Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM78IME)

Drug Name
Ergotidine Drug Info
Synonyms
Eramin; Ergamine; Histamine; Histaminum; Istamina; Theramine; Free histamine; Histamine Base; Histamine [USAN]; Istamina [Italian]; H7125_SIGMA; [3H]histamine; ALBB-005968; Beta-Aminoethylglyoxaline; Beta-Aminoethylimidazole; Beta-aminothethylglyoxaline; Histamine (DCF); Histamine, Free Base; Histaminum (TN); L-histamine; ZERO/004089; Imidazole-4-ethylamine; Beta-Imidazolyl-4-ethylamine; F411C768-A159-4FC0-A195-291A08BB03AA; 1H-Imidazole-4-ethanamine; 1H-Imidazole-5-ethanamine; 2-(1H-Imidazol-4-yl)ethanamine; 2-(1H-imidazol-4-yl)ethan-1-amine; 2-(1H-imidazol-5-yl)ethanamine; 2-(3H-Imidazol-4-yl)-ethylamine; 2-(4-Imidazolyl)ethylamine; 2-Imidazol-4-ylethylamine; 2-[4-Imidazolyl]ethylamine; 4-(2-Aminoethyl)-1H-imidazole; 4-Imidazoleethylamine; 5-Imidazoleethylamine
Indication
Disease Entry ICD 11 Status REF
Osteoarthritis FA00-FA05 Approved [1]
Respiratory allergy 4A80 Approved [2]
Therapeutic Class
Antiallergic Agents
Cross-matching ID
PubChem CID
774
ChEBI ID
CHEBI:18295
CAS Number
CAS 51-45-6
TTD Drug ID
DM78IME
VARIDT Drug ID
DR00081
INTEDE Drug ID
DR0810

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Histamine H1 receptor (H1R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [22]
Azelastine DMXTMBJ Allergic conjunctivitis 9A60.02 Approved [23]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [24]
Cinnarizine DM7U5QJ Meniere disease AB31.0 Approved [25]
Diphenhydramine DMKQTBA Hyperemesis gravidarum Approved [23]
Doxepin DMPI98T Anxiety Approved [26]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [23]
Epinastine DMX0K3Q Allergic conjunctivitis 9A60.02 Approved [27]
Desloratadine DM56YN7 Allergic rhinitis CA08.0 Approved [28]
Tranilast DME5Y64 Allergic rhinitis CA08.0 Approved [29]
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Drug(s) Transported By Organic cation transporter 2 (SLC22A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [31]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [32]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [33]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [7]
Propranolol DM79NTF Angina pectoris BA40 Approved [34]
Metformin DM89QE1 Colorectal carcinoma Approved [35]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [34]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [36]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [37]
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Drug(s) Transported By Organic cation transporter 3 (SLC22A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Propranolol DM79NTF Angina pectoris BA40 Approved [34]
Metformin DM89QE1 Colorectal carcinoma Approved [38]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [34]
Entecavir DM7VTQO Hepatitis B virus infection 1E51.0 Approved [39]
Epinephrine DM3KJBC Acute asthma CA23 Approved [7]
Norepinephrine DMOUC09 Alopecia ED70 Approved [7]
Amphetamine DMSZQAK Attention deficit hyperactivity disorder 6A05.Z Approved [40]
Acetylcholine DMDF79Z Cataract 9B10 Approved [41]
Sodium chloride DMM3950 Skin burns ME65.0 Approved [42]
Etilefrine DM67PWD Cardiovascular disease BA00-BE2Z Withdrawn from market [43]
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Drug(s) Transported By Vesicular amine transporter 2 (SLC18A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [44]
Norepinephrine DMOUC09 Alopecia ED70 Approved [44]
Methamphetamine DMPM4SK Anxiety Approved [45]
SEROTONIN DMOFCRY Discovery agent N.A. Investigative [44]
Drug(s) Transported By Vesicular amine transporter 1 (SLC18A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [44]
Norepinephrine DMOUC09 Alopecia ED70 Approved [44]
SEROTONIN DMOFCRY Discovery agent N.A. Investigative [44]
Drug(s) Transported By Equilibrative nucleoside transporter 4 (SLC29A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metformin DM89QE1 Colorectal carcinoma Approved [46]
SEROTONIN DMOFCRY Discovery agent N.A. Investigative [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [94]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [95]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [83]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [96]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [97]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [98]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [99]
Epinephrine DM3KJBC Acute asthma CA23 Approved [20]
Norepinephrine DMOUC09 Alopecia ED70 Approved [20]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [48]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [49]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [50]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [51]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [52]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [53]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [54]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [55]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [49]
Verapamil DMA7PEW Angina pectoris BA40 Approved [56]
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Drug(s) Metabolized By Thiopurine methyltransferase (TPMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [57]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [58]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [59]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [60]
Vitamin C DMXJ7O8 Adenocarcinoma 2D40 Approved [61]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [62]
Epinephrine DM3KJBC Acute asthma CA23 Approved [63]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [64]
Thioguanine DM7NKEV Acute lymphocytic leukaemia 2B33.3 Approved [65]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [66]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [67]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [68]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [69]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [70]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [71]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [70]
Verapamil DMA7PEW Angina pectoris BA40 Approved [72]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [73]
Estrone DM5T6US Acne vulgaris ED80 Approved [74]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
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Drug(s) Metabolized By Amiloride-sensitive amine oxidase (AOC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Putrescine DMWE6V1 Burn and burn infection ND90-NE2Z Discontinued in Phase 2 [76]
Drug(s) Affected By Histamine N-methyltransferase (HNMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Panobinostat DM58WKG Chronic graft versus host disease Approved [80]
Testosterone DM7HUNW Hot flushes GA30 Approved [81]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [83]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [84]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [85]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [86]
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Drug(s) Affected By Synaptic vesicular amine transporter (SLC18A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Norepinephrine DMOUC09 Alopecia ED70 Approved [87]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [87]
