Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM29XGY)

• Drug Name: HMPL-004 Drug Info
• Synonyms: Nuclear factor kappa B inhibitor (oral, IBD/ulcerative colitis/Crohns disease), Hutchson Medipharma; TNF alpha ligand inhibitor (oral, IBD/ulcerative colitis/Crohns disease), Hutchson Medipharma; IL-1 beta modulator (oral, IBD/ulcerative colitis/Crohns disease), Hutchson Medipharma; IL-6 antagonist (oral, IBD/ulcerative colitis/Crohns disease), Hutchson Medipharma

Indication

Disease Entry	ICD 11	Status	REF
Inflammatory bowel disease	DD72	Phase 3	[1]

• Cross-matching ID:
  PubChem CID: 5318517
  TTD Drug ID: DM29XGY

Molecule-Related Drug Atlas

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[8]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[8]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[8]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[9]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[10]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[11]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[12]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[13]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[14]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[15]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[16]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[17]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[18]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[19]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[20]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[20]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[21]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[22]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[23]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[24]

Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[25]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[20]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[19]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[9]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[26]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[20]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[27]
Fluconazole	DMOWZ6B	Cryptococcal meningitis		Approved	[19]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[20]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[15]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[28]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[29]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[30]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[32]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[33]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[34]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]

Drug(s) Affected By Collagen alpha-1(III) chain (COL3A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[28]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[38]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[42]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[43]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[45]

Drug(s) Affected By Collagen alpha-2(I) chain (COL1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[47]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[48]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[53]

Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[59]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[60]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[62]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[61]

Drug(s) Affected By NF-kappa-B inhibitor epsilon (NFKBIE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Bortezomib	DMNO38U	Leukemia		Approved	[68]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[69]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[63]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[70]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[73]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[74]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[75]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[76]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]

Drug(s) Affected By Transcription factor MafG (MAFG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[80]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[83]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[84]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[85]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[66]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]

Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[87]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[89]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[91]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[92]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[84]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[93]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[94]

Drug(s) Affected By Urokinase-type plasminogen activator (PLAU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[95]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[95]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[47]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[99]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[84]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[100]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[101]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[102]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[103]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[104]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Selenium	DM25CGV	N. A.	N. A.	Approved	[106]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[107]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[108]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[109]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]

Drug(s) Affected By Platelet-derived growth factor subunit B (PDGFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[80]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[111]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[112]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[113]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[116]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[117]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[15]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[118]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[119]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[121]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[122]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[123]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[124]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[125]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[127]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[128]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[129]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[130]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[131]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[132]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[133]

Drug(s) Affected By Endothelin-1 (EDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[141]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[142]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[143]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[144]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[145]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[146]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[147]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[108]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[149]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[151]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]

Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[153]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[98]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[154]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[155]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[60]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[85]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Selenium	DM25CGV	N. A.	N. A.	Approved	[158]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[161]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[162]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[163]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[99]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[164]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[165]

Drug(s) Affected By Matrilysin (MMP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[168]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[66]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[170]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[171]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[172]

Drug(s) Affected By Growth-regulated alpha protein (CXCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[173]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Selenium	DM25CGV	N. A.	N. A.	Approved	[175]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[96]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[176]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[177]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[178]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[177]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[179]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[182]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[183]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[184]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[185]
Selenium	DM25CGV	N. A.	N. A.	Approved	[186]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[187]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[188]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[173]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[189]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[73]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[191]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[192]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[191]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[193]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[194]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[196]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[197]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[198]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[199]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[15]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[173]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[200]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[201]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[202]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[203]

Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[204]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[205]
Selenium	DM25CGV	N. A.	N. A.	Approved	[106]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[206]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[207]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[208]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]

Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[173]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[103]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[209]
Selenium	DM25CGV	N. A.	N. A.	Approved	[106]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[210]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[211]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[212]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[213]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[214]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[30]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[215]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[216]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[217]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[218]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[219]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[47]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[220]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[87]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[221]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[222]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[121]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[223]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[187]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[224]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[225]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[226]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[87]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[227]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[222]
Selenium	DM25CGV	N. A.	N. A.	Approved	[158]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[228]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[193]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[229]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[230]

Drug(s) Affected By Beta-1,4-galactosyltransferase 1 (B4GALT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[231]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[232]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[233]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[53]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[234]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[234]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[234]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[85]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[80]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[236]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[237]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[238]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[239]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[240]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[241]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[176]

Drug(s) Affected By Platelet endothelial cell adhesion molecule (PECAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[242]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[227]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[243]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[42]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[244]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[245]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[246]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[247]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[248]

Drug(s) Affected By Vascular endothelial growth factor receptor 1 (FLT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[47]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[250]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Haloperidol	DM96SE0	Delirium		Approved	[251]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[252]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[233]

Drug(s) Affected By Cadherin-2 (CDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[253]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[47]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[254]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[244]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[255]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[256]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[257]

Drug(s) Affected By C-X-C motif chemokine 2 (CXCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[173]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Selenium	DM25CGV	N. A.	N. A.	Approved	[175]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[98]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[178]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[168]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[258]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[135]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[259]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[260]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[103]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[211]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[149]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[261]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[213]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[262]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[263]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[173]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[263]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[264]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[265]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[263]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[266]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[267]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[203]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[268]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[269]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[147]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[270]
Selenium	DM25CGV	N. A.	N. A.	Approved	[153]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[107]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[271]

Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[173]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[272]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[211]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[192]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[273]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[274]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[275]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[276]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[277]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[260]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[272]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[278]
Selenium	DM25CGV	N. A.	N. A.	Approved	[106]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[192]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[279]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[207]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[30]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[73]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[280]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[281]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[282]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[283]
Fructose	DM43AN2	Vomiting	MD90	Approved	[284]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[155]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[285]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[286]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[282]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[162]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[287]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[288]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[289]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[256]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[290]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[291]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[102]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[292]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[293]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[294]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[295]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[261]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]

Drug(s) Affected By Vascular endothelial growth factor receptor 2 (KDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[296]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[243]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[297]
Haloperidol	DM96SE0	Delirium		Approved	[251]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[232]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[251]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[298]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[299]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[300]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[301]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[302]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[71]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[147]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[74]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[303]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[192]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[304]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[15]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[305]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[306]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[307]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[308]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[309]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[96]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[310]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[311]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[312]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[313]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[314]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[315]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[128]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[316]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[317]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[318]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[319]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[321]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[322]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[323]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[324]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[281]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[325]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[326]
Fructose	DM43AN2	Vomiting	MD90	Approved	[284]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[327]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[328]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[329]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[80]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[185]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[330]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[331]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[332]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[333]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[334]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[335]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[80]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[336]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[331]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[337]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[163]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[156]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[338]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[340]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[341]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[146]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[342]
Selenium	DM25CGV	N. A.	N. A.	Approved	[153]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[343]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[344]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[345]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[346]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[347]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[348]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[349]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[173]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[201]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[350]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[351]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[73]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[352]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[353]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[354]

Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[305]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[73]
Selenium	DM25CGV	N. A.	N. A.	Approved	[355]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[345]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[356]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[357]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[358]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[359]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[66]

Drug(s) Affected By Oxidized low-density lipoprotein receptor 1 (OLR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[168]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[231]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[360]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[361]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[362]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[30]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[30]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[363]

Drug(s) Affected By C-C motif chemokine 20 (CCL20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[173]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[184]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[178]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[364]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[178]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[231]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[84]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[365]

Drug(s) Affected By Antigen peptide transporter 1 (TAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Selenium	DM25CGV	N. A.	N. A.	Approved	[153]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[232]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[233]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 9 (TNFRSF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[30]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[366]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[367]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[368]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[66]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[233]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[298]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[369]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[196]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[321]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[173]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[200]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[30]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[350]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[147]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[212]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[192]

Drug(s) Affected By Metastasis-associated protein MTA1 (MTA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[370]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[42]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[371]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[362]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[372]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[321]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[322]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[73]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[356]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[155]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[373]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[265]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[118]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[374]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[375]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[376]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[377]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[75]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[378]

Drug(s) Affected By Histone deacetylase 1 (HDAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[379]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[42]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[380]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[381]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[382]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[383]

Drug(s) Affected By Kelch-like ECH-associated protein 1 (KEAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[384]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[385]
Selenium	DM25CGV	N. A.	N. A.	Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[378]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[386]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[85]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[85]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[387]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[388]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[389]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[390]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[305]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[323]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[391]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[73]
Selenium	DM25CGV	N. A.	N. A.	Approved	[153]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[353]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[392]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[393]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[394]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[394]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[395]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[396]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[214]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[282]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[397]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[398]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[399]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[321]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[305]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[400]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[401]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[402]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[356]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[403]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[404]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[405]

Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[73]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[75]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[406]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[407]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[213]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[408]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[409]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[410]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[411]

Drug(s) Affected By Tribbles homolog 3 (TRIB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[412]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[155]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[156]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[338]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[413]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[414]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[60]

Drug(s) Affected By Sulfiredoxin-1 (SRXN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[80]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[415]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[85]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[84]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[85]

Drug(s) Affected By Egl nine homolog 1 (EGLN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[416]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[231]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[232]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[417]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[156]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[418]

Drug(s) Affected By Prolyl hydroxylase EGLN3 (EGLN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[419]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[420]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[421]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[422]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[66]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[423]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[424]

Drug(s) Affected By 5'-AMP-activated protein kinase subunit gamma-2 (PRKAG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[425]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[52]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[53]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[426]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[427]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[428]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[423]

Drug(s) Affected By Dual specificity protein phosphatase 10 (DUSP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[102]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[429]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[177]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[155]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[177]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[47]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[414]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[231]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[84]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Inflammation pathogenesis (IP)	TTBD054	NOUNIPROTAC	Antagonist	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
5'-AMP-activated protein kinase subunit gamma-2 (PRKAG2)	OTHTAM54	AAKG2_HUMAN	Gene/Protein Processing	[3]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[4]
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Gene/Protein Processing	[5]
Amino acid transporter heavy chain SLC3A2 (SLC3A2)	OTBR33M9	4F2_HUMAN	Gene/Protein Processing	[3]
AN1-type zinc finger protein 2A	OTTG7P8R	ZFN2A_HUMAN	Gene/Protein Processing	[3]
Antigen peptide transporter 1 (TAP1)	OTJL27PW	TAP1_HUMAN	Gene/Protein Processing	[3]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[6]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[7]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Gene/Protein Processing	[3]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[7]

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