Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8MNVO)

Drug Name
Tolcapone Drug Info
Synonyms
Tasmar; Roche brand of tolcapone; Ro 40-7592; Tasmar (TN); Tolcapone [USAN:INN]; Ro-40-7592; Tolcapone (JAN/USAN/INN); Methanone,(3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl); (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone; (3,4-dihydroxy-5-nitrophenyl)-(4-methylphenyl)methanone; 3,4-Dihydroxy-4'-methyl-5-nitrobenzophenone; 3,4-dihydroxy-5'-methyl-5-nitrobenzophenone
Indication
Disease Entry ICD 11 Status REF
Parkinson disease 8A00.0 Approved [1]
Therapeutic Class
Antiparkinson Agents
Cross-matching ID
PubChem CID
4659569
ChEBI ID
CHEMBL63630
CAS Number
CAS 134308-13-7
TTD Drug ID
DM8MNVO
ACDINA Drug ID
D00686

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Preclinical Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Catechol-O-methyl-transferase (COMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Entacapone DMLBVKQ Parkinson disease 8A00.0 Approved [7]
Opicapone DM1BKA6 Parkinson disease 8A00.0 Approved [8]
BIA 3-202 DMG3ON2 Parkinson disease 8A00.0 Phase 2 [9]
CGP-28014 DMYNTQV Major depressive disorder 6A70.3 Phase 2 [10]
Nitecapone DMSJYEX Pain MG30-MG3Z Discontinued in Phase 2 [11]
PGX-200097 DM1A2UI Schizophrenia 6A20 Preclinical [12]
1-(3,4-dihydroxy-5-nitrophenyl)-2-phenoxyethanone DMKI719 Discovery agent N.A. Investigative [13]
7,8-dihydroxy-4-phenyl-2H-chromen-2-one DMUB5E8 Discovery agent N.A. Investigative [14]
3,5-Dinitrocatechol DMBGSHD Discovery agent N.A. Investigative [15]
1-(3,4-dihydroxy-2-nitrophenyl)-2-phenylethanone DM9M5D1 Discovery agent N.A. Investigative [16]
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Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [4]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [17]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [17]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [18]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [4]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [17]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [19]
Gefitinib DM15F0X Colon adenocarcinoma Approved [4]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [20]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [4]
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Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [21]
Selenium DM25CGV N. A. N. A. Approved [22]
Methotrexate DM2TEOL Anterior urethra cancer Approved [23]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [24]
Epinephrine DM3KJBC Acute asthma CA23 Approved [25]
Quercetin DM3NC4M Obesity 5B81 Approved [26]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [27]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [28]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [29]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [30]
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Drug(s) Affected By Lipid transferase CIDEA (CIDEA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [31]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [32]
Menthol DMG2KW7 Back pain ME84.Z Approved [33]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [34]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [35]
Arsenic DMTL2Y1 N. A. N. A. Approved [36]
PF-02545920 DMJPE61 Huntington disease 8A01.10 Phase 2 [37]
Delphinidin DMS2WIN Cardiovascular disease BA00-BE2Z Phase 2 [38]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [39]
Milchsaure DM462BT Pruritus EC90 Investigative [40]
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Drug(s) Affected By Long-chain-fatty-acid--CoA ligase 1 (ACSL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [41]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [28]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Panobinostat DM58WKG Chronic graft versus host disease Approved [44]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [45]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [46]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [46]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [46]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [47]
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Drug(s) Affected By Microsomal triglyceride transfer protein large subunit (MTTP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [48]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [48]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [49]
Quercetin DM3NC4M Obesity 5B81 Approved [50]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [48]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [48]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [49]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [47]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [51]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
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Drug(s) Affected By Long-chain-fatty-acid--CoA ligase 5 (ACSL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [50]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [28]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [31]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [47]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [53]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [54]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [55]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [56]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [57]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [58]
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Drug(s) Affected By Proepiregulin (EREG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [59]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [3]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [3]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [3]
Methotrexate DM2TEOL Anterior urethra cancer Approved [60]
Quercetin DM3NC4M Obesity 5B81 Approved [50]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [61]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [62]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [3]
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Drug(s) Affected By Antileukoproteinase (SLPI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [3]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [3]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [3]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [3]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [3]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [3]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [63]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [3]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [3]
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Drug(s) Affected By Hepatocyte growth factor receptor (MET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cabozantinib DMIYDT4 Medullary thyroid gland carcinoma Approved [64]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [65]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [3]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [3]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [3]
Methotrexate DM2TEOL Anterior urethra cancer Approved [23]
Quercetin DM3NC4M Obesity 5B81 Approved [50]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [3]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [66]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [23]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [67]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [68]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [69]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [70]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [71]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [72]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [3]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [74]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Catechol-O-methyl-transferase (COMT) TTKWFB8 COMT_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Antileukoproteinase (SLPI) OTUNFUU8 SLPI_HUMAN Gene/Protein Processing [3]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [4]
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Gene/Protein Processing [3]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [3]
Lipid transferase CIDEA (CIDEA) OTDUTSOV CIDEA_HUMAN Gene/Protein Processing [5]
Long-chain-fatty-acid--CoA ligase 1 (ACSL1) OTB06ESI ACSL1_HUMAN Gene/Protein Processing [5]
Long-chain-fatty-acid--CoA ligase 5 (ACSL5) OT3L9XO3 ACSL5_HUMAN Gene/Protein Processing [5]
Microsomal triglyceride transfer protein large subunit (MTTP) OTNUVSDT MTP_HUMAN Gene/Protein Processing [5]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Gene/Protein Processing [3]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Gene/Protein Processing [6]

References

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5 Effect of the Catechol-O-Methyltransferase Inhibitors Tolcapone and Entacapone on Fatty Acid Metabolism in HepaRG Cells. Toxicol Sci. 2018 Aug 1;164(2):477-488.
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31 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
32 Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
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34 Dexamethasone and the inflammatory response in explants of human omental adipose tissue. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):292-8.
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37 A novel thermoregulatory role for PDE10A in mouse and human adipocytes. EMBO Mol Med. 2016 Jul 1;8(7):796-812. doi: 10.15252/emmm.201506085. Print 2016 Jul.
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39 Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
40 Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
41 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
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57 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
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59 Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
60 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
61 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
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64 ROS-dependent DNA damage contributes to crizotinib-induced hepatotoxicity via the apoptotic pathway. Toxicol Appl Pharmacol. 2019 Nov 15;383:114768. doi: 10.1016/j.taap.2019.114768. Epub 2019 Oct 19.
65 Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification. Mol Cancer Ther. 2012 Jul;11(7):1557-64. doi: 10.1158/1535-7163.MCT-11-0934. Epub 2012 Jun 22.
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67 Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro. Chem Biol Interact. 2018 Aug 1;291:237-244.
68 Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1 or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling. Arch Oral Biol. 2012 May;57(5):483-90. doi: 10.1016/j.archoralbio.2011.10.007. Epub 2011 Nov 25.
69 Ca(2+) Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2. Int J Mol Sci. 2018 Sep 19;19(9):2829. doi: 10.3390/ijms19092829.
70 Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
71 Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
72 ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
73 Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
74 Nitric oxide synthase inhibitors attenuate ozone-induced airway inflammation in guinea pigs. Possible role of interleukin-8. Am J Respir Crit Care Med. 2000 Jan;161(1):249-56. doi: 10.1164/ajrccm.161.1.9804096.