Methamphetamine DMPM4SK Anxiety Approved [88]
Haloperidol DM96SE0 Delirium Approved [89]
Leflunomide DMR8ONJ Arthritis FA20 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [83]
Dextroamphetamine DMMIHVP Attention deficit hyperactivity disorder 6A05.Z Approved [89]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [91]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [92]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [93]
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Drug(s) Affected By Solute carrier family 22 member 3 (SLC22A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Epinephrine DM3KJBC Acute asthma CA23 Approved [20]
Norepinephrine DMOUC09 Alopecia ED70 Approved [20]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Phenoxybenzamine DM8KSQH Malignant essential hypertension BA00 Approved [101]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [102]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [103]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [104]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [105]
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Drug(s) Affected By Cytosolic phospholipase A2 (PLA2G4A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [106]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [107]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [108]
Panobinostat DM58WKG Chronic graft versus host disease Approved [80]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Capsaicin DMGMF6V Back pain ME84.Z Approved [110]
Budesonide DMJIBAW Allergic rhinitis CA08.0 Approved [111]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [112]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [105]
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Drug(s) Affected By Beta-glucuronidase (GUSB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [113]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [83]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [114]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [115]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [85]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [116]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [102]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [117]
Paclitaxel DMLB81S Breast carcinoma Approved [117]
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Drug(s) Affected By Calcium-activated chloride channel regulator 1 (CLCA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [118]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [119]
Drug(s) Affected By Interferon gamma (IFNG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [120]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [121]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [122]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [123]
Methotrexate DM2TEOL Anterior urethra cancer Approved [124]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [125]
Quercetin DM3NC4M Obesity 5B81 Approved [126]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [127]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [128]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [129]
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Drug(s) Affected By Interstitial collagenase (MMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [130]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [131]
Etretinate DM2CZFA Keratosis ED56 Approved [132]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [133]
Methotrexate DM2TEOL Anterior urethra cancer Approved [134]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [135]
Quercetin DM3NC4M Obesity 5B81 Approved [136]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [137]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [139]
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Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor (CSF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [140]
Quercetin DM3NC4M Obesity 5B81 Approved [141]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [142]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [143]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [144]
Testosterone DM7HUNW Hot flushes GA30 Approved [81]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [145]
Acetylcholine DMDF79Z Cataract 9B10 Approved [146]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [147]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [97]
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Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [148]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [149]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [150]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [151]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [152]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [153]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [154]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [155]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [156]
Methotrexate DM2TEOL Anterior urethra cancer Approved [148]
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Drug(s) Affected By Beta-2 adrenergic receptor (ADRB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salmeterol DMIEU69 Allergic asthma CA23.0 Approved [157]
Bambuterol DMKLSHF Asthma CA23 Approved [158]
Terbutaline DMD4381 Asthma CA23 Approved [159]
Salbutamol DMN9CWF Acute asthma CA23 Approved [160]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [161]
Methotrexate DM2TEOL Anterior urethra cancer Approved [162]
Epinephrine DM3KJBC Acute asthma CA23 Approved [163]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [165]
Propranolol DM79NTF Angina pectoris BA40 Approved [166]
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Drug(s) Affected By Monocyte differentiation antigen CD14 (CD14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [167]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [168]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [169]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [171]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [172]
Testosterone DM7HUNW Hot flushes GA30 Approved [173]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [174]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [175]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [176]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [177]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [178]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [151]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [179]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [153]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [180]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [181]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [182]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [180]
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Drug(s) Affected By Tissue factor (F3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [183]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [184]
