Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFN58T)

Drug Name
ginsenoside Rg3 Drug Info
Synonyms (20S)-ginsenoside Rg3
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
9918693
ChEBI ID
CHEMBL67991
CAS Number
CAS 14197-60-5
TTD Drug ID
DMFN58T
INTEDE Drug ID
DR2671

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Voltage-gated potassium channel Kv11.1 (KCNH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
VESNARINONE DMBKX3C Cardiac failure BD10-BD13 Approved [6]
M100907 DM7ZFBA Sleep-wake disorder 7A00-7B2Z Phase 3 [7]
HP-184 DMNOMV2 Multiple sclerosis 8A40 Phase 2 [8]
NITD609 DMQHBSX Malaria 1F40-1F45 Phase 2 [9]
ABT-229 DMN3S1B Pain MG30-MG3Z Phase 2 [10]
ISOQUINE DMR17YI Malaria 1F40-1F45 Phase 1 [11]
Pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazine derivative 1 DMC8935 N. A. N. A. Patented [12]
Isoindoline derivative 5 DMIUTQW N. A. N. A. Patented [13]
Isoindoline derivative 3 DM2MYL9 N. A. N. A. Patented [13]
Isoindoline derivative 4 DMP1NKI N. A. N. A. Patented [13]
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Drug(s) Affected By CCN family member 1 (CCN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [14]
Methotrexate DM2TEOL Anterior urethra cancer Approved [15]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [16]
Quercetin DM3NC4M Obesity 5B81 Approved [17]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [18]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [15]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [20]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [21]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [22]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [23]
Gefitinib DM15F0X Colon adenocarcinoma Approved [24]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [25]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [26]
Etretinate DM2CZFA Keratosis ED56 Approved [27]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [28]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [29]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [30]
Quercetin DM3NC4M Obesity 5B81 Approved [31]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [32]
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Drug(s) Affected By Serine/threonine-protein kinase LATS1 (LATS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [33]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [34]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [35]
Leflunomide DMR8ONJ Arthritis FA20 Approved [36]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [37]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [39]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [40]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [41]
Napabucasin DMDZ6Q3 Colorectal cancer 2B91.Z Phase 3 [42]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [43]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [44]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [45]
Gefitinib DM15F0X Colon adenocarcinoma Approved [46]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Selenium DM25CGV N. A. N. A. Approved [48]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [49]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [50]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [51]
Methotrexate DM2TEOL Anterior urethra cancer Approved [52]
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Drug(s) Affected By Thy-1 membrane glycoprotein (THY1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [54]
Ethanol DMDRQZU Chronic pain MG30 Approved [55]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [56]
Paclitaxel DMLB81S Breast carcinoma Approved [57]
Bortezomib DMNO38U Leukemia Approved [58]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [59]
Arsenic DMTL2Y1 N. A. N. A. Approved [60]
Ximelegatran DMU8ANS Myocardial infarction BA41-BA43 Approved [61]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [62]
Gefitinib DM15F0X Colon adenocarcinoma Approved [63]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [26]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [65]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [66]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [65]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [67]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [68]
Methotrexate DM2TEOL Anterior urethra cancer Approved [69]
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Drug(s) Affected By Mast/stem cell growth factor receptor Kit (KIT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [70]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [72]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [73]
Panobinostat DM58WKG Chronic graft versus host disease Approved [74]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [76]
Ethanol DMDRQZU Chronic pain MG30 Approved [77]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [78]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [79]
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Drug(s) Affected By Epithelial cell adhesion molecule (EPCAM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [81]
Panobinostat DM58WKG Chronic graft versus host disease Approved [74]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [82]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [83]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [84]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [56]
Paclitaxel DMLB81S Breast carcinoma Approved [57]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [39]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [85]
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Drug(s) Affected By Alpha-(1,3)-fucosyltransferase 4 (FUT4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [86]
Panobinostat DM58WKG Chronic graft versus host disease Approved [74]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [87]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [22]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [84]
Ethanol DMDRQZU Chronic pain MG30 Approved [88]
Arsenic DMTL2Y1 N. A. N. A. Approved [89]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [90]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [91]
Urethane DM7NSI0 N. A. N. A. Phase 4 [92]
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Drug(s) Affected By CCN family member 2 (CCN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [62]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [93]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [94]
Quercetin DM3NC4M Obesity 5B81 Approved [17]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [15]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [34]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [97]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [98]
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Drug(s) Affected By Heat shock factor protein 1 (HSF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [99]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [100]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [100]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [101]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [102]
Ceftazidime DM41GRA Bacteremia 1A73 Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [100]
Ethacrynic acid DM60QMR Edema MG29 Approved [100]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [100]
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Drug(s) Affected By POU domain, class 5, transcription factor 1 (POU5F1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [103]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [104]
Quercetin DM3NC4M Obesity 5B81 Approved [105]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [106]
Panobinostat DM58WKG Chronic graft versus host disease Approved [74]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [34]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [107]
Testosterone DM7HUNW Hot flushes GA30 Approved [108]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [109]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [110]
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Drug(s) Affected By Serine/threonine-protein kinase 4 (STK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [111]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [112]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [113]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [39]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [114]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [115]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [41]
Bortezomib DMNO38U Leukemia Approved [116]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [117]
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Drug(s) Affected By Serine/threonine-protein kinase 3 (STK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [37]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [111]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [118]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [113]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [119]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [90]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [41]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [120]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [121]
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Drug(s) Affected By Homeobox protein NANOG (NANOG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [122]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [104]
Quercetin DM3NC4M Obesity 5B81 Approved [105]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [106]
Panobinostat DM58WKG Chronic graft versus host disease Approved [74]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [34]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [107]
Testosterone DM7HUNW Hot flushes GA30 Approved [108]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [111]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [123]
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Drug(s) Affected By Serine/threonine-protein kinase LATS2 (LATS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [103]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [20]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [124]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [37]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [111]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [39]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [40]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [125]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [103]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [126]
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Drug(s) Affected By Sal-like protein 4 (SALL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Lenalidomide DM6Q7U4 Adult T-cell leukemia/lymphoma Approved [127]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [127]
Testosterone DM7HUNW Hot flushes GA30 Approved [128]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [83]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [111]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [129]
Pomalidomide DMTGBAX Plasma cell myeloma 2A83.1 Approved [127]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [130]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [131]
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Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [132]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [132]
Gefitinib DM15F0X Colon adenocarcinoma Approved [133]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [134]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [135]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [104]
Methotrexate DM2TEOL Anterior urethra cancer Approved [136]
Quercetin DM3NC4M Obesity 5B81 Approved [137]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [138]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [139]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Voltage-gated potassium channel Kv11.1 (KCNH2) TTQ6VDM KCNH2_HUMAN Activator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Alpha-(1,3)-fucosyltransferase 4 (FUT4) OTIBXRTL FUT4_HUMAN Gene/Protein Processing [3]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [4]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Gene/Protein Processing [5]
CCN family member 1 (CCN1) OTKJBEMD CCN1_HUMAN Gene/Protein Processing [5]
CCN family member 2 (CCN2) OTC39NSU CCN2_HUMAN Gene/Protein Processing [5]
Epithelial cell adhesion molecule (EPCAM) OTHBZK5X EPCAM_HUMAN Gene/Protein Processing [5]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Gene/Protein Processing [3]
Homeobox protein NANOG (NANOG) OTUEY1FM NANOG_HUMAN Gene/Protein Processing [5]
Mast/stem cell growth factor receptor Kit (KIT) OTHUY3VZ KIT_HUMAN Gene/Protein Processing [5]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Gene/Protein Processing [5]

