Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFJZK3)

• Drug Name: Arecoline Drug Info
• Synonyms: arecoline; Arecholine; Arecaline; 63-75-2; Methylarecaiden; Methylarecaidin; Arecolin; Arekolin; Arecoline base; Arecaidine methyl ester; Arecholin; methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester; Methyl N-methyltetrahydronicotinate; C8H13NO2; N-Methyltetrahydronicotinic acid, methyl ester; Methyl 1,2,5,6-tetrahydro-1-methylnicotinate; UNII-4ALN5933BH; NSC 56321; Methyl N-methyl-1,2,5,6-tetrahydronicotinate; CCRIS 7688

Indication

Disease Entry	ICD 11	Status	REF
Parkinson disease	8A00.0	Phase 1	[1]

• Cross-matching ID:
  PubChem CID: 2230
  ChEBI ID: CHEMBL7303
  CAS Number: CAS 63-75-2
  TTD Drug ID: DMFJZK3

Molecule-Related Drug Atlas

Drug(s) Targeting Muscarinic acetylcholine receptor M1 (CHRM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ACECLIDINE	DMOLNCZ	Glaucoma/ocular hypertension	9C61	Approved	[6]
Fesoterodine fumarate	DM13495	Overactive bladder	GC50.0	Approved	[7]
SMT-D002	DM1I93C	Seborrhea	ED91.2	Approved	[8]
Clidinium	DMUMQZ0	Abdominal stomach pain	DD91.4	Approved	[9]
Trihexyphenidyl	DMB19L8	Dystonia	8A02	Approved	[10]
Oxyphenonium	DMMQHOZ	Visceral spasms	MD81.4	Approved	[11]
Benztropine	DMGZOVN	Parkinson disease	8A00.0	Approved	[12]
Glycopyrrolate	DM2M3ZA	Anaesthesia	9A78.6	Approved	[13]
Pirenzepine	DMP6M1N	Peptic ulcer	DA61	Approved	[14]
Cycrimine	DM8C43Q	Parkinson disease	8A00.0	Approved	[15]

Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[16]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[17]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[18]
Selenium	DM25CGV	N. A.	N. A.	Approved	[19]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[18]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[20]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[24]

Drug(s) Affected By Fanconi anemia group G protein (FANCG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[25]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[27]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[28]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[33]

Drug(s) Affected By Eukaryotic translation elongation factor 1 epsilon-1 (EEF1E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[35]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[36]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[37]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[39]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[40]

Drug(s) Affected By Cell cycle checkpoint protein RAD1 (RAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[46]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[47]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[48]

Drug(s) Affected By Aldo-keto reductase family 1 member A1 (AKR1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[49]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[53]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[51]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[49]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[54]

Drug(s) Affected By General transcription and DNA repair factor IIH helicase subunit XPD (ERCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[57]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[60]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]

Drug(s) Affected By DNA repair nuclease/redox regulator APEX1 (APEX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[63]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[36]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[64]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[65]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]

Drug(s) Affected By DnaJ homolog subfamily A member 1 (DNAJA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[69]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[70]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[71]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]

Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[74]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[75]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[79]

Drug(s) Affected By 4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[81]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[82]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]

Drug(s) Affected By Cyclin-H (CCNH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[84]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[81]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[86]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[86]

Drug(s) Affected By Protein S100-A12 (S100A12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[88]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Miglitol	DMXBQAM	Diabetic complication	5A2Y	Approved	[91]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[93]
D-glucose	DMMG2TO	Discovery agent	N.A.	Investigative	[94]

Drug(s) Affected By Heat shock 70 kDa protein 14 (HSPA14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[31]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[37]

Drug(s) Affected By Chromatin assembly factor 1 subunit A (CHAF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[98]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[28]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[97]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[35]

Drug(s) Affected By Chromatin assembly factor 1 subunit B (CHAF1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[28]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[57]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[97]

Drug(s) Affected By General transcription factor IIH subunit 2 (GTF2H2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[54]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[101]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[102]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[103]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[93]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[31]

Drug(s) Affected By Structural maintenance of chromosomes protein 1A (SMC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[25]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[104]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[105]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[104]
Bortezomib	DMNO38U	Leukemia		Approved	[108]

Drug(s) Affected By General transcription factor IIH subunit 5 (GTF2H5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[86]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[86]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[111]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[112]

Drug(s) Affected By DNA repair protein RAD50 (RAD50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[115]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]

Drug(s) Affected By 5' exonuclease Apollo (DCLRE1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[117]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[118]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[119]

Drug(s) Affected By Cytochrome P450 26B1 (CYP26B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[120]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[123]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[124]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[125]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[126]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[118]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[127]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[129]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[97]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[130]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[132]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[56]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[133]

Drug(s) Affected By N-acetyltransferase 8 (NAT8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[126]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[135]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[39]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[29]

Drug(s) Affected By Leucine carboxyl methyltransferase 1 (LCMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[109]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[51]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[93]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[136]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[137]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[138]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[139]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[140]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[141]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[142]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[143]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[144]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[145]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[143]

Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[146]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[147]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[148]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[149]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[150]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[151]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[152]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[153]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[55]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[155]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[156]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[157]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[160]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[161]

Drug(s) Affected By Cadherin-2 (CDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[161]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[165]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[166]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[167]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[168]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[169]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[170]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[171]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[173]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[174]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[175]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[176]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[177]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[178]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[180]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[171]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[181]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[182]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[170]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[16]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[184]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[173]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[174]

Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[25]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[132]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[186]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[28]

Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[187]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[188]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[189]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[190]
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[191]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[28]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[192]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[28]

Drug(s) Affected By Collagen alpha-6(IV) chain (COL4A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[193]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[45]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[194]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[195]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[110]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Muscarinic acetylcholine receptor M1 (CHRM1)	TTZ9SOR	ACM1_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1)	OTNWHUJ1	AL9A1_HUMAN	Gene/Protein Processing	[3]
5' exonuclease Apollo (DCLRE1B)	OT2LFW7A	DCR1B_HUMAN	Gene/Protein Processing	[3]
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Gene/Protein Processing	[4]
Aldo-keto reductase family 1 member A1 (AKR1A1)	OTZT9NOW	AK1A1_HUMAN	Gene/Protein Processing	[3]
Breast cancer type 1 susceptibility protein (BRCA1)	OT5BN6VH	BRCA1_HUMAN	Gene/Protein Processing	[3]
C-C motif chemokine 5 (CCL5)	OTSCA5CK	CCL5_HUMAN	Protein Interaction/Cellular Processes	[5]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Gene/Protein Processing	[4]
Cadherin-2 (CDH2)	OTH0Y56P	CADH2_HUMAN	Gene/Protein Processing	[4]
Cell cycle checkpoint protein RAD1 (RAD1)	OT886MA8	RAD1_HUMAN	Gene/Protein Processing	[3]
Chromatin assembly factor 1 subunit A (CHAF1A)	OTXSSY4H	CAF1A_HUMAN	Gene/Protein Processing	[3]

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