Methotrexate DM2TEOL Anterior urethra cancer Approved [185]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [186]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [187]
Quercetin DM3NC4M Obesity 5B81 Approved [188]
Fructose DM43AN2 Vomiting MD90 Approved [189]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [190]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [184]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [191]
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Drug(s) Affected By Cyclic AMP-responsive element-binding protein 1 (CREB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [192]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [193]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [194]
Selenium DM25CGV N. A. N. A. Approved [77]
Methotrexate DM2TEOL Anterior urethra cancer Approved [195]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [196]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [197]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [197]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [198]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [199]
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Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [200]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [201]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [167]
Gefitinib DM15F0X Colon adenocarcinoma Approved [202]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [203]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [204]
Methotrexate DM2TEOL Anterior urethra cancer Approved [205]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [206]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [207]
Quercetin DM3NC4M Obesity 5B81 Approved [208]
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Drug(s) Affected By Histamine H2 receptor (HRH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [209]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [83]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [116]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [210]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [119]
[3H]cAMP DMZRQU7 Discovery agent N.A. Investigative [211]
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Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [212]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [213]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [214]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [153]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [215]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [216]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [217]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [218]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [219]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [220]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [221]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [193]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [222]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [223]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [224]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [225]
Gefitinib DM15F0X Colon adenocarcinoma Approved [226]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [227]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [228]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [229]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [221]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [230]
Paclitaxel DMLB81S Breast carcinoma Approved [231]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [232]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [220]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [212]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [214]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [222]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [223]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-12 subunit alpha (IL12A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [233]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [127]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [234]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [235]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [112]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [236]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [237]
Arsenic DMTL2Y1 N. A. N. A. Approved [238]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [239]
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Drug(s) Affected By Interleukin-12 subunit beta (IL12B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [121]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [127]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [234]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [240]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [241]
Capsaicin DMGMF6V Back pain ME84.Z Approved [242]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [243]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [244]
Bryostatin-1 DM1JOXY Alzheimer disease 8A20 Phase 2 [245]
RGI-2001 DM4AC2F Graft-versus-host disease 4B24 Phase 2 [246]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [116]
Indomethacin DMSC4A7 Bursitis Approved [205]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [247]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [248]
Methotrexate DM2TEOL Anterior urethra cancer Approved [134]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [249]
Quercetin DM3NC4M Obesity 5B81 Approved [250]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [142]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [251]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [252]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Signal transducer and activator of transcription 6 (STAT6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [214]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [253]
Methotrexate DM2TEOL Anterior urethra cancer Approved [162]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [254]
Panobinostat DM58WKG Chronic graft versus host disease Approved [80]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [255]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [83]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [114]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [112]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [105]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aquaporin-5 (AQP5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [256]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [257]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [83]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [120]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [239]
Carbachol DMX9K8F Glaucoma/ocular hypertension 9C61 Approved [258]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [119]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [259]
Milchsaure DM462BT Pruritus EC90 Investigative [260]
