adenocarcinoma	DCTG1E3	SW-620	Investigative	[1]
Ewing sarcoma-peripheral primitive neuroectodermal tumour	DCWGFDK	ES2	Investigative	[1]
Malignant melanoma	DC1MOB9	RPMI7951	Investigative	[1]
Mesothelioma	DC7PA1E	MSTO	Investigative	[1]
Non small cell carcinoma	DCYID6P	SKMES1	Investigative	[1]
Prostate carcinoma	DCM8IQH	LNCAP	Investigative	[1]
Breast and ovarian cancer syndrome	DC2TGAA	UWB1289	Investigative	[85]
Breast and ovarian cancer syndrome	DCG57DL	UWB1289+BRCA1	Investigative	[85]
Breast carcinoma	DC0AGCJ	ZR751	Investigative	[85]
Breast carcinoma	DC3R9L4	KPL1	Investigative	[85]
Breast carcinoma	DCFCVHI	OCUBM	Investigative	[85]
Carcinoma	DCN1GAR	OV90	Investigative	[85]
Carcinoma	DCT2OFU	EFM192B	Investigative	[85]
Colon adenocarcinoma	DC333HS	LOVO	Investigative	[85]
Invasive ductal carcinoma	DCJL3TB	T-47D	Investigative	[85]
Rectal adenocarcinoma	DCYVMM0	SW837	Investigative	[85]

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