References

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2 Ginsenoside Rg(3) decelerates hERG K(+) channel deactivation through Ser631 residue interaction. Eur J Pharmacol. 2011 Aug 1;663(1-3):59-67.
3 Ginsenoside Rg3 induces FUT4-mediated apoptosis in H. pylori CagA-treated gastric cancer cells by regulating SP1 and HSF1 expressions. Toxicol In Vitro. 2016 Mar;31:158-66. doi: 10.1016/j.tiv.2015.09.025. Epub 2015 Sep 30.
4 [Ginsenoside Rg3 induces apoptosis of human lung squamous cell carcinoma SK-MES-1 cell line]. Nan Fang Yi Ke Da Xue Xue Bao. 2009 Sep;29(9):1823-6.
5 Ginsenoside Rg3 attenuates the osimertinib resistance by reducing the stemness of non-small cell lung cancer cells. Environ Toxicol. 2020 Jun;35(6):643-651. doi: 10.1002/tox.22899. Epub 2020 Jan 9.
6 Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2773-5.
7 Non-basic ligands for aminergic GPCRs: the discovery and development diaryl sulfones as selective, orally bioavailable 5-HT2A receptor antagonists ... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3708-12.
8 Emerging drugs for spinal cord injury. Expert Opin Emerg Drugs. 2008 Mar;13(1):63-80.
9 Spiroindolones, a potent compound class for the treatment of malaria. Science. 2010 Sep 3;329(5996):1175-80.
10 9-Dihydroerythromycin ethers as motilin agonists--developing structure-activity relationships for potency and safety. Bioorg Med Chem. 2010 Nov 1;18(21):7651-8.
11 Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for ... J Med Chem. 2009 Mar 12;52(5):1408-15.
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14 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
15 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
16 Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
17 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
18 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
19 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
20 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
21 Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3767-77.
22 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
23 mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
24 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
25 Assessment of the cytotoxic, genotoxic, and apoptotic potential of flurbiprofen in HeLa and HepG2 cell lines. J Biochem Mol Toxicol. 2021 Jun;35(6):1-11. doi: 10.1002/jbt.22770. Epub 2021 Mar 11.
26 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
27 Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
28 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
29 Apoptotic induction by simvastatin in human lung cancer A549 cells via Akt signaling dependent down-regulation of survivin. Invest New Drugs. 2011 Oct;29(5):945-52. doi: 10.1007/s10637-010-9450-2. Epub 2010 May 13.
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31 Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. Cancer Invest. 2009 Jul;27(6):604-12. doi: 10.1080/07357900802337191.
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33 Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
34 The antipsychotic chlorpromazine suppresses YAP signaling, stemness properties, and drug resistance in breast cancer cells. Chem Biol Interact. 2019 Apr 1;302:28-35. doi: 10.1016/j.cbi.2019.01.033. Epub 2019 Jan 28.
35 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
36 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
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