cordycepin DM72Y01 Discovery agent N.A. Investigative [256]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mucin-5AC (MUC5AC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [261]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [262]
Selenium DM25CGV N. A. N. A. Approved [263]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [261]
Capsaicin DMGMF6V Back pain ME84.Z Approved [264]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [261]
Dihydroxyacetone DMM1LG2 Sunburn EJ40 Approved [265]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [261]
Bleomycin DMNER5S Cervical cancer 2C77.0 Approved [266]
Arsenic DMTL2Y1 N. A. N. A. Approved [267]
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Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [214]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [268]
Selenium DM25CGV N. A. N. A. Approved [77]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [269]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [207]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [219]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [270]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [271]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [272]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [139]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [273]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [274]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [275]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [97]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [98]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [276]
Roflumilast DMPGHY8 Asthma CA23 Approved [277]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pro-interleukin-16 (IL16)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [124]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [257]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [83]
Ethanol DMDRQZU Chronic pain MG30 Approved [240]
Menthol DMG2KW7 Back pain ME84.Z Approved [278]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [279]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [236]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [280]
Arsenic DMTL2Y1 N. A. N. A. Approved [238]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-18 (IL18)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [214]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [203]
Methotrexate DM2TEOL Anterior urethra cancer Approved [124]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [281]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [282]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [209]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [283]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [284]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [283]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase STK11 (STK11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [285]
Selenium DM25CGV N. A. N. A. Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [83]
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [286]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [287]
Arsenic DMTL2Y1 N. A. N. A. Approved [288]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [289]
APR-246 DMNFADH Ovarian cancer 2C73 Phase 2 [290]
GDC-0980/RG7422 DMF3MV1 Non-hodgkin lymphoma 2B33.5 Phase 2 [291]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [292]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histamine H4 receptor (HRH4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [162]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [293]
Clobenpropit DM537OH Discovery agent N.A. Investigative [294]
5'-Guanosine-Diphosphate-Monothiophosphate DMIARG7 Discovery agent N.A. Investigative [295]
Drug(s) Affected By Leukotriene C4 synthase (LTC4S)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [296]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [297]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [83]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [298]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [299]
Pranlukast DMYHDCA Allergic rhinitis CA08.0 Approved [300]
Etazolate DMOCID7 Neurodegenerative disorder 8A20-8A23 Phase 2 [301]
PMID28870136-Compound-48 DMPIM9L N. A. N. A. Patented [301]
Forskolin DM6ITNG Solid tumour/cancer 2A00-2F9Z Investigative [301]
ROLIPRAM DMJ03UM Discovery agent N.A. Investigative [301]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [83]
Arsenic DMTL2Y1 N. A. N. A. Approved [267]
Diphenylpyraline DMW4X37 Allergic rhinitis CA08.0 Approved [302]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [296]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [119]
Butanoic Acid DMTAJP7 Discovery agent N.A. Investigative [303]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Protachykinin-1 (TAC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [304]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [154]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [305]
Fluphenazine DMIT8LX Psychotic disorder 6A20-6A25 Approved [306]
Panobinostat DM58WKG Chronic graft versus host disease Approved [80]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Nizatidine DMGFV3Z Acid-reflux disorder DA22 Approved [304]
Capsaicin DMGMF6V Back pain ME84.Z Approved [307]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [105]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histamine H1 receptor (H1R) TTTIBOJ HRH1_HUMAN Agonist [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Equilibrative nucleoside transporter 4 (SLC29A4) DT3EAQP S29A4_HUMAN Substrate [4]
Vesicular amine transporter 2 (SLC18A2) DTT7VPB VMAT2_HUMAN Substrate [5]
Vesicular amine transporter 1 (SLC18A1) DTM953D VMAT1_HUMAN Substrate [6]
Organic cation transporter 3 (SLC22A3) DT6201N S22A3_HUMAN Substrate [7]
Organic cation transporter 2 (SLC22A2) DT9IDPW S22A2_HUMAN Substrate [8]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [9]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [9]
Thiopurine methyltransferase (TPMT) DEFQ8VO TPMT_HUMAN Substrate [10]
Histamine N-methyltransferase (HNMT) DE3PZ0I HNMT_HUMAN Substrate [11]
Amiloride-sensitive amine oxidase (AOC1) DETECWH AOC1_HUMAN Substrate [12]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B) OTOA8WU2 PDE4B_HUMAN Gene/Protein Processing [13]
Aquaporin-5 (AQP5) OT77GBY8 AQP5_HUMAN Gene/Protein Processing [14]
Beta-2 adrenergic receptor (ADRB2) OTSDOX4Q ADRB2_HUMAN Gene/Protein Processing [15]
Beta-glucuronidase (GUSB) OT9N1DK3 BGLR_HUMAN Gene/Protein Processing [16]
Calcium-activated chloride channel regulator 1 (CLCA1) OTL9LPSI CLCA1_HUMAN Gene/Protein Processing [17]
Cyclic AMP-responsive element-binding protein 1 (CREB1) OT1MDLA1 CREB1_HUMAN Post-Translational Modifications [14]
Cytosolic phospholipase A2 (PLA2G4A) OTE70SOT PA24A_HUMAN Gene/Protein Processing [18]
Dicarboxylate carrier SLC25A8 OTA556MK UCP2_HUMAN Regulation of Drug Effects [19]
Equilibrative nucleoside transporter 4 (SLC29A4) OTWTZXMX S29A4_HUMAN Regulation of Drug Effects [20]
Granulocyte-macrophage colony-stimulating factor (CSF2) OT1M7D28 CSF2_HUMAN Gene/Protein Processing [21]

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